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简介：Thequantitativeinterpretationofgravityanomaliesduetoshallowstructuresneedsseparationbetweenlongwavelengthanomalies(regionalanomalies)andshortwavelengthanomalies(residualanomalies).Theregional-residualfieldseparationcanbecarriedoutusingthepolynomialmethod.Inthiscase,theso-calledregionalfieldofordernistreatedasapolynomialofdegreen.Thepresentstudyshowsthatthedegreenmustvarybetweenasmallestvaluenminandamaximumvaluenmax.Thisarticlepresentsamethodtoprocessgravitydatathatallowsdeterminationofnminandnmaxforagivenstudyarea.WeapplythemethodtogravitydataoftheSouth-WestCameroonzone.Inthischosenstudyarea,wefindthatregionalanomalymapsofordersrangingfrom1to9andresidualanomalymapsofordersrangingfrom1to8canbeusedforsuitableinterpretation.Theanalysesshowthatonemayneedresidualanomalymapsofseveralorderstoperformsatisfactoryquantitativeinterpretationofthedifferentintrusivebodiesfoundinagivenarea.

简介：Inthisstudy,theresidualstrainofathinconductivemetalwireonapolymersubstrateafterelectricalfailureismeasuredwithSEMmoir′e.Focusedionbeam(FIB)millingisappliedtofabricatemicronmoir′egratingsonthesurfacesofconstantanwiresandtherandomphaseshiftingtechniqueisusedtoprocessmoir′efringes.Thevirtualstrainmethodisbrieflyintroducedandusedtocalculatetherealstrainofspecimens.Inordertostudytheinfluenceofadefectontheelectricalfailureoftheconstantanwire,experimentswereconductedontwospecimens,onewithacrack,whiletheotheronewithoutanycrack.Bycomparingtheresults,wefoundthatthedefectmakesthecriticalbeamcurrentofelectricalfailuredecrease.Inaddition,thespecimensweresubjectedtocompressionafterelectricalfailure,inagreementwiththeobservedcrackclosureofthespecimen.Thesuccessfulresultsdemonstratethatthemoir′emethodiseffectivetocharacterizethefull-fielddeformationofconstantanwiresonthepolymermembrane,andhasagoodpotentialforfurtherapplicationtothedeformationmeasurementofthinfilms.

简介：AbstractBackground:Circular RNAs (circRNAs) are endogenous non-coding RNAs, some of which have pathological roles. The current study aimed to explore the role of circRNA BTG3-associated nuclear protein (circ-BANP) binding with let-7f-5p and its regulation of the toll-like receptor 4 (TLR4)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in residual hepatocellular carcinoma (HCC) after insufficient radiofrequency ablation (RFA).Methods:Circ-BANP, let-7f-5p, and TLR4 expressions in HCC samples were assessed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blotting. Bioinformatics prediction, RNA pull-down assay, and dual luciferase reporter gene assay were used to analyze the relationships among circ-BANP, let-7f-5p, and TLR4. Huh7 cells were used to generate an in vitro model of residual HCC, defined as Huh7-H cells, which were transfected with either a plasmid or the sequence of circ-BANP, let-7f-5p, or TLR4. Expression of circ-BANP, let-7f-5p, and TLR4 mRNA was determined by RT-qPCR. TLR4, STAT3, p-STAT3, vascular endothelial growth factor A, vascular endothelial growth factor receptor-2, and epithelial-mesenchymal transformation (EMT)-related factors proteins were determined by Western blotting. Cell proliferation was determined by cell counting kit-8 and 5-Ethynyl-2’-deoxyuridine (EdU) assay and cell migration and invasion by Transwell assay. Animal studies were performed by inducing xenograft tumors in nude mice.Results:Circ-BANP and TLR4 mRNAs were upregulated in HCC tissues (the fold change for circ-BANP was 1.958 and that for TLR4 was 1.736 relative to para-tumors) and expression further increased following insufficient RFA (fold change for circ-BANP was 2.407 and that of TLR4 was 2.224 relative to para-tumors). Expression of let-7f-5p showed an opposite tendency (fold change for let-7f-5p in HCC tissues was 0.491 and that in tumors after insufficient RFA was 0.300 relative to para-tumors). Competitive binding of circ-BANP to let-7f-5p was demonstrated and TLR4 was identified as a target of let-7f-5p (P < 0.01). Knockdown of circ-BANP or elevation of let-7f-5p expression inhibited the TLR4/STAT3 signaling pathway, proliferation, invasion, migration, angiogenesis, and EMT in Huh7 and Huh7-H cells (P < 0.01). The effects induced by circ-BANP knockdown were reversed by let-7f-5p inhibition. Overexpression of TLR4 reversed the impact of let-7f-5p upregulation on the cells (P < 0.01). Silencing of circ-BANP inhibited the in vivo growth of residual HCC cells after insufficient RFA (P < 0.01).Conclusions:Knockdown of circ-BANP upregulated let-7f-5p to inhibit proliferation, migration, and EMT formation in residual HCC remaining after insufficient RFA. Effects occur via regulation of the TLR4/STAT3 signaling pathway.

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简介：尽管高分辨率能被电的记载提供，测量电的木头范围是狭窄的并且被限制接近井。地上凿穿表面电的潜在的大小能检测一个足够宽的范围，但是它的分辨率是有限的，特别地为有复杂的油和水分发或复杂结构的水库。在这研究，我们试图精确地由联合地上凿穿表面和crosswell定位3-D水库水和油分发电的潜力。首先，在垂直、水平的方向的油和水的分布被地上凿穿表面和crosswell检测电的潜在的方法，分别地然后测量crosswell潜力结果被用来校准测量地上凿穿表面改进垂直分辨率以便剩余油分发在有三种尺寸的更低的一半空间是坚定的电的潜在的数据。剩余油分发的评估被水库的模拟结果之间的差别的调查有或没有水泛滥获得。有限差别数字模拟结果证明空间剩余油分发能被联合crosswell和地上凿穿表面有效地决定电的潜力。

简介：Minimalresidualdisease(MRD)playsacausativeroleintumorrecurrenceandestablishmentofeffectiveandsensitiveassessmentofMRDcouldbeveryusefulforstagingandevaluationoftreatmentofdisease.Inthisstudy,weassessedtheusefulnessofhcf-2/JHPCRanalysisonoccultlymphoma...

简介：AbstractWe reported a case of a 32 years old male presenting with a perforating gunshot injury in craniocerebral region 3 h after the assault. The bullet entered above the right zygomatic arch, travelling through the coronal plane, and exited from the left zygomatic arch. The patient was fully conscious at presentation and developed facial nerve palsy during his hospital stay. Non-contrast CT scan of the head revealed fractures of the right orbit, bilateral maxilla, bilateral pterygoid plates, ethmoid air cells, vomer and left zygoma, and without any cerebral damage. He was treated conservatively and the facial palsy was resolved. The patient survived without any complications. Such case has not been described in the available literature till date.

简介：连续冷却的用法在数字焊接的转变(CCT)图模拟现状。不过，说明在分别地导致不同CCT行为和CCT图的材料的化学作文提供限制。因此，在发展中的剩余压力上在CCT图分析变化的影响是必要的。在现在的纸，在剩余压力的数字计算以后的四张CCT图和他们的效果为煤气的金属弧焊(GMAW)焊接的广泛地使用的结构的钢S355J2+N被调查过程。而非执行CCT行为的任意的调整，四个有理由的数据集合被用作输入到数字计算：在Sysweld数据库，通过Gleebledilatometry测试获得的试验性的数据，和TTT/CCT预言可得到的数据从JMatPro和爱迪生焊接研究所(EWI)计算了虚拟加入门软件。执行数字分析就不同CCT图而言在剩余压力导致了显著偏差。而且，改进失真和剩余的预言的可能性基于CCT强调行为被讨论。

简介：Whenmeasuringresidualstressofcoarse-grainaluminumalloyusingX-raydiffractionmethod,thediffractionprofileshowstwopeaksandpositionofmeasured2dwillbechanged,whichleadtoaninaccuratemeasurementresult.Hence,inthispaper,somemethodswereemployedtoimprovethemeasurementaccuracy.Duringthemeasuringprocess,differentparameters(diameterofirradiatedarea,Ψ-oscillationrangeandexposuretime)wereselectedandprofilepeakshiftmethodwasutilized.Moreover,whenthe20ofprofileswasdetermined,differentcalculationmethodswereusedtocalculatetheresidualstress.TheresultsshowthatdiameterofirradiatedareaandΨ-oscillationrangehavesignificantinfluenceonthemeasuringresult.Forstressvaluecalculateddirectlyfromthetestequipment,crosscorrelationmethodismoreaccuratethantheabsolutepeak.Furthermore,anothertwocalculationmethodsofslopewith2θ-sin~2Ψande-sin~2Ψwereusedtocalculatethestressbasedonparameters(2θ,ε)obtainedfromcrosscorrelationmethod.Itisconcludedthat20-sin~2Ψmethodcanfurtherimprovethemeasurementaccuracy.

简介：Threeresidualheterozygouslines(RHLs)carryingheterozygoussegmentsintheintervalsRM587-RM225,RM204-RM6119andRM6119-RM402ontheshortarmofricechromosome6,respectively,wereselectedfromaricepopulationderivedfromanRHLfortheintervalRM587-RM402.Tenmaternalhomozygotes,10paternalhomozygotesand20heterozygoteswereselectedfromeachoftheF2populationsderivedfromthethreeRHLs.Thethreesetsofnearisogeniclines(NILs)weregrowntodetectthegrainyieldperplant,numberofpaniclesperplant,numberoffilledgrainsperpanicleand1000-grainweight.WithanalysisonthephenotypicdifferencesamongthethreegenotypegroupsineachNILsetandthoseamongoverlappingchromosomesegmentsubstitutionlines,threeQTLsfornumberoffilledgrainsperpanicleandtwoQTLsforgrainyieldperplantwereresolved.Theywerelocatedintheintervalsrangingfrom0.66Mbto2.49Mb.Theadditiveeffectwashigherthanthedominanceeffectateachlocus.ThealleleforincreasingthetraitvaluewasderivedfromthepaternalparentatqNFGP6-1,andfromthematernalallelesatotherQTLs.Basedonthepresentstudy,anapproachforconstructingnewgeneticresourcetofacilitatefinemappingofQTLsinricewasproposed.

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简介：剩余在SUS304不锈钢的墙中强调圆柱的绘画杯被裂口戒指测试评估，并且踩的影响死剩余压力上的参数被调查。裂口戒指测试的一个新理论模型被开发在一枚戒指评估剩余压力，它被验证由有ABAQUS代码并且由nanoindentation测试的数字模拟合理、可靠。七组裂口戒指测试被完成，并且剩余压力根据理论模型的意见是计算的。裂口戒指测试结果证明环绕的剩余在SUS304不锈钢的墙中强调圆柱的绘画杯很大并且没随着变化不同死角落半径。环绕的剩余压力首先随画punchdie清理的增加增加了，当清理增加了时，当时是几乎未改变的比空白的厚度大1?公里。因此，一个更小的清理被建议被选在拉杯的SUS304不锈钢的墙中减少剩余压力。

简介：ThestainlessFe-Mn-Sishapememoryalloy(SMA)coatingwaspreparedonthesurfaceofAISI304stainlesssteel.Theprincipalresidualstressmeasuredbythemechanicalhole-drillingmethodindicatesthattheFe-Mn-SiSMAcladdingspecimenpossessesalowerresidualstresscomparedwiththe304stainlesssteelcladdingspecimen.Themeanstressvaluesoftheformerandthelatteron10-mm-thicksubstrateare4.751MPaand7.399MPa,respectively.What’smore,theirdeformationvalueson2-mm-thicksubstrateareabout0°and15°,respectively.Meanwhile,thevariationtrendandthevalueoftheresidualstresssimulatedbytheANSYSfiniteelementsoftwareconsistwithexperimentalresults.TheX-raydiffraction(XRD)patternshowsε-martensiteexistsinFe-Mn-SiSMAcoating,whichverifiesthemechanismoflowresidualstress.That’stheγ→εmartensitephasetransformation,whichrelaxestheresidualstressofthespecimenandreducesitsdeformationinthelasercladdingprocessing.

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简介：摘要：本文以500CSL-18铜合金压载泵为例，为减少铜合金铸件的残余应力导致的泵体开裂，分别从自然时效、热时效、整体振动时效、局部振动时效几个方面进行数据分析。最终的实测结果验证了几种去除方法的效果，值得在实际生产中推广应用。

简介：WehavestudiedtheangularmagnetoresistanceofironpnictidesBaFe2-xNixAs2,whichshowsclear180degreeperiodicityasfittedbyacosinefunction.Inthex=0.065sample,thephaseofthetwo-foldsymmetrychanges90degreesabovethetetragonal-to-orthorhombicstructuraltransitiontemperatureTs.Sincethephaseatlowtemperatureisassociatedwiththerotationoforthorhombicdomainsbymagneticfield,weshowthatevenvacuumgreasecanpushthepresenceoforthorhombicdomainsattemperaturesmuchhigherthanTs.Ourresultssuggestthatresidualstressmayhavesignificanteffectsinstudyingthenematicordersanditsfluctuationsinironpnictides.

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简介：AbstractBackground:After neoadjuvant chemotherapy (NAC), non-pathological complete response of breast cancer patients can benefit from tailored adjuvant chemotherapy. However, it is difficult to select patients with poorer prognosis for additional adjuvant chemotherapy to maximize the benefits. Our study aimed to explore whether the subtypes of tumor-infiltrating lymphocytes (TILs) in residual tumors (RT) is related to the prognosis of triple-negative breast cancer (TNBC) after NAC.Methods:Data from patients with primary TNBC consecutively diagnosed at the Breast Disease Center of Peking University First Hospital from 2008 to 2014 were retrieved, and the cases with RT in the breast after NAC were enrolled. TILs subtypes in RT were observed by double-staining immunohistochemistry, and counted with the median TILs value per square millimeter as the cut-off to define high versus low TILs density in each subtype. The relationships between the TIL density of each subgroup and the clinicopathological characteristics of the RT after NAC patients were analyzed by Fisher exact test. Disease-free survival (DFS) and overall survival (OS) were analyzed by the Kaplan-Meier method and log-rank statistics.Results:A total of 37 eligible patients were included in this study, and the median follow-up period was 50 months (range 17–106 months). There was no significant correlation between the infiltrate density of CD4+, CD8+, CD20+, and CD68+ lymphocytes and clinic-pathological characteristics. Significantly better prognosis was observed in patients with high CD4+-TILs (DFS: P = 0.005, OS: P = 0.021) and high CD8+-TILs (DFS: P = 0.018) and low CD20+-TILs (OS: P = 0.042). Further analysis showed that patients with CD4+/CD20+ ratio greater than 1 (DFS: P = 0.001, OS: P = 0.002) or CD8+/CD20+ ratio greater than 1 (DFS: P = 0.009, OS: P = 0.022) had a better prognosis.Conclusions:Subtypes of TILs in RT is a potential predictive biomarker of survival in TNBC patients after NAC.