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简介：Naturalproductshavegainedpopularityworldwideforpromotinghealthcare,aswellasdiseaseprevention.Alkaloidsareimportantchemicalcompoundsthatserveasarichreservoirfordrugdiscovery.Severalalkaloidsisolatedfromnaturalherbsexhibitantiproliferation,antibacterial,antiviral,insecticidal,andantimetastaticeffectsonvarioustypesofcancersbothinvitroandinvivo.Thispaperfocusesonthenaturally-derivedalkaloidssuchasberberine,matrine,piperine,fritillarine,andrhynchophylline,etc.,andsummarizestheactionmechanismsofthesecompounds.Basedontheinformationintheliteraturethatissummarizedinthispaper,theuseofalkaloidsasdrugsisverypromising,butmoreresearchandclinicaltrialsarenecessarybeforefinalrecommendationsonspecificalkaloidscanbemade.Followingthis,itishopedthatasaresultofthisreview,therewillbeagreaterawarenessoftheexcellentpromisethatnaturalalkaloidsshowforuseinthetherapyofdiseases.

简介：Themechanismsfortheregulationofsynapticdopamine(DA)includeitsreleasefrompresynapticvesicles,itsinteractionwithpost-synapticandpre-synapticDAreceptors,thereuptakeofDA,viadopaminetransporter(DAT),thediffusionofDAanditsmetabolismbymono-amineoxidase(MAO)andcatechol-O-methyltransferase(COMT).DAcontrolscomplexand

简介：Acompetitiveenzyme-linkedimmunosorbentassay(ELISA)wasdevelopedtodetermineruscogenin(RUS)byusingthemonoclonalantibody(McAb).ThemonoclonalantibodyagainstRUS,secretedfromtheestablishedhybridomacelllines,wasidentifiedasbeingoftheIgG1isotype.TheMcAbexhibitedhighspecificitytoRUS,showingaveryslightcrossreactivitywithdiosgenin(15.7%),andnocross-reactivitytosarsasapogenin,diammoniumglycyrrhizinate,oleanolicacidandnotoginsenosideR1.TheestablishedELISA,atanIC50valueof157.55ng.mL-1andadetectionlimit(IC20)of20.57ng.mL-1,wascomparedwithHPLCanalyses,andagoodcorrelationbetweenELISAandHPLC-ELSDanalysesofRUSintheextractofRadixOphiopogoniswasobtained.TheexperimentaldataindicatedthattheELISAmethodexhibitsmoreadvantagesoverHPLC-ELSD,suchaslowdetectionlimit,highspecificity,lowbackground,andnorequirementforsamplepre-treatment,andismoresuitableforthedeterminationofnaturalcomponentsinChinesetraditionalmedicinesandinbiologicalsamplesforpharmacokineticstudies.

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简介：我们在奇塔贡·希尔道在Khagarachari山区域的Aatmile从二个代表性的地点收集了土壤样品。这些地点之一在转移耕作和其它下面是邻近的13年的旧柚木种植园。两个地点在有寓言土壤的地文学的状况和一样的方面打的一样，它使我们能测量在土壤上转移耕作的效果微植物群。我们学习了土壤物理化学的性质和土壤微生物的生物化学、生物的性质。象真菌和细菌的人口一样的潮湿和有机物内容，两个在表面和表面下的土壤，显著地(p0.001)在不在转移耕作下面与土壤相比转移栽培土壤更低，即柚木种植园地点。在表面(010厘米)的最丰富的细菌并且表面下(1020厘米)分别地，当时，在转移耕作下面的土壤是Pseudomonasdiminuta和Shigella在柚木种植园的相应土壤层，占优势的微生物是杆菌firmus(010厘米)和Xanthomonas(1020厘米)。因为，微生物引起的人口差别不能被土壤质地差别解释组织上从二个地点的土壤的类似但是能在在转移耕作下面的土壤与显著地更低的潮湿和有机物内容有关。

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简介：二新-hydroxy氨基的联合酸的secoiridoids，命名serinosecologanin(1)和threoninosecologanin(2)，从忍冬装饰用的梨树的花芽的一篇水的摘录被孤立。他们包括绝对配置的不平常的结构被分光镜的数据分析决定，并且从共同发生的secologanin(3)和secologanic酸(4)由semisynthesis证实了。从曲霉属菌尼日尔从杏仁和hesperidinase对-glucosidase加重1和2项展出抵抗活动，他们也在激活血小板的因素与抑制率导致的老鼠polymorphonuclear白血球对glucuronidase的版本显示出活动(34.9 ；± ；3.1)%并且(53.6 ；± ；2.6)%分别地。