简介：AbstractBackground:Hypertension is considered an important risk factor for the coronavirus disease 2019 (COVID-19). The commonly anti-hypertensive drugs are the renin-angiotensin-aldosterone system (RAAS) inhibitors, calcium channel blockers (CCBs), and beta-blockers. The association between commonly used anti-hypertensive medications and the clinical outcome of COVID-19 patients with hypertension has not been well studied.Methods:We conducted a retrospective cohort study that included all patients admitted with COVID-19 to Huo Shen Shan Hospital and Guanggu District of the Maternal and Child Health Hospital of Hubei Province, Wuhan, China. Clinical and laboratory characteristics were extracted from electronic medical records. Hypertension and anti-hypertensive treatment were confirmed by medical history and clinical records. The primary clinical endpoint was all-cause mortality. Secondary endpoints included the rates of patients in common wards transferred to the intensive care unit and hospital stay duration. Logistic regression was used to explore the risk factors associated with mortality and prognosis. Propensity score matching was used to balance the confounders between different anti-hypertensive treatments. Kaplan-Meier curves were used to compare the cumulative recovery rate. Log-rank tests were performed to test for differences in Kaplan-Meier curves between different groups.Results:Among 4569 hospitalized patients with COVID-19, 31.7% (1449/4569) had a history of hypertension. There were significant differences in mortality rates between hypertensive patients with CCBs (7/359) and those without (21/359) (1.95% vs. 5.85%, risk ratio [RR]: 0.32, 95% confidence interval [CI]: 0.13-0.76, χ2 = 7.61, P = 0.0058). After matching for confounders, the mortality rates were similar between the RAAS inhibitor (4/236) and non-RAAS inhibitor (9/236) cohorts (1.69% vs. 3.81%, RR: 0.43, 95% CI: 0.13-1.43, χ2 = 1.98, P = 0.1596). Hypertensive patients with beta-blockers (13/340) showed no statistical difference in mortality compared with those without (11/340) (3.82% vs. 3.24%, RR: 1.19, 95% CI: 0.53-2.69, χ2= 0.17, P= 0.6777).Conclusions:In our study, we did not find any positive or negative effects of RAAS inhibitors or beta-blockers in COVID-19 patients with hypertension, while CCBs could improve prognosis.

简介：Thepurposeofthisresearchistoinvestigatethepotentialofpre-treatmentwithphosphoricacid(PA)andmonobasiccalciumphosphate(MCP)forthestabilizationofheavymetalsinsludgeanditsbottomash.ThetannerysludgesampleswerecollectedinWenzhou,Chinaandheavilycontaminatedwithheavymetals,suchasPb,Crandsoon.Thesampleswerepre-treatedwithPAorMCP.ThenXRDandTCLPtestswereadoptedastheevaluatingmethodstocharacterizethePb,Cr,Cu,ZnandCdimmobilizationinthepre-treatedsludgeanditsbottomash.TheresultsshowedthatthistreatmenteffectivelyimmobilizedPbandCdinthesludge,lightlystabilizedthemetalCu,andadversely,enhancedtheleachabilityofZn.Afterincinerationat900℃,PbandCrinthebottomashofpre-treatedsludgeweresignificantlystabilizedduetotheformationoftheirhighlythermostablephosphatesandpyromorphite-likemineralsduringtheincinerationprocess.However,anincreaseofCuandZnsolubilitywasobservedwhichmightbeattributabletotheacidificationofsludgeduetotheadditionofPAorMCP.

简介：在Poaceae的钙举起，translocation和累积的机制充分还没被理解。处理这个问题，我们在钙(Ca2+)的silico分析进行了染色体宽的比较级二庄稼种，米饭和蜀黍的transporter基因家庭。基因注解，在上游的行动cis元素的鉴定，种系发生的树构造和基因家庭印射的syntenic用几个生物信息学工具被执行。31Ca2+transporters的一个总数，从12个染色体在9上散布了，从米饭染色体被预言，当除了染色体10，从蜀黍预言的28Ca2+transporters在所有染色体上是分布式的时(Chr10)。有趣地，大多数Chr1和Chr3上的基因显示出在米饭和蜀黍之间的一种反的syntenic关系。这些transporter蛋白质的多重顺序排列和主题分析揭示了在二种之间的高保存。种系发生的树能很好在基因家庭之中识别隧道，ATPases和exchangers的子类。在里面silicocis规章的元素分析建议了与光，应力和荷尔蒙应答以及内乳特定、分裂组织特定的基因表示联系的多样的功能。进一步的实验被保证验证在里面预言的transporter基因家庭的silico分析并且阐明在各种各样的生物进程的Ca2+transporters的函数。

简介：Usingeucollagensolutionsfromoxhide,wecastcollagenfilmstoassesstheinfluenceofcalciumandsilicaonthere-constitutionofthefibrousstructureofcollagen.Thetensilestrengthandthebreakingelongationofthereconstitutedcollagenfilmsweremeasuredandanalysed.Significantdifferenceswereobservedbetweenreconstitutedcollagenfilmswithandwithoutcalciumandsilica.Thebreakingelongationofthefilmsobtainedinthepresenceofsilicawassignificantlygreater,andthedegradationwaslowerthanotherfilmsofreconstitutedcollagen.Collagenandchitosandonotexisttogetherasblendsinnature,butthespecificpropertiesofeachmaybeusedtoproduceinbiomimeticwayman-madeblendswithbiomedicalapplications,thatconferuniquestructural,mechanical(detail)andinvivoproperties.

简介：AleachingexperimentwasCarriedoutwithrepackedsoilcolumnsinlaboratorytostudytheleachingprocessofaredsoilderivedfromsandstoneasaffectedbyvariousfertilizationpractices.ThetreatmentswereCK(asacontrol),CaCO3,CaSO4,MgCO3,Ca(H2PO4)2,Urea,KCl,Multiple(amixtureoftheabovementionedfertilizers)andKNO3,Thefertilizerswereaddedtothebaresurfaceofthesoilcolumns,andthenthecolumnswereleachedwith120mLdeionizedwaterdailythroughperstalticpumpsoveraperiodof92days,Attheendofleachingprocess,soilsweresampledfromdifferentdepthsofthesoilprofiles,i.o.,of92days,Attheendofleachingprocess,soilsweresampledfromdifferentdepthsofthesoilprofiles,I.e.0-5cm,5-10cm,10-20cm,20-40cm,and40-60cm,TheresultsshowedwhenapplyingCa,Mg,andKtothebaresurfaceofthesoilcolumns,exchangeableCa^2+,Mg^2+,andK^+intheupperlayerofthesoilprofileincreasedcorrespondingly,withanextentdependingmainlyontheapplicationratesofCa,Mg,andKandshowingadownwardtrend,CaCO3,CaSO4,MgCO3,andCa(H2PO4)2treatmentshadscarcelyandeffectonmovementofexchangeableK^+,whileCaCO3,andCaSO4treatmentssingnificantlypromotedthedownwardmovementofexchangealbleMg^2+althoughthesetwotreatmentshadnoobviouseffectonleachinglossesofMg,ThefactthatunderUreatreatment,exchangeableCa^2+andMg^2+,werehigherascomparedtoCKtreatmentshowedureacouldpreventleachingofexchangeableCa^2+andMg^2+,theobviousdownwardmovementofexchangeableCa^2+andMg^2+wasnoticedinKCltreatment,InMultipletreatment,thedownwardmovementofexchangeableCa^2+andMg^2+wasevident,whilethatofK^+waslessevident,ApplicationofKNO3stronglypromotedthedownwardmovementofexchangeableCa^2+andMg^2+inthesoilprofile.

简介：Objective:AnovelPVA-CaAlgcompositematerialbypolyvinylalcohol(PVA)andsodiumalginate(SA)wasfabricatedtoinvestigatethefeasibilityservingasascaffoldfortissueengineeringandtofindoutthemostidealproportionaccordingtotheirproperties.Methods:Film,graininessandspongescaffoldsofPVA-CaAlgwerefabricatedbythreedifferentmethods.Watercontentandswellingratioweretested.SEMwasusedtoobservetheconfigurationofthecrosssection.Results:DifferentproportionalscaffoldscouldbeobtainedwithdifferentPVAmolecularweight,alcoholysisdegreeanddifferentSAdosages.Thewatercontentofdifferentscaffoldsrangedfrom48%to93%andshoweddifferentinnerconfigurationwithswellingratiobetween120%and470%.SEMprovedthatdifferentcompositematerialshaddifferentporousstructures.Conclusion:AscaffoldfortissueengineeringwithhighwatercontentandproperswellingratiocanbefabricatedusingPVAandSA.Theporousstructureshowspotentialintissueengineeringandcellculture.

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简介：Afieldexperiment,involvinglimeN(calciumcyanamide,CaCN2)fertilizationasacontrolmeasure,wasconductedtostudyenvironmentalproblemsinducedbylong-termheavyNapplicationinJapaneseteafields.Long-termteacultivationcausedserioussoilacidification.Seventy-sevenpercentofthe70teafieldsinvestigatedhadsoilpHvaluesbelow4.0,and9%below3.0,withthelowestvalueof2.7.Moreover,excessNapplicationinteafieldsputathreattoplantgrowth,inducedseriousnitratecontaminationtolocalwater,andcausedhighnitrousoxideloss.ComparedwiththeconventionalhighNapplicationtreatment(1100kgNha-1)withoutlimeN,thelowNapplication(400kgNha-1)withcalciumcyanamideeffectivelystoppedsoilacidificationaswellasachievedthesameorslightlyhigherlevelsinteayieldandintotalNandaminoacidcontentsofteashoots.Theapplicationofcalciumcyanamidecouldbeasuitablefertilizationforthepreventionofenvironmentalproblemsinteacultivation.

简介：稳固的TiO2的电气化学的减小直接是当前的克罗尔过程的一种有希望的选择到稳固的金属。现在的工作针对在电气化学的减小的率上学习电解电压的效果。TiO2和Ti2O的电气化学的减小的产品用扫描电子显微镜学(SEM)和X光检查衍射(XRD)被检验技术。结果证明Ti2O在1.51.7V被归结为低valent钛氧化物，它是氧的电离的结果。TiO2和Ti2O在2.13.1V被归结为钛金属，它是协力氧和calciothermic减小的电离。氧内容很快减少了，电压从2.1～2.6V增加，当它从2.6～3.1V改变了很少时。优化房间电压是2.63.1V。

简介：Apoptosismanifestsintwomajorexecutionprogramsdownstreamofthedeathsignal:thecaspasepathwayandorganelledysfunction.Animportantantiapoptosisfactor,Bcl-2protein,contributesincaspasepathwayofapoptosis.Calcium,animportantintracellularsignalelementincells,isalsoobservedtohavechangesduringapoptosis,whichmaybeaffectedbyBcl-2protein.WehavepreviouslyreportedthatinHarringtonine(HT)inducedapoptosisofHL-60cells,there'schangeofintracellularcalciumdistribution,ovingfromcytoplastespeciallyGolgi'sapparatustonucleusandaccumulatingtherewiththehighestconcentration.Wereportherethatcaspase-3becomesactivatedinHT-inducedapoptosisofHL-60cells,whichcanbeinhibitedbyoverexpressionofBcl-2protein.NosignofapoptosisorintracellularcalciummovementfromGolgi'sapparatustonucleusinHL-60cellsoverexpressingBcl-2ortreatedwithAc-DEVD-CHO,aspecificinhibitorofcaspase-3.Theresultsindicatethatactivatedcaspase-2canpromotethemovementofintracellularcalciumfromGolgi'sapparatustonucleus,andtheprocessisinhibitedbyAc-DEVD-CHO(inhibitorofcaspase-3),andthatBcl-2caninhibitthemovementandaccumulationofintracellularcalciuminnucleusthroughitsinhibitiononcaspase-3.Calciumrelocalizationinapoptosisseemstobeirreversible,whichisdifferentfromtheintracellularcalciumchangescausedbygrowthfactor.

简介：这篇文章为综合盖住一个方法环境地友好的多功能的金属(钙，镁)有antioxidationproperty.These的油酸盐detergents多功能的金属(钙，镁)有antioxidation性质的油酸盐detergents用油可溶的液体抗氧化剂被综合(PPIBP，PPIBTSTBP，并且PPIBPDA)作为反应功能的materials.These，油可溶的液体抗氧化剂有潜力在综合为申请被用作功能的材料其它种s

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简介：<正>1IntroductionThereexistcalciumandsulfateionsoutsidesodiumchlorideinsolutionminingforcalciumsulfatebrine.Thecalciumandsulfateionsnotonlyaffectthepurityofthevacuumsaltproducts,butalsoincreasethescalingofvacuumevaporationtanksandbrinereusingpipes.Additiveshavecertainimpactsonthecrystallizationdynamics(Randolphetal.,1971).Thecrystallization

简介：Topreparecalcium-bindingpeptides,thefleshresidueofMactraVeneriformiswassubjectedtoenzymatichydrolysis.Bycomparingthecapabilityofcombiningcalciumofthehydrolyzates,pepsinwasconfirmedtobethemostsuitableenzymeforhydrolyzingthefleshresiduetoreleasecalcium-bindingpeptidesamongtheseventestedproteases.Thepepsinhydrolyzate(PHM)wasdividedintothreefractionsaccordingtothemoleculeweightofitscomposition,whichrangedfrom0.5to15kDa.Thelow-molecule-weightfractionnamedPHM-3hadthehighestcapabilityincombiningcalcium.ThepeptidesexistinginthePHM-3fractionconsistedofhighercontentsofGlu,AlaandLeu,andcouldproduceonetypeofcalcium-peptidecomplexbypowerfullychelatingcalciumions.PHM-3productscouldeffectivelyincreasecalciumabsorptionandretentionwhiletheydecreasedthecalciumexcretioninanimaltests.Additionally,symptomscausedbylowcalciumbioavailabilityinovariectomizedrats,suchasbonemineraldensityreductionandmechanicalstrengthlosscouldbesignificantlyamelioratedbythehydrolyticproductsadditionindiet.

简介：Calciumhexaluminateisonefromsuchperspectivematerials.Itischaracterizedbyhighrefractoriness(above1830℃),aswellaspropertiesstabilityinreducingatmosphere,highalkali-andslag-resistance,lowthermalconductivityandwettabilitybymoltenmetals.Inthisworkinfluenceresearchesoffusedcalciumhexaluminatematerialadditiveinamountof5%,15%and25%onthemainpropertiesofaluminarefractorieswerecarriedout.Itisestablishedthat,therefractoriescontainingtheadditiveof25%calciumhexaluminatematerialarecharacterizedbythehighestproperties,slightlyimpregnatedwithmetalmeltandthehighestmetalcorrosionresistance.ThealuminapurgingplugsforblowingofmetalwithcalciumhexaluminatematerialadditiveareproducedandintendedtoonemetallurgicalplantofUkraineforcarryingouttests.

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简介：ObjectiveThisstudyistoexploretherelationshipbetweenacetylcholine(ACh)-inducedcalciumreleasefromintracellularCa2+storesandfunctionofouterhaircell(OHC)motors,inanattempttoelucidatethemechanismofOHCelectromotilityatrestingstate.MethodsOHCswereisolatedfromadultguineapig(200-300g)cochleaandloadedwithFluo-3/AM.ThecellsweretreatedwithACh/dHBSS,ACh/HBSS,dHBSSonlyorHBSSonly.Intracellular[Ca2+]ivariationsincellsunderthefourtreatmentswereobservedusinganAr-Krlaserscanconfocalmicroscope.Results[Ca2+]ioscillationswererecordedinfiveOHCstreatedwithACh/dHBSSbutnotinothercells.ThisisthefirsttimethatAch-excited[Ca2+]ioscillationsarereportedinguineapigOHCsindependentofextracellularcalcium.ConclusionsACh-excited[Ca2+]ioscillationsinOHCsoriginatesfromintracellularcalciumreleaseandmayplayacrucialroleinmaintainingactivemechanicalmotilityoftheOHCatrestingandmodulatingOHCelectromotility.

简介：当演员组微观结构和有钙增加的Mg-6Zn-2Al-0.3Mn(ZA62)合金的机械性质被调查。基础合金ZA62的当演员组微观结构由a-Mg矩阵和最容易溶解的阶段Mg51Zn20组成。Mg51Zn20最容易溶解被MgZn阶段和Mg32逐渐地代替(艾尔，Zn)当钙被增加进基础合金时，49分阶段执行。钙的进一步的增加导致谷物边界阶段和新第四级的Mg-Zn-Al-Ca最容易溶解的混合物的形成的增加。与基础合金比较，基础合金的钙增加的增加由于包含Ca阶段的热稳定性在提高的温度在周围的温度，而是增加导致力量和韧性的减小。在提高的温度，ZA62的creep抵抗基于包含钙的合金比是通常使用的大多数的AZ91的显著地高镁合金。

简介：Calciumsulfatehemihydrate（CSH）whiskersweresynthesizedbyphasetransitioninCaCl2solutionunderatmosphericpressure.Analytical-gradecalciumsulfatedihydrate（ARCSD）wasusedastherawmaterialforthesynthesisofCSHwhiskers,accordingtoorthogonalexperiments.Theeffectsofreactiontemperature,ARCSDcontent,H2SO4content,andreactiontimewereinvestigated,andthecrystallizationconditionswereoptimized.Theas-preparedCSHwhiskersdisplayedaregularmorphologyandahighlyuniformsize,withanaspectratioof105.AsimulationsystemwasalsoestablishedbyblendingvarioussulfateswithARCSD,toevaluatetheeffectsofimpuritiesinfluegasdesulfurization（FGD）gypsum.ThemainaimwastoprepareCSHwhiskersdirectlyfromFGDgypsum,withoutanypurification,usingtheoptimizedconditions.Thisisafacilepotentialalternativeprocessforlarge-scaleproductionofCSHwhiskersusingabundantFGDgypsumassourcematerials.

简介：Theelectronicstructureandbondingnatureofaseriesofcollectorsinthecalciumandmagnesiumcontainingmineralssystemarestudiedusingquan-tumchemistryCNDO/2method.Thedifferenceincol-lectingpropertiesisdiscussedbymeansofcharac-teristicparametersderivedfromthequantumchem-istrycalculations,andthedevelopingdirectionoffattyacidcollectorsispredicted.