简介：Theaimofthisstudyistodesignabiologicalinformationretrievalandanalysissystem(BIRAS)basedontheInternet.Usingthespecificnetworkprotocol,BIRASsystemcouldsendandreceiveinformationfromtheEntrezsearchandretrievalsystemmaintainedbyNationalCenterforBiotechnologyInformation(NCBI)inUSA.Theliteratures,nucleotidesequence,proteinsequences,andotherresourcesaccordingtotheuser-definedtermcouldthenberetrievedandsenttotheuserbypopupmessageorbyE-mailinformingautomaticallyusingBIRASsystem.Alltheinformationretrievingandanalyzingprocessesaredoneinreal-time.Asarobustsystemforintelligentlyanddynamicallyretrievingandanalyzingontheuser-definedinformation,itisbelievedthatBIRASwouldbeextensivelyusedtoretrievespecificinformationfromlargeamountofbiologicaldatabasesinnowdays.Theprogramisavailableonrequestfromthecorrespondingauthor.

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简介：由于存在止痛剂的低效率和副作用，长期的疼痛在诊所成为了最复杂、困难的问题之一。Monoacylglycerol脂肪分解酵素(MAGL)是在endocannabinoid系统的必要hydrolase并且为疼痛的治疗作为一个潜在的目标被识别了。在现在的学习，我们设计了并且综合12tanshinoneIIA类似物并且对MAGL屏蔽了他们的活动。选择混合物在vivo为止痛活动被测试，与扭曲测试模型的醋酸。在测试混合物之中，加重III-3(IC50120nmol

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简介：A21-daylaboratoryincubationexperimentwasconductedtoinvestigatetheimpactofpesticides(Triazophos,ButachlorandJinggangmycin)onapaddyfieldsoilhealthundercontrolledmoisture(floodedsoil)andtemperature(25℃)conditions.Theelectrontransportsystem(ETS)/dehydrogenaseactivitydisplayedanegativecorrelationwithpesticidesconcentrations,andtheactivitywasaffectedadverselyastheconcentrationofthepesticidesincreased.Thehigherdosesofpesticides,5and10foldsfieldrates,significantlyinhibitedETSactivity,whilelowerratesfailedtoproduceanysignificantreducingeffectagainstthecontrol.TherelativetoxicitylevelofpesticidesindecreasingtheETSactivitywasinthefollowingorder;Triazophos>Jinggangmycin>Butachlor,irrespectiveoftheirratesofapplication.Thepesticidescausedanimprovementinthesoilphenolcontentanditincreasedwithincreasingtheconcentrationofagrochemicals.Thepesticideincorporationdidnotproduceanysignificantchangeinsoilproteincontent.TheresponseofbiomassphospholipidcontentwasnearlysimilartoETSactivity.ThephospholipidcontentwasdecreasedwiththeadditionofpesticidesinthegivenorderofTriazophos>Jinggangmy-cin>Butachlor;andthetoxicitywasintheorder:10FR(timesoffieldrate)>5FR~>1.0FR>0.5FR>control.

简介：Biologicalmaterialssuchasbone,tooth,andnacreareload-bearingnanocompositescomposedofmineralandprotein.Sincethemineralcrystalsoftenhaveslendergeometry,thenanocompositesaresusceptibletobuckleunderthecompressiveload.Inthispaper,weanalyzethelocalbucklingbehaviorsofthenanocompositestructureofthebiologicalmaterialsusingabeam-springmodelbywhichwecanconsiderplentyofmineralcrystalsandtheirinteractioninouranalysiscomparedwithexistingstudies.Weshowthatthereisatransitionofthebucklingbehaviorsfromalocalbucklingmodetoaglobalonewhenwecontinuouslyincreasetheaspectratioofmineral,leadingtoanincreaseofthebucklingstrengthwhichlevelsofftothestrengthofthecompositesreinforcedwithcontinuouscrystals.Wefindthatthecontactconditionatthemineraltipshasastrikingeffectonthelocalbucklingmodeatsmallaspectratio,buttheeffectdiminisheswhentheaspectratioislarge.Ouranalysesalsoshowthatthestaggeredarrangementofmineralplaysacentralroleinthestabilityofthebiologicalnanocomposites.

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简介：E26transformation-specific-1(ETS-1)，一个et家庭抄写因素，被报导了在前列腺癌症(PCa)在ETS-1表示的许多生理、病理学的过程，而是临床的含意起一个重要作用，特别地高风险的案例，包括对雄激素剥夺的反应，治疗(ADT)还得被阐明。我们用针活体检视从69个主要先进的PCa病人获得的嵌入石蜡的前列腺癌织物染色的immunohistochemical检验了ETS-1的表示。ETS-1表示与69个病人的clinicopathological特征相比，包括25作为主要治疗经历了ADT。作为结果，有ETS-1的更高的表示的PCa病人是显著地，可能舞台高的更多得分(P<；0.05)。在ETS-1表示和起始的前列腺特定的抗原(PSA)水平之间没有重要协会。在ADT对待的25个病人，为ETS-1的染色的分数显著地在24个月以内与阉割抵抗的疾病的快速的开发被联系(P<；0.05)，而格利森分数和PSA水平不是。在结论，增加了ETS-1表示与到阉割抵抗的前进的一个更高的阶段，更高级的格利森分数和更短的时间被联系。这些数据建议为ETS-1的immunostaining能是为为PCa病人预言差的临床的结果的一个分子的标记，特别地那些与高风险的疾病。

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简介：InteractionbetweencytotoxicTlymphocyte-associatedantigen-4(CTLA4,CD152)andB7molecules(B7-1andB7-2)isofimportanceinthecellulareventsoflymphocyte,includingantigen-specificT-cellactivationandinductionofautoreactiveT-cell.WedescribehaerethefirstintroductionofamurinesolubleCTLA4gene,CTLA4Ig,toMm1cells,amacrophagiccellline.CTLA4IgwassuccessfullyexpressedonMm1cellsandtheexpressedCTLA4IgwasfoundtobefunctionallyactiveintheirbindingtoB7moleculesbyflowcytometryandimmunofluorescencestudies.ThebiologicalactivityofCTLA4IgfromthetransfectedMm1cellswasstudiedandshowedinhibitoryactivityonmixedlymphocyteculture.AhighCTLA4Igproducingmacrophagiccelllinewasobtained.AsMm1cellswereregardedasdifficultforgenetransfectionandtherehassofarbeennoreportonexpressionofCTLA4IggeneonMm1cells,theseresultssuggestedthattheCELA4IgexpressingMm1cellscouldbeusefulforanalysisofCTLA4andB8moleculeinteractioninbothmacrophageandT-cell.

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简介：PolysaccharideextractedfromEnteromorphaproliferapossessedexcellentbiologicalactivities,butitsmolecularweightwasgreatlyhighwhichinfluencedtheactivity.OrganicSehadhigherbiologicalactivitiesandwassaferthaninorganicSespecies.Inthepresentstudy,Enteromorphapolysaccharidewasdegradedtolowmolecularweightbyfree-radicaldegradationmethodofH2O2andascorbicacid.Bysinglefactorandorthogonalexperiments,theoptimaldegradationconditionswerereactiontimeof2h,reactiontemperatureof50℃,H2O2/ascorbicacid(n/n=1:1)concentrationof15mmolL-1,andsolid-liquidratioof1:50(gmL-1).Then,thedegradedpolysaccharidewaschemicallymodifiedtoobtainitsselenidederivativesbynitricacid-sodiumselenitemethod.Theseleniumcontentwas1137.29μgg?1,whilethecontentofsulfateradicalhadnochange.IRspectraindicatedthattheseleniteestergroupwasformed.Degradedpolysaccharideselenidewascharacterizedandevaluatedforantioxidant,antifungalandantibacterialactivities.TheresultsshowedthatdegradedpolysaccharideselenidehadstrongcapacityofscavengingDPPHand·OHfreeradical.IthadsignificantantibacterialpropertiesforEscherichiacoli,BacillussubtilisandSalmonellaspp.,anditalsohadsignificantantifungalpropertiesforAppleanthrax.Theresultascertaineddegradationandselenylationmodificationdidnotchangethemainstructureofpolysaccharides.Itwaspossiblethatfree-radicaldegradationwasaneffectivewayforenhancingantioxidantactivitytodecreasemolecularweightofpolysaccharides.

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简介：抽象非庄稼产地可以在保存起一个重要作用生物控制。这研究测试了毒麦(LoliummultiflorumL.)的效果邻近的冬季小麦领域里的蚜虫和瓢虫人口上的脱衣。地实验在诺思中国在2010在三毒麦边缘小麦情节和三控制情节被进行。在春天，一样的蚜虫种类，Sitobionmiscanthi(Takahashi)，在毒麦脱衣和小麦情节被发现。在毒麦的瓢虫的人口密度脱衣(3.5瀠牡獡瑩穩瑡潩n

简介：Withthedevelopmentofbiomedicalengineering,thethermophysicalpropertiesoftheorgansandtissuesoflivinganimalsbecomeessential.However,becausetheytendtobeofirregularshapes,limitedsizesandwithlowintensityinnerheatsource,themeasuringofthethermophysicalpropertiesoftheorgansandtissuesoflivingan-imalsismuchmoredifficult.

简介：构造生物网络是在系统生物学的最重要的问题之一。然而，手工地从数据构造一个网络拿一可观大量时间，因此，一个自动化过程被倡导。自动化网络建设的过程，在这个工作，我们使用二种聪明的计算技术，基因编程和神经计算，推断使用连续变量的二种网络模型。验证介绍途径，实验被进行了，初步的结果证明两条途径能被用来成功地推断网络。

简介：客观:在乙醇的媒介(非极)，是的STMP和ADH，以由没有一个胶化阶段，得到稳定的cross-linked产品准备药交货microspheres，并且学习cross-linked产品的biocompatibility和biodegradability的crosslinkers哈。方法:是的生物医学的材料的ISO10993.1安全评估一本参考书，做溶血测试，经皮的刺激测试，vitro降级测试，和降级产品的尖锐毒性测试，和分析。结果:HA-STMPcross-linked产品没把溶血，没有激怒，没有尖锐全身的毒性，而是HA-ADH有温和皮肤激怒和不利尖锐全身的毒性。HA-STMPcross-linked产品HAse和曲线上的有的更低的敏感是flatting。随HA-STMP结果被结构分析改变的降级时间的增加，这些房间的降级产品不是毒性。结论:有到水解作用的更好的biocompatibility和更好的抵抗的HA-STMPcross-linked产品能推迟降级时间，它对可被细菌破坏的药搬运人的准备合适。