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简介：Throughthesinusoidloadingdynamictriaxialtest,theliquefactionpropertyofsaturatedloessandsandselectedfromacivilairportofLanzhou,Gansuisexamined.Basedonthelaboratoryresults,acomprehensiveassessmentontheearthquakeliquefactionpotentialoftheloessandsandisgiven,usingtheliquefactionresistanceshearstressmethodandtheresultsofseismichazardassessment.Itisfoundthatundertheeffectofgroundmotionwithexceedanceprobabilityof10%within50years,theloessinthestudyismoresusceptibletoliquefactionthansand.

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简介：Smallhydrositeslocatedinmountainenvironmentsareoftenonungaugedstreams.AsoftwarepackagecalledtheintegratedMethodforPower(IMP4.0)wasdesignedtoassistinexperienced,potentialdevelopersofsmaffhydrositesinsituationswherethecostofprofessionafengineeringadvicewouldbeprohibitive.

简介：KaifengwascalledBianliangorsimplyBianinancienttimes.The"capitalofsevendynasties"isoneofthesixancientculturalcentresandcapitalsofChina.AmongthetouristcentresofKaifengaretheIronPagoda,theXiangguoTemple,theDragonPavilion,theImperialStreetoftheSongDynastyCapitalCity,andsoon.

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简介：Translationinitiationsites(TISs)areimportantsignalsincDNAsequences.InmanypreviousattemptstopredictTISsincDNAsequences,threemajorfactorsaffectthepredictionperformance:thenatureofthecDNAsequencesets,therelevantfeaturesselected,andtheclassificationmethodsused.Inthispaper,weexaminedifferentapproachestoselectandintegraterelevantfeaturesforTISprediction.Thetopselectedsignificantfeaturesincludethefeaturesfromthepositionweightmatrixandthepropensitymatrix,thenumberofnucleotideCinthesequencedownstreamATG,thenumberofdownstreamstopcodons,thenumberofupstreamATGs,andthenumberofsomeaminoacids,suchasaminoacidsAandD.Withthenumericaldatageneratedfromthesefeatures,differentclassificationmethods,includingdecisiontree,naiveBayes,andsupportvectormachine,wereappliedtothreeindependentsequencesets.Theidentifiedsignificantfeatureswerefoundtobebiologicallymeaningful,whiletheexperimentsshowedpromisingresults.

简介：探索真核细胞的抄写因素(TF)的性质有约束力的地点并且决定他们怎么不同于包围DNA序列，我们检验了与DNA有约束力的地点联系的四个特征：G+C内容，模式复杂性，palindromic结构，和Markov定序订。我们规章的主题的分析从TRANSFAC数据库获得了，用酵母内部是的遗传因子的序列背景，表明这四个特征在主题序列显示出可变丰富。例如，主题序列比是背景序列是更可能的有palindromic结构。另外，这些特征对规章的主题紧局部性，显示他们自己是主题序列的一个性质并且没被一般倡导者分享规章的主题在住的“环境”。由根据他们绑在的TF班毁坏主题序列，更特定的协会被识别。最后，当其它例如复杂性丰富，越过检验的种类是通用的时，我们发现一些关联例如G+C内容丰富，是种类特定的。这里提供的定量分析应该增加我们protein-DNA相互作用的理解并且也帮助通过生物信息学便于规章的主题的发现。

简介：TheroleplayedbythefunctionalgroupsofLaminariajaponicatreatedbymethanolandformaldehydeinbiosorptionoftheheavymetalswasinvestigated.Infraredspectroscopyanalysisandbiosorptionexperimentsshowthatbothcarboxylandaminogroupsjoininthesorption;chemicaltreatmentdecreasedthebiosorptionefficiencyoftheheavymetals.

简介：Proteinphosphorylationplaysanimportantroleinvariouscellularprocesses.Duetoitshighcomplexity,themechanismneedstobefurtherstudied.Inthelastfewyears,manymethodshavebeencontributedtothisfield,butalmostalloftheminvestigatedthemechanismbasedonproteinsequencesaroundproteinsites.Inthisstudy,weimplementanexplorationbycharacterizingthemicroenvironmentsurroundingphosphorylatedproteinsiteswithamodifiedshellmodel,andobtainsomesignificantpropertiesbytherank-sumtest,suchasthelackofsomeclassesofresidues,atoms,andsecondarystructures.Furthermore,wefindthatthedepletionofsomepropertiesaffectsproteinphosphorylationremarkably.Ourresultssuggestthatitisameaningfuldirectiontoexplorethemechanismofproteinphosphorylationfrommicroenvironmentandweexpectfurtherfindingsalongwiththeincreasingsizeofphosphorylationandproteinstructuredata.

简介：六不同治疗在与变形阉割抵抗的前列腺癌症(mCRPC)指向到病人的阶段III试用表明了改进幸存。为mCRPC的前线的治疗学的选择包括docetaxel，sipuleucel-T，abiraterone和radium-223。Post-docetaxel选择包括cabazitaxel，abiraterone，enzalutamide和radium-223。尽管有最近的年里的许多进步，多是还未知的，争论发生在最佳的治疗选择和序列上。任何一个新代理人都没与对方相比，因此，在今天的实践的医生必须基于非使随机化的比较，毒性考虑和各种各样的假设做选择。Abiraterone现在正在移动直到给最近的规章的赞同的前面线mCRPC空间，enzalutamide将很快列在后面。当时，两个神经质的代理人有更少的毒性与化学疗法的选择和这两个神经质的代理人相比被期望向前在年里在mCRPC病人的一个可观的数字被过去常。很少数据都不为post-abiraterone或post-enzalutamide背景是可得到的。在这评论，当前可得到的定序数据被总结并且解释。生气抵抗是在各种各样的治疗之间的一个潜在的问题，现在是清楚的，特别指向雄激素轴的那些代理人。这评论加亮需要让另外的研究为这些病人优化当前的治疗。

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简介：Itiswidelyknownthattheseismicresponsecharacteristicsofasoilsitedependsheavilyonseveralkeydynamicpropertiesofthesoilstratum,suchaspredominantfrequencyanddampingratio.Awidelyusedmethodforestimatingthepredominantfrequencyofasoilsitebyusingmicrotremorrecords,proposedbyNakamura,isinvestigatedtodetermineitseffectivenessinestimatingthedampingratio.TheauthorsconductedsomemicrotremormeasurementsofsoilsitesinHongKongandfoundthatNakamura'smethodmightalsobeusedtoestimatethedampingratioofasoilsite.DampingratiodatafromseveraltypicalsoilsiteswereobtainedfrombothNakamura'sratiocurvesusingthehalfpowerpointmethodandresonantcolumntests.Regressionanalysisindicatesthatthereisastrongcorrelationbetweenthedampingratiosderivedfromthesetwodifferentapproaches.

简介：ThebackdoororinformationleakofWebserverscanbedetectedbyusingWebMiningtechniquesonsomeabnormalWeblogandWebapplicationlogdata.ThesecurityofWebserverscanbeenhancedandthedamageofillegalaccesscanbeavoided.Firstly,thesystemfordiscoveringthepatternsofinformationleakagesinCGIscriptsfromWeblogdatawasproposed.Secondly,thosepatternsforsystemadministratorstomodifytheircodesandenhancetheirWebsitesecuritywereprovided.Thefollowingaspectsweredescribed:oneistocombinewebapplicationlogwithweblogtoextractmoreinformation,sowebdataminingcouldbeusedtomineweblogfordiscoveringtheinformationthatfirewallandInformationDetectionSystemcannotfind.AnotherapproachistoproposeanoperationmoduleofwebsitetoenhanceWebsitesecurity.Inclusterserversession,Density-BasedClusteringtechniqueisusedtoreduceresourcecostandobtainbetterefficiency.

简介：Gastrointestinalmetastasisfromprimarylungcancerisrare.Inthepresentstudy,wereportthecaseofa78-year-oldmalewhowasadmittedtotheemergencydepartmentwithacutebleedingofthedigestivetract.Duringevaluation,hewasfoundtohavelungadenocarcinomametastasisinthesmallbowelleadingtohemorrhage.Ajejunumwedgeresectionwascarriedoutandbleedingwascontrolled.However,2monthsaftertheoperation,thepatientthedfromseverepulmonaryinfection.Wealsoreviewthepublishedliteratureofprimarylungcancerwithgastrointestinalmetastasis.

简介：Melanomaisthedeadliestformofskincancerandhasanincidencethatisrisingfasterthananyothersolidtumor.Metastaticmelanomatreatmenthasconsiderablyprogressedinthepastfiveyearswiththeintroductionoftargetedtherapy(BRAFandMEKinhibitors)andimmunecheckpointblockade(anti-CTLA4,anti-PD-1,andanti-PD-L1).However,eachtreatmentmodalityhaslimitations.Treatmentwithtargetedtherapyhasbeenassociatedwithahighresponserate,butwithshort-termresponses.Conversely,treatmentwithimmunecheckpointblockadehasalowerresponserate,butwithlongtermresponses.Targetedtherapyaffectsantitumorimmunity,andsynergymayexistwhentargetedtherapyiscombinedwithimmunotherapy.Thisarticlepresentsabriefreviewoftherationaleandevidenceforthepotentialsynergybetweentargetedtherapyandimmunecheckpointblockade.Challengesanddirectionsforfuturestudiesarealsoproposed.

简介：Thecalculationmethodaboutinfraredmulti-sitespassivesystemlocationisintroducedbasedontheprincipleoftheweightedleastsquaremethod,andthevariancematrixofestimatederrorisoffered.Throughdeduction,itcanbefoundoutthattreatedappraiseprecisioncanbedirectlyanalyzedanddeducedwithoutcarryingoutrealmeasureandreachingestimationvalue.Thesimulationresultshowsthatthesystemperformancebasedontheweightedleastsquaremethodismuchbetterthanthetraditionalpassivelocationmethod,anditcanbealsousedforreferencetotheresearchofthelocationalgorithmofsimilarsystem.

简介：抄写开始地点(TSS)区域与另外的倡导者元素相比显示出更大的可变性。我们被感兴趣由把信息内容用作一项措施寻找它的可变性。我们在这研究注意可变性在与15nt的块相比包围TSS区域的5核苷酸(nt)的块是重要的。这建议可以被包含的实际区域在在尺寸的5-10nt的范围。为Escherichia关口i，我们注意从dinucleotide替换矩阵的信息内容清楚地显示出更好的辨别，建议一些关联的存在。然而，为人，这效果是少得多，并且为老鼠，它实际上是不在的。我们能断定存在短期在TSS区域以内的关联是种类依赖者并且不是通用的。我们进一步观察到在除了TSS的mitochondrial控制元素有另外的可变区域。有效比较能仅仅在块上被做，这也被注意，当单个核苷酸比较不给我们任何可检测的信号时。