简介：Parkinson’sdisease(PD)isanage-relatedneurodegenerativedisordercharacterizedbytypicalmotorsignsandsymptomsthatareduetodopamine(DA)depletioninthebasalganglia.ThetreatmentofPDissymptomatic,andaimsatreplacingthelostDAinputusingeitherL-DOPAorDAagonists.ThecausesofPDareunknownin

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简介：Regenerationinthecentralnervoussystem(CNS)islimited,andCNSdamageoftenleadstocognitiveimpairmentorpermanentfunctionalmotorandsensoryloss.Impairedregenerativecapacityismultifactorialandincludesinflammation,lossofthebloodbrainbarrier,andalterationintheextracellularmatrix(ECM).OneofthemainproblemsistheformationofaglialscarandtheproductionofinhibitoryECM,suchasproteoglycans,that

简介：Spinalcordinjury(SCI)isadevastatingconditionthatnotonlyresultsinalossofmotorfunctionsbutalsosevereautonomicdysfunctions(KrassioukovandClaydon,2006).Autonomicdysreflexia(AD)isalifethreateningepisodeoftransienthypertensionthatoccursupto30x/day(11x/dayon

简介：TheP300,anendogenoussubcomponentoftheevent-relatedpotential,isthoughttoreflectcognitiveprocesses.Theevent-relatedpotentialevokedbytheold-newmemoryrecognitiontaskintheoddballparadigmissuitableforexaminingtheneuralprocessesinvolvedinmalingeredneurocognitivedeficits.Forty-fourundergraduateswererandomlyassignedtoasimulatedmalingeringgroupandatruth-tellinggroup.Another22patientswithheadinjurieswereenrolledasacontrolgroup.Allparticipantscompletedtheold-newmemoryrecognitiontaskintheoddballparadigm.ThemeanP300amplitudeofthesimulatedmalingeringgroupwassignificantlyreducedcomparedwiththetruth-tellinggroup(P<0.01),butwasincreasedcomparedwiththecontrolgroup(P<0.01).TheseresultsrevealedthattheP300,evokedbytheold-newmemoryrecognitiontaskoftheoddballparadigm,maybeahelpfulindicatorfordeterminingcognitivemalingering.