简介：Acombinedhistopathological,mucinhistochemi-calandimmunohistochemicalstudyofthetransitionalmucosa(TM)adjacenttocolorectalcancerispresented.Twenty-sixresectedspecimenswerestudiedbyhematoxylinandeosin(HE)andhighirondiamine-alcianblue(HID-AB).Carcinoem-bryonicantigen(CEA)wasdemonstratedbyperoxi-daseantiperoxidass(PAP)technique.TheappearanceoftheTMisusuallythicker,longeranddilatedcryptswithincreasedimmatureandintermediatecells.VariableamountofsialomucinsanddecreasesulphomucinscontentaswellasincreasedCEAcontentarefoundintheTM.Thesechangesarenotseeninnon-transitionalzoneandnormalcolorectalmucosa.ItissuggestedthatthemucinchangesandexpressionofCEAintheTMmayindicateanearlyprimarypremalignantchangesandmaybeoneofthereasonsfortheTMaffectingtheprognosisofpatientswithlargebowelcancerafterradicalresection.

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简介：Eosinophiliculceroforalmucosa(EUOM)isanonspecificclinicalappearance,whichappearstobefrequentlyunrecognizedormisdiagnosedusuallyassquamouscellcarcinoma(SCC),especiallyinoldpatients.Itisarareself-limitedbenignulcerativedisease,anditischaracterizedwiththeinfiltrationofeosinophilicleukocytesmixedwithotherinflammatorycells,1,2suchasthemitoticallyactivelargemononuclearcellswithroundorovoidpalenucleus.Thiscelltype,ofteninterpretedasahistiocyte,confoundsthehistologicevaluationandoccasionallyleadstotheerroneousdiagnosisoflymphohistiocyticmalignantcondition.Althoughithasassumedthattraumaisanimportantetiologicfactor,theexactpathogenesisremainsunclear.3ThemorbidityofthisdiseaseislowandtherearefewChineseliteraturesaboutit,4soitisnecessarytopaymoreattentiontoit.Inthisarticle,3outof5casesofEUOMaremisdiagnosedasSCC,andwewillreporttherecordsinordertoidentifyitfromSCCwell.

简介：InthiseditorialwecommentonthearticlebyFukushiKetalpublishedintherecentissueoftheWorldJournalofGastroenterology2018;24(34):3908-3918.Wefocusspecificallyonthemechanismsoftheanti-thromboticactionofaspirin,gastricmucosalinjuryandaging-relatedincreasedsusceptibilityofgastricmucosatoinjury.Aspiriniswidelyusednotonlyforthemanagementofacuteandchronicpainandarthritis,butalsoimportantlyfortheprimaryandsecondarypreventionofcardiovasculareventssuchasmyocardialinfarctsandstrokes.Clinicaltrialshaveconsistentlyshownthatantiplatelettherapywithlongterm,lowdoseaspirin(LDA)-75to325mgdaily,dramaticallyreducestheriskofnon-fatalmyocardialinfarcts,strokeandmortalityinpatientswithestablishedarterialdiseases.However,suchtreatmentconsiderablyincreasestheriskofgastrointestinal(GI)ulcerationsandseriousbleedingby>2-4fold,especiallyinagingindividuals.ThisriskisfurtherincreasedinpatientsusingLDAtogetherwithotherantiplateletagents,othernonsteroidalanti-inflammatoryagents(NSAIDs)and/oralcohol,orinpatientswithHelicobacterpylori(H.pylori)infection.Previousstudiesbyourgroupandothershavedemonstratedprominentstructuralandfunctionalabnormalitiesingastricmucosaofagingindividuals(whichwerefertoasaginggastricmucosaor“aginggastropathy”)comparedtothegastricmucosaofyoungerindividuals.Aginggastricmucosahasimpairedmucosaldefense,increasedsusceptibilitytoinjurybyavarietyofnoxiousagentssuchasaspirin,otherNSAIDsandethanol,anddelayedandimpairedhealingofinjury.Themechanismunderlyingtheseabnormalitiesofaginggastricmucosaincludereducedmucosalbloodflowcausinghypoxia,upregulationofPTEN,activationofproapoptoticcaspase-3andcaspase-9,andreducedsurvivin(anti-apoptosisprotein),importin-α(nucleartransportprotein),vascularendothelialgrowthfactor,andnervegrowthfactor.Thedecisionregardinginitiationofalong-termLDAtherapyshould

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简介：Toobservetheeffectofthepointinjectionmethodonthegastricmucosabarrierinratswithchronicatrophicgastritis.Method:RatmodelswithvaryingdegreesofchronicatrophicgastritisweremadeusingMNNGindifferentconcentrations.EqualamountsofHuangqi(RadixAstragali)injectionandDanggui(RadixAngelicaeSinensis)InjectionweremixedandinjectedintothepointZusanli(ST36)

简介：ＥＸＰＲＥＳＳＩＯＮＯＦＥＢＶＬＡＴＥＮＴＭＥＭＢＲＡＮＥＰＲＯＴＥＩＮＩＮＥＳＯＰＨＡＧＥＡＬＣＡＲＣＩＮＯＭＡＡＮＤＰＡＲＡＣＡＮＣＥＲＯＵＳＭＵＣＯＳＡＷｕＭｉｎｇｙａｏ吴名耀ＬｉａｎｇＹｉｎｇｒｕｉ梁英锐ＷｕＸｉａｎｙｉｎｇ吴贤英Ｄｅｐａｒ...

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简介：Toinvestigatethehistologicalchangeandtheexpressionsofepidermalgrowthfactor(EGF)andepidermalgrowthfactorreceptor(EGFR)inatrophicgastricmucosainratssoastoappraisetheeffectoftheseregulatorsontheformationofatrophicgastritis,tostudytheexpressionsofEGFandEGFRinratswithchronicatrophicgastritis(CAG)aftertheirradiationofHe-Nelaser,andtoinvestigatetherelationsofHe-Nelaserandprecancerouslesionorapoptosis.Theratsweredividedintonormalgroup,modelgroupandlasergroup.ThemodelsofCAGratswereestablishedwithenemawhichwasthemixedliquorconsistedofsodiumsalicylateandalcohol,combinedwithirregularfastingandcompulsivesportingaspathogenicfactors.He-Nelaser(3.36J/cm2)wasusedtoirradiateCAGrats,onceadayfor7min,20daysasacourseoftreatment;theexpressionsofEGFandEGFRweredetectedwithimmunohistochemicalmethod.Duringtheprocessofantralatrophy,theexpressionsofEGFandEGFRincreased,theywerehigherinmodelgroupthanthoseinnormalgroup(P<0.05).AftertheirradiationofHe-Nelaser,theexpressionsofEGFandEGFRwereobviouslylowerthanthoseinmodelgroup(P<0.05).Wedrawtheconclusionasfollows:gastricmucosaofmodelratisinahyper-proliferationstatus,withhighproteinexpressionsofapoptosissuppressorEGFandEGFR.CAGhassomecorrelationwiththeimbalancebetweencellproliferationandapoptosis.He-Nelaser(3.36J/cm2)canreducetheexpressionsofEGFandEGFR,whichisaneffectivephysiostimulatortostimulatethegastricmucosaofrat.TheappropriatesecretionsofEGFandEGFRarepropitioustotherepairandregenerationforthegastricmucosatissues,thuspreventingCAGtocanceration.

简介：背景：超声(美国)指导了锁骨的在上或下文锁骨的块通常为上面的极限外科被使用。这使随机化的研究的目的是比较块表演和发作时间，有效性，不利事件和病人的发生是指导美国的在上的接受锁骨或下文锁骨的块。我们假设了在上锁骨的途径，更表面、更容易设想使用10MHz变换器，将生产一更快并且更广泛的感觉的块。方法：120个病人被使随机化到二个相等的组：在上锁骨的(S)和下文锁骨的(I)。每个病人收到了包含ropivacaine的相等的体积的混合物7.5mg/ml和mepivacaine有肾上腺素5μg/ml的20mg/ml，0.5ml/kg身体重量(最小30ml，最大值50ml)。七根终端神经的感觉分数(0削尖的麻醉2点，痛觉缺失1点和疼痛)被估计每10min。当他们在肘下面有有效的外科的块麻醉或五根神经的痛觉缺失时，病人们为外科被宣布准备好了。在块以后的三十分钟，解块的神经被补充。块表演和潜伏时间，外科的有效性，不利事件和病人是接受被记录。结果：显著地，在I的更多的病人组织为在块以后的外科20和30min准备好了。吝啬的块表演时间在I组(NS)是在S组和5.0min的5.7min。块有效性在I组是优异的：93%对78%在S组(P=0.017)。S组病人有中部、尺骨的神经，而是腋的神经的更好的块的显著地更差的块。在10，20和30min的感觉分数不是显著地不同的。在S组的32个病人对在I组的九个病人经历了短暂不利事件(P<0.0001)。病人块的接受在两个组是类似的。结论：Infraclavicular块有更快的发作，更好外科的有效性和更少不利事件。块表演时间和病人是过程的接受在两个组是类似的。

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简介：探索二的保护的效果的目的与后部的手足的压碎损害在肠的mucosa障碍上ischemicpostconditioning(IP)录入兔子。这研究在损伤外科的部门在8月和2008年12月之间被进行的方法，弹跳的医院，第三所军事医药大学，重庆，中国。对兔子的后部的手足的压碎损害的模型被25kg目标第一开发，恰好后部的手足由木藤条修理了，然后IP的二种类型包括堵塞/打开被建立普通肠骨的动脉和静脉或者(传统的IP，IPA)并且binding/loosening受伤后部的手足的proximum或者(修改IP，IPB)。36只雄的新西兰白兔子随机被划分成三个组：IPA组，IPB组和控制组织，带着在每个组的12只兔子。肼oxidase(DAO)和肠的丰满的酸绑定的蛋白质(I-FABP)的浆液层次在损害以后在2，6，12和24个小时被检测。回肠的病理学的变化在损害以后在24个小时被检验。浆液在IPA和IPB组在损害以后在2，6，12和24个小时I-FABP铺平的结果有重要减少，与控制组相比。DAO层次也在损害以后在2和6个小时显示出一样的变化趋势，但是没显示出二个IP组之间的重要差别。在回肠的病理学的变化的差别都没在三个组之中被发现。结论IP能在兔子在后部的手足压碎损害的模型上保护肠的mucosa障碍功能。同时，修改IPB显示出象传统的IPA的一样的保护，并且值得在诊所适用。

简介：目的：观察针灸对溃疡性结肠炎（ulcerativecolitis，UC）大鼠结肠黏膜胰岛素样生长因子1（insulin-likegrowthfactor-1，IGF-1）和细胞因子信号转导抑制因子-2（suppressorofcytokinesignaling，SOCS2）表达的影响，探讨针灸治疗UC的作用机理。方法：将大鼠随机分为正常组、模型组、隔药灸纽和电针组，每组8只，采用免疫学方法加局部刺激制备UC大鼠模型。隔药灸组和电针组分别进行隔药灸和电针治疗，每目1次，连续治疗14d。光镜观察大鼠结肠黏膜形态学变化，采用PAS—AB、HID—AB染色观察结肠黏膜粘蛋白，免疫组织化学技术检测大鼠结肠黏膜IGF-1和SOCS2表达。结果：光镜下可见UC大鼠结肠溃疡形成和炎症，结肠黏膜粘蛋白减少（P〈0．01），IGF-1表达升高（P〈0．01），SOCS2表达降低（P〈0．01）；隔药灸、电针治疗后，结肠黏膜病理损伤减轻，粘蛋白增加（P〈0．01），IGF-1表达降低（P〈0．01），SOCS2表达升高（P〈0．01）。结论：UC大鼠结肠黏膜粘蛋白分泌减少，IGF-1表达升高、SOCS2表达下降；隔药灸、电针能改善UC大鼠结肠黏膜损伤，调节结肠粘蛋白的分泌及IGF-1和SOCS2的表达。

简介：临床的试用和动物实验的增加的数字显示出细菌为过敏症预防正在答应工具的那probiotic。这里，我们在过敏促进感受性上分析了三选择乳杆菌紧张的immunomodulatory性质和他们的混合的影响赌1用一只gnotobiotic老鼠建模的v。我们显示出那乳杆菌(L.)rhamnosusLOCK0900，L。rhamnosusLOCK0908和L。caseiLOCK0919经由像使用费的受体被认出2(TLR2)并且核苷酸绑定oligomerization包含域的蛋白质2(NOD2)受体并且刺激骨头在种类依赖者和紧张依赖者礼貌生产cytokines的导出髓的树枝状的房间。殖民无菌(GF)有所有三紧张(Lmix)的混合物的鼠标由加强enterocytes的顶端的junctional建筑群并且恢复延续到终端网的微细丝的结构改进了肠的障碍。与Lmix开拓殖民地于并且敏化1变应原到赌注v的老鼠显著地象一个增加的转变生长因素(TGF)一样在sera和肠的lavages显示出变应原特定的IgE，IgG1和IgG2a和提高的全部的IgA水平的底层-β；与敏化的GF老鼠相比铺平。从开拓殖民地于Lmix的老鼠的Splenocytes和mesenteric淋巴节点房间显示出TGF-β的重要upregulation；在以后在有赌注v的vitro刺激1。我们的结果证明Lmix殖民改进了内脏对赌注v的上皮的障碍和减少的过敏促进感受性1。而且，这些调查结果被传播和能分泌的IgA和规章的cytokineTGF-β的增加的生产伴随；。因此，三乳杆菌紧张的这混合物在人在增加的内脏渗透和过敏症的发作的预防为使用显示出潜力。

简介：ToinvestigatetheprotectiveeffectofdecoctionofliaoweiongastricmucosaofH.pyloriassociatedchronicatrophicgastritisinrats.TheH.pyloriassociatedchronicatrophicgastritismodelswereinducedwithsodiumdeoxycholate,sodiumsalicylate,ethanol,andculturebrothofH.pylori.ProtectiveeffectofdecoctionofliaoweiongastricmucosaofH.pyloriassociatedchronicatrophicgastritiswasobservedquantitatively.

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简介：Monoclonalantibody(MAb)toratlivercyto-chromeP-450jisozyme,anactivatingenzymespecifictonitrosaminemetabolism,wasusedcoupledwithimmunoblotting,densitometerscanningofSDS-PAGEgelsandimmunohistochemicaltechnique.ThetraceP-450HSjisozyme(Mr.51.5Kd)wasfoundinhumangastricmucosa.ItwassimilartoP-450jinmolecularweight,catalyticandimmunochemicalproperties.TheconcentrationsofP-450HSjinmucosaoflessercurvaturewerehigherthanthoseingreatercurvature.Thismightbeoneoftheimportantreasonsthatlessercurvatureisthecommonestareaforgastriccarcinoma.ButtherewaspossiblylessP-450HSjingastricmucosawithcancer.Im-munohistochemically,P-450HSjwasdiscoveredinthecytoplasmofsomeglandularepithelialcells,especiallyintheglandswithhyperplasticandintestinalmetaplasticchangesadjacenttocarcinoma.Itwasalsofoundinsomenormalglandsandintumorcellsofhigh-differentiatedadenocarcinoma,butnotinthoseoflow-differentia

简介：瞄准：与尖锐引起坏死胰腺炎在老鼠调查浆液IL-2，IL-10，IL-2/IL-10和sFas的动态变化。与尖锐引起坏死胰腺炎(ANP)在老鼠的肠粘膜探索船边交货的表示。方法：64只Sprague-Dawley(SD)老鼠的一个总数随机被划分成二个组：正常控制组(C组)，ANP组(P组)。一个ANP模特儿被50g/L牛磺胆酸钠的注射在胰腺的膜下面劝诱。正常控制用一样的方法组织9g/L生理盐水答案的收到的isovolumetric注射。在每个组的老鼠的血样品经由优异mes伤寒静脉被获得测量IL-2的层次，IL-10，sFas并且计算IL-2/IL-10的价值。IL-2，IL-10和sFas的层次被ELISA决定。肠的粘膜损害的严厉被病理学的分数评估。在肠的粘膜织物的船边交货的表示被染色的免疫组织化学决定。结果：浆液IL-2的层次比C组的那些在P组是显著地更高的(2.79+/-0.51对3.53+/-0.62，2.93+/-0.89对4.35+/-1.11，4.81+/-1.23对6.94+/-1.55和3.41+/-0.72对4.80+/-1.10，分别地P<0.01，为所有)并且它在6h的到达山峰。浆液IL-10的层次比在6h和12h的C组的那些在P组是显著地更高的(54.61+/-15.81对47.34+/-14.62，141.15+/-40.21对156.12+/-43.10，89.18+/-32.52对494.98+/-11.23和77.15+/-22.60对93.28+/-25.81，分别地P<0.01，为所有)。IL-2/IL-10的价值比在0.5h和2h的C组的那些在P组显著地是更高的(0.05+/-0.01对0.07+/-0.02和0.02+/-0.01对0.03+/-0.01，分别地P<0.01，为所有)，并且它是比在6h的C组的那些显著地低的(0.05+/-0.02对0.01+/-0.01，P<0.01)并且在12h回到了控制水平(0.04+/-0.01对0.05+/-0.02，P>0.05)。在sFas试金，在P组和C组之间没有有效差量(3.16+/-0.75对3.31+/-0.80，4.05+/-1.08对4.32+/-1.11，5.93+/-1.52对5.41+/-1.47和4.62+/-1.23对4.44+/-