简介：Retinoblastoma(RB)isthemostcommonintraocularcancerofinfancyandchildhood.ThiscancerisinitiatedbymutationonRB1,thetumorsuppressorgenethatisresponsiblefortheregulationofbothcellcycleandgnomestabilityinretinalcells.PatientswithaconstitutionalmutationonRB1canbeinherited.RBoccursapproximately1inevery15000-20000livebirths.Theworldwidemortalityforthiscancerisabout5%-11%.However,thisraterisestoabout40%-70%indevelopingcountriesduetoadelayindiagnosis.Awidevarietyofoptionsareavailableforthetreatment,butoftenacombinationoftherapiesisadoptedtooptimizeindividualizedcare.

简介：AIM:Todeterminewhetherretinalcirculatorychangesplayaroleinthepathogenesisofmaculardisordersinpatientswhoareotherwisehealthy.METHODS:Patientswithmaculardisordersthatrequiredangiographicimagingwereincludedinthisprospectivecaseseries.Afteracompleteocularexam,fluoresceinangiographywasperformedusingastandardizedtechniqueontheHRA-II(HeidelbergEngineering,Heidelberg,Germany)withspecialfocusontheposteriorpole.Onlypatientswithgoodqualityimageswereincludedintheanalysis.Circulatoryparametersrecordedincludedthearm-choroidtime,choroid-retinalartery,andfinallytheretinalartery-veintime.Zonalasymmetry(betweentheupperandlowerzonesdividedbyalinepassingthroughthecentreofthefovea)intransittimes,ifanywasalsonoted.Appropriatestatisticalanalysiswasdone.Circulationtimeswerecomparedwithagematchedhistoricalcontrols.Changesinretinaldyetransittimesrelativetohistoricalagematchedcontrols,ifany,werenotedandcomparedbetweenvariousdisorders.RESULTS:Atotalof156eyesof156patients(120males)wereincludedinthestudy.Meanage:49.14±14.93y.Maculardisordersstudiedwereagerelateddegeneration,polypoidalvasculopathy,centralserouschorioretinopathy(CSCR)andparafovealtelangiectasia.DelayedcirculationtimewasnotedinCSCRpatientsonly.CONCLUSION:CSCRpatientsappeartohavedelayedarterialfilling,retinalcirculatorydisturbancesdonotseemtocontributetothepathogenesisofothermaculardisorders.

简介：AIMTo检验light-emitting-diode(带)导致的网膜的neuronal房间损坏和它的波长驱动的病原的mechanisms.METHODSSprague-Dawley老鼠暴露于蓝色LEDs(460nm)，绿LEDs(530nm)，和红LEDs(620nm)。染色的网膜电图描述术(尔格)(H&E)，Hematoxylin和曙红，传播电子显微镜学(TEM)，标记的终端deoxynucleotidyltransferasedUTP刻痕结束(TUNEL)，和染色的immunohistochemical(IHC)，西方的弄污(WB)并且superoxide阴离子的察觉(O2桰獯桰牯汹瑡潩???歁???????????椠浭湵景畬牯獥散据??啓呌？？

简介：AIM:ToperformaMeta-analysistoexplorethecorrelationbetweenmetabolicsyndromeandintraocularpressure(IOP).METHODS:WesearchedPubMedandEmbaseinNovember2017forstudiesdiscussingtherelationshipbetweenmetabolicsyndromecomponentsandIOPinpatients.Pearsoncorrelationcoefficients,oddsratiosandstandardizedbetaswereextractedfrominclusivestudies.Heterogeneityandpublicationbiaswerechecked.RESULTS:Of295articles,10metinclusioncriteriaandprovidedsufficientdataforMeta-analysis.ResultsshowedasignificantpositiverelationbetweenmetabolicsyndromeandIOP(Z=0.47,95%CI:0.15-0.79,P=0.005).Thefivecomponents[waistcircumference,hypertriglyceridemia,highbloodpressure,highfastingglucoseandlowhighdensitylipoprotein(HDL)-cholesterol]ofmetabolicsyndromeallshowedpositivecorrelationwithIOPexceptthelowHDL-cholesterolwhichhadnostatisticalsignificance.ThepooledZwas0.08(95%CI:0.04-0.12),0.16(95%CI:0.11-0.21),0.16(95%CI:0.10-0.22),0.30(95%CI:0.20-0.40)and0.12(95%CI:0.08-0.16),respectively.Begg’stestandEgger’stestshowednoevidenceofsignificantpublicationbiasofthisMeta-analysis.CONCLUSION:OurfindingssuggestthatmetabolicsyndromeanditscomponentsaresignificantlyassociatedwithIOP,besidestheHDL-cholesterol.ThisassociationmaybeusedtocontrolIOPbyinterveningtheoccurrenceofmetabolicsyndrome.

简介：AIMTo在intraocularscattering.METHODSSixty上在小切口的lenticule抽取(微笑)和它的效果以后调查帽子形态学--经历微笑的33个病人的五只眼睛被注册。除了常规评估，Fourier域光连贯断层摄影术被用来在1d调查帽子厚度，1wk，1并且3mo手术后地。散布的光优秀包括调整转移函数截止频率，Strehl比率，光优秀分析系统(OQAS)值，和目的索引(OSI)，用OQAS.RESULTSCap厚度被评估从1d减少了到1wk(P<0.001)，但是仍然保持比120的打算的厚度高

简介：AIM:Toestablishtheratmodelofstreptozotocin(STZ)induceddiabeticretinopathy(DR),whichisthemostcommoncauseofvisuallossandblindnessinpatientswithdiabetes,andobservethegeneexpressionofvascularendothelialgrowthfactor(VEGF)anditsreceptorsduringthedevelopmentofDR.METHODS:AratmodelofdiabeteswasestablishedbyintraperitonealinjectionofSTZ.Thediabeticratswerehousedfor2,3and4monthsafterthedevelopmentofdiabetes.Retinalhistopathologicalobservationwasperformed.TheretinalvesselswereobservedbyimmunofluorescencestainingbyCD31.ThemRNAexpressionofVEGF,VEGFreceptor1and2(VEGFR1/2)inratretinawasdetectedbyreversetranscriptionpolymerasechainreaction(RT-PCR)analysis.RESULTS:Retinalhistopathologicalobservationshowedthemorphologicalchangesofinnernuclearlayer(INL)andouternuclearlayer(ONL)atanytime-point,andalsodemonstratedtheincreasednewvesselsatboth3,4monthsafterthedevelopmentofdiabetes.TheCD31stainingresultsshowedthatthenumberofvesselswasincreasedintheretinasofdiabeticratsatboth3and4monthsafterthedevelopmentofdiabetes.Ascomparedtothenormalrats,themRNAexpressionofVEGFwasincreasedinretinasofdiabeticratsat3monthsafterthedevelopmentofdiabetes,whileVEGFR1andVEGFR2mRNAexpressionwasincreasedat2,3and4monthsafterthedevelopmentofdiabetes.CONCLUSION:Takentogether,ourresultsdemonstratedthatDRwasoccurredat3monthsafterthedevelopmentofdiabetes,andthemRNAexpressionofVEGF,VEGFR1andVEGFR2wereincreasedintheprocessofDR.ThepresentstudyfurtherevidencedtheinvolvementofVEGFanditsreceptorsintheprocessofDR.

简介：AIM:TostudytheevolutionoftherefractivestatusandexaminetheaffectedfactorsininfantsduringthefirstyearoflifeinalargesamplesizeinChina.METHODS:Atotalof1258babies(2516eyes)aged32wkgestationalageto1yparticipatedinthestudy,including766prematureand492full-terminfants.First,eachbabyreceivedanorthopticexamination,slit-lampcheckingandfundusimaging.Patientswithdiseaseswhichmightaffectrefractivestatuswereexcludedfromthecohort.Thecycloplegiaretinoscopywasperformed.Theirneonatalhistorieswerereviewed.Eachmeasurementcontainedtherefractivestatusandcalculationofthesphericalequivalent(SE).RESULTS:Refractivestateshowedanaveragehyperopiaof+0.94±1.63Datearlyages,followedbyatrendtowardmorehyperopia.Therefractivestatereachedthetop(+2.43±1.46D)attheageofonetotwomonths.Thenglidingtilloneyearoldwhentherefractivestatereached+0.59±1.41D.Theprevalenceofastigmatismwas42.17%inthestudy,being2.82%myopicastigmatismand39.35%hyperopicastigmatism.The94.1%ofhyperopicastigmatismwaswith-the-ruleastigmatismand71.83%ofmyopicastigmatismwaswith-the-ruleastigmatism.Refractivestatebetweenboysandgirlswasdifferent.ThemeanSEofboyswas+1.97±1.57D,whilethatofgirlswas+1.79±1.46D,andthedifferencewassignificant.CONCLUSION:Beforeoneyearold,thechangeofrefractivestatusisassociatedwithcheckingageandsex.Attheageofonetotwomonths,thedegreeofhyperopiareachesthetop.Boyshavemorehyperopicdegreethangirls,andwiththe-ruleastigmatismispredominant.Excludingprematureinfantswithadvancedretinopathyofprematurity,prematureandfull-termchildrenhavesamerefractionstatus.

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简介：AIMTo比较在两个的灌注由使用光连贯断层摄影术angiography(OCTA)与正常控制组一起单方的自发的有斑点的洞(IMH)看的眼的神经头(ONH)并且调查它的correlationship，有斑点的血perfusion.METHODSWe表现了包括了19个病人与的未来、代表性的研究完整厚度单方IMH和24匹配年龄、匹配性的控制。所有参加者收到了OCTA测试。ONH灌注被peripapillary和全部的区域在脸(peripapillary和眼的圆盘的和)评估。在ONH和parafovea之间的潜在的correlationship被暗示。所有数据用介绍的ONH的nonparametrictest.RESULTSThe平均数值被执行那正常控制>IMH>未受影响的眼睛。一个统计变化在这个区域在三个组之间被发现时间(P=0.007)。容器密度著名地在层上减少了表面，深并且在IMH的parafovea区域的脉络膜组。关联词系数在脸和深视网膜完全分别地显示出那：r=0.528，peripapillary和深视网膜：r=0.525，在脸和choriocapillaries整个：r=0.569，peripapillary和choriocapillaries：r=0.504.CONCLUSIONOur学习在IMH眼睛在IMH病人和ONH的容器密度的两只眼睛表明减少的ONH容器密度断然在parafoveal与毛状的视网膜和choriocapillary被相关。容器密度的减小可以在IMH眼睛显示hypoperfusion。