简介:PlatycodinD(PD),从Platycodonis根值孤立的triterpenoidsaponin,是被显示了在几根癌症房间线有anti-proliferative效果的一副著名中草药。这研究的目的是用proteomics途径与PD在hepatocellular癌HepG2房间的治疗以后在细胞的蛋白质决定变化。房间生存能力用MTT试金被决定。proteome被二维的差别胶化电气泳动和帮助矩阵的激光解吸附作用/电离time-of-flight团spectrometry分析。西方的污点分析被用来证实改变的蛋白质的表示。我们的结果证明PD在集中依赖者和时间依赖者礼貌禁止了HepG2房间的增长。十六蛋白质被识别在对待PD的HepG2房间起来调整包括ATP5HOXCT1,KRT9,CCDC40,ERP29,RCN1,ZNF175,HNRNPH1,HSP27,PA2G4,哲学学士,BANF1,TPM3,ECH1,LGALS1,和MYL6三蛋白质(即,RPS12,EMG1,和KRT1)与PD在治疗以后在HepG2房间减少了。在HSP27和哲学学士的变化被西方的弄污进一步证实。在结论,我们的结果为PD的反癌症活动在行动的机制上打开新灯。
简介:摘 要: 中文摘要:作为当代社会文化传播的重要力量,公益广告在我国已经取得了很大程度的发展。本文 从公益广告的特点和表达形式出发,首先分析了二维动画在公益广告应用的特点; 然后研究了二维动画在公益广告创作中的作用,通过二维动画能够使公益广告有效地传达信息,引起人们的关注; 最后阐述了自己利用二维动画进行环保类公益广告的设计心得。
简介:Removalofcondensatesfromwetsteamflowinthelaststagesofsteamturbinessignificantlypromotesstageefficiencyandpreventserosionofrotors.Inthispaper,homogeneousspontaneouscondensationintransonicsteamflowinthe2-Drotor-tipsectionofastageturbineisinvestigated.Calculatedresultsagreewithexperimentaldatareasonablywell.Onthebasisoftheabovework,a2-Dnumericalsimulationofwetsteamflowinadjacentrootsectionsofacomplexsteamturbinestagewascarriedout.Computationalresultswereanalyzedandprovideinsightsintoeffectiveremovalofhumidity.
简介:AIM:Toinvestigatetheefficacyofneoadjuvantchemoradiotherapy(NACRT)forresectabilityoflocallyadvancedgastriccancer(LAGC).METHODS:BetweenNovember2007andJanuary2014,29patientswithLAGC(clinicallyT3withdistalesophagusinvasion/T4orbulkyregionalnodemetastasis)thatweretreatedwithNACRTfollowedbyD2gastrectomywereincludedinthisstudy.ResectabilitywasevaluatedwithradiologicandendoscopicexamsbeforeandafterNACRT.Usingthreedimensionalconformalradiotherapy,patientsreceived45Gy,withadailydoseof1.8Gy.Theentiretumorextentandtheregionalmetastaticlymphnodeswereincludedinthegrosstumorvolume.PatientspresentingwitharesectabletumorafterNACRTreceivedatotalorsubtotalgastrectomywithD2dissection.ThepathologictumorresponsewasevaluatedusingJapaneseGastricCancerAssociationhistologicevaluationcriteria.PostoperativemorbiditywasevaluatedusingtheNationalCancerInstitute-CommonTerminologyCriteriaforAdverseEventsversion4.0.Overallsurvival(OS)andprogression-freesurvival(PFS)rateswereestimatedusingaKaplan-Meieranalysisandcomparedusingthelog-ranktest.RESULTS:Allpatientswereassessedasunresectablecases.Twenty-fourpatients(24/29;82.8%)showedLAGConpositronemissiontomography-computedtomography(CT)andcontrast-enhancedCT,whereasfourpatients(4/29;13.8%)withvagueinvasionorabutmenttoanadjacentorganunderwentdiagnosticlaparoscopy.Onepatient(1/29;3.4%),initiallyassessedasaresectablecase,underwentan'openandclosure'afterthetumorwasfoundtobeunresectable.Abutmenttoanadjacentorgan(34.5%)wasthemostcommonreasonforNACRT.TheclinicalresponserateonemonthafterNACRTwas44.8%.AfterNACRT,69%(20/29)ofpatientshadaresectabletumor.Ofthe20patientswitharesectabletumor,18patients(62.1%)underwentaD2gastrectomy.TheR0resectionratewas94.4%andtwopatients(2/18;11.1%)showedacompleteresponse.Themedianfollow-updurationwas13.5mo.Theone-yearOSandPFS
简介:摘要目的探讨进展期远端胃癌淋巴结3站转移率,以规范化指导D2、D2+根治术中淋巴结清扫的正确方法。方法回顾性总结2003年1月~2011年1月期间我院收治的进展期远端胃癌患者62例,分析其淋巴结转移特点及其D2、D2+根治术手术关联。结果存有第Ⅰ站淋巴结转移例数49例,占79.03%;第Ⅱ站淋巴结转移例数17例,占27.42%。肿瘤的胃壁浸润深度pT、区域淋巴结转移站数及pN个数和Borrmann分型成为重要的预后指标,中pT、pN最为重要;全组病人3年总生存率为56.45%(35/62),死亡27例,其中pT4、pT3、pN3、pN2、BorrmannⅢ、Ⅳ型病人占绝对大多数。结论进展期远端胃癌外科治疗以D2淋巴结清扫范围较合理,随着pT、pN分期偏晚,区域淋巴结转移站数和个数依次增加,其预后一定出现渐差的趋势。其次须权衡利弊,谨慎把握D2+PAND。
简介:在经过NaOH-HCl预处理的镍钛合金基体上,采用溶胶-凝胶法制备纳米多孔TiO2薄膜;当涂覆一层致密内膜和一层多孔外膜时,可得到无裂纹的薄膜(试样TC1+1)。X射线衍射表明,TiO2薄膜由锐钛矿组成,在热处理的基体中还检测到少量的Ni4Ti3相。X射线光电子谱分析表明,试样TC1+1的TiO2薄膜完全覆盖了镍钛合金基体。试样TC1+1的表面亲水,接触角约为20°,紫外光照处理15min后接触角降低到(9.2±3.2)°。在0.9%NaCl溶液中的动电位极化实验表明,试样TC1+1的耐蚀性高于抛光的镍钛合金试样的。