简介：Inthisstudy,weinvestigatedthepreventiveeffectsofaprobioticpreparation(MiyaBM)containingClostridiumbutyricumsporesagainstthesideeffectsofHelicobacterpylorieradication.Theratswereadministeredomeprazole,amoxicillinandclarithromycin,whichcombinationofdrugswasanewtriple-therapyproposedforthefirstlinetherapybytheguidelineofthetreatmentofH.pyloriinfectioninJapan.ObligateanaerobesandLactobacillusweredecreasedmarkedly,whileaerobeswereincreasedafterthethreedrugsadministration.Moreover,Clostridiumdifficilecausativeofantibioticassociateddiarrheawasisolatedfromfecesafterthe7th.AdministrationofMiyaBMdecreasedthenumberofC.difficileinthefecesandincreasedtheshortchainfattyacidsintheintestinalcontents.

简介：Tamiflu(Oseltamivirphosphate)seemstobeadouble-edgedswordtosomeinAsia.Whileitiscountedonagainstinfluenzaandafearedavianinfluenzapandemic[1],thedrugisalsoassociatedwithsideeffects,rangingfromneu-ropsychiatric,gastrointestinal,tohyperthenniaandskinproblems.AccordingtoadocumentfromUSFoodandDrugAdministrationin2005[2],1184casesofsideeffectshavebeenreported.Interestingly69outofthe75pediatriccaseswerefromJapan,includingtwoteensuicides.Thesituationseemedtohavemadeagloomierturnrecently.ItwasreportedinFebruary,2007thattwoJapaneseteenagersjumpedfromapartmentbuildingsaftertakingTamifluanddied,bringingthetotalnumberofdeathsaftertakingTamiftuinJapanto54[3,4].Althoughnodirectcausalrelationshiphadbeenes-tablishedyet,theJapanHealthMinistrywarneddoctorsaboutgivingthedrugtoteenagers.Incomparison,relativelyfewcasesofseveresideeffectswerereportedfromAmericaandEuropeancountries[5].Whatiswrongwiththispicture?Ithasconcernedandbewilderedmany.Thepagesinthisissue[6]offeronefascinatinghypothesisthattriestoexplainthemysteryusinganintegratedapproachcombiningstructuralbioinformaticanalysisandenzymeassays.

简介：AnovelnumericalmodelbasedontheimageGreenfunctionandfirst-orderTaylorexpansionboundaryelementmethod(TEBEM),whichcanimprovetheaccuracyofthehydrodynamicsimulationforthenon-smoothbody,wasdevelopedtocalculatethesidewalleffectsonfirst-ordermotionresponsesandsecond-orderdriftloadsuponoffshorestructuresinthewavetank.Thismodelwasconfirmedbycomparingittotheresultsfromexperimentsonhydrodynamiccoefficients,namelythefirst-ordermotionresponseandsecond-orderdriftloaduponahemisphere,prolatespheroid,andbox-shapedbargeinthewavetank.Then,thehydrodynamicsoftheKVLCC2modelwerealsocalculatedintwowavetankswithdifferentwidths.Itwasconcludedthatthismodelcanpredictthehydrodynamicsforoffshorestructureseffectively,andthesidewallhasasignificantimpactonthefirstorderquantitiesandsecond-orderdriftloads,whichsatisfiedtheresonantrule.

简介：Ephedrinehasaprotectiveeffectagainstcerebralischemia,butitssideeffectslimititsclinicalapplication.Resultsfromapreviousstudyshowedthat1.5mg/kgperdayephedrinecanpromotemotionrecoveryinratsfollowingcerebralischemia/reperfusionwithoutsignificantsideeffects.Inthepresentstudy,ephedrineatdosesof3.0,2.5and2.0mg/kgwasusedtotreatratswithcerebralischemia/reperfusionandtheeffectsofephedrineontheheart,liver,kidneyandcerebrumwereobserved.Resultsshowedthatthebloodpressureofratswithcerebralischemia/reperfusioninjuryfollowingephedrinetreatmentwaslowerthaninratsthatrecoverednaturallyfromcerebralischemia/reperfusion,butthepressuredecreasedwithincreasingdosesofephedrine.Inaddition,serumaspartatetransaminase,alkalinephosphataseandcreatinineconcentrationinratswithcerebralischemia/reperfusioninjuryfollowingephedrinetreatmentweregreaterthaninratsthatrecoverednaturallyfromcerebralischemia/reperfusion.Theconcentrationsoftheseenzymesweredecreasedwithincreasingdosesofephedrine.Ephedrine-treatedratsdisplayedhyperemia,degenerationandedemainthecerebrum,liver,heartandkidney.Resultsdemonstratedthatephedrineexhibitedsideeffectsonthecerebrum,heart,liverandkidneyinratsfollowingcerebralischemia/reperfusioninadose-dependentmanner.

简介：Inthisstudy,etherificationofginkgolideBanddimethylaminoethylchloridehydrochloridewasinvestigatedasamodelreactioninamicro-flowsystem(MFS),providingtheresultingethersinhighyieldwithfewersideeffects.Meanwhile,thisnovelprocessinMFSworkedwellforotherginkgolidesfromGinkgolbilobaandhalides,givingmoderateyields.

简介：有在结构的不同方面链的Polyimides(PI)被pyromelliticmdianhydride(PMDA)的copolycondensation与3,5-diamino-综合(4甲烷酸己基的酉旨)phenyl-benzamide(C6-PDA)，(4-butoxybiphenol)-3,5-diaminobenzoate(C4-BBDA)并且3，5-diamino-benzoic酸decyl酉旨(C10-DA)说出PI-PDA，PI-C4，PI-DA分别地。PI-PDA和PI-DA的方面链的长度象PI-C4的一样类似。通过pretilt角度测试，方面链的长度什么时候是类似的，被表明方面链也不磨擦过程的结构能也不在垂直排列性质上有明显的差别，站在约1.6nm。PI表面的表面精力的测量进一步证明了这结果。X光检查光电子分光镜测量的结果显示PI的方面链从聚合物体积阶段外面拉长了并且在表面上积累了。

简介：Theprocessingmethodappliedtothesidesurfaceisdifferentfromthemethodappliedtothelightpasssurfaceinneodymiumphosphateglass(Nd:glass),andthussubsurfacedefectsremainafterprocessing.ThesubsurfacedefectsinthesidesurfaceinfluencethegainuniformityofNd:glass,whichisakeyfactortoevaluatetheperformanceofamplifiers.Thescatteringcharacteristicsofsidesubsurfacedefectsweresimulatedbyfinitedifferencetimedomain(FDTD)Solutionssoftware.Thescatteringpowersoftheglassfabricatedbyacomputernumericalcontrol(CNC)machinewithoutcladdingweretestedatdifferentincidentangles.Thetrendofthecurvewassimilartothesimulatedresult,whilethesmallestpointwasdifferentwiththecomplextruemorphology.Thesimulationshowedthattheequivalentresidualreflectivityofthecladdingglasscanbemorethan0.1%whenthenumberofdefectsinasinglegriddingisgreaterthan50.

简介：BACKGROUND:GenetherapyforParkinson'sdiseaseisbeingexploredasaneffectivestrategytorestoreandprotectthefunctionofneuronalcellsinthesubstantianigra.Regulationofgeneexpressionisnecessaryforgenetherapytoavoidadverseeffectsduetoexcessivesynthesisoftransgeneproducts.OBJECTIVE:Herewedevelopedrecombinantadeno-associatedvirus(AAV)asaviralvector-mediatedgeneregulationsystembasedonCrerecombinasefusedtothemutatedligand-bindingdomainoftheestrogenreceptor(CreERT2)+inducingagenttamoxifen.InducibleCrerecombinasewasusedtoreducetyrosinehydroxylasegeneexpressionandtopreventtheexcessiveincreaseindopamine.DESIGN,TIMEANDSETTING:Ageneticengineeringinvitrocomparativestudyandrandomizedcontrolledanimalexperiment.ThisstudywasconductedattheGeneTherapyCenter,JichiMedicalSchool,JapanfromJune2002toJune2004.METHODS:ToconstructarecombinantAAVvectorcarryingadopaminesynthasegene.ThetyrosinehydroxylasegenewasinsertedusingaloxPfragmentthatcouldberegulatedbyCrerecombinase.TherecombinantAAVvectorcarryingtheCreERT2genewasco-transducedwithHEK293cellsandthecorpusstriatuminaratmodelofParkinson'sdisease,withinducingagenttamoxifentoregulategeneexpression.MAINOUTCOMEMEASURES:ThelevelsofdopamineandaromaticL-aminoaciddecarboxylase(AADC)activityweredetectedinHEK293cellmediumandinthecorpusstriatuminaratmodelofParkinson'sdiseaseusinghigh-performanceliquidchromatography.ImmunofluorescencedoublestainingwasusedtoobservetyrosinehydroxylaseandCreorAADCco-expressioninHEK293cellmedium.ImmunohistochemicalstainingwasemployedtoobservetyrosinehydroxylaseandAADCexpressionandbehavioralchangesweremeasuredinParkinson'srats.RESULTS:TransfectedAAV-CreERT2andAAVexpressingdopaminesynthesisenzymescouldincreasethesynthesisofdopamineinHEK293mediumandParkinson'sratstriatum(P<0.01)andimprovetherotationalbehaviorofParkin

简介：以便改进一个卸载的系统的安全性质与(SBS)一起在FPSO被一个蛋黄系统在BZ25-1的域里在哪个系在系在，分析那些性质是必要的。根据类似的工程的经验，拖引不同卸载的策略安排被使用3-D放射/衍射理论和伪静电干扰时间领域方法估计他们的各自的安全性质讨论。通过不同安排比较的安全评价分析，改进与一起系在卸载系统的安全性质的各种各样的方法被在系在的线和fender偏转分析紧张验证。通过比较，由适当地扩大关键因素，包括象大索的数字一样的fenders和大索的尺寸，更好的安全表演能被完成，这能被结束。

简介：AlkylatingagentsarechemicallyreactivedrugsthatreactwithDNAtoformcovalentbonds,causingsingle-strandordouble-strandDNAbreaksthatleadtointerstrandandintrastrandDNAcross-linking.Theseagentsareusedextensivelyincancerchemotherapy.Theyhaveasteepdose-responsecurveandarethereforeusefulindoseintensificationstrategies(e,g.inbonemarrowtransplantation).Thesubclassesofalkylatingagentsareasfollows.

简介：一个创新水动力学理论和数字模型被开发帮助在二一起深海的漂浮身体上改进波浪飘移力量的数字预言的效率，精确性，和集中。波浪飘移力量被来源力量和相应格林函数的双集成在身体表面上表示，它基于动量保存与远域公式一致并且分享在每身体上提供飘移力量的近的域计算的优点。数字结果通过比较一般的远地模型和压力积分模型，以及用软件HydroStar开发的中间的地模型被验证。

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简介：Mostcytotoxicchemotherapydrugsexerttheireffectbyinhibitingoneormoreoftheprocessesinvolvedincelldivision.Itappearsthatthefateofcellsdamagedbychemotherapyistodieprimarilybyinductionofapoptosis(prograrmnedcelldeath).Chemotherapyisgenerallyusedtotreatcanceratanadvancedorearlystage.

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简介：Epithelialovariancancerisprimarilyadiseaseofolderwomen.Advancedageisriskfactorfordecreasedsurvival.Optimalsurgeryandthesafeandeffectiveadministrationofchemotherapyareessentialforprolongedprogression-freeandoverallsurvival(OS).Inthisarticle,theavailableregimensinboththeprimarytreatmentandrelapsedsettingarereviewed.

简介：暗面是指我们自己内在的消极因素。学会承认并去喜欢自己的暗面，就会减少它对我们生活的影响，努力从暗面中发掘出积极的能量，促进蓬勃向上的生活!