简介：AIM:Toinvestigatetheprevalenceandriskfactorsofdiabeticretinopathy(DR)innorthernChinesepatientswithtype2diabetesmellitus(T2DM).METHODS:Thisretrospectivecross-sectionalstudywasperformedbetweenMay2011andApril2012.Atotalof1100patients(male/female,483/617)wereincludedinthisstudy.DRwasdefinedfollowingtheEarlyTreatmentDiabeticRetinopathyStudy(ETDRS)severityscale.Allincludedpatientsacceptedacomprehensiveophthalmicexaminationincludingretinalphotographs.Logisticregressionmodelswereusedtoestimateoddsratios(ORs)and95%confidenceinterval(CI)afteradjustingforageandgender.RESULTS:Retinopathywaspresentin307patientswithaprevalenceof27.9%.Inunivariatelogisticanalysis,presenceofDRwasassociatedwithlongerdurationofdiabetes(OR,5.70;95%CI,2.91-12.56),higherconcentrationoffastingbloodglucose(OR,12.94;95%CI,2.40-67.71),higherlevelofglycosylatedhemoglobinHbA1c(OR,5.50;95%CI,3.78-11.97)andinsulintreatment(OR,6.99;95%CI,1.39-35.12).ThelifestyleofpatientswithT2DMincludingsmoking,alcoholconsumptionandregularexerciseseemednotassociatedwiththedevelopmentofDR.CONCLUSION:Ourstudysuggeststhatfastingserumglucoseconcentration,HbA1clevel,durationofdiabetesandinsulintreatmentarepotentialriskfactorsforDRinnorthernChinesepatientswithT2DM,whilethelifestyleofincludedpatientsseemsnotassociatedwithDR.

简介：AIM:TostudytheevolutionoftherefractivestatusandexaminetheaffectedfactorsininfantsduringthefirstyearoflifeinalargesamplesizeinChina.METHODS:Atotalof1258babies(2516eyes)aged32wkgestationalageto1yparticipatedinthestudy,including766prematureand492full-terminfants.First,eachbabyreceivedanorthopticexamination,slit-lampcheckingandfundusimaging.Patientswithdiseaseswhichmightaffectrefractivestatuswereexcludedfromthecohort.Thecycloplegiaretinoscopywasperformed.Theirneonatalhistorieswerereviewed.Eachmeasurementcontainedtherefractivestatusandcalculationofthesphericalequivalent(SE).RESULTS:Refractivestateshowedanaveragehyperopiaof+0.94±1.63Datearlyages,followedbyatrendtowardmorehyperopia.Therefractivestatereachedthetop(+2.43±1.46D)attheageofonetotwomonths.Thenglidingtilloneyearoldwhentherefractivestatereached+0.59±1.41D.Theprevalenceofastigmatismwas42.17%inthestudy,being2.82%myopicastigmatismand39.35%hyperopicastigmatism.The94.1%ofhyperopicastigmatismwaswith-the-ruleastigmatismand71.83%ofmyopicastigmatismwaswith-the-ruleastigmatism.Refractivestatebetweenboysandgirlswasdifferent.ThemeanSEofboyswas+1.97±1.57D,whilethatofgirlswas+1.79±1.46D,andthedifferencewassignificant.CONCLUSION:Beforeoneyearold,thechangeofrefractivestatusisassociatedwithcheckingageandsex.Attheageofonetotwomonths,thedegreeofhyperopiareachesthetop.Boyshavemorehyperopicdegreethangirls,andwiththe-ruleastigmatismispredominant.Excludingprematureinfantswithadvancedretinopathyofprematurity,prematureandfull-termchildrenhavesamerefractionstatus.

简介：AIMTo与类型2糖尿病mellitus(T2DM)在中国病人的一个队调查在C反应的蛋白质(CRP)和糖尿病的retinopathy(医生)之间的关系基于.METHODSCommunity的观察的队学习。有1131个参加者，在城市的北京在Desheng社区从2009年11月招募到2011年9月。病人们诊断了T2DM被招募并且经历由一张问询表，眼睛、人体测量的检查和实验室调查组成的标准化评估。医生的存在和严厉由七个领域被估计30°；渲染宫底相片。题目然后没有医生，任何医生，或威胁视觉的克尔普博士被分类进组与T2DM从1007个病人全部的学习subjects.RESULTSA的浆液被分析为分析被包括，包括408(40.5%)男人并且599(59.5%)女人。中部的CRP水平为男人是为女人和1.1mg/L的1.5mg/L(P=0.004，或0.37，95%CI0.18-0.74)。在为可能的covariates调整以后，CRP的高水平与任何医生的更低的流行被联系(P=0.02，或0.55，95%CI0.35-0.89)，然而并非与威胁视觉的医生联系了(P=0.62，或0.78，95%CI0.28-2.14)。在由性的层化以后，在CRP和医生之间的反的协会被发现在男人统计上重要(P=0.006，或0.35，95%CI0.16-0.73)，然而并非在女人(P=0.58，或0.88，95%CI0.29-1.16)与T2DM从一张中国人口拉的.CONCLUSIONThe数据建议那增加的CRP层次可以相反地与医生的开发被联系。

简介：第二等的绿内障的长期的结果在回顾的学习包括了的一系列中国patients.METHODSThe与Ahmed绿内障阀门(AGV)由于眼色素层炎对待培植的AIMTo报告从经历了AGV培植的有uveitic绿内障的56个病人的67只眼睛。治疗的成功被定义为完成压力(IOP)从基线IOP在6和21公里Hg之间铺平与或没有另外的反绿内障药或最少20%减小的intraocular的病人。主要结果大小包括了IOP，在1点的绿内障药的数字，3，6，12，24，36，48并且在外科以后的60mo，外科的复杂并发症，最后的改正最好的视觉尖酸(BCVA)，吗视觉地(VF)和网膜的神经纤维层(RNFL).RESULTSThe平均数后续是53.3灡?潬桲硥獩？？

简介：AIM:Tomakecomprehensivemoleculardiagnosisforretinitispigmentosa（RP）patientsinaconsanguineousHanChinesefamilyusingnextgenerationsequencingbasedCapture-NGSscreentechnology.METHODS:Afive-generationHanChinesefamilydiagnosedasnon-syndromicX-linkedrecessiveRP（XLRP）wasrecruited,includingfouraffectedmales,fourobligatefemalecarriersandelevenunaffectedfamilymembers.Capture-NGSwasperformedusingacustomdesignedcapturepanelcovers163knownretinaldiseasegenesincluding47RPgenes,followedbythevalidationofdetectedmutationusingSangersequencinginallrecruitedfamilymembers.RESULTS:Capture-NGSinoneaffected47-year-oldmalerevealsanovelmutation,c.24172418insG:p.E806fs,inexonORF15ofRPGTPaseregulator（RPGR）generesultsinaframeshiftchangethatresultsinaprematurestopcodonandatruncatedproteinproduct.Themutationwasfurthervalidatedinthreeoffouraffectedmalesandtwooffourfemalecarriersbutnotintheotherunaffectedfamilymembers.CONCLUSION:Wehaveidentifiedanovelmutation,c.24172418insG:p.E806fs,inaHanChinesefamilywithXLRP.OurfindingsexpandthemutationspectrumofRPGRandthephenotypicspectrumofXLRPinHanChinesefamilies,andconfirmsCapture-NGScouldbeaneffectiveandeconomicapproachforthecomprehensivemoleculardiagnosisofRP.

简介：AIM:ToinvestigatetheChineseversionoftheLowVisionQualityofLifeQuestionnaire(CLVQOL)asaninstrumentforobtainingclinicallyimportantchangesaftercataractsurgery.METHODS:PatientsunderwentcataractsurgeryinShanghaiGeneralHospital,ShanghaiJiaoTongUniversity,whofittheinclusioncriteriawererecruited.TwoCLVQOLswereadministered,includingapreoperativeCLVQOLandaCLVQOLattheendofthe3mofollow-upperiod,andwerecompletedusingface-to-faceinterviewsorphoneinterviewsconductedbytrainedinvestigators.Theminimalclinicallyimportantdifference(MCID)wascalculatedusingananchor-basedmethodandadistributionmethod.Inaddition,theresponsivenessofthequestionnairewasmeasured.RESULTS:Atotalof155residentswereenrolled.Theaveragevisualacuity(VA)preoperativelywas0.08(SD=0.05),anditincreasedto0.47(SD=0.28)attheendoffollowup.StatisticallysignificantpositivechangesintheCLVQOLscoresindicatedsignificantimprovementofvisionrelatedqualityoflifeaftercataractsurgery.Withthelargervaluebetweenthetworesultsasthefinalvalue,theMCIDvaluesoftheCLVQOL(scoresofthefourscalesaswellasthetotalscore)were8.94,2.61,4.34,3.10and17.63,respectively.TheCLVQOLhasbothgoodinternalandexternalresponsiveness.CONCLUSION:CLVQOLscoresareappropriateinstrumentsforobtainingclinicallyimportantchangesaftercataractsurgery.Thisstudyisaneffectiveexplorationforestablishingcataractsurgeryefficacystandards,whichhelpsclinicalandscientificresearchworkersinophthalmologytogainamorein-depthunderstandingwhenusingCLVQOL.

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简介：AIM:ToInvestigatethegeneticfindingsandphenotypiccharacteristicsofaChinesefamilywithNorriedisease（ND）.METHODS:MoleculargeneticanalysisandclinicalexaminationswereperformedonaChinesefamilywithND.MutationsintheNorriediseasepseudoglioma（NDP）geneweredetectedbydirectsequencing.Haplotypeswereconstructedandcomparedwiththephenotypesinthefamily.Evolutionarycomparisonsandmutantopenreadingframe（ORF）predictionwerealsoundertaken.RESULTS:TwofamilymemberswithocularmanifestationswerediagnosedwithND.Nosignsofsensorineuralhearinglosswereobservedineitherpatient,whileoneofthemshowedsignsofmildmentalretardation.AnovelheterozygousmutationintheNDPgene,c.-12delAAT,wasdetectedinbothpatients.ThemutationandthemutationbearinghapiotypecosegregatedwiththeNDphenotypeinmalesandwastransmittedfromtheirmothersand/orgrandmothers（Ⅱ:2）.ThemalewithoutNDdidnotharborthemutation.Themutationoccurredatthehighlyconservednucleotides.DRFfinderpredictedthatthemutationwouldleadtotheproductionofatruncatedproteinthatlacksthefirst11N-terminalaminoacids.CONCLUSION:Anovelmutation,c.-12delAATintheNDPgene,wasidentifiedinaChinesefamilywithND.ThismutationcausedNDwithoutobvioussensorineuralhearingloss.Mentaldisorderwasfoundinonebutnottheotherpatients.Theclinicalheterogeneityinthefamilyindicatedthatothergeneticvariantsandepigeneticfactorsmayalsoplayaroleinthediseasepresentation.

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简介：CornealdiseasesarecurrentlythesecondmaincauseofblindnessinChina.Althoughmostofthecornealblindnesscouldbetreatedbycornealtransplantation,onlyabout10000operationswerecarriedouteachyearowingtothesevereshortageofcornealdonorsandlimitedeyebankprograms.AfeasiblecorneadonationprogramwasestablishedthroughtheorganizationoftheRedCross,andinsitucornealremovaltechniquesweredevelopedtoavoidconflictswithChinesetraditionsofkeepingthedeceasedintact.Thenumberofdonatedcorneas,whichhadasafeandsecurequality,increasedsignificantlyyearbyyear.

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简介：AIM:Toinvestigatetheefficacyandsafetyofkryptonlaserperipheraliridoplasty(LPIP)forChinesepatientswithprimaryangleclosure(PAC)orprimaryangle-closureglaucoma(PACG)statuspostlaseriridotomyinreversingthepositiveresultsofthedarkroomprovocativetest(DRPT).METHODS:Thisstudywasprospective,noncomparative,interventionalcaseseries.Thirty-threepatients(thirty-eighteyes)withPACorPACGstatuspostpatentlaseriridotomyandmaintainednormalintraocularpressure(IOP)butwithpositiveDRPTresultswereenrolled.AllthesubjectsweretreatedwithkryptonLPIP.DRPTwasrepeatedafterkryptonLPIP.ResultsofDRPTwererecorded.Thevisualacuity,IOPandgonioscopywereanalyzedbeforeandafterkryptonLPIP.Aminimumtimelimitforfollow-upwas6mo.RESULTS:Thirty-threepatients(thirty-eighteyes)werefollowedfor17.7±8.37mo(range7-41mo)afterLPIP.PositiveresultsofDRPTdecreasedfrom38eyesto9eyes(23.7%)afterLPIP.Peripheralanteriorsynechiaeofanglein34of38eyes(89.5%)remainedunchangedatdynamicgonioscopythroughoutthefollow-upperiodafterLPIP.CONCLUSION:LPIPdecreasedpositiveratesoftheDRPTsignificantly.ThemechanismmaybethatLPIPminimizedcontactbetweentheperipheralirisandtrabecularmeshwork,whichisakeyfactorfordevelopingperipheralanteriorsynechiae.