简介：Twonewlimonoids,12-ethoxynimbolininsGandH(compounds1and2),andoneknowncompound,toosendanin(Chuanliansu)(compound3),wereisolatedfromthebarkofMeliatoosendan.TheirstructureswereelucidatedbyspectroscopicanalysisandX-raytechniques.Theabsoluteconfigurationoftoosendanin(3)wasestablishedbysingle-crystalX-raydiffraction.Compounds1-3wereevaluatedfortheircytotoxicityagainstfivetumorcelllines.

简介：ThepresentstudywasdesignedtoinvestigatethechemicalconstituentsoftherootsofCudraniafruticosaWight.Compoundswereisolatedbyvariouscolumnchromatographicmethodsincludingsilicagel,polyamide,sephadexLH-20,andsemi-preparativeHPLC.Theirstructureswereelucidatedbyacombinationof1Dand2DNMRtechniques,massspectrometry,andchemicalmethods.Twonewxanthones,CudraxanthoneTandU(1-2),alongwithfourknowncompounds(3-6)wereisolatedfromtherootsofCudraniafruticosaWight.

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简介：现在的学习被设计从大戟属植物helioscopiaL的整个植物孤立并且评估混合物的抗菌剂活动...各种各样的色析法的技术被用来孤立并且净化混合物。混合物的结构在基础上被阐明光谱数据(1HNMR，13CNMR，1H-1H舒适，HSQC，HMBC，NOESY，红外，和HR-ESI-MS)。新jatrophone类型diterpenoid(14,15-diacetoxy-3-benzoyloxy-7-nicotinoyloxy-9-oxo-jatropha-5E,11E-diene)，命名euphoheliosnoidE(1)，从E的整个植物被孤立。helioscopiaL。对口头的病原体加重1项显示出的重要抗菌剂活动。

简介：新-alkylated--butyrolactone,把melongenolideA(1)称为，与九一起已知的混合物从茄属melongena的根被获得，并且他们的结构作为melongenolideA(1)被识别，(+)-syringaresinol(2)，(+)-lyoniresinol(3)，5,5′-dimethoxylariciresinol(4)，(+)-(7R,8R)-4-hydroxy-3,3′,5′-trimethoxy-8′,9′-dinor-8,4′-oxyneoligna-7,9-diol-7′-aldehyde(5)，kaempferol-3-O-(2″，6″-di-O-p-trans-coumaroyl)--配糖物(6)，arjunolic酸混合物2，6，和7显示出的有势力氮的氧化物生产在上的禁止的效果导致lipopolysaccharide未加工264.7个巨噬细胞，与IC50价值是5.62±0.86，11.47±0.98，和27.75±1.26mol·L−1,分别地。

简介：二新naphthalenone混合物从Juglansmandshurica的绿核桃外壳被孤立，他们的结构作为4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one(1)被识别，4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one(2)。1和2作为JuglanstetraloneA(1)和JuglanstetraloneB(2)被说出的混合物。对胃的癌症BGC-823房间比2加重1项显示出的更重要的反肿瘤活动，wih125.89的IC50(g(mL−1。

简介：现在的学习被设计决定Pinelliapedatisecta的茎tuber的化学成分。化学成分被各种各样的色析法的技术，和他们的结构孤立并且净化根据物理化学的性质被阐明并且光谱数据。三新碱(加重1，2，和3)作为9-被获得并且识别((5-methoxypyridin-2-yl)甲基)-9H-purin-6-amine(1)，4-(2-(2，5-dioxopyrrolidin-1-yl)乙醇)苯基醋酸盐(2)，并且N-(9-((5-methoxypyridin-2-yl)甲基)-9H-purin-6-yl)acetamide(3)。这些混合物与人的颈的癌症HeLa房间为他们的cytotoxicity被作比较。混合物1和3显著地与是的IC50价值禁止了HeLa房间的增长3.02???????┱??????????????愠摮潲牧灡潨楬敤？？

简介：试图在安息香perkinsiae的bark学习化学成分。混合物与色析法的方法被孤立的方法，和他们的化学结构被阐明根据光谱数据。结果十混合物作为5-(2-propen-1-one)被孤立并且鉴别-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran(1)，1-hydryoxyegonolgentiobioside(2)，obassiosideB(3)，egonol(4)，egonol配糖物(5)，egonolgentiobioside(6)，egonolgentiotrioside(7)，styraxlignolideB(8)，styraxjaponosideC(9)，和masutakeside我(10)。结论混合物1和2是新2-phenylbenzofurans。

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简介：TagetonesA(1)andB(2),twonewmonocyclicditerpenoidswereisolatedfromthen-hexanefractionoffreshflowersofTagetesminutaL.(Asteraceae).Theirstructureswereestablishedbymultiplespectroscopicmethods(IR,HR-ESI-MS,and1D-,and2D-NMR),inadditiontocomparisonwithliteraturedata.Compound1showedcytotoxicactivitytowardsMCF7andA549cancercellswithIC_(50)valuesbeing4.68and4.24μmol·L~(-1),respectively,comparedtodoxorubicin(IC_(50)0.13and1.12μmol·L~(-1),respectively).Compound2alsoexhibitedsignificantactivityagainstHCT116cancercells(IC_(50),6.30μmol·L~(-1)).

简介：试图从MomordicacharantiaL的新鲜水果调查化学成分。方法化学成分被层析在硅石胶化和octadecylsilanized(ODS)硅石上孤立并且净化胶化，和结构被决定由光谱数据和化学证据。结果A新C30甾醇glycoside，命名25-isopropenylchole-5，(6)-ene-3-O--D-glucopyranoside(1)，从M的新鲜水果被孤立。charantiaL。结论化合物1是新C30甾醇glycoside。

简介：Twonewfuranfragmentisomerizedlimonoids,meliazedalidesAandB(compounds1and2),wereisolatedfromthefruitsofMeliaazedarachLinn..TheirchemicalstructureswereelucidatedonthebasisofHR-ESI-MSand1Dand2DNMRdata,whichbelongedtonimbolinin-andtrichilin-class,respectively.Compound2exhibitedweakinhibitoryeffectonNOproductioninlipopolysaccharide(LPS)-activatedRAW264.7macrophageswithIC50being37.41μmol·L^-1.

简介：ThepresentstudywasdesignedtoisolateandcharacterizetheanalgesiccompoundsofArtemisasacrorumLedeb.TheEtOAccrudeextractsfromtheaerialpartsofArtemisasacrorumLedebwereseparatedbychromatographyandthestructuresofnewcompoundswereelucidatedbasedonspectralanalyses.Analgesicactivitiesoftheisolatedcompoundswereassessedinratswithhotplatetestandpawpressureassay.TwonewflavoneC-glycosides,namedasSacrorosideAandB(Compounds1and2)wereisolatedfromtheEtOAccrudeextractoftheaerialpartsofArtemisasacrorumLedeb.Theyshowedsignificantanalgesiceffects.Inconclusion,Compounds1and2arenewnaturalproducts,whichshowsignificantanalgesiceffectsinadose-dependentmanner.

简介：Twonewcompounds,(22E)-25-carboxy-8β,14β-epoxy-4α,5α-dihydroxyergosta-2,22-dien-7-one(1)andfusidione(3),alongwithtwoknowncompounds,5α,8α-epidioxyergosta-6,22-diene-3β-ol(2)andmicroperfuranone(4),wereisolatedfromthefermentationproductsofthemarine-sourcedfungusAcremoniumfusidioidesRZ01.Thestructuresofcompounds1and3wereelucidatedbyextensivespectroscopicmethods,especially2DNMR,andtheirabsoluteconfigurationsweresuggestedonthebasisofthecirculardichroismspectralanalysisandtheNOESYdata.BothnewcompoundsshowedinhibitoryactivityagainstHL-60cellswithIC50valuesbeing16.6and44.9μmol·L-1,respectively.