简介:Aseriesoffuroxan-basednitricoxide-releasingmatrinederivatives(10a-f)weresynthesized.Thebiologicalevaluationshowedthatcompounds10a,10b,10eand10fhadstrongercytotoxicactivitiesthan5-fluorouracilagainsthumanhepatomacells(HepG2)invitro.
简介:Fromthepress-residueofthefreshroottuberofTrichosantheskirilowiiMaxim(Cu-curbitaceae),anewribosome-inactivatingprotein(RIP),trichobitacin,wasisolated.IthastheactivityofRNAN-glycosidaseandcaninhibitthegrowthofhumanplacentaltrophoblasticcells.Itsmolecularweightis27,228Da(ES-MS)andpI9.6.ItisasinglechainbasicRIP.Itsaminoacidcompositionwasdetermined.ItisanewRIP.Itconsistsof0.7~0.9%galactoseandmaybeaglycoprotein.ItsA’-andC-terminalaminoacidisAspandAla,respectively.ItsN-terminalpreliminaryaminoacidsequencehasbeendetermined.
简介:Thetwocompounds,2,2-dimethyl-4-S-(N,N-dimethyldithiocarbamato)-5-(1,2,4-triazol-l-yl)-propione(1)and2,2-dimethyl-4-S-(N,N-diethyldithiocarbamato)-5-(1,2,4-triazol-1-yl)-3-propione(2),werepreparedbyreactingN,N-dialkyldithiocarbamatesodiumwith2,2-dimethyl-4-bromo-5-(1,2,4-triazol-1-yl)-propione.Theirstructureswereidentifiedbyelementalanalysis,IRand^1HNMRspectroscopy.Thestructureof1hasbeendeterminedbyX-raysinglecrystalstructureanalysis.ItcrystallizesinmonoclinicsystemwithspacegroupP21/c,a=1.2315(3)nm,b=1.2057(2)nm,c=1.2532(3)nm,β=118.55(3)°,Z=4,V=1.6345(6)nm^3,Dc=1.221g/cm^3,μ=0.324mm^-1,F(000)=640,finalR1=0.0449.ThereisobviouspotentiallyweakC—H...Nintermolecularinteractioninthecrystal,whichstabilizesthecrystalstructure.Theresultofthebiologicaltestshowedthatthetwocompoundshavefungistasisandplantgrowthregulatingactivities.
简介:TwoN-dichloroacetyloxazolidinesweresynthesizedwithasimple,mildandconvenientmethod.AllthecompoundswerecharacterizedbyIR,^1HNMRandelementalanalysis.Thepreliminarybiologicaltestshowedthatthecompoundsprotectedmaizeagainstinjurybysomeherbicidestosomeextent.
简介:Aseriesofethyl6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylatesweredesignedandsynthesized.Theirstructureswereconfirmedby~1HNMR,~(13)CNMR,IRandHRMS.ThebiologicalactivitieswereprimarilyevaluatedagainstEimeriatenellaaccordingtoAnticoccidialIndex(ACI)methodinvivo.Theresultsshowedthatcompounds5e,5fand5iexhibitedanticoccidialactivitiesagainstE.tenellaat27mgkg~(-1).
简介:Shortpeptidesbasedonthetripeptides,Leu-Arg-ProandLeu-Lys-Pro,weresynthesizedbymicrowaveassistedsolid-phasesynthesismethod,inordertomakeasearchforpotentialinhibitorsforangiotensinI-convertingenzyme(ACE)withminimumsideeffectsinthetreatmentofhypertension.OnepeptidewiththesequenceLeu-Arg-Pro-Phe-PheshowsthestrongestinhibitiontowardsACEwithanIC50valueof0.26μmol/Linvitro.Thestudyofstructure-activityrelationshipshowsthattheintroductionofabulkygroupintotheN-terminalofthisseriesofinhibitorsmayenlargesterichindrance,resultinginthepoorinhibitoryactivitytowardsACE.TheinhibitoryactivitydecreasedinturnwhenL-Pro,D-ProorAc6cwasattheC-terminalrespectively.ThebindinginteractionbetweeneachoftheseinhibitorsandtesticularACE(tACE)wasperformedbymoleculardocking.TheresultssuggestthatLeu-Arg-Pro-Phe-PhemainlyoccupiedtheS1subsiteoftACE,andmadecontactwithtACEviasevenH-bonds.ItappearedthatthesiteonthepeptidethatboundwithtACEwasinfluencedbytheconfigurationoftheaminoacid,LorD-form,attheC-terminalofthepeptide.
简介:SimultaneousBiparametricDeterminationofTotalCalciumandPotassiuminBiologicalFluidsbyFlowInjectionAnalysis──UseofPowell'sMethod...
简介:AseriesofnovelN-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl)amidesderivativesweredesignedandsynthesized.Theirstructureswereconfirmedby1HNMR,13CNMRandHRMS.Alltitlecompoundswereevaluatedfortheirherbicidalandantifungalactivities.Preliminarybioassayresultsindicatedthatthetitlecompoundsshowedgoodtomoderateherbicidalactivityat1000mg/L.Compound6qpresentedthebestactivityagainstDigitariasanguinalis(L)Scop.,AmaranthusretroflexusL.andArabidopsisthalianawithaninhibitiondegreeoffive.Compound6dalsoshowedaninhibitiondegreeoffiveagainstD.sanguinalis.Inaddition,at50mg/L,mostcompoundsexhibitedgoodinvitroantifungalactivityagainstSclerotiniasclerotiorum,withcompound6cshowingover90%antifungalactivityagainstS.sclerotiorumandPelliculariasasakii.
简介:二新-hydroxy氨基的联合酸的secoiridoids,命名serinosecologanin(1)和threoninosecologanin(2),从忍冬装饰用的梨树的花芽的一篇水的摘录被孤立。他们包括绝对配置的不平常的结构被分光镜的数据分析决定,并且从共同发生的secologanin(3)和secologanic酸(4)由semisynthesis证实了。从曲霉属菌尼日尔从杏仁和hesperidinase对-glucosidase加重1和2项展出抵抗活动,他们也在激活血小板的因素与抑制率导致的老鼠polymorphonuclear白血球对glucuronidase的版本显示出活动(34.9 ;± ;3.1)%并且(53.6 ;± ;2.6)%分别地。