简介：INTRODUCTIONSincetheirintroductioninmid-1980s,polyamidoamide(PAMAM)dendrimershaveattractedconsiderableattentionbecauseoftheiruniquestructuresandproperties.Accordingtopreliminarystudiesinanimals,PAMAMdendrimersarenon-immunogenic,verylowinvivotoxicityandcanbeexcretedbyurineandfeces.

简介：AbstractInfectious diseases are an increasing threat to global biosafety. Vaccination is the most effective and cost-efficient method for preventing and controlling infectious diseases. The development of new vaccines is inextricably linked to the advancement of materials that serve as essential components of vaccines, such as antigens, adjuvants, and their carriers. The physicochemical and biological properties of vaccines—such as the kinetics of antigen retention and presentation—are determined by the material compositions of vaccines and carriers, affecting the overall efficacy. The sustained release of antigens prolongs their retention time in germinal centers and improves humoral immune responses. Pulsatile release that imitates clinical dosing regimens can improve patient adherence to vaccination, affording increased vaccine coverage. Herein, we review progress of materials innovation on altering vaccine release kinetics, which affects the overall vaccine efficacy, safety, and compliance.

简介：Colorectalcancer（CRC）isthethirdmostcommoncancerdiagnosedworldwideinhumanbeings.Surgery,chemotherapy,radiotherapyandtargetedtherapiesaretheconventionalfourapproacheswhicharecurrentlyusedforthetreatmentofCRC.Thesitespecificdeliveryofchemotherapeuticstotheirsiteofactionwouldincreaseeffectivenesswithreducingsideeffects.Targetedoraldrugdeliverysystemsbasedonpolysaccharidesarebeinginvestigatedtotargetanddeliverchemotherapeuticandchemopreventiveagentsdirectlytocolonandrectum.Site-specificdrugdeliverytocolonincreasesitsconcentrationatthetargetsite,andthusrequiresalowerdoseandhenceabridgedsideeffects.Somenoveltherapiesarealsobrieflydiscussedinarticlesuchasreceptor（epidermalgrowthfactorreceptor,folatereceptor,wheatgermagglutinin,VEGFreceptor,hyaluronicacidreceptor）basedtargetingtherapy;colontargetedproapoptoticanticancerdrugdeliverysystem,genetherapy.EventhoughgoodtreatmentoptionsareavailableforCRC,theultimatetherapeuticapproachistoaverttheincidenceofCRC.ItwasalsofoundthatCRCscouldbepreventedbydietandnutritionsuchascalcium,vitaminD,curcumin,quercetinandfishoilsupplements.ImmunotherapyandvaccinationareusednowadayswhichareshowingbetterresultsagainstCRC.

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简介：Timelyandcost-efficientmulti-hopdatadeliveryamongvehiclesisessentialforvehicularad-hocnetworks(VANETs),andvariousroutingprotocolsareenvisionedforinfrastructure-lessvehicle-to-vehicle(V2V)communications.Generally,whenapacket(oraduplicate)isdeliveredoutoftheroutingpath,itwillbedropped.However,weobservethatthesepackets(orduplicates)mayalsobedeliveredmuchfasterthanthepacketsdeliveredalongtheoriginalroutingpath.Inthispaper,weproposeanoveltreebasedroutingscheme(TBRS)forultilizingthedroppedpacketsinVANETs.InTBRS,thepacketisdeliveredalongaroutingtreewiththedestinationasitsroot.Andwhenthepacketisdeliveredoutitsroutingtree,itwon'tbedroptimmediatelyandwillbedeliveredforawhileifitcanarriveatanotherbranchofthetree.WeconducttheextensivesimulationstoevaluatetheperformanceofTBRSbasedontheroadmapofarealcitycollectedfromGoogleEarth.ThesimulationresultsshowthatTBRScanoutperformtheexistingprotocols,especiallywhenthenetworkresourcesarelimited.

简介：Thephenomenonofparticleinteractioninvolvedinpulmonarydrugdeliverybelongstoawidevarietyofdisciplinesofparticletechnology,inparticular,fluidization.Thispaperreviewsthebasicconceptsofpulmonarydrugdeliverywithreferencestofluidizationresearch,inparticular,studiesonGeldartgroupCpowders.Drypowderinhalerdevice-formulationcombinationhasbeenshowntobeaneffectivemethodfordeliveringdrugstothelungfortreatmentofasthma,chronicobstructivepulmonarydiseaseandcysticfibrosis.Evenwithadvanceddesigns,however,deliveryefficiencyisstillpoormainlyduetopowderdispersionproblemswhichcausepoorlungdepositionandhighdosevariability.Drugparticlesusedincurrentinhalersmustbe1-5mindiameterforeffectivedepositioninsmall-diameterairwaysandalveoli.Thesepowdersareverycohesive,havepoorflowability,andaredifficulttodisperseintoaerosolduetocohesionarisingfromvanderWaalsattraction.Theseproblemsarewellknowninfluidizationresearch,muchofwhichishighlyrelevanttopulmonarydrugdelivery.

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简介：Thearticleisaboutsolvingthelastmiledeliveryprobleminruraltownorvillage.Wewanttotestthedrone’spotentialinparceldelivery.Theobjectivesare1)tointroducetheclusterandtruck-droneintandemdeliverymethod,2)tocomparethenewmethodwiththetraditionalTSPmethodinaspectoftruckrunningdistance,energyusingandtimeoccupation.Theparceldeliverydemandissparse,soitisnotdenseenoughforatrucktocarryondelivery.Wetrytoidentifythebestrouteforthedronetodeliverthegoods.Weusek-meanmethodtocarryonclustering,thenweuseenumerationmethodtofulfillthecentroidsdelivery,whichcomesfromthedepot.Wedesignamodelandcalculatetheenergy,timeanddistancesavingbetweendroneusingmethod(DTSP)andtraditionalTSPmethod.Thedroneattendeddeliverysavestruckdeliverydistance,energyconsumptionandtime.ThetruckrunningdistanceofDTSPmethodsaves91.87%,thetruckrunningdistanceisshortenedfrom189.69kmto15.4252km.TheDTSPmethodsaves90.45%ofenergy.TheDTSPmethodbringsa29.75%cutoffintimeaspectwhentherearetwodroneinrunning.TheresearchintroducestheclusterandTSPcombinationmethod,whichisagoodwaytocarryonlastmiledelivery.Theresultshowsabrightfuturefordronetoattendparceldelivery.Thee-commercecorporationcanapplythismethodinpractice.

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简介：AbstractEnhanced recovery after cesarean (ERAC) delivery is an evidence-based, multi-disciplinary approach throughout pre-, intra-, post-operative period. The ultimate goal of ERAC is to enhance recovery and improve the maternal and neonatal outcomes. This review highlights the role of anesthesiologist in ERAC protocols. This review provided a general introduction of ERAC including the purposes and the essential elements of ERAC protocols. The tool used for evaluating the quality of ERAC (ObsQoR-11) was discussed. The role of anesthesiologist in ERAC should cover the areas including management of peri-operative hypotension, prevention and treatment of intra- and post-operative nausea and vomiting, prevention of hypothermia and multi-modal peri-operative pain management, and active pre-operative management of unplanned conversion of labor analgesia to cesarean delivery anesthesia. Although some concerns still remain, ERAC implementation should not be delayed. Regular assessment and process improvement should be imbedded into the protocol. Further high-quality studies are warranted to demonstrate the effectiveness and efficacy of the ERAC protocol.

简介：Inordertoinvestigatetheimmtmogenicityofthecontrolled-releasemicroencapsulatedhepatitisBvaccineinmice,polyethyleneglycol-poly-dl-lactide(PELA)microsphereswithentrappedHSsAgwerepreparedbydoubleemulsionW/O/Wbasedonsolventextractionmethods.BALB/cmicewereimmunizedwiththeencapsulatedvaccinebyoralfeedingorinjection.Bloodsampleswerecollectedat8^th,10^th,14^thand24^thweeks,respectively,andthelevelsofantibodyresponseweredetectedbyEI.ISA.Itwasfoundthatthescanningelectronmicroscopyshowedthepreparedmicrosphereshadsmoothandsphericalsurface,suitableforvaccinedelivery.Twogroupsofmiceorallyfedwiththeencapsulatedorconventionalrecombinantvaccines,respectively,theresereshowednoobviousdifferenceintheIgGlevels.At14^thweek,thegroupinjectedwithasingledoseofencapsulatedvaccinehadasimilarlevelofIgGresponsetothegroupinjectedwithtwodosesoftherecombinationvaccine.At24^thweek,theIgGlevelsofthegroupinjectedwithtwodosesofencapsulatedvaccinewerehigherthanthoseofthegroupinjectedwithtwodosesoftherecombinationvaccine.ItconcludesthatControlled-releasemicroencapsulatedhepatitisBvaccinepossessesthefeatureofslowlyreleasinginv/voandlongtimesimmtmogenicity.

简介：AbstractNucleic acid therapeutics, which involve transferring exogenous genes inside target cells, are a promising clinical treatment option that can regulate gene expression at the transcriptional or post-transcriptional level. Ideally, this kind of treatment modality will not lead to an unwanted immune response. Compared with traditional treatment methods, nucleic acid therapeutics can achieve prolonged and stable curative effects. As an emerging treatment method, nucleic acid therapeutics have played an increasingly important role in clinical settings for the treatment of various conditions, including infectious diseases, cancer, immune-related diseases, and monogenetic diseases. To date, a large number of clinical trials have been conducted, and more than 30 nucleic acid drugs have been approved, highlighting the strong potential of this approach in clinical practice. Diverse carriers are used to protect nucleic acids from being degraded and to help them reach their targets accurately. However, some carriers are known to cause negative effects on the release and expression of nucleic acid drugs as well as adverse effects such as allergic reactions and accumulation in the liver. Therefore, biosafety assessment of delivery systems before their application in clinical settings is critical. In this review, we describe different delivery systems for nucleic acid drugs and discuss their biosafety in both preclinical and clinical studies, with particular focus on the carriers themselves, drug administration method, and overall treatment of the disease.

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简介：在这个工作，chitosan/cellulose醋酸盐microspheres(CCAM)被W/O/W乳剂的方法没有有毒的试剂准备。microspheres是球形的，免费流动，并且非聚集，它有狭窄的尺寸分布。超过90%microspheres有直径从200～280m。hemolytic分析显示CCAM是安全的并且没有hemolytic效果。植入的CCAM没在Sprague-Dawley(SD)老鼠的血液学生产任何重要变化，例如血红素的白血房间，红血房间，血小板，和体积。另外，浆液丙氨酸aminotransferase，血脲氮，和creatinine的层次没在没有任何培植，与CCAM，surger线，或正常SD老鼠植入的SD老鼠有明显的变化。因此，CCAM有好血相容性并且没有hepatotoxicity或肾的毒性到SD老鼠。而且，CCAM与或没有模型药在SD老鼠关于煽动性的反应有好织物相容性并且没从与外科线植入的SD老鼠的显示出重要差别。CCAM表演作为一个长行动的交货系统答应，它有好biocompatibility和biodegradability。

简介：在亚毫米尺寸的空幸运微范围被准备；作为药交货车辆调查了。LCB(锂钙硼酸盐)微范围，通过火焰水花过程被做，为空幸运微范围被选择为先锋的玻璃。LCB玻璃微范围与磷酸盐缓冲剂(K2HPO4)反应了在37°C的5天的答案。在反应期间，Ca-P-OH混合物在LCB玻璃的表面上猛抛微范围；形成的多孔的壳。然后，微范围转弯了是有象在LCB玻璃以后的微范围在化学反应跑出去的玻璃的一样的直径的空的。在以后在为4h的600°对待热，Ca-P-OH混合物成为了幸运，因此，空幸运微范围被生产。形成空幸运的机制通过在磷酸盐缓冲剂之间的化学反应的微范围；LCB玻璃被XRD分析证实。空、多孔的微范围的微观结构特征被SEM观察。

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简介：IntroductionTheMedicalResearchFoundationistheMedicalResearchCouncil's(MRC)independentlymanagedcharity.Itreceivesfundsfromthegivingpublictosupportmedicalresearch,training,publicengagementanddisseminationofknowledge.Sinceitwasfirstestablishedin1920,theMRChasbeenabletoacceptcharitablebequests,endowmentsanddonationsfromthepublictocontributetowardsthecostsoftheresearchthatitundertakes.TheMRCregisteredthesecharitablefundswiththeCharityCommissioninthelate1960'sanditscharity-theMedicalResearchFoundation-hasbeensuccessfullysupportingmedicalresearchforover80years.Duringtheplanningphase,thedeliveryplanhelpsyoutoputyourinitialthoughtsandideasintoaformatthatisstraightforward.Thisoverviewwillenableyoutodeviseappropriatelearningstrategiesforyourtargetaudience,matchthelearningoutcomes,identifymaterialsandresources,andestimatetimeperiodsforlearningactivities,suchasdemonstrations,practiceandconsolidation,collaborationandquestiontime.

简介：Thephotoacoustictomographybyusingthehandheldprobehasagreatpotentialinclinicalbreastimaging.However,theshapeoftheprobelimitsthechoiceoflightdeliveryinthissetup.Inthisletter,westudytwocommonlyusedilluminationtypesforhandheldprobe:bright-fieldilluminationanddark-fieldillumination.Ourresultsdemonstrateseveralparametershaveimportantimpactonthephotonfluenceindeepbreasttissue.Theresultswillhelptooptimizethedesignofthephotoacousticbreastimagingsystemwithahandheldprobe.