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简介：Toobservetheeffectofthepointinjectionmethodonthegastricmucosabarrierinratswithchronicatrophicgastritis.Method:RatmodelswithvaryingdegreesofchronicatrophicgastritisweremadeusingMNNGindifferentconcentrations.EqualamountsofHuangqi(RadixAstragali)injectionandDanggui(RadixAngelicaeSinensis)InjectionweremixedandinjectedintothepointZusanli(ST36)

简介：Objective:Toobserveclinicaltherapeuticeffectsofelectroacupuncturepluspoint-penetrationforchronicanklejointsprain.Methods:76patientswererandomlydividedintotreatmentgroup(n=43)andcontrolgroup(n=33).Inteatmentgroup,penetrationneedlingfromQiuxu(丘墟GB40)toZhaohai(照海KI6)wasperformed,combinedwithelectricalstimulationfor30min.PatientsofcontrolgroupwereorderedtotakeAntinfan(50mg,b.I.d.),supplementedwithlocalexternalapplicationofVotalincream(b.I.d.).After14treatments(twocourses),thetherapeuticeffectwasassessed.Results:Followingtwocoursesoftreatment,ofthe43casesand33casesintreatmentandcontrolgroups,33(76.7%)and15(45.5%)werecured,4(9.3%)and7(21.2%)hadmarkedimprovementintheirsymptoms,3(7.0%)and2(6.1%)hadimprovement,and3(7.0%)and9(27.3%)failed,withtheeffectiveratesbeing93.0%and72.7%respectively.Thetherapeuticeffectoftreatmentgroupwassignificantlysuperiortothatofcontrolgroup(P<0.05).Conclusion:PenetrativeneedlingplusEAissignificantlysuperiortomedicationinrelievingchronicanklespainpatient'sclinicalsymptomsandsigns.

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简介：为了在长期的绿内障patients.METHODSA评估有中央角膜的subbasal神经纤维层的眼睛的表面变化和它的关联，没有任何眼睛的问题，眼睛的表面评估的未来的比较学习为至少6mo和25个正常题目的50只眼睛在使用二的25个病人或更多的antiglaucoma药的50只眼睛被执行作为控制。评估的学习参数包括了视觉尖酸，intraocular压力，眼睛的表面评估参数[荧光黄分散时间(FTBUT)，我测试的Schirmers，眼睛的表面染色分数和眼睛的表面疾病索引分数(OSDI)]，中央角膜的感觉(CochetBonnettaesthesiometer)，由在绿内障盒子和控制组中的共焦的microscopy.RESULTSThe平均数值的中央subbasal神经纤维层密度(SBNFLD)分别地如下：OSDI分数(35.89祣潴楫敮????????????木????€???€乔????偉?‰??????????倨???‵？？

简介：AbstractAspirin-exacerbated respiratory disease (AERD) is characterized by the triad of chronic rhinosinusitis with nasal polyposis, adult-onset asthma and non-IgE mediated reactions to aspirin and other cyclooxygenase-1 (COX-1) inhibitors. Patients with AERD are dependent on COX-1 activity to maintain production of prostaglandin (PG) species, such as PGE2, which maintain physiologic levels of inflammation and limit the production of pro-inflammatory cysteinyl leukotrienes. The endogenous cannabinoid system is a family of immunomodulatory lipids and their innate g-protein coupled receptors that are closely related to arachidonic acid and may modulate inflammation via several pathways, including the direct production of metabolically active prostaglandin glycerol-esters. A recent pilot study has identified the significant up-regulation of the peripherally expressed, type-2 cannabinoid receptor (CB2) in AERD nasal polyps versus control tissues from patients with either allergic fungal rhinosinusitis or no history of chronic sinonasal inflammation. These early findings suggest the involvement of increased endogenous cannabinoid activity in prostaglandin deficient states such as AERD. Future study is needed to explore the significance of these findings, with specific investigation of the impact of CB2 activation on markers of airway inflammation, as well as the potential to measure CB2 expression as a screening biomarker for the evaluation of unrecognized disease.

简介：Wehadtreated102casesofobstinatepepticulcerandchronicgastritiswithametalringembeddedinZusanliacupointsinceOctober1989toOctober1992,andgotsatisfactorytherapeuticeffects.Thetotaleffectiverateis96.08%,thecurerateofpepticulceris87.32%,therecurrencerateissignificantlylowerthanthatofcontrolgroup(P<0.001),andithasnoside-effect.

简介：AIM:Todiscussandcomparethefundusautofluorescence(FAF)andopticalcoherencetomography(OCT)inacuteorchroniccentralserouschorioretinopathy(CSCR).METHODS:Medicalrecordsof100casesofCSCRwerereviewed.Acuteandchroniccaseswereevaluatedaccordingtothedurationofdecreasedvisualacuity,serousretinaldetachment(RD)andfocalleakageonfluoresceinangiography(FA).Chi-squaretestwasusedforstatisticalanalysis.RESULTS:Fortycaseshadacuteand60caseshadchronicCSCR.FAFshowedfocalhypo-autofluorescencein34(85%)andiso-autofluorescencein6(15%)ofacutecasesandhypo-autofluorescencein51(85%),hyperautofluorescencein6(10%)andiso-autofluorescencein3(5%)ofchroniccases.OCTshowedserousRDwithdistinctborderscorrelatedwithFAFfindings(hypoautofluorescence)inallacuteCSCRcases.InchronicCSCRgroup,OCTshowedserousRDwithindistinctborderscorrelatedwithFAFfindings.ThedifferencesbetweentheOCTandFAFfindingsofthetwogroupsweresignificant(P=0.000).CONCLUSION:OCTandFAFfindingscansupporttheclinicalobservationsindifferentialdiagnosisofacuteandchronicCSCRandhelpclinicianstoevaluateretinalpigmentepithelium,outersegmentsofphotoreceptorsandthecomponentsofserousRD.

简介：AbstractObjective:The study aimed to detect and analyze long non-coding RNAs (lncRNAs) in plasma of children diagnosed with chronic gastritis, and to explore its biological functions and involved signaling pathways.Methods:The plasma samples were collected from six children that were diagnosed with chronic gastritis by physical examination, gastroscopy, and pathological examination and six healthy children. The plasma samples were assayed for determining the expression profiles of lncRNA based upon the gen chip detection. The specific expression of lcnRNA in plasma of children with chronic gastritis was analyzed and its biological functions were speculated.Results:Five lncRNAs (RP11-697M17.1, RP11-388M20.9, AFAP1-AS1, BC062758, and XLOC001406) were significantly upregulated, and five lncRNAs (UNQ697, BX571672.5, CYP4F35P, ANKRD20A5P, and AL832737) were observed to be significantly down-regulated. The lncRNAs RP11-697M17.1, and UNQ697 were detected with the highest up-regulation and down-regulation, respectively. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that the up-regulated lncRNAs were significantly enriched in 20 signaling pathways such as phosphoinositide-3-kinase-protein kinase B (PI3K-Akt) pathway, and the down-regulated lncRNAs target genes were significantly enriched in 20 signaling pathways such as the metabolic pathway.Conclusion:The analysis of the lncRNA expression profiles in plasma of children with chronic gastritis revealed that the lncRNA RP11-697M17.1, and lncRNA UNQ697 may act as plasma markers for predicting chronic gastritis in children.

简介：Levofloxacin是通常被用来对待长期的细菌的前列腺炎的合成fluoroquinolone。我们在中国病人为长期的细菌的前列腺炎的治疗与ciprofloxacin相比调查了levofloxacin的安全和功效。这是multicenter，开标签的、使随机化的控制非低劣试用。有临床的症状/症状的471个病人被注册进学习，并且408个病人是微生物学地证实的长期的细菌的前列腺炎，被使随机化到也口头的levofloxacin(500 ；mgq.d)或ciprofloxacin(500 ；mgb.i.d)为4个星期。细菌的清理率，临床的症状/症状，不利反应和疾病复发被估计。临床的症状和症状和在与levofloxacin对待的209个病人和与ciprofloxacin对待的199个病人的细菌文化(包括的尿痛，会阴的不快或疼痛)是类似的。最普通的细菌是Escherichiacoli和葡萄球菌aureus。在4星期治疗的结束以后的一～四个星期，细菌的清理率(86.06%；对60.03%；P<；0.05)并且临床的功效(包括临床的痊愈和临床的改进(93.30%；对71.86%；P<；0.05))比在对待ciprofloxacin的组在对待levofloxacin的组是显著地更高的。microbiological复发率比在对待ciprofloxacin的组在对待levofloxacin的组是显著地更低的(4.00%；对19.25%；P<；0.05)。不利事件和处理相关的不利事件的率比在对待ciprofloxacin的组在对待levofloxacin的组是稍微更低的。Levofloxacin以临床的功效和疾病复发在ciprofloxacin上显示出一些优点，与不利事件的低率，为在中国病人的长期的细菌的前列腺炎的治疗。

简介：ObjectivesToinvestigatethechangesofβ3-adrenoceptor(β3-AR)mRNAexpressionintheratswithchronicheartfailure(CHF),andtoexploretheeffectofβblockers(βBs)onβ3mRNAexpression.MethodsThirty-fourratswererandomlydividedintoShamgroup(n=10)andheartfailuregroup(n=24).Ratmodelwasestablishedbyaorticconstriction.Thesurvivalratsinheartfailuregroupweredividedintoheartfailurecontrolgroup(HFgroup,n=6),metoprololgroup(METgroup,n=8)andcarvedilolgroup(CARgroup,n=8)threemonthsafteroperation.Metoprololtartartewasstartedorallywith12mg·kg-1·d-1,carvedilolwith6mg·kg-1·d-1,isometricsalinewasstartedinHFgroup.Afterthreemonthsofdrugtherapy,measurementofhemodynamics,indexofventricularmass,thelevelofβ3-ARmRNAexpressionwereperformed.ResultsComparedwithShamgroup,leftventricularendsystolicpressure(LVESP),andtheabsolutevaluesofmaximalrateofriseandfall(±dp/dtmax)ofleftventricularpressurewereallsignificantlydecreased(P<0.01),leftventricularenddiastolicpressure(LVEDP)wassignificantlyincreasedinHFgroup(P<0.01).ThehemodynamicparameterswereimprovedbyβBs,andcarvedilolwasmoreeffectivethanmetoprolol(P<0.01).TheindexofventricularmasswashigherinHFgroupthanMETgroup,CARgroupandShamgroup(P<0.01).βBssignificantlydecreasedtheindexofleftventricularmass(LVMI),andCarvedilolwasmoreeffectivethanmetoprolol(P<0.01).Theindexofrightventricularmass(RVMI)didnotchangeinMETgroup(P>0.05),butsignificantdecreasecouldbeseeninCARgroup(P<0.01).Thelevelofβ3-ARexpressioninleftventriclewasgreaterthanthatinrightventriclewhetherinthefailingheartorinthenon-failingheart.ComparedwithShamgroup,thelevelofβ3-ARmRNAexpressionwassignificantlyincreasedinHFgroup(P<0.01).Thelevelsofβ3-ARmRNAexpressionshowedaremarkabledecreaseinCARgroup(P<

简介：Acupmoxitherapy,retention-enemaandoraladministrationofherbalmedicinewerecombinedtotreat86patientswithchroniculcerativecolonitis.Acomparisonbetweenpretreatmentandposttreatmentwasmadebyfibercolonoscopy.Theresultsshowedthattheshort-termcureoccurredin36cases,effectivenessin46casesandineffectivenessin4cases,thetotaleffectiveratebeing95.3%.

简介：目的：讨抑郁症的神经生物学发病机制，揭示针刺治疗抑郁症的机理。方法：以Wistar大鼠为受试对象，采用给予孤养大鼠以长期不可预见的中等强度刺激的方法建立抑郁大鼠模型，检测应激后造成的抑郁模型大鼠行为学改变、下丘脑垂体肾上腺皮质轴（HPA）的变化，同时观察针刺干预效应及不同针法的疗效比较。结果：型组、生理盐水组血清CORT和ACTH含量明显高于正常对照组（P〈0．05）；手针治疗组、电针治疗组血清CORT和ACTH含量明显低于模型组（P〈0．05）；药物组血清CORT和ACTH含量明显低于生理盐水组（P〈0．05）：手针治疗组、电针治疗组、药物组比较差别无统计学意义。结论：刺百会、太冲具有较明显的抗抑郁效应，其机制可能与针刺对HPA轴的调整有关。

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简介：AbstractLow-level viremia (LLV) was defined as persistent or intermittent episodes of detectable hepatitis B virus (HBV) DNA (<2000 IU/mL, detection limit of 10 IU/mL) after 48 weeks of antiviral treatment. Effective antiviral therapies for chronic hepatitis B (CHB) patients, such as entecavir (ETV), tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF), have been shown to inhibit the replication of HBV DNA and prevent liver-related complications. However, even with long-term antiviral therapy, there are still a number of patients with persistent or intermittent LLV. At present, the research on LLV to address whether adversely affect the clinical outcome is limited, and the follow-up treatment for these patients is open to question. At the same time, the mechanism of LLV is not clear. In this review, we summarize the incidence of LLV, the association between LLV and long-term outcomes, possible mechanisms, and management strategies in these patient populations.

简介：AbstractBackground:Fibrosis in the peripheral airways contributes to airflow limitation in patients with chronic obstructive pulmonary disease (COPD). However, the key proteins involved in its development are still poorly understood. Thus, we aimed to identify the differentially expressed proteins (DEPs) between smoker patients with and without COPD and elucidate the molecular mechanisms involved by investigating the effects of the identified biomarker candidate on lung fibroblasts.Methods:The potential DEPs were identified by isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis. The messenger RNA and protein levels of clusterin (CLU) in COPD patients and 12% cigarette smoke extract (CSE)-treated human bronchial epithelial cells were determined at the indicated time points. Furthermore, an in vitro COPD model was established via the administration of 8% CSE to normal human lung fibroblasts (NHLFs) at indicated time points. The effects of CSE treatment and CLU silencing on proliferation and activation of lung fibroblasts were analyzed.Results:A total of 144 DEPs were identified between COPD patients and normal smokers. The iTRAQ-based proteomics and bioinformatics analyses identified CLU as a serum biomarker candidate. We also discovered that CLU levels were significantly increased (P < 0.0001) in Global Initiative for Obstructive Lung Disease II, III, and IV patients and correlated (P < 0.0001) with forced expiratory volume in 1 s (R=-0.7705), residual volume (RV) (R = 0.6281), RV/total lung capacity (R = 0.5454), and computerized tomography emphysema (R = 0.7878). Similarly, CLU levels were significantly increased in CSE-treated cells at indicated time points (P < 0.0001). The CSE treatment significantly inhibited the proliferation, promoted the inflammatory response, differentiation of NHLFs, and collagen matrix deposition, and induced the apoptosis of NHLFs; however, these effects were partially reversed by CLU silencing.Conclusion:Our findings suggest that CLU may play significant roles during airway fibrosis in COPD by regulating lung fibroblast activation.

简介：AbstractChronic obstructive pulmonary disease (COPD) is a heterogeneous disease characteristic of small airway inflammation, obstruction, and emphysema. It is well known that spirometry alone cannot differentiate each separate component. Computed tomography (CT) is widely used to determine the extent of emphysema and small airway involvement in COPD. Compared with the pulmonary function test, small airway CT phenotypes can accurately reflect disease severity in patients with COPD, which is conducive to improving the prognosis of this disease. CT measurement of central airway morphology has been applied in clinical, epidemiologic, and genetic investigations as an inference of the presence and severity of small airway disease. This review will focus on presenting the current knowledge and methodologies in chest CT that aid in identifying discrete COPD phenotypes.