简介：Ephedrinehasaprotectiveeffectagainstcerebralischemia,butitssideeffectslimititsclinicalapplication.Resultsfromapreviousstudyshowedthat1.5mg/kgperdayephedrinecanpromotemotionrecoveryinratsfollowingcerebralischemia/reperfusionwithoutsignificantsideeffects.Inthepresentstudy,ephedrineatdosesof3.0,2.5and2.0mg/kgwasusedtotreatratswithcerebralischemia/reperfusionandtheeffectsofephedrineontheheart,liver,kidneyandcerebrumwereobserved.Resultsshowedthatthebloodpressureofratswithcerebralischemia/reperfusioninjuryfollowingephedrinetreatmentwaslowerthaninratsthatrecoverednaturallyfromcerebralischemia/reperfusion,butthepressuredecreasedwithincreasingdosesofephedrine.Inaddition,serumaspartatetransaminase,alkalinephosphataseandcreatinineconcentrationinratswithcerebralischemia/reperfusioninjuryfollowingephedrinetreatmentweregreaterthaninratsthatrecoverednaturallyfromcerebralischemia/reperfusion.Theconcentrationsoftheseenzymesweredecreasedwithincreasingdosesofephedrine.Ephedrine-treatedratsdisplayedhyperemia,degenerationandedemainthecerebrum,liver,heartandkidney.Resultsdemonstratedthatephedrineexhibitedsideeffectsonthecerebrum,heart,liverandkidneyinratsfollowingcerebralischemia/reperfusioninadose-dependentmanner.
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