简介:DEVELOPMENTOFAVERSATILESENSINGMEMBRANEFORIMMUBILIZATIONOFPROTEINANDANEWIMMOBILIZATIONMETHODY.K.Zhou,J.W.Yuan,S.Q.Xu,B.H.Shu(D...
简介:ScientistsattheUniversityofPittsburghSchoolofMedicinehavediscoveredanewbiologicalpathwayofinnateimmunitythatrampsupinflammationandthenidentifiedagentsthatcanblockit,leadingtoincreasedsurvivalandimprovedlungfunctioninanimalmodelsofpneumonia.TheyreportedtheirfindingstodayinNatureImmunology.
简介:IntroductionAsamemberofthebonemorphogeneticprotein(BMP)family,BMP-2playsimportantrolesnotonlyinboneregenerationandbonerepairbutalsoincellproliferation,apoptosis,differentiationandmorphogenesis.TheBMP-2remarkableabilitytostimulatenewbonegrowthresultsinthedevelopmentofanoveltherapystrategyforbonemassdefectduetoaccidentsordiseases.BecausetheBMP-2itself,inconjunctionwithasuitablematrix,issufficienttostimulategenesisofnewbone,thegeneticallyengineeredBMP-2hasgoodappliedprospects.
简介:Bonemorphogeneticprotein(BMP)isanefficientbone-inducingproteinwhichmainlyexistsinbonematrix.TheimplantsofBovineBMP(bBMP)extractedfrombovinebonematrixcaninducedifferentiationofmesenchymalcellsofmicemusclein-tochondroandosteo-cytesandformnewbonefurther.Inordertoevaluateim-plantablebiomaterialthatpossessesnotonlyosteogenicability,butalsostengtn,
简介:Inthepresentstudywehavefoundthatproto-oncogenec-fosproteincanexpressinthenoradrenergicneuronsofrathindbrainfollowingperipheralelectricalstimulation.Ratsweregivenperipheralelectricalstimulationviathinstainlesssteelpinsinsertedintothepointsnearkneejoint(S36)andanklejoint(Sp6)whichmimicthemanipulationofelectroacupuncture(EA)performedinhumans.Animalswereperfusedfordoublestainingimmunohistochemistry2haftertheterminationofEA.InratssubjectedtoEAstimulationFos-likeproteinwasfoundinthetyrosinehydroxylase(TH)-likeimmunoreactiveneuronsinrathindbrain.TheFosandTHcoex-istingneuronsweredistributedinthelocuscoeruleus,solitarytractnucleus,ventrolateralmedul-la,periaqeductalgray,aswellassuperiorcolliculus.ThepercentageofthecoexistingneuronscomparedwiththetotalnumberofneuronscontainingFos-likeproteininthesenucleirangedfrom6%to32%.Theresultssuggestthatthenoradrenergicneuronsintheseregionsmaybeac-tivtedbyacupuncturestimulation.