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简介：为了评估antithyroidantibodie层次，有甲状腺疾病的526个病人和292健康的意义，从Yuci使区域遭到，山西省，中国，被学习。浆液层次为甲状腺荷尔蒙受体抗体(TRAb)被决定，microsomal抗体(TMAb)和thyrogiobulin抗体(TGAb)。在病人之中，为榴状的甲状腺肿和甲状腺腺瘤，坟的疾病，和Hashimoto的甲状腺炎的百分比分别地是44.1%，19.6%和17.7%。到男性的女性的比率是2.0～15.6个.Antibody积极的病人因为TMAb，TGAb和TRAb为Hashimoto的甲状腺炎作为94.6%，76.3%和20.4%可检测，并且40.0%，30.0%和90.3%为格雷夫斯的疾病。为描绘疾病和forusingas的流行病学的基础在结论，在Hashimoto的甲状腺炎和自发的甲状腺机能减退的TGAb/TMAb的在坟的疾病的TRAb的高水平，和那些是有意义的为在单个病人的恶化的预示的指示物。

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简介：导致的模仿的微严肃(SMG)的知识在微生物的致病力变化为长期的空间飞行的成功是重要的。在用高方面比率容器生物反应器的以前的研究，当在建模的微严肃成长时，我们证明酵母种类Saccharomycescerevisiae经历了重要phenotypic回答，它在基因表达侧面的分析被反映。在这研究，我们证实Candidaalbicans以一种类似的方式对SMG作出回应，证明在到这个环境压力的酵母之中有保存回答。我们也报导C的生长。在SMG的albicans导致与提高的致病力一致的一个morphogenic开关。明确地，我们在有机体的细丝状的形式观察了增加，在二基因的表示伴随变化与酵母菌丝的转变联系了。词法反应可以为宇航员的安全有重要含意，当真菌的病原体可以在空间飞行期间变得更剧毒。

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简介：1.ThedevelopmentofChina-U.S.relationsin2007willbeinfluencedmainlybythefollowingfactors:(1)ThetrendofU.S.economicdevelopment;(2)ThechangesinU.S.domesticpolitics;(3)theIraqissue;(4)TheTaiwanquestion;(5)ThewayChinadealswithChina-U.S.relations.

简介：前列腺癌症是在人的最普通的恶意之一。以前的研究决定了那雄激素剥夺治疗(ADT)可以被不利新陈代谢的侧面伴随。在这未来的研究，133个人被招募，包括经历了双边的orchiectomy并且在flutamide(ADT组)上的46个前列腺癌症病人，经历了激进的前列腺切除术(non-ADT组)的有前列腺癌症的37个人并且50个正常控制题目(控制组)。所有题目被跟随至少12个月。从基线到3个月，在ADT组的人与另外的二个组相比增加了fasting浆液胰岛素和低密度的脂蛋白的层次(P<；0.05)。没有明显的变化在另外的参数被发现(P>；0.05)。在12个月以后，在ADT组的人增加了腰的层次与另外的二个组相比的圆周，fasting浆液胰岛素和葡萄糖，全部的胆固醇，高密度的脂蛋白和低密度的脂蛋白(P<；0.05)。另外，在ADT组的新陈代谢的症候群的病态率更高(P<；0.05)与另外的二个组相比。通过为有前列腺癌症的人的外科的阉割的ADT可以与不利新陈代谢的变化被联系。治疗的好处应该对这些风险谨慎地被平衡。

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简介：MinistryofCommercereleasedtheincreasequantityofChina'smainimportgoods.Wheninternationaloilpricekeepsincreasing,Chinashowsthesituationofquantityandpriceincreasing.Amongwhichtheimportcrudeoilincreased15.6%year-on-year,thevalueincreased53.9%;whileoilimportquantityincreased

简介：AlaskanArcticwatershaveparticipatedinhemispheric-wideArcticwarmingoverthelasttwodecadesatovertwotimestherateofglobalwarming.During2008-13,thisrelativewarmingoccurredonlynorthoftheBeringStraitandtheatmosphericArcticfrontthatformsanorth-souththermalbarrier.ThisfrontseparatesthesoutheasternBeringSeatemperaturesfromArcticairmasses.ModelprojectionsshowthatfuturetemperaturesintheChukchiandBeaufortseascontinuetowarmatarategreaterthantheglobalrate,reachingachangeof＋4℃by2040relativetothe1981-2010mean.Offshoreat74~N,climatemodelsprojecttheopenwaterdurationseasontoincreasefromacurrentaverageofthreemonthstofivemonthsby2040.Theseratesareoccasionallyenhancedbymidlatitudeconnections.BeginninginAugust2014,additionalArcticwarmingwasinitiatedduetoincreasedSSTanomaliesintheNorthPacificandassociatedshiftstosoutherlywindsoverAlaska,especiallyinwinter2015-16.WhileglobalwarmingandequatorialteleconnectionsareimplicatedinNorthPacificSSTs,theendingofthe2014-16NorthPacificwarmeventdemonstratestheimportanceofinternal,chaoticatmosphericnaturalvariabilityonweatherconditionsinanygivenyear.ImpactsfromglobalwarmingonAlaskanArctictemperatureincreasesandsea-iceandsnowloss,withoccasionalNorthPacificsupport,areprojectedtocontinuetopropagatethroughthemarineecosystemintheforeseeablefuture.TheecologicalandsocietalconsequencesofsuchchangesshowaradicaldeparturefromthecurrentArcticenvironment.

简介：BackgroundIncreasedserumleveloflipoprotein(a)(Lp(a))isassociatedwithatherosclerosis.WhetherincreasedLp(a)levelisindependentlyassociatedwiththeseverityofcoronaryarterydisease(CAD)isunclear.MethodsSubjectswereenrolledandreceivedcoronaryangiographytoassessthenumberofstenosedcoronaryartery.ThesubjectswithCADweredividedintonon-significant(<50%stenosis),singleandmultivesselstenosis(≥50%stenosis)groups.Parametersofinterestatbaselinewerecollected.StatisticalanalyseswereperformedtoevaluatetherelationshipbetweenLp(a)levelandCADseverity.ResultsTotally745populationswereenrolledanddiagnosedasCAD(n=605)orwithoutCAD(n=140)onthebasisofangiographyexamination.AscomparedtothesubjectswithoutCAD,serumlevelsofLp(a)andCRP,andthepercentagesofsubjectswithsmokingordiabetesweresignificantlyhigherinsubjectswithCAD.Incontrast,serumlevelsofHDL-CandApo-AweresignificantlylowerinsubjectswithCADascomparedtosubjectswithoutCAD.Incomparisonofsubjectswithnon-significantstenosis(serumLp(a)level,170.0±19.7mg/dL),serumLp(a)levelwassignificantlyhigherinsubjectswithsingle(245.5±22.3mg/dL)ormultiplevesselstenoses(265.8±14.0mg/dL).Withmultivariateregressionanalyses,afteradjustedforage,gender,smoking,familyhistoryandhypertension,therewasstillsignificantassociationbetweenserumLp(a)levelandthenumberofcoronaryarterystenosis.Afteradditionaladjustmentfordiabetes,HbA1c,totalcholesterol,LDL-C,Apo-A,uricacidandCRP,Lp(a)remainedstronglyassociatedwithCADseverity.ConclusionSerumLp(a)levelwassignificantlyassociatedwiththeseverityofcoronaryarterystenosis,whichmayaddthevalueoncardiovascularriskevaluation.

简介：BackgroundIncreasedlevelofglycatedhemoglobin(HbA1c)isassociatedwithhigherincidenceofcoronaryarterydisease(CAD)inthediabetics.However,therelationshipbetweenHbA1candtheriskofcoronaryarterystenosisinthenon-diabeticsiscontroversial.MethodsAretrospectiveresearchwasconductedon338enrolledparticipantswhohaveundergone2timesofcoronaryangiographicexaminationwithinthepastyear.Clinicalandlaboratoryvariablesattheinitialandthesecondtimeofadmissionwerecollected.AccordingtotheinitialmedianHbA1clevel,allparticipantsweredividedintotwogroupsnamedlowerandhighergroups.TherelationshipbetweenHbA1clevelandtheriskofcoronaryarterystenosisovertimewasevaluated.ResultsTheinitialvaluesofHbA1cinloweranduppergroupswere5.78±0.35%and6.21±0.32%(P<0.05).Ascomparedtothelowergroup,thepercentagesofmaleandsmokingparticipants,andtheserumlevelofCRPweresignificantlyhigherinthehighergroup(P<0.05).Othertraditionalriskfactorswerecomparablebetweenthetwogroups.Therewere54.2%and55.2%participantswithsinglevesselstenosis,and45.8%and44.8%withmultiplevesselstenoses,respectivelyinthetwogroupswithoutsignificantdifference.Thesecondtimeofadmission,were308.5±25.4days(lowergroup)and300.7±30.1days(highergroup)fromtheinitialadmission.AlthoughnosignificantchangesofHbA1clevelwereobservedwhencomparedtoinitial,HbA1clevelinthehighergroupwasstillsignificantlyhigherincomparisontothelowergroup(6.24±0.39%vs.5.80±0.36%,P=0.008).Thepercentageofnewcoronaryarterystenosis(≥50%stenosis)washigherinthehighergroupthanthatinthelowergroup(41.7%vs.32.3%,P<0.001).MultivariateregressionanalysessuggestedthatHbA1cremainedindependentfactorassociatedwithcoronaryarterystenosesafterextensiveadjustmentforriskfactors.ConclusionInthenondiabetics,increasedbaselineHbA1clevelportendstheriskofcorona

简介：AbstractBackground:School closure is a common mitigation strategy during severe influenza epidemics and pandemics. However, the effectiveness of this strategy remains controversial. In this study, we aimed to explore the effectiveness of school closure on seasonal influenza epidemics in provincial-level administrative divisions (PLADs) with varying urbanization rates in China.Methods:This study analyzed influenza surveillance data between 2010 and 2019 provided by the Chinese National Influenza Center. Taking into consideration the climate, this study included a region with 3 adjacent PLADs in Northern China and another region with 4 adjacent PLADs in Southern China. The effect of school closure on influenza transmission was evaluated by the reduction of the effective reproductive number of seasonal influenza during school winter breaks compared with that before school winter breaks. An age-structured Susceptible-Infected-Recovered-Susceptible (SIRS) model was built to model influenza transmission in different levels of urbanization. Parameters were determined using the surveillance data via robust Bayesian method.Results:Between 2010 and 2019, in the less urbanized provinces: Hebei, Zhejiang, Jiangsu and Anhui, during school winter breaks, the effective reproductive number of seasonal influenza epidemics reduced 14.6% [95% confidential interval (CI): 6.2-22.9%], 9.6% (95% CI: 2.5-16.6%), 7.3% (95% CI: 0.1-14.4%) and 8.2% (95% CI: 1.1-15.3%) respectively. However, in the highly urbanized cities: Beijing, Tianjin and Shanghai, it reduced only 5.2% (95% CI: -0.7-11.2%), 4.1% (95% CI: -0.9-9.1%) and 3.9% (95% CI: -1.6-9.4%) respectively. In China, urbanization is associated with decreased proportion of children and increased social contact. According to the SIRS model, both factors could reduce the impact of school closure on seasonal influenza epidemics, and the proportion of children in the population is thought to be the dominant influencing factor.Conclusions:Effectiveness of school closure on the epidemics varies with the age structure in the population and social contact patterns. School closure should be recommended in the low urbanized regions in China in the influenza seasons.

简介：Recently,theDepartmentofLandandResourcesofGuangxiandtheGuangxiBureauofGeology&MineralProspecting&Exploitationannouncedthatsince2011,76mineralshadbeendetected,38ofwhichweremiddleandlargeminerals.About200milliontonsofbauxiteandmanganeseoreresourcesweredetectedintwonationalintegratedexplorationareas,and317milliontonsoftin,tungsten,lead,zinc,copper,gold,silver,andkaolinresources,etc.

简介：植物侵略创造新奇plantinsect相互作用。EICA(增加的竞争能力的进化)因为他们逃离他们的共同演变的昆虫天赋敌人，假设建议侵略植物将从防卫重新分配资源到生长或复制。由monophagous和寡食性的草食动物和各种各样的植物特点的同时的测量的严峻的多重herbivory将提供新卓见进侵略植物的进化变化。在这上下文，我们进行了一个普通花园实验比较植物生长和复制，化学、物理的防卫，和对由在侵略北美的人口和mile-a-minute的本国的东方亚洲人口之间的草食动物的不同类型的herbivory的植物回答除草，Persicariaperfoliata。我们发现侵略mile-a-minute展出了更低的生物资源，flowered更早、有的更大的繁殖输出比从本国的范围的植物。与本国的人口相比，从侵略人口的植物有更低的丹宁内容，但是在节点和叶子上展出了更高的皮刺密度。因此，我们的结果部分支持EICA假设。当暴露了到monophagous昆虫，Rhinoncomimuslatipes和寡食性的昆虫时，Gallerucidagrisescens和Smaragdinanigrifrons，由herbivory的更多的损坏比在土著人上在侵略植物上被发现。R。latipes，G。grisescens和S。nigrifrons分别地在mile-a-minute的生长和繁殖上有强壮、中等、弱的影响。结果显示mile-a-minute可能发展了一个更高繁殖的能力在里面与缺乏一起的介绍范围，和这寡食性并且在新范围的monophagous草食动物可能在北美洲贡献了它的侵略。

简介：AccordingtoShaanxiDaily,ShaanxiProvincewillimplementactiveemploymentpolicyin2011.Itguaranteesthatnewemploymentintownswillbeincreasedby330,000,employmenttransferofruralLabourwillbe6.2million,registeredurbanunemploymentratewillbecontrolledwithin4.5%.In2011,Shaanxiwillcombineindustrialupgrading,cultivateanddevelopstrategicemergingindustries,boostthedevelopmentofserviceindustryandgradientshiftofprocessingmanufacturingindustry,improve

简介：我们分析了20化学感应的蛋白质(CSP)蚕Bombyxmori的基因。我们发现了在introns插入的retrotransposons的一个高数字。我们然后用量的即时聚合酶链反应(PCR)越过纸巾分析了20BmorCSP基因的表示。BmorCSPs的相对低的表示层次在内脏和胖身体纸巾被发现。我们因此在BmorCSP基因表示上测试了endectocyte杀虫药剂abamectin(B1a和B1bavermectins)的效果。量的即时PCR实验证明到杀虫药剂abamectin的单个简短暴露戏剧性地不仅在天线而且在大多数纸巾增加了CSP表示，包括内脏和胖身体。而且，我们的学习响应杀虫药剂以一种织物依赖者方式显示出CSP和新陈代谢的细胞色素P450酶的并列表示。CSP的功能仍然保持未知。基于我们的结果，我们在检测然后被细胞色素P450anti-xenobiotic酶除去的xenobiotics建议一个角色。

简介：InthiseditorialwecommentonthearticlebyFukushiKetalpublishedintherecentissueoftheWorldJournalofGastroenterology2018;24(34):3908-3918.Wefocusspecificallyonthemechanismsoftheanti-thromboticactionofaspirin,gastricmucosalinjuryandaging-relatedincreasedsusceptibilityofgastricmucosatoinjury.Aspiriniswidelyusednotonlyforthemanagementofacuteandchronicpainandarthritis,butalsoimportantlyfortheprimaryandsecondarypreventionofcardiovasculareventssuchasmyocardialinfarctsandstrokes.Clinicaltrialshaveconsistentlyshownthatantiplatelettherapywithlongterm,lowdoseaspirin(LDA)-75to325mgdaily,dramaticallyreducestheriskofnon-fatalmyocardialinfarcts,strokeandmortalityinpatientswithestablishedarterialdiseases.However,suchtreatmentconsiderablyincreasestheriskofgastrointestinal(GI)ulcerationsandseriousbleedingby>2-4fold,especiallyinagingindividuals.ThisriskisfurtherincreasedinpatientsusingLDAtogetherwithotherantiplateletagents,othernonsteroidalanti-inflammatoryagents(NSAIDs)and/oralcohol,orinpatientswithHelicobacterpylori(H.pylori)infection.Previousstudiesbyourgroupandothershavedemonstratedprominentstructuralandfunctionalabnormalitiesingastricmucosaofagingindividuals(whichwerefertoasaginggastricmucosaor“aginggastropathy”)comparedtothegastricmucosaofyoungerindividuals.Aginggastricmucosahasimpairedmucosaldefense,increasedsusceptibilitytoinjurybyavarietyofnoxiousagentssuchasaspirin,otherNSAIDsandethanol,anddelayedandimpairedhealingofinjury.Themechanismunderlyingtheseabnormalitiesofaginggastricmucosaincludereducedmucosalbloodflowcausinghypoxia,upregulationofPTEN,activationofproapoptoticcaspase-3andcaspase-9,andreducedsurvivin(anti-apoptosisprotein),importin-α(nucleartransportprotein),vascularendothelialgrowthfactor,andnervegrowthfactor.Thedecisionregardinginitiationofalong-termLDAtherapyshould

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