简介：AbstractBackground:Time in range (TIR) refers to the time an individual spends within their target glucose range, which now has been popularized as an important metric to classify glycemic management and also recognized as an important outcome of current diabetes therapies. This study aimed to investigate the association between TIR and the severity of the urinary albumin excretion rate (UAER) in patients with type 2 diabetes mellitus (T2DM).Methods:We retrospectively analyzed the data of 1014 inpatients with T2DM at the Department of Endocrinology and Metabolism of Peking University International Hospital, China. TIR was defined as the percentage of blood glucose within the target range of 3.90-10.00 mmol/L. Urine samples for assessment of UAER were collected for 3 consecutive days from the start of hospitalization.Results:The TIR values for patients with normal urine levels of albumin, microalbuminuria, and macroalbuminuria were 70% ± 20%, 50% ± 20%, and 30% ± 20%, respectively (all P < 0.001). The patients were stratified according to quartiles of TIR as follows: quartile (Q) 1, <55%; Q2, 55%-72%; Q3, 73%-83%; and Q4, >83%. The incidences of microalbuminuria in Q1, Q2, Q3, and Q4 were 41.1%, 21.6%, 7.1%, and 5.5% (all P < 0.001), respectively. The respective incidences of macroalbuminuria were 24.2%, 1.1%, 1.4%, and 0% (all P < 0.001). In multinomial logistic regression analyses, TIR was significantly correlated with microalbuminuria (odds ratio [OR] 0.58, 95% confidence interval [CI]: 0.52-0.65, P < 0.001) and macroalbuminuria (OR 0.26, 95% CI: 0.18-0.38, P < 0.001) after adjusting for age, sex, body mass index, diabetes duration, systolic blood pressure, and levels of triglycerides, glycosylated hemoglobin A1c, and creatinine.Conclusion:The proportion of blood glucose in TIR is closely related to the severity of UAER in patients with T2DM.

简介：AbstractBackground:The low accuracy of equations predicting 24-h urinary sodium excretion using a single spot urine sample contributed to the misclassification of individual sodium intake levels. The application of single spot urine sample is limited by a lack of representativity of urinary sodium excretion, possibly due to the circadian rhythm in urinary excretion. This study aimed to explore the circadian rhythm, characteristics, and parameters in a healthy young adult Chinese population as a theoretical foundation for developing new approaches.Methods:Eighty-five participants (mean age 32.4 years) completed the 24-h urine collection by successively collecting each of the single-voided specimens within 24 h. The concentrations of the urinary sodium, potassium, and creatinine for each voided specimen were measured. Cosinor analysis was applied to explore the circadian rhythm of the urinary sodium, potassium, and creatinine excretion. The excretion per hour was computed for analyzing the change over time with repeated-measures analysis of variance and a cubic spline model.Results:The metabolism of urinary sodium, potassium, and creatinine showed different patterns of circadian rhythm, although the urinary sodium excretion showed non-significant parameters in the cosinor model. A significant circadian rhythm of urinary creatinine excretion was observed, while the circadian rhythm of sodium was less significant than that of potassium. The circadian rhythm of urinary sodium and creatinine excretion showed synchronization to some extent, which had a nocturnal peak and fell to the lowest around noon to afternoon. In contrast, the peak of potassium was observed in the morning and dropped to the lowest point in the evening. The hourly urinary excretion followed a similar circadian rhythm.Conclusion:It is necessary to consider the circadian rhythm of urinary sodium, potassium, and creatinine excretion in adults while exploring the estimation model for 24-h urinary sodium excretion using spot urine.

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简介：技术突破推进了诊断成像的时间、空间的决定，并且3维(3-D)重建技术被介绍了进日常临床的实践。虚拟内视镜检查法(VE)是在3-D空格放大代表性的图象的感觉的一种非侵略的技术，提供病理学的区域和他们的包围结构的精确空间关系。许多计算机算法能被用来产生3-D图象，利用螺线计算了断层摄影术或磁性的回声成像(MRI)的在也固有的信息。VE图象通过空机关启用endoluminal航行，因此模仿常规内视镜检查法。几临床的研究验证了虚拟膀胱镜检查的诊断用途，它在膀胱肿瘤的察觉有高敏感和特性率。在肾盂，输尿管和尿道的虚拟探索的出版经验令人鼓舞却仍然少见。VE是一只保险箱，能与ureteropelvic连接阻塞在病人的长期的后续被使用的非侵略的方法，膀胱肿瘤和输尿管或尿道狭窄。它的主要限制是无能为组织病理学说的检查和联系电离放射危险提供活体检视织物标本(除非MRI被使用)。在endoluminal狭窄或阻塞的情况中，然而，VE向头部地允许虚拟endoluminal航行并且对小型机关枪的一种尾耳的片断。得出结论，VE提供评估泌尿道的一个不太侵略的方法，特别为比放射线学者不太熟悉代表性的成像的临床医生。

简介：尽管测试的前列腺特定的抗原(PSA)无疑增加了的浆液的平淡的使用前列腺癌症(PCa)察觉，它的主要缺点之一是它特性的缺乏。作为后果，许多人为懒惰的瘤经历不必要的活体检视或治疗。PCa特定的标记为疾病和一个前列腺瘤的攻击性的预言的早察觉被需要。因为PCa是异构的疾病，瘤标记的一块面板为更精确的诊断是基本的。几biomarkers由于他们为在组织的疾病的特性是有希望的。然而，织物是象一个可能的屏蔽工具不合适。因为尿能容易以一种非侵略的方式被获得，它是为测试的biomarker的有希望的底层。这篇文章为在尿的PCa的非侵略的测试考察biomarkers。

简介：Inordertocreateanewmimicofglutathioneperoxidase(GPx),bioimprintingwasusedtogenerategluta-thione(GSH)bindingsiteandchemicalmodificationwasusedtoincorporatecatalyticgroupselenocystine(Sec).Humanserumalbumin(HSA)andS-substituteddinitrophenylglutathione(GSH-S-DNP)werechosenastheimprintedmatrixandimprintingtemplate,respectively,togenerateaGSH-imprintedprotein(GSH-HSA)bybioimprinting.SecwasincorporatedintotheGSH-HSAbychemicalmodificationtogiveanewGPxmimic(Se-GSH-HSA).Se-GSH-HSAdisplayedconsiderablyhigherGPxactivitythannon-printedHSA(Se-HSA).TheenzymicpropertiesandkineticsofSe-GSH-HSAwerestudied.Moreover,Se-GSH-HSAwasconfirmedtohavestrongerantioxidantabilitytoprotectmitochondriaagainstoxidativedamagewithferroussulfate/ascorbate-inducedmitochondriadamagemodel,indicatingthatSe-GSH-HSAhaspotentialapplicationinmedicine.

简介：ThispaperanalyzestheimpactsofurbanizationandunemploymentrateonChina’sdivorceratewiththepaneldataof31Chineseprovincesfrom2000to2011.Thestudymanifestsasfollows.First,thesignificantinfluenceofurbanizationcannotbeobservedontherisingbreakdownsincethelatterisnottheinevitableresultoftheformer.Inthesecondplace,unemploymentratehasasignificantnegativeinfluenceondivorcerate,namely,withtheformerincreasing,thelatterwilldecrease,whichechoestheperspectiveofdivorcecost.Andfinally,thispaperalsofindspositiveeffectsofpercapitafixedinvestment,old-agedependencyrate,averagehouseholdsize,theproportionoffloatingpopulationandpopulationdensity,andnegativecorrelationofaverageeducationattainmentondivorcerate.

简介：目的：观察推拿治疗手术后尿潴留的临床疗效。方法：对37例手术后尿潴留患者施行穴位推拿治疗，穴位选用气海、关元、中极，双侧三阴交。结果：治疗1～3次后，治愈36例，1例因退出治疗而未统计疗效。结论：穴位推拿是治疗手术后尿潴留的一种有效方法。

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简介：有在15和37污慫楬敮猠汯瑵潩的牛的浆液白朊(BSA)的gatifloxacin(HGA)的相互作用？

简介：在这个工作，我们通过腐蚀测试在纯镁的腐蚀上在氯化物离子和白朊的synergistic效果上报导。我们证明白朊的吸附主要在NaCl答案影响纯镁的阳极的极化行为。白朊的低集中在起始的沉浸时间提高纯镁的反应反应和氢的起始的发展。1g/L白朊的增加在NaCl答案为纯镁提供有限腐蚀控制。与低集中白朊比较，10g/L白朊的增加能有效地与0.20.8wt.%的NaCl集中在测试答案禁止纯镁的进一步的溶解，但是这效果与增加氯化物离子的集中逐渐地降低。

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简介：62patientswithtraumaticparaplegiaweretreatedwithacupuncture(GovernorVesselelectro-stimulation),accordingtothetheoriesofTCMsuchasdredgingthemeridians,regu-latingvitalenergyandblood,improvingbloodcirculation,reinforcingmarrowandreplenishingbrain.Theeffectofacupunctureonurinarybladderdisturbancewasstudied.Theresultsindicatedthattotaleffectratewas96.8%(Ⅰ—Ⅲ),markedeffectratewas66.1%(Ⅰ—Ⅱ).Themarkedeffectrateincompleteparaplegiawassignificantlydifferentfromthatinimcompleteparaplegia;itwas63.0%and87.5%respectively.Furthermore,theresultssuggestedthatthedegreeofspinalcordinjurywasveryimprotantfactorthataffectedtheeffectofacupuncturetherapy.

简介：ItwasreportedthatProf.YUandhiscolleaguesfromtheFirstAttachedHospitalofHarbinMedicalUniversityhadachievedanewdevelopmentinelectroacupuncture(EA)treatmentofurinarylithiasisinclinic.Bycombiningthemeridian-collateraltheoryoftraditionalChinesemedicine(TCM)andthesegmentaldistributionofthespinalnerveroots

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简介：我们决定了在prostatic演算和更低的尿道之间的关联症状(LUTS)，以及prostatic演算的预先安排的因素。为LUTS在我们的诊所介绍了的1527个病人，802经历了完全的评估，包括transrectalultrasonography，voidedbladder-3标本和国际prostatic症状分数(IPSS)。有prostatic演算的335个病人和没有prostatic演算的467个病人的一个总数分别地被划分成演算和没有演算组。严重LUTS和prostatic演算的预兆的因素用uni/multivariate分析被决定。全面IPSS分数是15.7卤9.2在演算和没有演算组织的9.2和14.1卤，分别地(P=0.013)。最大的流动率是12.1卤6.9和14.2卤8.2mLs?1在演算和没有演算组织，分别地(P=0.003)。在为预言严重LUTS的因素的univariate分析上，在年龄的差别(P=0.042)，prostatic演算(P=0.048)并且前列腺炎(P=0.018)是统计上重要的。在multivariate分析上，然而，没有因素是重要的。在为预先安排的multivariate分析上prostatic演算的因素，在年龄的差别(P<0.001)并且前列腺体积(P=0.001)是重要的。到我们的知识，有prostatic演算的病人抱怨更严重的LUTS。然而，prostatic演算不是严重LUTS的一个独立预兆的因素。因此，不仅因为prostatic演算而且因为年龄和另外的因素，有prostatic演算的人有更严重的LUTS。另外，老年和大前列腺体积是为prostatic演算的独立人士预先安排因素。

简介：我们在朝鲜良性的prostatic增生(BPH)在更低的尿道症状(LUTS)上分析了肥胖的效果病人。这是multicenter，在朝鲜在四个中心进行的代表性的、未来的学习。有对BPH第二等的LUTS的602个人的一个总数被包括。BPH/LUTSs盒子是有8削尖的国际前列腺症状分数(IPSS)的40年的人。高度，重量和腰圆周被测量。在602个病人之中，156个病人在90厘米上面有腰圆周，代表中央肥胖，并且215个病人在25kgm-2上面有一个身体团索引。腰圆周断然与前列腺体积被相关(P=0.034)。有腰圆周的人>90厘米富有经验1.36褶层与腰圆周90厘米与人相比增加了严重LUTS(95%CI0.82鈥?.41)的风险。前列腺体积断然与中央肥胖在人与紧急和nocturia被相关。在与BPH诊断的朝鲜的人的这张人口，中央肥胖而非全面肥胖似乎是LUTS的更重要的预言者与BPH相关。