简介：Immunecheckpointinhibitorsareincreasinglydrawingmuchattentioninthetherapeuticdevelopmentforcancertreatment.However,manycancerpatientsdonotrespondtotreatmentswithimmunecheckpointinhibitors,partlybecauseofthelackoftumor-infiltratingeffectorTcells.CancervaccinesmayprimepatientsfortreatmentswithimmunecheckpointinhibitorsbyinducingeffectorT-cellinfiltrationintothetumorsandimmunecheckpointsignals.Thecombinationofcancervaccineandanimmunecheckpointinhibitormayfunctionsynergisticallytoinducemoreeffectiveantitumorimmuneresponses,andclinicaltrialstotestthecombinationarecurrentlyongoing.

简介：整体的一个混血儿实验模式分解和实验模式分解(EEMD-EMD)被介绍诊断阀门耳光颤动信号，它相对一台柴油机引擎在最高的死了的中心(TDC)附近给出的主导的燃烧敲击颤动信号。EEMD-EMD分解的内在的模式功能(IMF)的时间频率代表被适应概括S变换(AGST)获得。A类型493柴油机引擎被用于实验，并且结果显示柴油机引擎的阀门耳光是严肃的，并且颤动频率比燃烧敲击高。与EEMD-EMD-AGST途径，阀门耳光能被柴油机引擎的颤动分析识别。

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简介：分析了ArcGISEngine在开发、部署和应用等方面的优越性，探讨了应用ArcGISEngine进行GIS开发的关键技术，结合电缆信息系统的数据库设计开发了一个实验系统，并对ArcGISEngine在GIS应用系统开发中的特点进行了总结。

简介：Themarinemedium-speeddieselenginesarestartedbytwomethods;oneistheelectricmotors,andtheotherairstartingmotors.Eventhoughairstartingmotorisdependentoftheenginetypesandsizes,ithasbeenwidelyusedinthisareaduetoitssimplicity,convenienceandreliability.Thepurposeofthispaperistogivethedesigningparametersinordertomakeaproper'AirStartingMotor'usingCFD.Theaerodynamicapproachesweregiventounderstandtheinternalflowcharacteristicsoftheairstartingmotor.Inaddition,wehavecarriedouttheinvestigationofeffectsoftipclearance.Inthecalculationsthetipclearanceofairstartingmotorhasbeenvariedbetween0,2.8,4.3and5.7%ofbladespan.Theresultsofcomputationarethetipclearanceincreasedto2.8%,thetorquedecreased24%,andtherewasnomorelargechangeswhentheclearancesincreasedto4.3%and5.7%.

简介：小RNA(sRNAs)是直接在房间施加他们的功能的非编码的抄本。sRNAs的鉴定由于清楚的顺序和结构的偏爱的缺乏是一项困难的任务。大多数sRNAs在类以内被识别在相关染色体的特定的intergenic区域。然而，几个这些区域仍然保持由于顺序相同或有势力的缺乏未注解统计鉴定工具。一台计算引擎被造了在intergenic区域以内寻找在Enterobacteriaceae染色体识别并且粗略地注解新通常认为的sRNA区域。在相关询问染色体识别类似的sRNA区域作为模板利用试验性地已知的sRNA数据和他们的flankinggenes/KEGGOrthology(击倒)数字。搜索引擎不仅有能力为特定的sRNAs定位通常认为的intergenic区域，而且有力量定位保存，洗牌或删除了在询问染色体的基因簇。因为它使用KO术语定位象sRNAs那样的机能上地重要的区域，更进一步，到另外的基因的击倒数字赋值将增加敏感。PsRNA服务者通过从兴趣的sRNA检索的信息被用于通常认为的sRNA区域的鉴定。计算引擎在http://bioserver1.physics.iisc.ernet.in/psrna/和http://bicmku.in:8081/psrna/在网上是可得到的。

简介：Inthispaper,amulti-objectiveparticleswarmoptimization(MOPSO)algorithmandanondominatedsortinggeneticalgorithmⅡ(NSGA-Ⅱ)areusedtooptimizetheoperatingparametersofa1.6L,sparkignition(SI)gasolineengine.Theaimofthisoptimizationistoreduceengineemissionsintermsofcarbonmonoxide(CO),hydrocarbons(HC),andnitrogenoxides(NOx),whicharethecausesofdiverseenvironmentalproblemssuchasairpollutionandglobalwarming.Stationaryenginetestswereperformedfordatageneration,covering60operatingconditions.Artificialneuralnetworks(ANNs)wereusedtopredictexhaustemissions,whoseinputswerefromsixengineoperatingparameters,andtheoutputswerethreeresultingexhaustemissions.TheoutputsofANNswereusedtoevaluateobjectivefunctionswithintheoptimizationalgorithms:NSGA-ⅡandMOPSO.Thenadecision-makingprocesswasconducted,usingafuzzymethodtoselectaParetosolutionwithwhichthebestemissionreductionscanbeachieved.TheNSGA-Ⅱalgorithmachievedreductionsofatleast9.84%,82.44%,and13.78%forCO,HC,andNOx,respectively.WithaMOPSOalgorithmthereachedreductionswereatleast13.68%,83.80%,and7.67%forCO,HC,andNOx,respectively.

简介：夫妻关系是人类社会关系中最重要的一种，也是家庭关系中最核心的一环。研究夫妻性别角色差异有助于我们更好地理解其对婚姻家庭的影响。用强大的语料库检索工具SketchEngine分析研究Husband（丈夫）和Wife（妻子）这两个名词在BNC（BritishNationalCorpus英语国家语料库）中的语法搭配模式，为从性别语言差异的角度分析丈夫和妻子在婚姻家庭中的角色地位差异提供有力的数据支持，摆脱非数据研究阶段，使研究结果更具可信度和说服力。

简介：Whenanaircraftishoveringordoingadive-hikeflightatafixedspeed,aconstantadditionalinertialforcewillbeinducedtotherotorsystemoftheaero-engine,whichcanbecalledaconstantmaneuverload.Takehoveringasanexample.AJeffcottrotorsystemwithabiasedrotorandseveralnonlinearelasticsupportsismodeled,andthevibrationcharacteristicsoftherotorsystemunderaconstantmaneuverloadareanalyticallystudied.Byusingthemultiple-scalemethod,thedifferentialequationsofthesystemaresolved,andthebifurcationequationsareobtained.Then,thebifurcationsofthesystemareanalyzedbyusingthesingularitytheoryforthetwovariables.IntheEG-plane,whereEreferstotheeccentricityoftherotorandGrepresentstheconstantmaneuverload,twohysteresispointsetsandonedoublelimitpointsetareobtained.Thebifurcationdiagramsarealsoplotted.Itisindicatedthattheresonanceregionsofthetwovariableswillshifttotherightwhentheaircraftismaneuvering.Furthermore,themovementalongthehorizontaldirectionisfasterthanthatalongtheverticaldirection.Thus,thedifferentoverlappingmodesofthetworesonanceregionswillbringaboutdifferentbifurcationmodesduetothenonlinearcouplingeffects.Thisresultlaysatheoreticalfoundationforcontrollingthestabilityoftheaero-engine’srotorsystemunderamaneuverload.

简介：Gas-liquidcouplingoscillationisanovelapproachtoreducingtheresonantfrequencyandtoelevatingthepressureamplitudeofathermoacousticengine.Ifathermoacousticengineisusedtodrivelow-frequencypulsetuberefrigerators,thefrequencymatchingbetweenthethermoacousticengineandtherefrigeratorplaysanimportantrole.Basedonanacoustic-electricanalogy,alumpedparametermodelisproposedtoestimatetheresonantfrequencyofastanding-wavethermoacousticenginewithgas-liquidcouplingoscillation.Furthermore,asimplifiedlumpedparametermodelisalsodevelopedtoreducethecomputationcomplexity.Theresonantfrequencydependenceonthemeanpressure,thegasspacevolume,andthewatercolumnlengthiscomputedandanalyzed.Theimpactofdifferentworkinggasesontheresonantfrequencyisalsodiscussed.Theeffectivenessofthemodelsisvalidatedbycomparingthecomputedresultswiththeexperimentaldataofthegas-liquidcouplingoscillationsystem.Anincreaseinthemeanworkingpressurecanleadtoariseintheresonantfrequency,andalowerresonantfrequencycanbeachievedbyelongatingtheliquidcolumn.Incomparisonwithnitrogenandargon,carbondioxidecanrealizealowerfrequencyduetoasmallerspecificheatratio.

简介：以目标域为LOVE的概念隐喻为研究对象，依据检索工具SketchEngine词汇素描功能对love在BNC大型语料库中的语法知识列表，识别语言层面的隐喻表达，再借助语义知识库WordNet聚类功能，归纳推导认知层面的LOVE概念隐喻，并梳理各概念隐喻源域的语义关系。研究发现BNC中包含大量以love为目标域的动词性、形容词性和名词性隐喻，以此为基础可推导出21个概念隐喻，这些概念隐喻的源域在语义上存在上下位关系。SketchEngine和WordNet在本研究中发挥显著作用，是日后隐喻语料库研究的重工具。

简介：Icing(oriceaccretion)isaphenomenoninwhichsuper-cooledwaterdropletsimpingeandaccreteonabody.Itiswellknownthaticeaccretiononbladesandvanesleadstoperformancedegradationandhascausedsevereaccidents.Althoughvariousanti-icinganddeicingsystemshavebeendeveloped,suchaccidentsstilloccur.Therefore,itisimportanttoclarifythephenomenonoficeaccretiononanaircraftandinajetengine.However,flighttestsforiceaccretionareveryexpensive,andinthewindtunnelitisdifficulttoreproduceallclimateconditionswhereiceaccretioncanoccur.Therefore,itisexpectedthatcomputationalfluiddynamics(CFD),whichcanestimateiceaccretioninvariousclimateconditions,willbeausefulwaytopredictandunderstandtheiceaccretionphenomenon.Ontheotherhand,althoughtheicingcausedbysuper-cooledlargedroplets(SLD)isverydangerous,thenumericalmethodhasnotbeenestablishedyet.ThisiswhySLDicingischaracterizedbysplashandbouncephenomenaofdropletsandtheyareverycomplexinnature.Inthepresentstudy,wedevelopaniceaccretioncodeconsideringthesplashandbouncephenomenatopredictSLDicing,andthecodeisappliedtoafanrotorblade.ThenumericalresultswithandwithouttheSLDicingmodelarecompared.Throughthisstudy,theinfluenceoftheSLDicingmodelisnumericallyclarified.

简介：基于小浪包转变(WPT)，基因算法(GA)，神经网络(BPNN)和支持向量用机器制造的背繁殖(SVM)，柴油机引擎阀门清理的一个差错诊断方法被介绍。与力量光谱密度分析，与运用条件的引擎有关的典型频率能从颤动信号被提取。小浪系数和根的最大的单个值(BSV)意味着在典型频率亚乐队的颤动的平方(RMS)值在颤动信号的第三水平分解的目的被提取，并且他们被用作BPNN或SVM的输入向量。为了避免，在本地最小被套住，GA被采用。正常和处于不同阀门清理条件测量的差错颤动信号被分析。BPNN，GA背繁殖神经网络(GA-BPNN)，SVM和GA-SVM被用于为不同特征的抽取训练并且测试，并且分类精确性和训练时间与相比决定最佳差错分类器和特征选择。试验性的结果证明建议特征和分类算法给100%的分类精确性。

简介：Thispaperprovidesanumericalanalysismodelofunsteadyheattrans-ferinpiston-linersetofaninternalcombustionengine.Themodelsimulatestheun-steadyheattransferprocessamongthecombustionmixture,pistonset,lubricantfilm,linerandcoolantinawholeenginecycle,andcanpredictthetemperaturefluc-tuationanddistributiononpistoncrown,innersurfaceofliner,pistonringandthelubricantfilm.Acomputerprogramisdevelopedtocalculatetheunsteadyheattrans-ferprocessofpiston-linersysteminawater-cooleddieselengine.

简介：Theoilpanusedinearengineisoneoftheimportantstructurepartsinthecar,whichis,ingeneral,deepdrawnanddifficulttofrom.Thedeep-drawingprocessesoftheoilpanusedintheenginefor'SmallFlag'CaroflheFirstAutomobileManufactoryisanalyzedbyusingtheintegrativeCAD/CAE/CAMtechniqueofstampingdie,ineludingtheCADsoftwareCATIAandthesheet-metalstampingCAEsoftwareKMASdevelopedindependently.ThroughananalysisofdiestructureandformabilityusingtheKMASsoft-ware,theprimarytwi-offdeep-drawinghassuccessfullybeenchangedtotheone-offdeep-drawing,solvingthekeyteehniealdifficultiesforthemanufactory.

简介：钓鱼是在马来西亚的主要本地工业，特别地在农村区域。然而，燃料的很快增加的价格严重正在影响工业生存能力。目前，因为他们交付高速度和低重量的优点，舷外的汽油引擎是为在小规模的钓鱼的船的使用的比较喜欢的选择，他们是安逸的安装，并且他们使用最小的空间。汽油舷外的引擎被知道消费燃料的更大的数量比向内柴油机引擎，而是有在存在的常规沉没推进器的安装柴油机引擎小规模的钓鱼船因为主要hullform修正和额外的开销被要求完成这，不是经济地可行的。这研究描述一个建议由介绍一台柴油机引擎和穿透表面的推进器(SPP)的联合使用在燃料消费启用减小。燃料消费减小的分析被介绍，和经济可行性研究。产生数据表明建议修正的使用将与舷外的马达相比每旅行(40.75%)节省燃料的23.31公升，每年等于RM3962的年度积蓄。

简介：Toexploretheeffectofthegassourceflowrateontheactualdieselexhaustparticulatematter(PM),atestbenchfordieselengineexhaustpurificationwasconstructed,usingindirectnonthermalplasmatechnology.Theeffectsofdifferentgassourceflowratesonthequantityconcentration,composition,andapparentactivationenergyofPMwereinvestigated,usinganengineexhaustparticlesizerandathermo-gravimetricanalyzer.Theresultsshowthatwhenthegassourceflowratewaslarge,notonlythemaximumpeakquantityconcentrationsofparticleshadalargedrop,butalsothepeakquantityconcentrationsshiftedtosmallerparticlesizesfrom100nmto80nm.Whenthegassourceflowratewas10Lmin~(-1),thetotalquantityconcentrationgreatlydecreasedwheretheremovalrateofparticleswas79.2%,andthevariationofthedifferentmodeparticleproportionwasobvious.Non-thermalplasma(NTP)improvedtheoxidationabilityofvolatilematteraswellasthatofsolidcarbon.However,theNTPgassourceratehadlittleeffectsonoxidationactivityofvolatilematter,whileitstronglyinfluencedtheoxidationactivityofsolidcarbon.Consideringthequantityconcentrationandoxidationactivityofparticles,agassourceflowrateof10Lmin~(-1)wasmoreappropriateforthepurificationofparticles.

简介：本文基于语料库研究的方法,运用在线语料库检索工具SketchEngine,根据英语国家语料库（BNC）中大量的事实语料,对MALE和FEMALE两个名词的词汇语法搭配行为和模式进行比较研究,从而为性别语言差异的研究提供更加有力的数据支持,使研究结果更加具有可信度和说服力。

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