简介：Weinvestigatetheinteractionbetweenapositivemassandanegativeeffectivemassthroughathreemasschainconnectedwithelasticsprings,apairofmassesisdesignedtohaveaneffectivenegativemass,anditinteractswiththethirdpositiveoneasifanequivalenttwo-masschain.Thedynamicsoftheequivalenttwo-masschainshowsthatthetwobodiesmaybeself-acceleratedinsamedirectionwhentheeffectivemassbecomesnegative,theexperimentisalsoconductedtodemonstratethistypeofmotion.Wefurthershowthattheenergyprinciple(Hamilton’sprinciple)isapplicableiftheenergyofthenegativemassunitisproperlycharacterized.Theresultmayberelevanttocompositewithcellsofeffectivenegativemass,theirinteractionwithmatrixmayleadtomorericherunexpectedmacroscopicresponses.

简介：Aninvestigationismadeonthesoilpressureinaninecabinopenedbottomellipticalbarrelstructure.Thecalculationmodelsusingthepenetrationofnegativepressuremethodhavebeendeveloped.Thefirstcalculationmodelisisfortheconstructionstageinvolvingthreezones,namely,passive,transitional,andactiveestablishedforthesoilpressureincabins.Theothercalculationmodelisbasedontheusestage,withthetwo(passiveandactive)zonesforthesoilpressureincabins.Theheightofzonesandthetheoreticalanalyticalsolutionsofinnersoilpressurearederived.Theanalyticalformulasofthemodelsareprovedusingthefiniteelementmethodandexperimentaldata,andtheformulasareanalyzedintheinnersoilpressureinthesamecondition.Thecalculationmodelscanbeusedforothermulti-positionstructuraldesignorconstruction.

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简介：AbstractBackground:Time in range (TIR) refers to the time an individual spends within their target glucose range, which now has been popularized as an important metric to classify glycemic management and also recognized as an important outcome of current diabetes therapies. This study aimed to investigate the association between TIR and the severity of the urinary albumin excretion rate (UAER) in patients with type 2 diabetes mellitus (T2DM).Methods:We retrospectively analyzed the data of 1014 inpatients with T2DM at the Department of Endocrinology and Metabolism of Peking University International Hospital, China. TIR was defined as the percentage of blood glucose within the target range of 3.90-10.00 mmol/L. Urine samples for assessment of UAER were collected for 3 consecutive days from the start of hospitalization.Results:The TIR values for patients with normal urine levels of albumin, microalbuminuria, and macroalbuminuria were 70% ± 20%, 50% ± 20%, and 30% ± 20%, respectively (all P < 0.001). The patients were stratified according to quartiles of TIR as follows: quartile (Q) 1, <55%; Q2, 55%-72%; Q3, 73%-83%; and Q4, >83%. The incidences of microalbuminuria in Q1, Q2, Q3, and Q4 were 41.1%, 21.6%, 7.1%, and 5.5% (all P < 0.001), respectively. The respective incidences of macroalbuminuria were 24.2%, 1.1%, 1.4%, and 0% (all P < 0.001). In multinomial logistic regression analyses, TIR was significantly correlated with microalbuminuria (odds ratio [OR] 0.58, 95% confidence interval [CI]: 0.52-0.65, P < 0.001) and macroalbuminuria (OR 0.26, 95% CI: 0.18-0.38, P < 0.001) after adjusting for age, sex, body mass index, diabetes duration, systolic blood pressure, and levels of triglycerides, glycosylated hemoglobin A1c, and creatinine.Conclusion:The proportion of blood glucose in TIR is closely related to the severity of UAER in patients with T2DM.

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简介：Atunablenegativecoefficientband-passmicrowavephotonicfilter(MPF)withimprovedmainlobe-to-sidelobesup-pressionratio(MSSR)byaSagnacinterferometer(SI)isexperimentallydemonstrated.ThenegativecoefficientcharacteristicofMPFisachievedbyusingthephasemodulationtechnology.Thecentralfrequencyoftheband-passMPFistunablecontinuouslybychangingthewavelengthseparationofmulti-wavelengthopticalcarriers.A38-tapnegativecoefficientband-passMPFwhoseMSSRisincreasedbyabout6.371dBisachievedinexperimentbyapodizingthetapcoefficientwiththeSagnacinterferometer.

简介：Thebandgappropertiesofone-dimensionalphotoniccrystalswithadefectlayerofnegativerefractiveindexmaterialsarestudied.Thedefectmodewidthisbiggerthanthatofconventionalone-dimensionalphotoniccrystalswithadefectlayerofpositiverefractiveindexmaterials.Thedefectmodeoftheformerisdifferentfromthatofthelatter,shiftstowardsthedirectionofhighfrequency(shortwavelength),andhasabiggershiftingvelocity.Furthermoretheeffectsonthetransmissionpropertiesoftheformerphotoniccrystalscausedbychangeinthepositionofthedefectlayerofnegativerefractiveindexareinvestigated.Finallytheopticalenhancementoftheformerphotoniccrystalsisalsoinvestigated.

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简介：Thenegativeionfastatombombardment(NIFAB)massspectraofmono-,di-saccharidesandglycosidesusingphenylboronicacid(PBA)asreagenthavebeenstudied.Intheionsource,PBAreactsstereospecificallywiththemoleculescontainingcis-vicinalglycolstoformcharacteristicions,fromwhichthestereo-isomersofsaccharidescanbedefinitelydistinguished.Disaccharidesandglyco-sideswithβ-glycosidiclinkageseemtobeunfavorabaletoreactwithPBA,therefore,bycomparisonoftheabundancesofthecharacteristicions,theconfigurationoftheglycosidiclinkageinthesecompoundsmaybeinferred.

简介：在华南的Dajiangbian形成是统治siliciclastic的沉积继任，低档变态在卡赛西亚·布洛克的西方的边缘上扔了，并且被glaciogenicdiamictite(Sizhoushan形成)盖住。Sizhoushanglaciogenic阶层能被归因于Jiangkou冰川(Sturtian冰川)他们在华南与Jiangkou阶层分享stratigraphic和lithological类似的事件。在整个Dajiangbian形成的上面的部分的一些碳酸盐，燧石和页岩单位为碳酸盐碳同位素被取样(13Ccarb)和器官的碳同位素(13Corg)分析。geochemical的一个范围索引包括氧同位素(18O)并且Mn/Sr(Fe/Sr)比率建议主要的碳同位素价值在上面的Dajiangbian形成被保存。上面的Dajiangbian形成表演13C向上减少向的-0.1,的carb到-5.4。我们建议否定13在Sizhoushandiamictite下面的C旅行是有Pre-SturtianIslay13Ccarb异例并且与全球Neoproterozoic同位素地层学允许关联。我们发现碳酸盐和上面的Dajiangbian形成的器官的碳同位素数据被联合，与13Ccarb-13C在多重大陆上观察的org模式。

简介：在这研究，被尝试了从他们的氨基酸序列预言克否定的细菌的蛋白质的主要功能。使用训练并且测试的数据集由670非冗余的克否定的细菌的蛋白质(255细胞的过程，60个信息分子，285新陈代谢，和70个毒力因素)组成。首先，我们开发了使用氨基酸和dipeptide作文的一个基于SVM的方法并且分别地完成了52.39%和47.01%的全面精确性。我们基于tetrapeptides，我们在识别了显著地在蛋白质的一个班上发现的唯一的tetrapeptides为蛋白质的分类介绍了一个新概念。这些tetrapeptides作为输入特征被使用预言蛋白质的功能并且完成了68.66%的全面精确性。我们也开发了tetrapeptide信息与氨基酸作文在被使用并且完成了70.75%的全面精确性的一个混合方法。五倍的生气确认被用来评估这些方法的表演。网服务器VICMpred为预言克否定的细菌的蛋白质(http://www.imtech.res.in/raghava/vicmpred/)的函数被开发了。

简介：BackgroundSepticshockcausedbybacteremiaisalife-threateninginfectionwhoseprognosisishighlydependentonearlyrecognitionandappropriatetreatment.Procalcitonin(PCT)hasbeenshowntoaccuratelyandquicklydistinguishbacteremiafromnoninfectiousinflammatorystatesincriticallyseverepatients.However,theextentofPCTmagnitudeelevationaccordingtotheGramstainresultinelderlypatientswithcoronaryheartdisease(CHD)attheonsetofsepticshockcausedbybacteremiavaries,andhasnotbeenclearlyelucidated.MethodsThemedicalrecordsofadvancedage(non-neutropenic)patientwithCHDandsepticshockbetweenMar2013andJun2015whohadbacteremiacausedbyeitherGram-positive(GP)bacteriaorGram-negative(GN)bacteriawerereviewed,andthelevelsofPCT,C-reactive(CRP)proteinandwhitebloodcellscount(WBC)inbothgroupswereanalyzed.Results75episodesofeitherGNbacteremia(n=40)orGPbacteremia(n=35)wereenrolled.PCTlevelswerefoundtobemarkedlyhigherinpatientswithGNbacteremiathaninthosewithGPbacteremia[(8.93±17.58)vs.(64.42±58.56)ng/L(P<0.001)],whereastherewasnosignificantdifferenceinCRPandWBC(P>0.05).Moreover,ahighPCTlevelwasfoundtobeindependentlyassociatedwithGNbacteremiainthisstudypopulation.APCTlevelof19.69ng/mLyieldeda72.5%sensitivity,a91.4%specificity,an8.43positivelikelihoodratioanda0.30negativelikelihoodratioforGN-relatedbacteremiainthestudycohort[AUROCC=0.870(0.041),95%CI(0.790-0.949)].ConclusionInanelderlypatient(non-neutropenic)withCHDandsepticshock,GNbacteremiacouldbeassociatedwithhigherPCTvaluesthanthosefoundinGPbacteremia(PCT>19.69ng/mL).

简介：AbstractNearly 70% of breast cancer (BC) is hormone-receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, and endocrine therapy is the mainstay of treatment for this subtype. However, intrinsic or acquired endocrine resistance can occur during the endocrine treatment. Based on insights of endocrine resistance mechanisms, a number of targeted therapies have been and continue to be developed. With regard to HR-positive, HER2-negative advanced BC, aromatase inhibitor (AI) is superior to tamoxifen, and fulvestrant is a better option for patients previously exposed to endocrine therapy. Targeted drugs, such as cyclindependent kinases (CDK) 4/6 inhibitors, mammalian target of rapamycin (mTOR) inhibitors, phosphoinositide-3-kinase (PI3K) inhibitors, and histone deacetylase (HDAC) inhibitors, play a significant role in the present and show a promising future. With the application of CDK4/6 inhibitors becoming common, mechanisms of acquired resistance to them should also be taken into consideration.

简介：<正>Usingsubtractioncloning,weidentifiedthehumanN-MycDownstream-RegulatedGene-2(hNDRG2),locatedat14q11.2,asacandidatetumorsuppressorgene.Semi-quantitativeRT-PCRshowedthattheexpressionofhNDRG2in15of27(56%)humanGBMtissuesandall6humanglioblastomacelllineswassignificantlylowerthanthatinthenormalbrain.TheexpressionofhNDRG2alsowasevaluatedin60lung-carcinomapatients.17of26casesofsquamouscarcinomaand4of11casesofsmallcelllungcancerdisplayed

简介：AbstractBackground:After neoadjuvant chemotherapy (NAC), non-pathological complete response of breast cancer patients can benefit from tailored adjuvant chemotherapy. However, it is difficult to select patients with poorer prognosis for additional adjuvant chemotherapy to maximize the benefits. Our study aimed to explore whether the subtypes of tumor-infiltrating lymphocytes (TILs) in residual tumors (RT) is related to the prognosis of triple-negative breast cancer (TNBC) after NAC.Methods:Data from patients with primary TNBC consecutively diagnosed at the Breast Disease Center of Peking University First Hospital from 2008 to 2014 were retrieved, and the cases with RT in the breast after NAC were enrolled. TILs subtypes in RT were observed by double-staining immunohistochemistry, and counted with the median TILs value per square millimeter as the cut-off to define high versus low TILs density in each subtype. The relationships between the TIL density of each subgroup and the clinicopathological characteristics of the RT after NAC patients were analyzed by Fisher exact test. Disease-free survival (DFS) and overall survival (OS) were analyzed by the Kaplan-Meier method and log-rank statistics.Results:A total of 37 eligible patients were included in this study, and the median follow-up period was 50 months (range 17–106 months). There was no significant correlation between the infiltrate density of CD4+, CD8+, CD20+, and CD68+ lymphocytes and clinic-pathological characteristics. Significantly better prognosis was observed in patients with high CD4+-TILs (DFS: P = 0.005, OS: P = 0.021) and high CD8+-TILs (DFS: P = 0.018) and low CD20+-TILs (OS: P = 0.042). Further analysis showed that patients with CD4+/CD20+ ratio greater than 1 (DFS: P = 0.001, OS: P = 0.002) or CD8+/CD20+ ratio greater than 1 (DFS: P = 0.009, OS: P = 0.022) had a better prognosis.Conclusions:Subtypes of TILs in RT is a potential predictive biomarker of survival in TNBC patients after NAC.

简介：用微数组技术的高产量的全球基因表示上的研究曾经产生了大量系统的transcriptome数据。在利用这些异构的数据集的主要挑战是怎么由内部试金的方法使表示侧面正常化。不同非线性、线性的正规化方法被开发了，它实质上依靠在二不同试金之间的真或察觉的对数的褶层变化分布在自然是对称的假设。然而，不对称的基因表达式变化经常被观察，导致非最优的正规化结果并且在后果潜在地到几千假调用。因此，我们明确地调查了不对称的比较transcriptome侧面并且为柔韧、全球的内部试金的正规化用指数的错误工作的加权的否定的秒顺序(NeONORM)开发了正规化。NeONORM高效地抑制规章的事件处理以便在正规化上最小化他们的似是而非的影响的真基因。我们用人工、真的试验性的数据集评估了NeONORM的适用性，哪个证明NeONORM能系统地被用于内部试金、内部条件的比较。

简介：AbstractBackground:Helicobacter pylori (HP) has been considered to be one of the primary causes of gastric mucosa-associated lymphoid tissue (MALT) lymphoma since 1993. Low-grade gastric MALT lymphoma with HP is widely treated with HP eradication therapy, according to each specific clinical situation. However, several studies and guidelines indicate that the modified HP eradication therapy is also valid for HP-negative gastric MALT lymphoma. The aim of this study was to perform a meta-analysis of the clinical efficacy of the modified HP eradication therapy for gastric MALT lymphoma without HP.Methods:We searched studies that reported the response rate of the modified HP eradication therapy regimen for gastric MALT lymphoma without HP by using PubMed, Medline, and Ebsco from January 1971 until February 2019. All statistical analyses were carried out using R 3.5.3 (Mathsoft Company, Cambridge, MA, USA). The pooled response rate was expressed as a decimal. The heterogeneity test was performed using the I-squared (I2) statistic.Results:A total of 14 studies were selected with a total of 148 patients with HP-negative gastric MALT lymphoma. The overall pooled response rate was 0.38 (95% confidence interval [CI]: 0.29-0.47). The combined estimate is I2 = 57% (P < 0.01). The study subjects were categorized by factors (area of patients). The pooled response rate of the sub-groups (Korea, Japan, China, and Western countries) was 0.63 (95% CI: 0.50-0.76), 0.16 (95% CI: 0.05-0.30), 0.38 (95% CI: 0.20-0.55), and 0.57 (95% CI: 0.08-1.00). The response rate showed that the modified HP eradication therapy was effective for patients with HP-negative gastric MALT lymphoma, especially in Korea and Western countries.Conclusion:Therefore, the modified HP eradication therapy can be considered an optional therapy for patients with low-grade HP-negative gastric MALT lymphoma. However, several limitations were revealed in the meta-analysis. Further systematic reviews and research are required.

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简介：Toinvestigatetheroleofnegative-regulatoryfactorsA20,IRF-4andTRAF4ofthetoll-likereceptor(TLR)signalpathwaysinimmunologicalpathogenesisofKawasakidisease(KD),48childrenwithKawasakidisease,16childrenwithinfectiousdisease(ID)and16age-matchedhealthychildrenwerestudied.Reverse-transcriptionPCR(RT-PCR)andreal-timePCRwereusedtoevaluatetheexpres-sionlevelsofnegative-regulatoryandeffectivefactorsintoll-likereceptor4(TLR4)signalpathwaysandproinflammatoryfactorsinperipheralbloodmonocyte/macrophage(MC).Inthisstudy,expressionlevelsofTLR4,MD-2,MyD88,IRAK-4,TRAF6,TAK1,andTAB2mRNAinKDgroupweredetectedtobeelevatedsignificantlyduringacutephaseofKD.Transcriptionlevelsofnegative-regulatoryfactorsA20,IRF-4andTRAF4mRNAinKDorIDpatientsincreasedremarkably.However,expressionsofIRF-4andTRAF4inKDpatientsweredetectedtobelowerthanthatinIDpatients,exceptthattran-scriptionlevelsofA20werefoundtobehigherthanthatinIDpatients.Simultaneously,expressionsofproinflammatorycytokinessuchasL-1β,IL-6andTNF-αinKDpatientsweresignificantlyelevatedcom-paredwiththoseinIDpatients.Furthermore,itwasfoundthatstimulationoflipopolysaccharide(LPS)remarkablyup-regulatedtheexpressionsofnegative-regulatoryfactorsA20,IRF-4andTRAF4inKDpa-tientsorhealthyvolunteers.ThemRNAlevelsofallthethreefactorsinKDpatientswerefoundtobelowerthanthatinthelatter.Inaddition,transcriptionlevelsofIRF-4andTRAF4inKDpatientswithcoronaryarterylesion(KD-CAL~+)weredetectedtobelowerthanthoseinKDpatientswithoutcoronaryarterylesion(KD-CAL~-)duringacutephase,whilethatofA20inKD-CAL~+groupwerelowerthanthatinthelatter.AndthelevelsofexpressionsofproinflammatorycytokinesinKD-CAL~+groupwerefoundtobehigherthanthoseinKD-CAL-group(P<0.01).Thesefindingssuggestthataberrantexpressionofnegative-regulatoryfactorsofTLRssignalpathwaysmaybeinvolved

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