简介：

简介：Ourpreviousreportshaveshownthatlamininglycopeptides(LN-GPs),thetotalglycopeptidespreparedfromlaminin(LN),canpreventtheexperimentallungmetastasisandlivermetastasisofmousecancercells.Inordertoexploretheanti-metastaticmechanismofLN-GPs,westudiedtheeffectsofLN-GPsonmetastasisrelatedbehaviorsofcancercellsinvitro.LN-GPsdidnotaffectcellsurvival.However,LN-GPsinhibitedcellattachmentandspreadingofS180cellsonLN-andMatrigelsubstrateindose-dependentandtime-dependentmanners.Moreover,inhibitionofcellattachmentandspreadingonMatrigelsubstratesweremuchgreateronMatrigelsubstratethanonLNsubstrate.InthegresenceofLN-GPs,S180cellsonLNsubstratechangedfromaflattenedpolygonalshapetoaroundone,themigrationofS180cellsonLNsubstratedecreased,andthenumberofahighlyinvasivehumanpulmonarygiantcarcinomaPGcellsinvadingMatrigelfilterinaBoydenchamberwasreduced.LN-GPsthushavemultipleinhibitoryeffectsoncancermetastasisrelatedbehaviors.

简介：Currentlytheclinicalmanagementofbreastcancerreliesonrelativelyfewprognostic/predictiveclinicalmarkers(estrogenreceptor,progesteronereceptor,HER2),basedonprimarytumorbiology.Circulatingbiomarkers,suchascirculatingtumorDNA(ctDNA)orcirculatingtumorcells(CTCs)mayenhanceourtreatmentoptionsbyfocusingontheverycellsthatarethedirectprecursorsofdistantmetastaticdisease,andprobablyinherentlydifferentthantheprimarytumor'sbiology.Toshiftthecurrentclinicalparadigm,assessingtumorbiologyinrealtimebymolecularlyprofilingCTCsorctDNAmayservetodiscovertherapeutictargets,detectminimalresidualdiseaseandpredictresponsetotreatment.Thisreviewservestoelucidatethedetection,characterization,andclinicalapplicationofCTCsandctDNAwiththegoalofprecisiontreatmentofbreastcancer.

简介：Hepatoma房间(Hepg2s)在氢氧根上有教养的同样典型的癌症房间(哦)并且甲基(CH3)组表面被显示展出不同增长和词法变化。Hepg2s房间在上哦表面在CH3表面上比那些更快成长了。Hepg2s房间在上哦表面有更大的接触区域和更多的弄平的形态学，当那些在CH3表面上展出了更小的接触时，区域和更多绕行形态学。在7天文化以后，进CH3表面上的簇的Hepg2s房间的迁居在OH表面上比那慢显著地表现了。这些化学上修改的表面在增长，粘附，和移植上展出了Hepg2s房间的规定，提供肝癌症的潜在的治疗。

简介：目的这研究被设计评估tanshinone的反癌症行动我和tanshinoneIIA，和正常、癌的冒号房间上的tanshinoneIIA的六衍生物。结构活动关系(SAR)分析被进行描出为改进反癌症的tanshinones的结构的修正的意义行动。方法Tanshinone衍生物根据文学被设计并且综合。结肠癌房间上的不同混合物的cytotoxicity被MTT试金决定。tanshinones的Apoptotic活动被流动cytometry(FCM)测量。结果Tanshinone我和tanshinoneIIA两个都在结肠癌房间上展出了重要cytotoxicity。他们在p53+/+结肠癌房间线是更有效的。这也被注意我是的tanshinone的反癌症活动更多的有势力并且选择。tanshinoneIIA(N1和N2)的二衍生物也在结肠癌房间上展出了cytotoxicity。结论tanshinone的反冒号癌症活动我是更多的有势力并且比tanshinoneIIA选择，并且p53依赖者。tanshinoneIIA的结构的修正获得的衍生物在正常和结肠癌房间上展出了更低的cytotoxicity。从位、电子的特征观点，戒指A和呋喃或dihydrofuran的结构的修正在tanshinones影响的基本结构上包围D，这被结束这项活动。A和B戒指的delocalization的增加能提高如此的混合物的cytotoxicity，当一个非平面、小的大小的D戒指区域将提供改进反癌症活动时。

简介：Objective:Toinvestigatetherelationshipbetweengenemutationandpathologicaltypeoflungcancer,inspectandverifytheconsistencybetweenhomologousgenesmutationinvariouspathologictype.Methods:CombinedwiththeCOSMICandUniProtdatabase,weobtainedthereportedoverallbig-samplemutationdataoflungcancerandtheproteinsequencesofthetop20mutatedgenes,respectively.Analyzethedataandclustertheproteinsequencesandthendeducethehomologousgene.Ultimately,analyzethemutationsofdifferentpathologicaltypesofhomologousgenes.Results:TP53(32.32%)hasthehighestmutationrateinlungcancer,followedbyEGFR(29.12%).Thecopynumbervariability(CNV)ofgenes:KRAS,LRP1B,CDKN2A,KMT2C,FAT1,PIK3CA,RB1,ERBB4,GRIN2AandKDRbetweeneachpathologicaltypeisstaticallysignificant(P<0.05).ThegenedifferentialexpressionratebetweenadenocarcinomaandsquamouscarcinomaofgeneTP53,KRAS,LRP1B,CDKN2A,STK11,FAT4,KMT2D,NFE2L2,KEAP1,PIK3CA,RB1,ERBB4,SMARCA4andKDRarestatisticallysignificant(P<0.05).ThesimilarityoftheproteinsequenceofEGFRandERBB4canreach93%,andFAT4andFAT1are81%.Forsmallcellcarcinoma,there’snodifferenceinCNVbetweenthetwogroupsofhomologousgenes,andnodifferencebetweenFAT4andFAT1inadenocarcinoma.Conclusion:TheCNVandgeneexpressionoflungcancer-associatedgenesarerelevanttopathologictypes.GFRandERBB4arehomologous,FAT4andFAT1arealsoamongthetop20mutationgenes.Additionally,there’snodifferenceinCNVbetweenthetwogroupsofsmallcellcarcinoma,whichisthesamebetweenFAT4andFAT1inadenocarcinoma.

简介：AbstractThe aim of this paper is to discuss the risk of recurrence in patients with differentiated thyroid cancer and emphasize the importance of risk-group stratification, early recurrence identification and application of new imaging modalities, what is the PET-CT. Moreover, follow-up of patients with thyroid carcinoma should be carried out by specialized teams throughout life. Therefore, interdisciplinary case discussions in tumor conferences may improve the use of multimodal therapy especially in patients with poorly differentiated thyroid carcinomas. After baseline follow-up, if there is a suspicion of thyroid carcinoma, early PET-CT should be used for early detection and appropriate planning. Fortunately, due to the good localization possibility, the PET-CT enables a focused surgical procedure with avoidance of an unnecessary tumor search and thereby a reduction of the risk of injury of neighboring structures which is a concern with reoperative neck surgery.

简介：Livercancer,primarilyhepatocellularcarcinoma(HCC),isamajorcauseofcancer-relateddeathworldwide.HCCisasuitablemodelofinflammation-inducedcancerbecausemorethan90%ofHCCcasesarecausedbyliverdamageandchronicinflammation.Severalinflammatoryresponsepathways,suchasNF-κBandJAK/STAT3signalingpathways,playrolesinthecrosstalkbetweeninflammationandHCC.MicroRNAs(miRNAs)areevolutionarilyconserved,shortendogenous,non-codingsingle-strandedRNAsthatareinvolvedinvariousbiologicalandpathologicalprocessesbyregulatinggeneexpressionandproteintranslation.EvidenceshowedthatmiRNAsplayapivotalroleinhepatitisvirusinfectionandserveaspromotersorinhibitorsofinflammatoryresponse.AberrantmiRNAwasobservedduringliverinflammationandHCC.ManydysregulatedmiRNAsmodulatetheinitiationandprogressionofinflammation-inducedHCC.ThisreviewsummarizestheroleandfunctionsofmiRNAsininflammation-associatedHCC,aswellasthedesignedtherapeuticstargetingmiRNAstotreatliverinflammationandHCC.

简介：

简介：客观：在食管的恶意的阻塞上学习内视镜的治疗的效果。方法：先进食道的癌症病人的64个盒子有食管的阻塞，7个盒子不能被操作，57个盒子复发了在操作以后的损害和放射治疗。阻塞都与食道的扩张器被扩大，然后用elemene乳剂注射和stent的本地化疗，或本地管理被对待被放在食道的腔。结果：阻塞与膨胀被减轻仅仅大约一个星期，而是阻塞，用用另外的治疗在膨胀以后减轻了超过三个月。在膨胀以后，然而，癌的PR在本地化疗组是大约80%CR是大约8%，PR在elemene的组是大约92%乳剂注射。结论：内视镜的治疗是为先进食道的癌症的一个有效辩解的方法。

简介：无

简介：AbstractBackground:The standard treatment for pediatric differentiated thyroid carcinoma (DTC) still requires consideration because of a lack of clinical evidence. The purpose of this study was to summarize the clinical experiences and explore the risk factors for post-operative recurrence through a retrospective analysis to develop better clinical strategies for pediatric DTC.Methods:This study retrospectively analyzed children and adolescents with DTC who were treated between January 1999 and December 2014 at the Cancer Hospital, Chinese Academy of Medical Sciences. Clinicopathological results and outcomes were collected. A log-rank test of Kaplan-Meier curves and the Cox regression model were used to determine the factors associated with recurrence.Results:Data of 150 patients were collected in this study. During the follow-up, there was only one disease-related death. The recurrence rates at 3, 5, and 10 years were 13.6%, 18.7%, and 28.6%, respectively. There was a significant difference in the rate of recurrence according to age (P < 0.001), extrathyroidal extension (P < 0.001), lymph node metastasis (P = 0.023), and invasion of the trachea and esophageal wall (P = 0.004). Cox regression analysis demonstrated that age (P = 0.006) and extrathyroidal extension (P = 0.013) were significant dependent factors of post-operative recurrence.Conclusions:The prognosis of DTC in children and adolescents is favorable. A close follow-up is recommended because of the high recurrence rate. A comparatively higher recurrence rate was observed in the younger age group, and new age-based divisions may be needed to conveniently evaluate the possibility of recurrence.

简介：

简介：

简介：客观：在主要胃的癌症的开始和发展调查染色体错误和他们的角色。方法：从稳固的肿瘤的改进、直接染色体准备为分析在decolored乐队G染色体上由鱼跟随了的乐队G被采用以便染色体错误能在DNA水平被证实。结果：28个主要胃的癌症标本的一个总数是研究。大小写1和大小写2有的简单染色体数字变化：49，XY，+2，+8，+9并且48，+8，+20分别地。几乎，大小写1和2有复杂染色体畸形。经常的出现结构的染色体深奥del(7q)(21/26)，del(3p)(14/26)，del(lp)(U/26)和del(17p)(10/26)。染色体畸形能简单、复杂。在前者，包含1～3个染色体的数字变化能被观察。8和9可能代表的三染色体性主要胃的癌症的细胞发生的亚群。在里面以后，del(7q)是最一致的错误。7q32-qter是通常失去的片断结论：染色体的数字、结构的改变在主要胃的癌症是在场的。Del(7q)是主要胃的癌症的结构的变化特征之一。在7q32-qter碎片，肿瘤suppressor基因可能存在并且它可以有靠近的关系到胃的癌症的开始和前进。

简介：

简介：Baseduponstudiesfromrandomizedclinicaltrials,theextended(D2)lymphnodedissectionisnowrecommendedasastandardprocedureforlocaladvancedgastriccancerworldwide.However,therationalextentlymphadenectomyforlocaladvancedgastriccancerhasremainedatopicofdebateinthepastdecades.Duetothelimitationoflowmetastaticrateinpara-aorticnodes(PAN)inJCOG9501,theclinicalbenefitofD2+para-aorticnodaldissection(PAND)forpatientswithstageT4and/orstageN3disease,whichisverycommoninChinaandothercountriesexceptJapanandKorea,cannotbedetermined.Furthermore,theroleofsplenectomyforcompleteresectionofNo.10andNo.11nodeshasbeencontroversial,andhowever,thefinalresultsfromtherandomizedtrialofJCOG0110haveyettobecompleted.GastriccancerwiththeNo.14andNo.13lymphnodemetastasisisdefinedasM1stageinthecurrentversionoftheJapaneseclassification.WeproposethatD2+No.14vand+No.13lymphadenectomymaybeanoptioninapotentiallycurativegastrectomyfortumorswithapparentmetastasistotheNo.6nodesorinfiltratetoduodenum.Theexaminedlymphnodeandextranodalmetastasisaresignificantlyassociatedwiththesurvivalofgastriccancerpatients.

简介：

简介：Objective:Theaimofthepresentstudywastoconstructariskassessmentmodelwhichwastestedbydisease-freesurvival(DFS)ofesophagealcancerafterradicalsurgery.Methods:Atotalof164consecutiveesophagealcancerpatientswhohadundergoneradicalsurgerybetweenJanuary2005andDecember2006wereretrospectivelyanalyzed.Thecutpointofvalueatrisk(VaR)wasinferredbystem-and-leafplot,aswellasbyindependent-samplest-testforrecurrence-freetime,furtherconfirmedbycrosstabchi-squaretest,univariateanalysisandCoxregressionanalysisforDFS.Results:ThecutpointofVaRwas0.3onthebasisofourmodel.Therateofrecurrencewas30.3%(30/99)and52.3%(34/65)inVaR<0.3andVaR≥0.3(chi-squaretest,χ2=7.984,P=0.005),respectively.The1-,3-,and5-yearDFSofesophagealcancerafterradicalsurgerywas70.4%,48.7%,and45.3%,respectivelyinVaR≥0.3,whereas91.5%,75.8%,and67.3%,respectivelyinVaR<0.3(Log-ranktest,χ2=9.59,P=0.0020),andfurtherconfirmedbyCoxregressionanalysis[hazardratio=2.10,95%confidenceinterval(CI):1.2649-3.4751;P=0.0041].Conclusions:Themodelcouldbeappliedforintegratedassessmentofrecurrenceriskafterradicalsurgeryforesophagealcancer.

简介：Objective:ToanalyzetheincidenceandmortalityratesoflungcancerinChinafrom2008to2012.Methods:IncidentanddeathcasesoflungcancerwereretrievedfromtheNationalCentralCancerRegistry(NCCR)databasecollectingfrom135cancerregistriesinChinaduring2008-2012.Thecrudeincidenceandmortalityratesoflungcancerwerecalculatedbyarea(urban/rural),region(eastern,middle,western),genderandagegroup(0,1-4,5-9,…,85+).Chinacensusin2000andSegi’sworldpopulationwereappliedforagestandardizedrates.JoinPoint(Version4.5.0.1)modelwasusedfortimetrendanalysis.Results:Thecrudeincidencerateoflungcancerwas54.66/100,000whichrankedthefirstinoverallcancers.Theage-standardizedincidenceratesbyChinapopulation(ASIRC)andbyWorldpopulation(ASIRW)were35.13/100,000and34.86/100,000,respectively.ThecrudemortalityoflungcancerinChinawas45.60/100,000anditwasthefirstcauseofcancer-relateddeathinoverallcancers.Theage-standardizedmortalityratesbyChinesestandardpopulation(ASMRC)andbyworldstandardpopulation(ASMRW)were28.57/100,000and28.22/100,000,respectively.Incidenceandmortalityratesoflungcancerwerehigherinmalesthaninfemalesandhigherinurbanareasthaninruralareas.Easternareashadthehighestincidenceandmortalityratesfollowedbymiddleandwesternareas.Incidenceandmortalityratesoflungcancerretainedlowlevelinagegroupsbefore40yearsoldbutincreasedgreatlyafterandpeakedinagegroupof80-84.During2003-2012,thetemporaltrendoftheincidencerateoflungcancerinbothsexesinChinawasgeneralstable(P<0.05).Thelungcancerincidencerateincreasedby0.71%peryearinfemales(P<0.05)and2.26%peryearinruralareas(P<0.05).Themortalityrateoflungcancerdecreasedslightlyannuallyduring2003-2012inChina(P>0.05).Inurbanareas,itdeclinedby0.76%peryear(P<0.05),butroseby2.09%peryear(P<0.05)inruralareas.Conclusions:Appropriatetargetedprevention,earlydetectionandtreatment