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简介：Thispaperpresentsaheattransfermodelforthehyperthermiatreatmentofcervixcancerusingaintracavitarymicrowaveapplicatorandbasedonwhichthe3-Dfiniteelementsimulationofthetemperaturefieldshavedone,Beforethenthespecificabsorptionrate(SAR)distributionforthetransvaginalprobehavebeenmeasuredinaphantom.Thevariationsoftheparametershavebeeninvestigated.Too,foroptimization.Atlast,thersultsofsimulationarecomparedtothatmeasuredinthephantomandsomeinstructiveconclusionsarepresentedforcriticalapplication.

简介：高度强制的钴铁酸盐nanoparticles被他们的暂停的直接注射为加热为磁性的过高热综合并且学习进一个强壮的听觉频率的磁场的一个肿瘤和应用。物理(在液体和稳固的分散的动态磁性的磁滞现象和热产生)，生物(在进老鼠肿瘤织物的治疗学的数量的粒子的毒性和穿入)象其它一样，粒子的性质被学习。一个模型被开发为Brownian和常规旋转与一篇报道在磁性的nanoclusters的暂停描述magnetodynamics，到提供观察现象的理解。开发的试验性、理论的技术为低频率的热产生为磁性的nanoparticles的可控制的合成形成了一个基础在医药并且另外的应用程序。

简介：AbstractPurpose:There are many infectious and inflammatory causes for elevated core-body temperatures, though they rarely pass 40 ℃ (104 ℉). The term "quad fever" is used for extreme hyperpyrexia in the setting of acute cervical spinal cord injuries (SCIs). The traditional methods of treating hyperpyrexia are often ineffective and reported morbidity and mortality rates approach 100%. This study aims to identify the incidence of elevated temperatures in SCIs at our institution and assess the effectiveness of using a non-invasive dry water temperature management system as a treatment modality with mortality.Methods:A retrospective analysis of acute SCI patients requiring surgical intensive care unit admission who experienced fevers ≥ 40 ℃ (104 ℉) were compared to patients with maximum temperatures < 40 ℃. Patients ≥18 years old who sustained an acute traumatic SCI were included in this study. Patients who expired in the emergency department; had a SCI without radiologic abnormality; had neuropraxia; were admitted to any location other than the surgical intensive care unit; or had positive blood cultures were excluded. SAS 9.4 was used to conduct statistical analysis.Results:Over the 9-year study period, 35 patients were admitted to the surgical intensive care unit with a verified SCI. Seven patients experienced maximum temperatures of ≥ 40 ℃. Six of those patients were treated with the dry water temperature management system with an overall mortality of 57.1% in this subgroup. The mortality rate for the 28 patients who experienced a maximum temperature of ≤ 40 ℃ was 21.4% (p = 0.16).Conclusion:The diagnosis of quad fever should be considered in patients with cervical SCI in the presence of hyperthermia. In this study, there was no significant difference in mortality between quad fever patients treated with a dry water temperature management system versus SCI patients without quad fever. The early use of a dry water temperature management system appears to decrease the mortality rate of quad fever.

简介：Toimprovemicrowavehyperthevmiaincancertherapy,thethermaleffectoffer-rimagneticresonance(FMR)duringmicrowaveirradiationwasstudied.Resonanttemperatureelevation(RTE)ofsinglecrystalgrainandpolycrystalpowderofresonantmediawasmeasuredaloneandinimitativemuscleandeggwhiteandinmice.TheresultsindicatedthattheRTEproducedbyFMRcouldbeusedtoimprovepenetrationdeepness,heatingselectivityandtemperaturedistributionofmicrowavehyperthermiaincancertreatment.ItwasexpectedthatthepotentialfunctionoftheFMRheatingsystemwouldbeex-ploitedgreatlyforcancertherapy,andthenmagneticallyguidedmicrowavehyperthermiathera-py,chemotherapy,radiotherapyandimmunotherapymighthecombinedmultiplywithinthissys-tembymeansofthestaticmagneticfield(SMF)andmagneticmicrocarrier.Limitationofreso-nantheatingwasalsodiscussedinthispaper.

简介：Objective:Toassessthesafetyandclinicalantiangiogeniceffectofrecombinantadenovirus-p53(rAd-p53)combinedwithhyperthermiaplusornotplusradiotherapyinadvancedcancer.Methods:ExpressionofVascularepithelialgrowthfactor(VEGF)afterintratumoralinjectionofrAd-p53wasassayedbyimmunohistochemistry(IHC)imaging.Forty-fourpatientswithadvancedcancerwereenrolledintothisclinicalstudy.ThepatientswereintratumorallyinjectedwithrAd-p53(Gendicine)atadoseof1×1012vponceaweek,withatotalof4-54(mean7.7)times.Totalof4-29(mean8.5)timesofhyperthermiawasgiventothepatients.Amongthe44patients,30patientswereconcurrentlyaddedwithradiotherapyofatotaldose30-76Gy/15-38f/3-8w(mean58Gy).Results:BeforeandafterintratumoralinjectionofrAd-p53,theVEGFIHCpositivecellscoreswere2.80and1.50,respectively(P=0.031).ThetreatmentofrAd-p53combinedwithhyperthermiaplusornotplusradiotherapyinadvancedcancerachievedCRrateof13.60%(6/44),andPRrateof29.6%(13/44),andthustheeffectiveratewas43.2%.Inadditionto6patientswithCR,19patients(19/38,50.0%)hadlowdensityarea(LDA)ofmorethan50%areaonCTimagewithintumorindicatingtumortissuenecrosis.Conclusions:OurdataindicatethatrAd-p53inhibitsVEGFexpressionandangiogenesis,andpromotestumornecrosisandshrinkageinducedbyhyperthermiaplusornotplusradiotherapyinadvancedcancer.

简介：ＴＨＥＳＴＵＤＩＥＳＯＦＲＥＶＥＲＳＡＬＯＮＩＮＨＩＢＩＴＩＮＧＤＮＡＳＹＮＴＨＥＳＩＳＡＮＤＣＬＯＮＡＬＦＯＲＭＡＴＩＯＮＯＦＨＬ－６０ＣＥＬＬＳＷＩＴＨＨＹＰＥＲＴＨＥＲＭＩＡＣｈｅｎＸｉｅｑｕｎ；ＳｈｅｎＳｕｙｕｎ；ＨｕＳｈｅｎｇｈｕｉ；ＷｕＢ...

简介：AbstractBackground:Hyperthermia in combination with DnaJA4-knockout (KO) obviously affects the anti-viral immunity of HaCaT cells. The mechanisms of this process are not yet fully explored. However, it is known that DnaJA4 interacts with actin cytoskeleton after hyperthermia. Our aim was to investigate the effects of DnaJA4 on F-actin in HaCaT cells following hyperthermia.Methods:Wild-type (WT) and DnaJA4-KO HaCaT cells were isolated at either 37°C (unheated) or 44°C (hyperthermia) for 30 min followed by testing under conditions of 37°C and assessing at 6, 12, and 24 h after hyperthermia. The cytoskeleton was observed with immunofluorescence. Flow cytometry and Western blotting were used to detect the expression of F-actin and relevant pathway protein.Results:DnaJA4-KO and hyperthermia changed the cytoskeleton morphology of HaCaT cells. F-actin expression levels were elevated in DnaJA4-KO cells compared with WT cells (6364.33 ± 989.10 vs. 4272.67 ± 918.50, P < 0.05). In response to hyperthermia, F-actin expression levels of both WT and DnaJA4-KO cells showed a tendency to decrease followed by an obvious recovery after hyperthermia (WT cells: unheated vs. 6 h after hyperthermia or 24 h after hyperthermia: 0.34 ± 0.02 vs. 0.24 ± 0.01, 0.31 ± 0.01, P < 0.001, P < 0.05; DnaJA4-KO cells: unheated vs. 6 h after hyperthermia or 24 h after hyperthermia: 0.44 ± 0.01 vs. 0.30 ± 0.01, 0.51 ± 0.02, P < 0.001, P < 0.01). WT cells restored to baseline levels observed in the unheated condition, while DnaJA4-KO cells exceeded baseline levels in the recovery. As the upstream factors of F-actin, a similar profile in rho-associated serine/threonine kinase 1 (ROCK 1) and RhoA expressions was observed after hyperthermia. While E-cadherin expression was decreased in response to hyperthermia, it was increased in DnaJA4-KO cells compared with WT cells.Conclusions:Hyperthermia affects the expression levels of F-actin in HaCaT cells. DnaJA4 knockout increases the expression of F-actin in HaCaT cells after hyperthermia. DnaJA4 regulates the expressions of F-actin and the related pathway proteins in response to hyperthermia in HaCaT cells.

简介：ThispaperdealswiththetemperaturecorrelationofgrayscaleofBmodeultrasoundimagefromheatedtissue.Inthisstudy,manyin-vitrofreshpigliversareheatedinatemperaturerangefrom28℃to45℃,fromwhichaseriesofB-modeultrasonicimagesofliverswereobtained.Thegray-valueisevaluatedfromtheultrasoundimagesrespectively.Acorrelationofthemeangrayvalueoftheselectedregions(12×12pixels)inB-modeultrasonicimagesofliveranditstemperaturewaspointedout.Andtheexperimentresultsagreedtheevaluationwell.Anditispossibletomonitorthetissuetemperaturechanginginhyperthermiausingthiscorrelation.

简介：Systemictoxicityandinsufficientdrugaccumulationatthetumours让earemainbarriersinchemotherapy.Thermosens让iveliposomes(TSL)combinedwithhighintensityfocusedultrasound(HIFU)hasemergedasapotentialsolutiontoovercomethesebarriersthroughtargeteddrugdeliveryandlocalisedrelease.Owingtothemultiplephysicalandbiochemicalprocessesinvolvedinthiscombinationtherapy,mathematicalmodellingbecomesanindispensabletoolfordetailedanalysisofthetransportprocessesandpredictionoftumourdruguptake.Tothisend,amultiphysicsmodelhasbeendevelopedtosimulatethetransportofchemotherapydrugsdeliveredthroughacombinedHIFU-TSLsystem.Allkeydeliveryprocessesareconsideredinthemodel;theseineludeinterstitialfluidflow,HIFUacoustics,bioheattransfer;drugreleaseandtransport,aswellastumourdruguptake.Thecapabilityofthemodelisdemonstratedthroughitsapplicationtoa2-Dprostatetumourmodelreconstructedfrommagneticresonanceimages.Ourresultsnotonlydemonstratethefeasibilityofthemodeltosimulatethiscombinationtherapy,butalsoconfirmtheadvantageofHIFU-TSLdrugdeliverysystemwithenhancementofdrugaccumulationintumourregionsandreductionofdrugavailabilityinnormaltissue.ThismultiphysicsmodellingframeworkcanserveasausefultooltoassistinthedesignofHIFU-TSLdrugdeliverysystemsandtreatmentregimenforimprovedanticancerefficacy.

简介：Objective:Humaninducedpluripotentstem(iPS)cellsexhibitgreatpotentialforgeneratingfunctionalhumancellsformedicaltherapies.Inthispaper,wereportforuseofhumaniPScellslabeledwithfluorescentmagneticnanoparticles(FMNPs)fortargetedimagingandsynergistictherapyofgastriccancercellsinvivo.Methods:HumaniPScellswerepreparedandculturedfor72h.Theculturemediumwascollected,andthenwascoincubatedwithMGC803cells.CellviabilitywasanalyzedbytheMTTmethod.FMNP-labeledhumaniPScellswerepreparedandinjectedintogastriccancer-bearingnudemice.Themousemodelwasobservedusingasmall-animalimagingsystem.Thenudemicewereirradiatedunderanexternalalternatingmagneticfieldandevaluatedusinganinfraredthermalmappinginstrument.Tumorsizesweremeasuredweekly.Results:iPScellsandthecollectedculturemediuminhibitedthegrowthofMGC803cells.FMNP-labeledhumaniPScellstargetedandimagedgastriccancercellsinvivo,aswellasinhibitedcancergrowthinvivothroughtheexternalmagneticfield.Conclusion:FMNP-labeledhumaniPScellsexhibitconsiderablepotentialinapplicationssuchastargeteddual-modeimagingandsynergistictherapyforearlygastriccancer.

简介：纸由使用biomagnetic液体动力学(BFD)的原则通过一个多孔的中等题目处理biomagnetic液体流动的一个基本问题的理论调查到一个磁场。学习与液体的磁化与温度变化的一种状况相关。液体被认为非牛顿，其流动被一个二年级的方程管理粘弹性的液体。隧道的墙被假定可拉长，在表面速度与从坐标的起源的纵的距离成正比的地方。这个问题首先被归结为解决包含七个参数的联合非线性的微分方程的一个系统。把血看作biomagnetic液体并且使用现在的分析，被尝试由开发一个合适的数字方法并且由设计一个适当有限差别计划计算血流动的一些参数。计算结果在图形的形式被介绍，并且从而，一些理论预言在一个磁场的行动下面处于一个过高热的状态关于血的hemodynamical流动被做。结果清楚地显示磁性的偶极子的存在忍受潜力以便在电磁的过高热的治疗学的过程期间在动脉影响血流动的特征到重要程度。学习将吸引临床医生，结果将在由电磁的过高热的方法的癌症病人的治疗是谁有用的注意。