简介：Poisoningcanpresentinvariousways.Doctorsaremostfamiliarwithacutecases,butpoisoningmaybechronic,fromsourcessuchastheenvironmeng,footandwatersuppoliesandthereleaseofindustrialwasteproducts.Poisoningmayalsobeclassifiedasaccidentalordeliberate(Figure1).Sourcesfromwhichinformationonpoisoningineidentscanbeobtaindeincludemortalitydataforaccidentalpoisoningandsuicide,hospitaladmissionofrdischargedata,andenquiriestopoisonsinformationservices.Inaddition,somecountriescollectseparateinformationonchemicalexposures.

简介：Inthemindsofmanydoctors,exposuretoasubstanceisequatedwithpoisoningHowever,uptakeisnecessaryfortheretobeatoxiceffetand,evenifthisoccurs,poisoningdoesnotnecessarilyresult,becausetheamoundabsorbedmaybetoosmall.

简介：StabilizedorChebyshevexplicitmethodshavebeenwidelyusedinthepasttosolvestiffordinarydifferentialequations.MakinguseofspecialpropertiesofChebyshev-likepolynomials,thesemethodshavefavorablestabilitypropertiescomparedtostandardexplicitmethodswhileremainingexplicit.Anewclassofsuchmethods,calledROCK,introducedin[Numer.Math.,90,1-18,2001]hasrecentlybeenextendedtostiffstochasticdifferentialequationsunderthenameS-ROCK[C.R.Acad.Sci.Paris,345(10),2007andCommun.Math.Sci,6(4),2008].InthispaperwediscusstheextensionoftheS-ROCKmethodstosystemswithdiscretenoiseandproposeanewclassofmethodsforsuchproblems,theT-ROCKmethods.Onemotivationforsuchmethodsisthesimulationofmulti-scaleorstiffchemicalkineticsystemsandsuchsystemsarethefocusofthispaper,butournewmethodscouldpotentiallybeinterestingforotherstiffsystemswithdiscretenoise.TwoversionsoftheT-ROCKmethodsarediscussedandtheirstabilitybehaviorisanalyzedonatestproblem.ComparedtotheT-leapingmethod,asignificantspeed-upcanbeachievedforsomestiffkineticsystems.Thebehavioroftheproposedmethodsaretestedonseveralnumericalexperiments.

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简介：AbstractBackground:Carbon monoxide (CO) poisoning remains a major cause of accidental injuries and multiple studies have indicated that CO is also associated with significantly severe or long-term toxicity to the central nervous system. Given that CO poisoning causes serious morbidity and mortality, a better understanding of epidemiological features and clinical characteristics of acute CO poisoning in China is crucial.Methods:We collected the clinical data of acute CO poisoning in patients between November 2019 and April 2020 across Shandong province, China and analyzed its characteristics focusing on the weekly amount and the severity of the confirmed cases.Results:A total number of 21,088 acute CO poisoning cases were diagnosed. The overall incidence of acute CO poisoning was approximately 0.021%. On severity rankings, 63% of confirmed cases (n = 13,378) were mild, 27% (n = 5635) were moderate, and 10% (n = 2075) were severe. Interestingly, the coastal cities had more confirmed cases than the inland/suburban areas in Shandong. Meanwhile, the number of confirmed cases was negatively correlated with the local mean daily temperature (P = 0.0167).Conclusions:Mild acute CO poisoning cases accounted for the majority of all confirmed cases during the winter of 2019. In Shandong province, which is located in east China, residents of the coastal cities are more susceptible to CO poisoning than residents of inland cities.

简介：摘要Carbon monoxide (CO) is an odorless and colorless gas with multiple sources that include engine exhaust, faulty furnaces, and other sources of incomplete combustion of carbon compounds such as house fires. The most serious complications for survivors of consequential CO exposure are persistent neurological sequelae occurring in up to 50% of patients. CO inhibits mitochondrial respiration by speci-fically binding to the heme a3 in the active site of CIV-like hydrogen sulfide, cyanide, and phosphides. Although hyperbaric oxygen remains the cornerstone for treatment, it has variable efficacy requiring new approaches to treatment. There is a paucity of cellular-based therapies in the area of CO poisoning, and there have been recent advancements that include antioxidants and a mitochondrial substrate prodrug. The succinate prodrugs derived from chemical modification of succinate are endeavored to enhance delivery of succinate to cells, increasing uptake of succinate into the mitochondria, and providing metabolic support for cells. The therapeutic intervention of succinate prodrugs is thus potentially applicable to patients with CO poisoning via metabolic support for fuel oxidation and possibly improving efficacy of HBO therapy.

简介：ＣＬＩＮＩＣＡＬＩＮＦＯＭＡＴＩＯＮＡＮＤＭＥＴＨＯＤＳＴｈｅ４２ｏｒｇａｎｉｃｐｈｏｓｐｈｏｒｕｓｐｏｉｓｏｎｅｄ，１６ｍａｌｅａｎｄ２６ｆｅｍａｌｅ，ａｇｅｄ１８～６１，ｈａｖｅａｎａｖｅｒａｇｅｏｆ３４．６ｙｅａｒｓ．Ｔｈｅｔｏｘｉｃａｎｔａｒ...

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简介：Inthispaper,standardandeconomicalcascadicmultigridmethodsareconsideredforsolvingthealgebraicsystemsresultingfromthemortarfiniteelementmethods.Bothcascadicmultigridmethodsdonotneedfullellipticregularity,sotheycanbeusedtotacklemoregeneralellipticproblems.Numericalexperimentsarereportedtosupportourtheory.

简介：付春敏老师向我们推荐了这篇罗德尼·马丁有关教师在培养学生写作结构中促进思维能力发展的文章。在文中我们可以看到,以英文为母语的西方,教师更加着力于对学生的构思结构"大局"观的思维培养。文中对培养学生写作结构思维能力的剖析,望能对老师们的教育教学有所启示。

简介：BioscienceMethods(ISSN1925-1920)isanopenaccess,peerreviewedjournalpublishedonlinebyBioPublisher.Thejournalpublishesallthelatestandoutstandingresearcharticles,lettersandreviewsinallareasofbioscience,therangeoftopicsincluding(butarenotlimitedto)technologyreview,techniqueknow-how,labtool,statisticalsoftwareandknown

简介：BioscienceMethods(ISSN1925-1920)isanopenaccess,peerreviewedjournalpublishedonlinebyBioPublisher.Thejournalpublishesallthelatestandoutstandingresearcharticles,lettersandreviewsinallareasofbioscience,therangeoftopicsincluding(butarenotlimitedto)technologyreview,techniqueknow-how,labtool,statisticalsoftwareandknown

简介：BioscienceMethods(ISSN1925-1920)isanopenaccess,peerreviewedjournalpublishedonlinebyBioPublisher.Thejournalpublishesallthelatestandoutstandingresearcharticles,lettersandreviewsinallareasofbioscience,therangeoftopicsincluding(butarenotlimitedto)technologyreview,techniqueknow-how,labtool,statisticalsoftwareandknowntechnologymodification.Casestudiesontechnologiesforgenediscoveryandfunction

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简介：摘要Background and objectiveCloser monitoring and treatment is vital for pregnant carbon monoxide (CO) poisoning cases due to fetal poisoning component. Permanent damage can occur in both the mother and the baby. It may cause stillbirth even though no serious clinical symptoms occur in the mother. Hyperbaric oxygen (HBO) treatment is advised for all pregnant patients regardless of their clinical symptoms. Pregnant CO poisoning patients that received HBO treatment and their fetal status were evaluated in this study.MethodsPregnant patients poisoned with CO treated in the same hyperbaric clinic were evaluated. Pregnant patients that received HBO treatment in a multiplace chamber were evaluated in terms of clinical status, demographic structure, laboratory tests, fetal effects and progress of the fetus until birth and 6 months postpartum.ResultsA total number of 32 pregnant cases were treated. COHb values were over 20% (min 6.9- max 40.2) in 23 patients, 11 patients had a history of syncope. All patients took HBO treatment under 2.4 ATA pressure for 120 min. 3 patients received more than 1 session of HBO treatments due to fetal stress; all other cases took 1 session of HBO treatment. No spontaneous abortus occurred in early follow-ups; only 4 babies were born prematurely. 2 of the babies were lost in the early phases after birth, due to causes non-related to CO poisoning complications (cyanotic heart disease, necrotizing enterocolitis). No significant difference were observed in the comparison of laboratory results of patients with syncope and of those who did not have syncope and comparison of patients with COHb value higher than 20% and patients with COHb value lower than 20% (P>0.05)．ConclusionHBO is not advisable for pregnant patients except for CO poisoning. In this study it is observed that HBO treatment under 2.4 ATA pressure for 120 min has no harmful effects on the mother and the fetus. It is observed that continuation of HBO treatment in the cases with fetal distress findings has beneficial effects. COHb levels and syncope were shown to have no significant effect on clinical symptoms and on blood tests.

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简介：CascadicmultigridtechniqueformortarWilsonfiniteelementmethodofhomogeneousboundaryvalueplanarlinearelasticityisdescribedandanalyzed.FirstthemortarWilsonfiniteelementmethodforplanarlinearelasticitywillbeanalyzed,andtheerrorestimateunderL2andH1normisoptimal.Thenacascadicmultigridmethodforthemortarfiniteelementdiscreteproblemisdescribed.Suitablegridtrans-feroperatorandsmootheraredevelopedwhichleadtoanoptimalcascadicmultigridmethod.Finally,thecomputationalresultsarepresented.

简介：Inthepresentpaperweextendthemethodpresentedby0.AxelssonandP.VassilevskicalledAMLPversion(i)ofrecursivelyconstructingpreconditionerforthestiffnessmatrixinthediscretizationofselfadjointsecondorderellipticboundaryvalueproblems.Inourextendedmethodthesystemstobeeliminatedoneachlevelcontainingthemajorblockmatricesofthegivenmatrixcanbesolvedapproximately,whiletheymustbesolvedexactlyintheoriginalmethod.

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简介：在这篇论文，我们考虑椭圆形的问题为第二份订单混合了有限元素方法。在最低顺序Brezzi-Douglas-Marini元素的情况中(如果d=2)orBrezzi-Douglas-Duran-Fortin元素(如果d=3)在矩形的平行六面体上，我们证明由合并某些照规则，混合方法系统能作为一个简单、以房间为中心的有限差别方法被写。这导致答案一稀少，positivesemidefinite为未知的数量的线性系统。为一个斜张肌系数，为未知的数量的稀少模式是五个点模板如果d=2，和七如果d=3。为一个一般张肌系数，它是九个点模板，并且十九分别地。是的混合方法实现的应用对的有限差别非等温多相，多，在多孔的媒介的部件流动被介绍。