简介：现在的学习被设计从大戟属植物helioscopiaL的整个植物孤立并且评估混合物的抗菌剂活动...各种各样的色析法的技术被用来孤立并且净化混合物。混合物的结构在基础上被阐明光谱数据(1HNMR，13CNMR，1H-1H舒适，HSQC，HMBC，NOESY，红外，和HR-ESI-MS)。新jatrophone类型diterpenoid(14,15-diacetoxy-3-benzoyloxy-7-nicotinoyloxy-9-oxo-jatropha-5E,11E-diene)，命名euphoheliosnoidE(1)，从E的整个植物被孤立。helioscopiaL。对口头的病原体加重1项显示出的重要抗菌剂活动。

简介：EuphorbiakansuiisacommonlyusedtraditionalChinesemedicineforthetreatmentofedema,pleuraleffusion,andasthma,etc.Accordingtothepreviousresearches,terpenoidsinE.kansuipossessvariousbiologicalactivities,e.g.,anti-virus,anti-allergy,antitumoreffects.Inthiswork,twentyfiveterpenoidswereisolatedfromE.kansui,includingthirteeningenane-andeightjatrophane-typediterpenoids(withtwonewcompounds,kansuininPandQ)andfourtriterpenoids.EighteenofthemwereanalyzedbyMTSassayforinvitroanticanceractivityinfivehumancancercelllines.Structure-activityrelationshipfor12ingenane-typediterpenoidsincolorectalcancerColo205cellswerepreliminarystudied.Significantanti-proliferationactivitieswereobservedinhumanmelanomacellsbreastcancerMDA-MB-435cellsandColo205cells.Morethanhalfoftheisolatedingenane-typediterpenoidsshowedinhibitoryactivitiesinMDA-MB-435cells.Eightingenane-andonejatrophane-typediterpenoidspossessedmuchlowerIC_(50)valuesinMDA-MB-435cellsthanpositivecontrolstaurosporine.Preliminarystructure-activityrelationshipanalysisshowedthatsubstituentonposition20wasimportantfortheactivityofingenane-typediterpenoidsinColo205cellsandsubstituentonposition3contributedmoresignificantbiologicalactivityofthecompoundsthanthatonposition5inbothMDA-MB-435andColo205cells.