简介：Drugscancauseobviousdamagetothebrain.Toverifytherelationshipbetweenacupuncture,neurotrophicfactorexpressionandbraincellstructuralchanges,thisstudyestablishedaratmodelofheroinrelapseusingintramuscularinjectionofincreasingamountsofheroin.Duringthedetoxificationperiod,ratmodelsreceivedacupunctureatBaihui(DU20)andDazhui(DU14).Electronmicroscopydemonstratedthatthestructureoftheventraltegmentalareainheroinrelapseratsgraduallybecamenormalizedafteracupuncturetreatment.Immunohistochemicalstainingexhibitedthattheexpressionofbrain-derivedneurotrophicfactorandglialcellline-derivedneurotrophicfactorincreasedintheventraltegmentalareafollowingacupuncture.Moreover,theeffectsweresimilartothatofmethadone,atypeofmedicinecalledanopioid.ResultssuggestedthatacupunctureatBaihuiandDazhuiprotectedbrainneuronsagainstinjuryinratswithheroinrelapsebypromotingbrain-derivedneurotrophicfactorandglialcellline-derivedneurotrophicfactorexpression.

简介：Thecentralnervoussystem(CNS)containsthetwomostimportantorgans,thebrainandspinalcord,fortheorchestrationofthementalandphysicalactivitiesoflife.Becauseofitsimportance,thehumanbodyhasevolvedbarriersystemstoprotectCNStissuefromtheexternalenvironment.Thisbarrierisamembranecomposedoftightlyapposedcellsandisselectivelypermeabletospecificmoleculesbywayofmembranetransporters.Themajorbarriersinthebrainandtheircorrespondingcellularconstituentsarethebloodbrainbarrier(BBB)composedofendothelialcellsinbrain

简介：BACKGROUND:Functionalmagneticresonanceimaging(fMRI)isinitiallyusedforvisualcortexlocation.However,theapplicationoffMRIininvestigatingthedevelopmentofvisualpathwaylesionsneedstobefurtherobserved.OBJECTIVE:Thisstudyistolongitudiallyobservethedynamicchangesincorticalfunctionandwhitematterfibrousstructureofpatientswithvisualpathwaylesionsbybloodoxygenationleveldependent-functionalmagneticresonanceimaging(BOLD-fMRI)combinedwithdiffusiontensorimaging(DTI),andtoanalyzethecharacteristicsofbrainfunctionandstructuralrecombinationatconvalescentperiodoflesions.DESIGN:Randomizedcontrolledobservation.SETTING:DepartmentofRadiology,theGeneralHospitalofNanjingMilitaryAreaCommandofChinesePLA.PARTICIPANTS:Eightpatientswithunilateralorbilateralvisualdisordercausedbyvisualpathwaylesions,whoadmittedtoDepartmentofRadiology,theGeneralHospitalofNanjingMilitaryAreaCommandofChinesePLAfromJanuarytoSeptember2006wereinvolved,andservedasexperimentalsubjects.Thepatients,6malesand2females,wereaged16-67years.Theyhadvisualdisorderconfirmedbyclinicalexamination,i.e.visualpathwaylesion,whichwasfurtherdiagnosedbyMRorCT.Another12subjectsgenerallymatchingtothosepatientsofexperimentalgroupingender,ageandsight,whoreceivedhealthexaminationinsynchronizationwereinvolvedandservedascontrols.Thesubjectshadnohistoryofeyediseases.Theirbinocularvisualacuity(orcorrectedvisualacuity)wasover1.0.Bothroutineexaminationofophthalmologyandexaminationoffunduswerenormal.Informedconsentsofdetecteditemswereobtainedfromallthesubjects.METHODS:SignaExciteHD1.5Tmagneticresonanceimagingsystemwith16passages(GECompany,USA)andcoilwith8passageswereused;brainfunctionalstimulusapparatus(SAV-8800.MeideCompany)wasusedforshowingexperimentalmission.Attheearlystageandconvalescentperiodoflesions,thepatie