简介:Genisteiniseffectiveagainstamyloid-βtoxicity,buttheunderlyingmechanismsareunclear.Wehypothesizedthatgenisteinmayprotectneuronsbyinhibitingthemitochondrialapoptoticpathway,andtherebyplayaroleinthepreventionofAlzheimer'sdisease.AratmodelofAlzheimer'sdiseasewasestablishedbyintraperitonealinjectionofD-galactoseandintracerebralinjectionofamyloid-βpeptide(25–35).Inthegenisteintreatmentgroups,a7-daypretreatmentwithgenistein(10,30,90mg/kg)wasgivenpriortoestablishingAlzheimer'sdiseasemodel,for49consecutivedays.Terminaldeoxyribonucleotidyltransferase-mediateddUTPnickendlabelingassaydemonstratedareductioninapoptosisinthehippocampusofratstreatedwithgenistein.Westernblotanalysisshowedthatexpressionlevelsofcapase-3,Baxandcytochromecweredecreasedcomparedwiththemodelgroup.Furthermore,immunohistochemicalstainingrevealedreductionsincytochromecandBaximmunoreactivityintheserats.MorriswatermazerevealedasubstantialshorteningofescapelatencybygenisteininAlzheimer'sdiseaserats.Thesefindingssuggestthatgenisteindecreasesneuronallossinthehippocampus,andimproveslearningandmemoryability.Theneuroprotectiveeffectsofgenisteinareassociatedwiththeinhibitionofthemitochondrialapoptoticpathway,asshownbyitsabilitytoreducelevelsofcaspase-3,Baxandcytochromec.
简介:摘要目的探讨5S在医院感染控制管理中的作用。方法2015年7月开始将5S管理工具运用到医院感染控制管理中。结果5S管理前后科室清洁消毒合格率由46.50%升到87.33%、无菌物品储存合格率由64.00%升到100.00%、医疗废物分类合格率由77.00%升到94.50%、输血袋规范处置率由20.00%上升至71%、污衣存放合格率由19.42%上升至75.47%。结论5S管理能加强医院感染环节管理,可营造整齐、清洁、美观、安全、舒适的工作环境,减少浪费,减少库存,提高工作效率,增加患者的安全感,确保了医疗质量和医疗安全1,增强患者对医院的满意度,提高医院在医疗市场中的竞争力。
简介:灼伤抵抗的钛合金的开发是在喷气引擎减轻钛火的点火和繁殖的最直接的方法。WSTi3515S合金(Ti-35V-15Cr-0.3Si-0.1C)是一种新高alloying贝它类型灼伤抵抗的钛合金,属于在在过去设计技术被使进步重要的Ti-V-Cr类型合金5?年。象有弹性的性质那样的WSTi3515S灼伤抵抗的钛合金的物理性质和热性质处于不同条件被测量并且分析。结果两个都显示出那幼仔模量并且砍WSTi3515S合金减少的模量稍微变化,温度在测试温度增加。WSTi3515S合金的泊松比率在0.36附近。然而,象特定的热,热扩散性,热传导性和热扩大那样的热性质增加,温度增加,它源于在提高的温度加强格子热颤动。并且WSTi3515S合金的房间温度密度是5.295?g????????????敮睴牯晫牯??
简介:摘要一体化教学过程中运用7S管理方法有助于营造企业化教学情境,有助于学生职业习惯、职业道德的养成,有助于保障一体化教学过程中的师生安全,有助于一体化教学设备设施的维护和一体化教学成本的节约,有助于学生综合职业能力的培养,从而提升一体化教学的实效性。
简介:摘要总结了MZ900S/32m型上行式移动模架墩间桥位安装工艺及注意事项,对类似移动模架的安装提供参考。
简介:Inthispaper,thefuzzyreliabilityfunctionZ=X+Yhasbeenderived.InthecaseofthatX,YsubjectstoMarshall-Olkinbivariateexponentialdistribution,assumingμ=μ1μ2.
简介:GreaterChinaonceagainledtheglobalmarketforinitialpublicofferings(IPOs)with372IPOsraisingUS$60.3billion,amidtheglobalmarketexperienceddivergentperformanceacrossregionsinahighervolatilityenvironmentandagreaterrangeoffinancingoptionsnowavailable,accordingtoEY’sGlobalIPOMarketStudyReport:2015reviewand2016outlook.Despitearollercoasterridein2015,theMainlandA-sharemarketisexpectedtohavearewardingyearaheadfollowingthe
简介:It’sbeenwellrecognizedforthebigroleplayedbyinnovativeruralcooperativefinancialorganizationsintermsofspreadingfarmers’operationrisk,increasingfarmers’income,anddevelopingruraleconomy.However,nosufficientresearchhasbeenconductedregardingthosefactorswhichmayhaveeffectsonthefarmer’swillingnesstoparticipateinthenewruralfinancialorganization.Thispapertriestofilloutthegapofidentifyingvariousfactorswhichmayhavepotentialinfluenceonthefarmer’swillingnesstoparticipateinthenewtypeofruralfinancialcooperatives.Intheprocess,442farmerhouseholdsandsmall-micro-enterprisesaresampledfromthecooperativefinanceexperimentvillagesinPanjinmunicipalityofLiaoningprovince.Thepotentialinfluencingfactorsareclassifiedintofourcategories,includingthefamerhousehold’scharacteristics,financialcooperativereputation,transactioncosts,andservicequality.AdiscreteLogitmodelisusedfortheparameterestimations.Theresultsshowthatmostassumedfactorsdisplaystatisticalsignificanceeffectonthefarmer’swillingnesstotakepartintheruralcooperativefinancingorganizationsbutwithdifferentlevelofsensitivity.Thecauseandeffectarefullydiscussedfollowingbyaddressingpolicyissuesrelatedtotheruralfinancingcooperativereforms.
简介:对AC-25S沥青混合料进行大、小马歇尔试验对比,指出小马歇尔设计法用于AC-25S沥青混合料的不足,并阐述大马歇尔设计法对于AC-25S沥青混合料设计的适用性,以对AC-25S沥青混合料大马歇尔设计法的技术标准进行优化。
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简介:Background:Manydisease-specificfactorssuchasmuscularweakness,increasedmusclestiffness,varyingposturalstrategies,andchangesinposturalreflexeshavebeenshowntoleadtoposturalinstabilityandfallriskinpeoplewithParkinson'sdisease(PD).Recently,analyticaltechniques,inspiredbythedynamicalsystemsperspectiveonmovementcontrolandcoordination,havebeenusedtoexaminethemechanismsunderlyingthedynamicsofposturaldeclinesandtheemergenceofposturalinstabilitiesinpeoplewithPD.Methods:Awavelet-basedtechniquewasusedtoidentifylimitcycleoscillations(LCOs)intheanterior–posterior(AP)posturalswayofpeoplewithmildPD(n=10)comparedtoage-matchedcontrols(n=10).Participantsstoodonafoamandonarigidsurfacewhilecompletingadualtask(speaking).Results:Therewasnosignificantdifferenceintherootmeansquareofcenterofpressurebetweengroups.Threeoutof10participantswithPDdemonstratedLCOsonthefoamsurface,whilenoneinthecontrolgroupdemonstratedLCOs.AninvertedpendulummodelofbipedalstancewasusedtodemonstratethatLCOsoccurduetodisease-specificchangesassociatedwithPD:time-delayandneuromuscularfeedbackgain.Conclusion:Overall,theLCOanalysisandmathematicalmodelappeartocapturethesubtleposturalinstabilitiesassociatedwithmildPD.Inaddition,thesefindingsprovideinsightsintothemechanismsthatleadtotheemergenceofunstablepostureinpatientswithPD.