简介：Intheindustrializedcountriesthemaingoalatthenationalhealthcarepolicymakinglevelistocontaincostswithoutcompromizingthetwogoalsofhealthcare:accessandquality.Atthesametimemedicineisevolvingthroughinevntions,inno-vationsandimprovements.Technologieswhichcanbeusedtoprolonglifebutwhicharenotcurativehavealsoimprovedandbecomewidelyused.Withtheageingpopu-lationsoftheindustrializedcountriescontainingcostsisgettingextremelydifficult.

简介：Thequantumvibrationalenergy-spectraincludinghighexcitedstatesoftheproteinmoleculeshavebeencalculatedbynewtheoryofbio-energytransportalongtheproteinmoleculesanditsdynamicequation,discretenonlinearSchrodingerequation,appropriatetotheproteinmoleculesonthebasisofthelevelofmolecularstructure.Thisenergy-spectraobtainedarebasicallyconsistentwiththeexperimentalvaluesbyinfraredabsorptionandradiatedmeasurementofperson'shandsandlaser-RamanspectrumfrommetabolicallyactiveE.Coli..Fromthisenergy-spectraweknowthattheinfraredlightswith(1-3)x1000nmand(5-7)x1000nmwavelengthcanbeabsorbedbytheproteinmoleculesinthelivingsystems.Inaccordancewiththenon-lineartheoryofthebio-energytransportweknowthattheenergyoftheinfraredlightabsorbedbytheproteinscanresultinvibrationsofamide-Iinaminoacidsandcanfacilitatethebio-energytransportalongtheproteinmolecularchainsfromoneplacetootherforthegrowthoflivingbodies.Thisprocesseisnon-thermal.Thisisjustnon-thermaleffectoftheinfraredlights.Accordingtothemechanismweexplainedfurtherthemedicalfunctionsoftheinfraredlightsabsorbed.

简介：AbstractThe time of birth is a critical determinant of perinatal and long-term outcomes, and even trans-generational effects. Preterm birth is still the leading cause of infant mortality and morbidity. Unfortunately, rates of preterm birth remain high worldwide. Preterm parturition is a complex syndrome, which can be induced by several factors such as infection, cervical pathology, uterine overdistension, progesterone deficiency, vascular alterations (utero-placental ischemia, decidual hemorrhage), maternal and fetal stress, allograft reaction, allergic phenomena, and probably other several unknown factors. The mechanisms responsible for early labor activation have been partially identified and involve receptors, chemokines, and inflammatory cytokines. It is very useful to understand the cellular and biochemical pathways responsible for preterm labor activation to identify, treat, and prevent negative outcome in a timely manner. Researchers and clinicians play a key role in improving biochemical knowledge on preterm delivery, identifying risk factors, and applying multilevel preventive strategies.

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简介：基因的表示“在正确地方以内”并且在正确时间被限制，这通常被相信。这个原则长也被认为适用到免疫球蛋白(Ig)的表示B的淋巴细胞房间系。然而，增加证据证明了Ig“似非而是地”在上皮的起源的恶意的肿瘤表示了。我们在导出癌症的Ig的学习考察了最近的进步，并且也讨论了它的机制和可能的功能，试着引起到那些在免疫学和肿瘤学的领域里工作的兴趣和注意。

简介：Naturalproductshavegainedpopularityworldwideforpromotinghealthcare,aswellasdiseaseprevention.Alkaloidsareimportantchemicalcompoundsthatserveasarichreservoirfordrugdiscovery.Severalalkaloidsisolatedfromnaturalherbsexhibitantiproliferation,antibacterial,antiviral,insecticidal,andantimetastaticeffectsonvarioustypesofcancersbothinvitroandinvivo.Thispaperfocusesonthenaturally-derivedalkaloidssuchasberberine,matrine,piperine,fritillarine,andrhynchophylline,etc.,andsummarizestheactionmechanismsofthesecompounds.Basedontheinformationintheliteraturethatissummarizedinthispaper,theuseofalkaloidsasdrugsisverypromising,butmoreresearchandclinicaltrialsarenecessarybeforefinalrecommendationsonspecificalkaloidscanbemade.Followingthis,itishopedthatasaresultofthisreview,therewillbeagreaterawarenessoftheexcellentpromisethatnaturalalkaloidsshowforuseinthetherapyofdiseases.

简介：精子chromatin/DNA正直为父亲的基因信息的精确传播是必要的，并且正常精子染色质结构为使肥沃的精子是重要的能力。精液的常规检查，包括精子集中，活动性和形态学，不在精子染色质结构识别缺点。为它的评价的精子DNA损坏和许多方法的起源被描述。精子DNA损坏的评估看起来是为估计男富饶潜力的一个有用工具在活体内和在试管内。后代上的精子DNA缺点的可能的影响也被讨论。

简介：BACKGROUND:Presently,over40kindsofduralgraftshavebeensuccessivelyusedinclinic.Amongthem,lyophilizedhumanduramaterwithgoodhistocompatibilityandlesscomplicationsisappliedmostwidely.Butthereareafewreportsoncasesofinfectedspongiformencephalopathyfollowingapplicationoflyodura.Moreidealrepairmaterialsdeservetobefurtherinvestigated.OBJECTIVE:Toinvestigatetheefficiencyandsafetyofbiologicalduralgraftmadebymeningesfromporkerstorepairmeningealinjury.DESIGN:Aself-controlobservation.SETTING:WuhanGeneralHospitalofGuangzhouMilitaryAreaCommandofChinesePLA.MATERIALS:SixteenNewZealandRabbits,ofeithergender,weighingfrom2to3kg,ofcleangradeⅡ,withtheageof0.5–1year,wereinvolvedinthisexperiment.TheinvolvedrabbitswereprovidedbytheAnimalExperimentalCenteroftheFirstMilitaryMedicalUniversityofChinesePLA.Biologicalsurgicalpatch(duralgraft)wasdevelopedbyGuangdongGuanhaoBiotechnologicalCo.,Ltd.Itwasprocessedbyusingmeningesfromporkersbytissueengineeringtechnology.METHODS:ThisexperimentwascarriedoutintheExperimentalCenterofthe157HospitalofChinesePLAbetweenDecember2003andJune2004.①Theexperimentalrabbitswereanesthetized.Duramaterwasexposedfromtwosidesofpostmediallineofcoronalsuture.Arectangularduramaterabout8mm×8mminsizewascutoff.Thenabiologicalsurgicalpatch(duralgraft)wasshearedintoinsertwith8mmdiameterandsutured.Theleftduramaterwasuntouchedandusedascontrol.Scalpwassutured,andpostoperativewoundhealingandrecoverywereobserved.②Theanesthetizedrabbitsweresacrificedatpostoperative3,14,30and90days,4rabbitsonce.Thewholeheadwascutoff,anditsscalpwasremoved.Afterwards,theheadwasfixedbyformalin.Tissuesinoperativesitewereobtained,performedroutineparaffinembedding,slicedandconductedHEstaining,finally,thesectionswereobserved.Whitebloodcellsinv

简介：客观:兔子的生物特征口头的mucosal上皮的房间(OMEC)被学习，为OMEC的文化的合适的过程被探索。方法:由不同表面消毒的有教养的OMEC由不同Dispase准备，在不同媒介，在K-SFM的不同calciumion集中中等。结果:文化能显著地与2%碘答案减少的房间的微生物引起的污染以前为口头的洞的消毒使用了房间文化。在K-SFM与Dispase消化的OMEC能快速属于文化烧瓶，在PBS与Dispase消化的OMEC稀罕属于文化烧瓶。在K-SFM媒介的0或0.09mmol/L钙集中有教养的OMEC的增长出现了不统计上重要。OMEC与浆液变得快，但是区分进像成纤维细胞的房间是容易的。结论:OMEC能成长很好并且有由在这描述了的过程的上皮的房间形态学试验的典型口头的mucosal。

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简介：ＰＲＥＬＩＭＩＮＡＲＹＲＥＳＥＡＲＣＨＯＦＨＵＭＡＮＨＥＰＡＴＯＣＹＴＥＣＥＬＬＬＩＮＥＡＳＴＨＥＢＩＯＬＯＧＩＣＡＬＭＡＴＥＲＩＡＬＯＦＥＬＡＤＰＲＥＬＩＭＩＮＡＲＹＲＥＳＥＡＲＣＨＯＦＨＵＭＡＮＨＥＰＡＴＯＣＹＴＥＣＥＬＬＬＩＮＥＡＳＴＨＥＢＩＯ...

简介：由于存在止痛剂的低效率和副作用，长期的疼痛在诊所成为了最复杂、困难的问题之一。Monoacylglycerol脂肪分解酵素(MAGL)是在endocannabinoid系统的必要hydrolase并且为疼痛的治疗作为一个潜在的目标被识别了。在现在的学习，我们设计了并且综合12tanshinoneIIA类似物并且对MAGL屏蔽了他们的活动。选择混合物在vivo为止痛活动被测试，与扭曲测试模型的醋酸。在测试混合物之中，加重III-3(IC50120nmol

简介：E26transformation-specific-1(ETS-1)，一个et家庭抄写因素，被报导了在前列腺癌症(PCa)在ETS-1表示的许多生理、病理学的过程，而是临床的含意起一个重要作用，特别地高风险的案例，包括对雄激素剥夺的反应，治疗(ADT)还得被阐明。我们用针活体检视从69个主要先进的PCa病人获得的嵌入石蜡的前列腺癌织物染色的immunohistochemical检验了ETS-1的表示。ETS-1表示与69个病人的clinicopathological特征相比，包括25作为主要治疗经历了ADT。作为结果，有ETS-1的更高的表示的PCa病人是显著地，可能舞台高的更多得分(P<；0.05)。在ETS-1表示和起始的前列腺特定的抗原(PSA)水平之间没有重要协会。在ADT对待的25个病人，为ETS-1的染色的分数显著地在24个月以内与阉割抵抗的疾病的快速的开发被联系(P<；0.05)，而格利森分数和PSA水平不是。在结论，增加了ETS-1表示与到阉割抵抗的前进的一个更高的阶段，更高级的格利森分数和更短的时间被联系。这些数据建议为ETS-1的immunostaining能是为为PCa病人预言差的临床的结果的一个分子的标记，特别地那些与高风险的疾病。

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简介：Withthedevelopmentofbiomedicalengineering,thethermophysicalpropertiesoftheorgansandtissuesoflivinganimalsbecomeessential.However,becausetheytendtobeofirregularshapes,limitedsizesandwithlowintensityinnerheatsource,themeasuringofthethermophysicalpropertiesoftheorgansandtissuesoflivingan-imalsismuchmoredifficult.

简介：客观:在乙醇的媒介(非极)，是的STMP和ADH，以由没有一个胶化阶段，得到稳定的cross-linked产品准备药交货microspheres，并且学习cross-linked产品的biocompatibility和biodegradability的crosslinkers哈。方法:是的生物医学的材料的ISO10993.1安全评估一本参考书，做溶血测试，经皮的刺激测试，vitro降级测试，和降级产品的尖锐毒性测试，和分析。结果:HA-STMPcross-linked产品没把溶血，没有激怒，没有尖锐全身的毒性，而是HA-ADH有温和皮肤激怒和不利尖锐全身的毒性。HA-STMPcross-linked产品HAse和曲线上的有的更低的敏感是flatting。随HA-STMP结果被结构分析改变的降级时间的增加，这些房间的降级产品不是毒性。结论:有到水解作用的更好的biocompatibility和更好的抵抗的HA-STMPcross-linked产品能推迟降级时间，它对可被细菌破坏的药搬运人的准备合适。

简介：CymbopogoncitratusisawidelydistributedperennialherbbelongingtothePoaceaefamilyandhasbeenextensivelyconsumedforitsmedicinal,cosmetic,andnutritionaleffectsforcenturies.Alargenumberofreportshavebeenpublisheddescribingthepharmacological,biological,andtherapeuticactionsofthisherb.Inthisreview,wesummarizedtheliteraturesonrelatedstudies(uptoJanuary,2014)thathighlightedthepharmacologicandbiologicaleffectsofthemajorphytochemicalsisolatedfromC.citratusextractsanditsessentialoil.ThecomponentsoftheessentialoilsfoundinC.citratushaveasimilarpharmacokineticproperties,includingabsorption,distribution,metabolism,andexcretion.Theyarequicklyabsorbedfollowingoral,pulmonary,anddermaladministration.Basedonthepublishedreports,itcanalsobeinferredthat,afterabsorptionfromthesmallintestine,somephytochemicalsinC.citratuscanundergooxidation,glucuronidation,sulfation,and/orO-methylation.Excretionisthroughurine,fecesand/orexpiredvolatiles.ThebiotransformationreactionsofC.citratusbioactiveconstituentsareessentialforitsrelativelysafeconsumptionandtherapeuticapplications.ThedataavailablesofarwarrantfurtherstudiesevaluatingC.citratuspharmacokinetics.ReliablepharmacokineticdatainhumanswouldbecriticalforabetterunderstandingofthethesystemichandlingofC.citratus.

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