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  • 作者: Zhao Jia-Cong Deng Kai
  • 学科: 医药卫生 >
  • 创建时间:2021-01-17
  • 出处:《中华医学杂志(英文版)》 2020年第23期
  • 机构:Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China; Department of Immunology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, Chi
  • 简介:AbstractAntiretroviral therapy (ART) can effectively inhibit human immunodeficiency virus-1 (HIV-1) replication, but is not curative due to the existence of a stable viral latent reservoir harboring replication-competent proviruses. In order to reduce or eliminate the HIV-1 latent reservoir, characteristics of the latently infected cells need to be intensively studied, and a comprehensive understanding of the heterogenous nature of the latent reservoir will be critical to develop novel therapeutic strategies. Here, we discuss the different cell types and mechanisms contributing to the complexity and heterogeneity of HIV-1 latent reservoirs, and summarize the key challenges to the development of cure strategies for acquired immunodeficiency syndrome (AIDS).

  • 标签: Clonal expansion Heterogeneity human immunodeficiency virus-1 HIV-1 Integration sites Latent reservoirs
  • 简介:ThickenedheavyoilsinChinaaregeneticallycharacteristicofcontinenta.Astotheirphysico-chemicalproperties,theseoilsareveryhighinviscosityandlowinsulphurandtraceelementcon-tents.Inthegroupconstituents,theconcentrationsofnon-hydrocarbonsandasphalteneareveryhighbutthoseofsaturatedhydrocarbonsandaromaticsareverylow.Thegaschromatogramsofalkanesshowthattheseheavyoilshavehighabundancesofiso-alkanesandcyclichydrocarbons.Inallthesteroidsandterpenoids,bicyclicsesquiterpenoids,tricyclicditerpenoids,re-arrangedsteranesandgammaceranearestronglybildegradation-resistent.Theformationofheavyoilreservoirsiscontrolledmainlybylatebasinascendance,biodegradation,flushingbymeteoricwaterandoxidationintheoil-bearingformations.Ac-cordingtotheirformationmechanisms,heavyoilreservoirscanbeclassifiedasfourcategories:weatheringanddenudation,marginaloxidation,secondarymigrationandthickeningofbottomwater.Spacially,heavythickoilreservoirsaredistributedregularly:theyusuallyshowsomeparageneticrelationshipswithnormaloilreservoirs.Heavyoilreservoirsoftenoccurinstructuralhighsorinoverlyingyoungerstrata.Theirburialdepthisabout200m.Horizontally,mostofthemaredistributedonthemarginsofbasinsordepressions.

  • 标签: 地球化学 重油 中国 地质构造 石油 碳氢化合物
  • 简介:Previousstudiesathomeandabroadhavemainlyfocusedonsingledam-break,andlittleattentionhasbeenpaidsofartothedam-breakofcascadereservoirs.Multi-sourceflooding,whichcanleadtothree-dimensionalturbulentphenomenaandsuperpositioneffects,isthemaindifferencebetweenthedam-breakofcascadeandsinglereservoirs.Detaileddescriptionsofthecouplednumericalsimulationofmulti-sourcefloodinghavelittlebeenreported,andtheinitialwetriverbedisrarelyconsideredincurrentmodels.Therefore,inthispaper,amethodbasedonthethree-dimensionalk_eturbulencemodelcoupledwiththevolume-of-fluidmethodisproposedtosimulatethedam-breakfloodingofcascadereservoirs.Theupstreamriver,reservoir,anddownstreamriverareconnectedbytheinternalboundarymethod,andtheinitialconditions,includingriverflowandreservoirwater,aredeterminedaccordingtotheresultsofthenumericalsimulation.Couplednumericalsimulationofdifferentdam-breakfloodingisthenachieved.Thepresentworksolvesthechallengespresentedbytheenhancementandsuperpositionofnaturalriverflow,upstreamflooding,anddownstreamflooding.Thispaperprovidesatheoreticalbasisforfuturestudiesonthedam-breakfloodroutingofcascadereservoirs.

  • 标签: DAM-BREAK CASCADE RESERVOIRS MULTI-SOURCE FLOOD Three-dimensional
  • 简介:Thearticlepresentsthatinthehydropowerplanning,theregulationcapacityofreservoirsshouldbemeasuredbytheirenergystoragecapacity.BycalculatingtheenergystoragecapacityofthelargereservoirsinChinaandabroad,itshowsthattheenergystoragecapacityoftheLongyangxiaReser-voirontheupperYellowRiverisoneofthelargest.EnormousbenefitcanbeobtainedthroughcompensationregulationofthecascadehydropowerprojectsontheupperYellowRiverandthenearbyinterbasinhydropowerprojectsbytheaidoftheenergystoragecapacityoftheLongyangxiaReservoir.

  • 标签: 加代
  • 简介:Fluidinclusionsinmineralsfilledinporesofreservoirrockscanbeusedasagoodindicatorofporegenesisanddevelopmentsoastoshedlightonoilgeneration,migrationandaccumulation.TherelationshipbetweenporeevolutionandoilgenerationhasbeenestablishedbasedonfluidinclusionstudiesontheLowerOrdoviciancarbonatereservoirstrataintheOrdosBaisn,NorthwestChina.Sevenstagesofporositydevelopmentcanberecogmized.i.e.,thepenecontemporaneous,theearlyandmiddle-latediagenetic,thesupergene,theearly,middleandlatere-buryingstages.Thedissolutionporesanfissuresformedinthesupergeneandmiddle-latereburyingstageandthestructuralfracturesformedinthelatere-buryingstageconstitutethemajortrapsofoilandgas.ThemajorphaseofoilmigrationandaccumulationtookplacebetweenLateJurassicandCretaceous,Correspondingtothemiddleandlatere-buryingstages.ThegenerationandaccumulationofoilcanbecloselyrelatedtoYenshaniantectonics.

  • 标签: 流体包裹体 碳酸盐 多孔性 地球化学 沉积物
  • 简介:一个速度模型是影响microseismic事件地点的一个重要因素。我们为为异乎寻常的油和煤气的水库在探索定位microseismic事件考察当模特儿的速度和倒置技术。我们首先描述与在异质,anisotropy,和可变性的水力的断裂有关的水库形成的地质、地球物理的特征,然后在决定microseismic事件地点在精确性上讨论速度评价,anisotropy模型,和他们的微速摄影的变化的影响,然后为在定位事件地点造速度模型调查一些典型方法。我们断定水库的三个纠缠的物理属性使监视的microseismic很挑战性。在速度的无常当模特儿,在水力的断裂忽略它的anisotropies和它的变化能引起在监视的microseismic不能接受的microseismic事件的系统的错误地点。那么,我们为造精确速度模型建议一些潜在的方法。

  • 标签: 微震事件 定位误差 反演技术 速度建模 各向异性模型 微震监测系统
  • 简介:近的表面黄土在油和煤气的区域有磁性的危险性异例,这是一个事实。这些异例为什么并且是否发生他们有任何重要价值因为油和煤气的水库的探索是地球物理学者主要被担心关于并且学习的问题。我们在油和煤气的区域分析表面黄土危险性异例的形成的原因,处理与合适的数学方法在西方的中国从油和煤气的区域拿的黄土样品的危险性的观察,并且决定黄土危险性的背景值。这些结果被用来决定油和气体基于危险性异例与一个数字评估因素勘探区域。实际油井用危险性异例验证了那显示油和煤气的水库的地点是有效的。关键词危险性-油和煤气的水库-表面黄土-并且油井第一作者邵光洲在2003从Chang鈥檃n大学在应用地球物理收到了他的M.Sc。他现在为他的博士正在学习并且在Chang鈥檃n大学里教。他出版了五份科学报纸。他的兴趣包括主要地震的探索,水库参数的倒置,和高度--精确gravity/磁性的数据处理。

  • 标签: 石油 天然气 磁化率 储集特征
  • 简介:In1997,theTZ-162wellinTazhongareaoftheTarimbasinhitthelowerPaleozoicdolomitereservoiratadepthof5,900m.Thedistributionofthedolomitereservoir,however,wasverydifficulttodelineateduetothecomplexsurfaceconditionsandpoorseismicproperties.High-precisiontransientelectromagneticsounding(TEM)wasconductedandgoodresultsobtainedinthisarea.Thispaperdiscussedtheprinciple,dataprocessingandinterpretationofthismethod.Theresultsofstudyingthedolomitereservoirsdemonstratedtheeffectivenessofthemethodinstudyingthelow-resistancedolomitereservoirsinthehigh-resistancecarbonates.Thismethodshouldbeaneffectiveonetostudyreservoirsinareaswithsimilarphysicalpropertiesaswell.

  • 标签: 碳酸盐 电磁法 塔里木盆地 古生代
  • 简介:Thispaperestablishesseveralmathematicalmodelsforinter-basincompensationschedulingofhydropowerreservoirs,takingintoaccountmakingfulluseofhydropowerandsatisfyingtheloaddemandinthepowergrid.Amethodisalsoprovidedforsolvingthemathematicalmodels.ThesemodelswereappliedtotheGuangxipowergrid;anditisprovedthatthemodelsplayaguidingroleinproduction.

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  • 简介:煤气忍受的暴烈的水库在深Songliao盆被发现了,中国。为日志评估选择合适的解释参数由于复杂矿物质作文和可变矿物质内容是困难的。基于IUGS给的QAPF分类计划,我们建议一个方法用木头数据和一个基因算法决定暴烈的岩石的矿物质内容。根据QAPF计划,在暴烈的岩石中的矿物质被划分成五个组:Q(石英),A(碱的长石),P(斜长石),M(mafic)和F(feldspathoid)。我们建议一个模型为水库的容量的分析包括孔叫了QAPM。为密度,明显的中子孔,运输时间,鲸鱼群妈光线和卷相片的日志反应方程电的生气的节索引首先被建立,矿物质参数从日志矿物质参数的Schlumberger手册获得了。然后,在矩阵的四种矿物质的体积用基因算法(GA)被计算。基于解释参数,计算的孔能与核心孔,和根据四个矿物质内容基于QAPF分类在纸给的岩石名字相比与从核心样品的化学分析的那些兼容。

  • 标签: 矿物模型 遗传算法 火山 水库形成
  • 简介:1.ObjectivesThestudyofthepaleo-reservoirisofgreatsignificanceforoilandgasexploration.Firstly,theexistenceofpaleoreservoirscanreflecttherehasbeenhydrocarbonaccumulationprocessinthisarea,wherethereoncewastheadvantageousconditionwithsource-reservoir-capcombination;secondly,itcanindicatethatthisareahascertainresourcepotential.Thepurposeofthisresearchis:throughthestudyofthepaleo-reservoirofCSDP-2wellintheLaoshanupliftoftheSouthYellowSeaBasin,whichisascientificinvestigationwell,itcanprovidegeologicalbasisformarineoilandgasexplorationoftheMesozoicandPaleozoicintheLaoshanupliftoftheSouthYellowSeaBasin,andatthesametimecanprovideimportantinformationforfutureexplorationtargetselection.

  • 标签: Objectives aleoreservoirs advantageous CONDITION
  • 简介:Inthispaperweshallgivethecharacteristicdifferencemethodsfortwophasedisplacemeatprobleminnaturallyfracturedreservoirs.Weshallprovetheexistence,uniquenessoftheapproximatesolutionandaprioridiscreteL2-errorestimates.

  • 标签: DIFFERENCE METHOD TWO-PHASE DISPLACEMENT naturally fructured
  • 简介:Transientratedeclinecurveanalysisforconstantpressureproductionispresentedinthispaperforanaturallyfracturedreservoir.Thisapproachisbasedonexponentialandconstantbottom-holepressuresolution.Basedonthismethod,whenln(flowrate)isplottedversustime,twostraightlinesareobtainedwhichcanbeusedforestimatingdifferentparametersofanaturallyfracturedreservoir.Parameterssuchasstoragecapacityratio(ω),reservoirdrainagearea(A),reservoirshapefactor(C_A),fracturepermeability(k_f),interporosityflowparameter(λ)andtheotherparameterscanbedeterminedbythisapproach.TheequationsarebasedonamodeloriginallypresentedbyWarrenandRootandextendedbyDaPratetal.andMavorandCinco-Ley.Theproposedmethodhasbeendevelopedtobeusedfornaturallyfracturedreservoirswithdifferentgeometries.Thismethoddoesnotinvolvetheuseofanychartandbyusingthepseudosteadystateflowregime,theinfluenceofwellborestorageonthevalueoftheparametersobtainedfromthistechniqueisnegligible.Inthistechnique,alltheparameterscanbeobtaineddirectlywhileinconventionalapproachesliketypecurvematchingmethod,parameterssuchasωandλshouldbeobtainedbyothermethodslikebuild-uptestanalysisandthisisoneofthemostimportantadvantagesofthismethodthatcouldsavetimeduringreservoiranalyses.Differentsimulatedandfieldexampleswereusedfortestingtheproposedtechnique.Comparisonbetweentheobtainedresultsbythisapproachandtheresultsoftypecurvematchingmethodshowsahighperformanceofdeclinecurvesinwelltesting.

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  • 简介:这研究在Jiaoshiba区域和煤气的累积模式的Longmaxi形成基于沉积条件,器官的地球化学,存储空格,物理性质,岩性学和页岩气体水库的煤气的内容被总结然后与那相比在北美洲。在在Jiaoshiba的Longmaxi形成的页岩气体水库有好地质的条件,优秀页岩的大厚度,高器官的满意的、高煤气的内容,好物理性质,合适的深度,好保藏条件和好水库类型。在深架的底部的优秀页岩是为页岩气体探索和开发的主要目标间隔。在Longmaxi形成的页岩气体经历了三个主要reservoiring阶段:烃产生和压缩的早阶段页岩气体水库是什么时候,首先形成了;深埋葬和大规模烃产生的中间的阶段,它与页岩气体引起了水库的丰富;迟了的阶段高举,侵蚀和破裂开发当页岩气体水库最后被形成时。

  • 标签: 油气成藏模式 龙马溪组 页岩气 气藏 地质特征 有机地球化学
  • 简介:油气体累积(OGA)的地球年代学是在多周期的石油地质学的一个挑战性的题目附加的盆。由K-Ar,authigenicillite(AI)和液体包括(FI)分析标明日期与磷灰石分裂轨道结合了(在船尾)热建模,在东北Ordos盆(击)抑制二叠的水库的OGA时间的案例研究在这份报纸被进行了。二叠的oil-gas-bearing沙岩核心样品标明日期的AI显示出178108妈的一个宽时间领域。AI年龄的分发介绍主要OGA在二叠的水库处理的2阶段,它分别地与165妈和130妈的2山峰年龄在175155妈和145115妈的时间域发展了。现在二组织与的在船尾热的路径上的样品和他们的投射年龄的FI温度山峰不仅一低并且一座高山峰在9078hallow地下水的范围的温度能满足国家标准。(2)从coalbed生产的水主要包含了NaCl獲漠?慗整?潃牰摯'讚攥?潃污敢?慇?湡?桓污潬?片畯摮慷整?湩?畩楬?潃污楦汥?景?楨慮

  • 标签: 鄂尔多斯盆地 二叠系 油气藏 储层 地质记录 东北