简介：ChineseJournalofCancerResearch,aninternationalbiomedicaljournaleditedandpublishedquarterlyinEnglishbyChinaAnti-CancerAssociation(CACA),isacomprehensiveacademicjournal,aimingtoreflectprimarilythecreativeorinnovativeachievementsinallfieldsofcancerresea...

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简介：Inordertofurtherpromotethestandardizationofdiagnosisandtreatmentofgastrointestinalstromaltumor(GIST)inChina,themembersofChineseSocietyofClinicalOncology(CSCO)ExpertCommitteeonGISTthoroughlydiscussedthekeycontentsoftheconsensusguidelines,andvotedonthecontroversialissue.Infinal,theChineseconsensusguidelinesforthediagnosisandmanagementofGIST(2017edition)wasformedonthebasisof2013editionconsensusguidelines,whichisherebyannounced.Theconsensusincludedthepathologicaldiagnosis,recurrenceriskclassificationevaluation,targetedagenttherapy,surgeryandprinciplesofsurveillanceofGIST.

简介：EpidemiologicalstudiesshowedtheincidencemortalityratesofcancerwereincreasinginrecentdecadesinChinesepopulation.Nationalandregionalpreventiveprogramsaimtoreducethehealthhazardsofcancerandfocusethepopulationathighrisksforspecificcancer,particularlyinruralareasandtooffertheaccesstoearlydetectionformultlplecancersinurbanareas.Theearlyscreening,earlydetectionandtreatmenthavebeenputintooperationforthepopulationatrisksinruralareasatfirst,andintheurbanareasinrecentyears.Tounderstandtheepidemicpatternsandtrendsofcancer,andtheexperiencesinapplyingearlydetectionstrategiesinChina,selectedliteratureswerereviewedforbriefsummary.

简介：Theincidenceofpapillarythyroidcarcinoma(PTC)hasexponentiallyincreasedinrecentyears.Papillarythyroidmicrocarcinoma(PTMC)accountsforthemajorityofthereportedcasesofPTC.ThedebatesandcrucialissuesinPTMCmanagementhavereceivedresearchers'attention.TofurtherimprovetheclinicalmanagementofPTMCinChina,

简介：包括肠的组织变形(IM)和发育异常(Dys)评估在前列腺干细胞抗原(PSCA)和先进癌症前期的胃的损害的风险的基因多型性之间的关系的目的，基于人口的研究在Linqu被进行县，在中国的胃的癌症(GC)的一个高风险的区域。包括表面的胃炎(SG)的胃的损害的流行，长期的衰退胃炎(CAG)，IM和Dys被组织病理学说的检查决定的方法。遗传型被聚合酶链反应限制决定碎片长度多型性(PCR-RFLP)技术。IM和Dys的风险上的PSCA基因变体的效果被无条件的逻辑回归计算。结果Multivariate分析表明带PSCArs2294008CT/TT遗传型的题目与IM的增加的风险被联系(OR=1.38，95%CI=1.111.71)并且Dys(OR=1.75，95%CI=1.362.26)，特别为有H.pylori感染的题目(IM：OR=1.34，95%CI=1.051.71；Dys：OR=1.82，95%CI=1.372.42)。而且，H。pylori感染和PSCArs2294008CT/TT遗传型被观察联合提高IM的风险(OR=3.32，95%CI=2.334.71)并且Dys(OR=4.58，95%CI=2.997.04)。这研究建议了那PSCArs2294008的结论可能在GC的高风险人口之中影响IM或Dys的风险。

简介：Inrecentyears,theclinicalincidenceofthyroidcancerhasbeenincreasingyearbyyear,anditsriskassessmentandclinicalmanagementmethodshavealsobeenaccordinglymodifiedandconstantlyimproved.TherearegreatdifferencesbetweentheclinicaldiagnosticandtherapeuticmodesanddiseasemanagementofthyroidcanceremployedbyvariousmedicalinstitutionsinChina,particularlywithregardtotheclinicalapplicationofserummarkerofthyroidcancer.Tothisend,theChinaAnti-CancerAssociationThyroidCancerSpecializedCommitteeChineseAssociationofThyroidOncologyorganizedthiscompilationofExpertConsensusonClinicalApplicationofSerumMarkerofThyroidCancertohelpandimpelrelevantclinicalinstitutionsandprofessionalstostandardizeclinicaldiagnosis,treatment,andlong-termmanagementofthyroidcancer,andtoproperlyutilizetheserummarkerforscientificauxiliaryclinicaldiagnosisandassessmentofthyroidcancerbeforeandafteroperation.

简介：客观干扰素(IFN)和ribavirin(RBV)的联合是为丙肝的标准治疗病毒(HCV)感染。HCV遗传型2a对治疗证明了更顺从，但是它的功效是还有限的。这研究试图在HCV遗传型2a感染的一种情况中调查差的反应的机制。方法：我们从一个病人分析了HCVRNA的动态变化，与HCV遗传型2a感染了，显示出差的virological回答到是的IFN/RBV判定了12在由HCV的治疗的开始以后的星期克隆定序。然后，我们构造了subgenomic日语有人性化的Gaussia的暴发性的hepatitis-1(JFH1)replicon和不同妄想的replicons酶基因。妄想的replicons从subgenomicJFH1replicon，NS5A区域被病人顺序从pre/posttreatment在代替被导出，并且到IFN的妄想的replicons危险性被相对Gausia酶活动评估。预告的处理HCV定序的结果显得几乎一致，并且quasispecies变化是进一步的在12星期治疗以后简化的更多。而且，quasispecies变化似乎相对，在NS5A更多样化为IFN反应关键的一个区域，和每妄想的replicons展出了不同反应到IFN。结论在长期的感染的功课期间，HCV人口似乎被使适应病人免疫学的系统，并且推进被IFN/RBV治疗的联合选择，显示quasispecies可以完全与IFN的与那些不同的目标由另外的药的增加消除了。另外，到IFN的妄想的replicon的各不同的反应与氨基酸变化在或在在长期的感染和IFN/RBV治疗期间决定NS5A的区域(ISDR)的IFN敏感附近有关是最可能的。

简介：Objective:RecentevidenceindicatesthatdysregulationofmicroRNA(miRNA)biogenesisisimplicatedincancerdevelopmentandprogression.BasedontheimportantroleofmiRNAbiogenesisgenesincarcinogenesis,wehypothesizedthatgeneticvariationsofthemiRNAbiogenesisgenesmaymodulatesusceptibilitytocervicalcancer.Methods:Weidentifiedthreesinglenucleotidepolymorphisms(SNPs)locatedinthe3’-untranslatedregions(3’-UTR)ofofmiRNAbiogenesiskeygenes(rs1057035inDICER,rs3803012inRANandrs10773771inHIWI)andgenotypedtheseSNPsinacase-controlstudyof1,486cervicalcancercasesand1,549cancer-freecontrolsinChinesewomen.Results:LogisticregressionanalysesshowedthatnosignificantassociationswereobservedbetweenthethreeSNPsandcervicalcancerrisk[rs3803012inRANAG/GGvs.AAadjustedOR=1.104,95%confidenceinterval(CI):0.859-1.419;rs1057035inDICERCT/CCvs.TTadjustedOR=0.962,95%CI:0.805-1.149;rs10773771inHIWICT/CCvs.TTadjustedOR=0.963,95%CI:0.826-1.122].Conclusions:Thefindingsdidnotsuggestthatgeneticvariantsinthe3’-UTRofRAN,DICERandHIWIofmiRNAbiogenesisgeneswereassociatedwiththeriskofcervicalcancerinthisChinesepopulation.

简介：Objective:Toinvestigatetheuptakerateofprostatespecificantigen(PSA)testingamongHongKongChinesemalesaged50orabove,andidentifyfactorsassociatedwiththelikelihoodofundergoingaPSAtest.Methods:Apopulation-basedtelephonesurveywasconductedinHongKongin2007.Thesurveycovereddemographicinformation,perceivedhealthstatus,useofcomplementarytherapy,cancerscreeningbehavior,perceivedsusceptibilitytocancerandfamilyhistoryofcancer.Descriptivestatistics,percentagesandlogisticregressionanalysiswereusedfordataanalysis.Results:Atotalof1,002menaged50orabovetookpartinthestudy(responserate=67%),andtheuptakerateofPSAtestingwasfoundtobe10%.Employmentstatus,useofcomplementarytherapy,perceivingregularvisitstoadoctorasgoodforhealthandtherecommendationsofhealthprofessionalsweresignificantfactorsassociatedwithPSAtesting.Conclusion:TheuptakerateofPSAtestinginthestudypopulationwasverylow.Amongallthefactorsidentified,recommendationsfromhealthprofessionalshadthestrongestassociationwiththeuptakeofPSAtesting,andtheyshouldthereforetakeanactiveroleineducatingthispopulationaboutcancerpreventionanddetection.

简介：Next-generationsequencing(NGS)technologyiscapableofsequencingmillionsorbillionsofDNAmoleculessimultaneously.Therefore,itrepresentsapromisingtoolfortheanalysisofmoleculartargetsfortheinitialdiagnosisofdisease,monitoringofdiseaseprogression,andidentifyingthemechanismofdrugresistance.OnbehalfoftheTumorBiomarkerCommitteeoftheChineseSocietyofClinicalOncology(CSCO)andtheChinaActionableGenomeConsortium(CAGC),thepresentexpertgroupherebyproposesadvisoryguidelinesonclinicalapplicationsofNGStechnologyfortheanalysisofcancerdrivergenesforprecisioncancertherapy.Thisgroupcomprisesanassemblyoflaboratorycancergeneticists,clinicaloncologists,bioinformaticians,pathologists,andotherprofessionals.Aftermultipleroundsofdiscussionsandrevisions,theexpertgrouphasreachedapreliminaryconsensusontheneedofNGSinclinicaldiagnosis,itsregulation,andcompliancestandardsinclinicalsamplecollection.Moreover,ithaspreparedNGScriteria,thesequencingstandardoperationprocedure(SOP),dataanalysis,report,andNGSplatformcertificationandvalidation.

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简介：Objective:Thisstudyaimedtodetermineifgastriccardiaadenocarcinoma(GCA)riskwasassociatedwiththelys(Aor*2)alleleatthers671(glu504lys)polymorphismwithinthealdehydedehydrogenase2(ALDH2)geneinaChineseHanpopulation.WealsoaimedtoinvestigateALDH2genotypicdistributionsbetweensubjectsfromhigh-andlow-incidenceareasforbothGCAandesophagealsquamouscellcarcinoma(ESCC).Methods:Wedesignedacase-controlstudyincluding2,686patientswithGCAand3,675controlsubjectsfromhigh-andlowincidenceareasforbothGCAandESCCinChina.TaqManallelediscriminationassaywasusedtogenotypethers671polymorphism.χ~2testandbinarylogisticregressionanalysiswereusedtoestimatetheoddsratiosforthedevelopmentofGCA,andmultivariateordinallogisticregressionwasusedtoanalyzeALDH2genotypicdistributionsamongdifferentgroups.Results:ComparedwithALDH2*1/*1homozygotes,ALDH2*1/*2andALDH2*2/*2carriersdidnotincreasetheriskforGCAintheChineseHanpopulation(P>0.05).Interestingly,theratioofhomozygousorheterozygousALDH2*2carriersinhighincidenceareasforbothGCAandESCCwaslowerthanthatinlow-incidenceareas(P<0.001).Conclusions:Genotypesofrs671atALDH2maynotincreaseGCAsusceptibilityinChineseHanpopulations.Inaddition,theALDH2genotypicdistributiondiffersbetweenChineseHanpopulationsfromhigh-andlow-incidenceareasforbothGCAandESCC.OurfindingsmayshedlightonthepossiblegeneticmechanismforthedramaticgeographicdifferencesofGCAoccurrenceinChina.