简介:SincePresidentObamaannouncedthePrecisionMedicineInitiativeintheUnitedStates,moreandmoreattentionhasbeenpaidtoprecisionmedicine.However,clinicianshavealreadyusedittotreatconditionssuchascancer.Manycardiovasculardiseaseshaveafamilialpresentation,andgeneticvariantsareassociatedwiththeprevention,diagnosis,andtreatmentofcardiovasculardiseases,whicharethebasisforprovidingprecisecaretopatientswithcardiovasculardiseases.Large-scalecohortsandmultiomicsarecriticalcomponentsofprecisionmedicine.Herewesummarizetheapplicationofprecisionmedicinetocardiovasculardiseasesbasedoncohortandomicstudies,andhopetoelicitdiscussionaboutfuturehealthcare.
简介:Somehavesuggestedtheterm“Precision”medicinereplace“Personalized”medicine.Idon’tlikeeithertermandI’lltellyouwhy.WhatisPrecision?ThewordPrecisioncanbedefinedsimplyasreproducibilityanddoesnotnecessarilymeanthatthediagnosisisaccurate.Thus,ifthemedicaldecisionisprecisebutnotnecessarilyaccurateitisnotveryuseful.Accuracyisdefinedasbeingneartothetrueordesiredvalue.e.g.consideratargetonariflerange;iftheshotshaveatightgroupinganywhereonthetarget,theyareprecisebuttheyareonlypreciseandaccurateifthattightgroupingisintheBull’seye.
简介:AbstractOver the last 20 years, it has become possible to use a precision medicine approach to the management of chronic obstructive pulmonary disease (COPD). Clinical and physiological features as well as a blood biomarker can be used to target treatments to patients most likely to benefit and avoid treatment in patients less likely to benefit. Future advances in a precision medicine approach to COPD will depend on more precise characterization of individual patients, possibly using quantitative imaging, new physiological techniques, novel biomarkers and genetic profiling. Precision medicine has led to significant improvements in the management of COPD and clinicians should use all available information to optimize the treatment of individual patients.
简介:Precisionmedicineaimstoidentifytherightdrug,fortherightpatient,attherightdose,attherighttime,whichisparticularlyimportantincancertherapy.Problemssuchasthevariabilityoftreatmentresponseandresistancetomedicationhavebeenlongstandingchallengesinoncology,especiallyfordevelopmentofnewmedications.Solidtumors,unlikehematologicmalignanciesorbraintumors,areremarkablydiverseintheircellularoriginsanddevelopmentaltiming.Theabilityofnext-generationsequencing(NGS)toanalyzethecomprehensivelandscapeofgeneticalterationsbringspromisestodiseasesthathaveahighlycomplexandheterogeneousgeneticcompositionsuchascancer.HereweprovideanoverviewofhowNGSisabletofacilitateprecisionmedicineandchangetheparadigmofcancertherapy,especiallyforsolidtumors,throughtechnicaladvancements,moleculardiagnosis,responsemonitoringandclinicaltrials.
简介:AbstractTumor biomarkers play important roles in tumor growth, invasion, and metastasis. Imaging of specific biomarkers will help to understand different biological activities, thereby achieving precise medicine for each head and neck squamous cell carcinoma (HNSCC) patient. Here, we describe various molecular targets and molecular imaging modalities for HNSCC imaging. An extensive search was undertaken in the PubMed database with the keywords including "HNSCC," "molecular imaging," "biomarker," and "multimodal imaging." Imaging targets in HNSCC consist of the epidermal growth factor receptor, cluster of differentiation 44 variant 6 (CD44v6), and mesenchymal-epithelial transition factor and integrins. Targeted molecular imaging modalities in HNSCC include optical imaging, ultrasound, magnetic resonance imaging, positron emission tomography, and single-photon emission computed tomography. Making the most of each single imaging method, targeted multimodal imaging has a great potential in the accurate diagnosis and therapy of HNSCC. By visualizing tumor biomarkers at cellular and molecular levels in vivo, targeted molecular imaging can be used to identify specific genetic and metabolic aberrations, thereby accelerating personalized treatment development for HNSCC patients.
简介:Acutemyeloidleukemia(AML)isageneticallyheterogeneousmyeloidmalignancythatoccursmorecommonlyinadults,andhasanincreasingincidence,mostlikelyduetoincreasingage.PrecisediagnosticclassificationofAMLrequiresclinicalandpathologicinformation,thelatterincludingmorphologic,immunophenotypic,cytogeneticandmoleculargeneticanalysis.RiskstratificationinAMLrequirescytogeneticsevaluationasthemostimportantpredictor,withgeneticmutationsprovidingadditionalnecessaryinformation.AMLwithnormalcytogeneticscomprisesabout40%-50%ofallAML,andhasbeenintensivelyinvestigated.Thecurrentlyused2008WorldHealthOrganizationclassificationofhematopoieticneoplasmshasbeenproposedtobeupdatedin2016,alsotoincludeanupdateontheclassificationofAML,duetothecontinuouslyincreasingapplicationofgenomictechniquesthathaveledtomajoradvancesinourknowledgeofthepathogenesisofAML.ThepurposeofthisreviewistodescribesomeoftheserecentmajoradvancesinthediagnosticclassificationandriskstratificationofAML.
简介:Next-generationsequencing(NGS)technologyiscapableofsequencingmillionsorbillionsofDNAmoleculessimultaneously.Therefore,itrepresentsapromisingtoolfortheanalysisofmoleculartargetsfortheinitialdiagnosisofdisease,monitoringofdiseaseprogression,andidentifyingthemechanismofdrugresistance.OnbehalfoftheTumorBiomarkerCommitteeoftheChineseSocietyofClinicalOncology(CSCO)andtheChinaActionableGenomeConsortium(CAGC),thepresentexpertgroupherebyproposesadvisoryguidelinesonclinicalapplicationsofNGStechnologyfortheanalysisofcancerdrivergenesforprecisioncancertherapy.Thisgroupcomprisesanassemblyoflaboratorycancergeneticists,clinicaloncologists,bioinformaticians,pathologists,andotherprofessionals.Aftermultipleroundsofdiscussionsandrevisions,theexpertgrouphasreachedapreliminaryconsensusontheneedofNGSinclinicaldiagnosis,itsregulation,andcompliancestandardsinclinicalsamplecollection.Moreover,ithaspreparedNGScriteria,thesequencingstandardoperationprocedure(SOP),dataanalysis,report,andNGSplatformcertificationandvalidation.
简介:THE“CATERPILLARANDHERB”INCHINESEMEDICINEANDINMESOPOTAMIANMEDICINEWuYuhong,IHACScurlockinNABU95/110discusesaninterestingMeso...
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简介:TibetanmedicinecompaniesinT.A.Rcanmanufacturemorethan360Tibetanpatentmedicines.Thereare18TibetanmedicinefactoriesinTibet,andtotaloutvalueexceeds3billionyuan.24kindsofTibetanpatentmedicineshavebeenincorporatedintoStateFundamentalMedicineList,inwhich14Tibetanpatentmedicinesarelistedinnationalprotectedtraditionalmedicinecategory.