简介：CyclicADP-ribose(cADPR)isauniversalCa2+mobilizingsecondmessengerinmanydifferentcelltypesandorganisms.cADPRactivatesCa2+releasefromendo/sarcoplasmicreticulumviaryanodinereceptors.Inaddition,Ca2+entrysecondarytoCa2+depletionisatleastoneofthemechanismsinwhichcADPRtriggersCa2+inflow,too.AnaloguesofcADPRhavebeenpreparedbychemicalandchemo-enzymaticroutes.MostoftheanalogueswereanalyzedforbiologicalactivityinintactorpermeabilizedJurkatTcells(ahumanT-lymphomacellline).Asasystematicapproach,analoguesweregroupedaccordingtoalterationsinthebase,thenorthernribose,thesouthernribose,thepyrophosphatebackbone,orincomplexmodifications,comprisingmorethanonepartofthemolecule.Biologicalactivityoftheanaloguesisreviewed,withspecialemphasisonJurkatTcells.