简介：Anall-solid-statesingle-frequency1064nmlaserwitha100μspulsewidth,500Hzrepetitionrateand700mJsinglepulseenergyisdesignedusingseedinjectionandathree-stagemasteroscillatorpoweramplifier(MOPA)construction.Usingthisasabasis,researchonlong-pulselaserfrequencydoublingiscarriedout.Bydesigningandoptimizingthelithiumtriborate(LBO)crystal,thetheoreticallycalculatedmaximumconversionefficiencyηmaxreaches68%atM2=1,whileηminis33%atM2=3.Generationof212mJpulsesofgreenlightwitharepetitionrateashighas500Hzisobtainedfromafundamentalenergyof700mJ.Theexperimentalconversionefficiencyreaches31%andthepowerstabilityisbetterthan±1%.

简介：AbstractObjective:The study aimed to detect and analyze long non-coding RNAs (lncRNAs) in plasma of children diagnosed with chronic gastritis, and to explore its biological functions and involved signaling pathways.Methods:The plasma samples were collected from six children that were diagnosed with chronic gastritis by physical examination, gastroscopy, and pathological examination and six healthy children. The plasma samples were assayed for determining the expression profiles of lncRNA based upon the gen chip detection. The specific expression of lcnRNA in plasma of children with chronic gastritis was analyzed and its biological functions were speculated.Results:Five lncRNAs (RP11-697M17.1, RP11-388M20.9, AFAP1-AS1, BC062758, and XLOC001406) were significantly upregulated, and five lncRNAs (UNQ697, BX571672.5, CYP4F35P, ANKRD20A5P, and AL832737) were observed to be significantly down-regulated. The lncRNAs RP11-697M17.1, and UNQ697 were detected with the highest up-regulation and down-regulation, respectively. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that the up-regulated lncRNAs were significantly enriched in 20 signaling pathways such as phosphoinositide-3-kinase-protein kinase B (PI3K-Akt) pathway, and the down-regulated lncRNAs target genes were significantly enriched in 20 signaling pathways such as the metabolic pathway.Conclusion:The analysis of the lncRNA expression profiles in plasma of children with chronic gastritis revealed that the lncRNA RP11-697M17.1, and lncRNA UNQ697 may act as plasma markers for predicting chronic gastritis in children.

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简介：Klein-Gordon-Schroedinger(KGS)equationsareveryimportantinphysics.Somepapersstudiedtheirwell-posednessandnumericalsolution[1-4],andanotherworksinvestigatedtheexistenceofglobalattractorinR^nandΩ包含于R^n(n≤3)[5-6,11-12].Inthispaper,wediscussthedynamicalbehaviorwhenweapplyspectralmethodtofindnumericalapproximationforperiodicinitialvalueproblemofKGSequations.ItincludestheexistenceofapproximateattractorAN,theuppersemi-continuityonAwhichisaglobalattractorofinitialproblemandtheupperboundsofHausdorffandfractaldimensionsforAandAN,etc.

简介：Along-termexperimentbeginningin1981inJinxianCountyofJiangxiProvince,subtropicalChina,wasconductedinapaddyfieldunderadoublericecroppingsystemwithfourdifferentfertilizationregimes,including1)nofertilizerascontrol(CK),2)balancedchemicalN,P,andKfertilizers(NPK),3)organicmanureusingmilkvetchandpigmanureintheearlyandlatericegrowingseason,respectively(OM),and4)balancedchemicalfertilizerscombinedwithorganicmanure(NPKM).Samples(0-17cm)ofthepaddyfieldsoil,whichwasderivedfromQuaternaryredclay,werecollectedafterthelatericeharvestinNovember2003fordeterminationoftotalorganiccarbon(TOC)andtotalnitrogen(TN)andfractionsoforganicCandN.ResultsshowedthatTOCandTNintheNPKMandOMtreatmentsweresignificantlyhigherthanthoseinothertwotreatments(CKandNPK).ApplicationoforganicmanurewithorwithoutchemicalfertilizerssignificantlyincreasedthecontentsofallfractionsoforganicCandN,whereaschemicalfertilizerapplicationonlyincreasedthecontentsofoccludedparticulateorganicC(oPOC)andaminoacidN.Inaddition,applicationoforganicmanuresignificantlyenhancedtheproportionsoffreeparticulateorganiccarbon(fPOC)andoPOCintotalC,andthoseofaminosugarNandaminoacidN(P<0.01)intotalN.Incontrast,chemicalfertilizerapplicationonlyincreasedtheproportionsofoPOCandaminoacidN(P<0.05).TherewerenosignificantdifferencesineithercontentsorproportionsofsoilorganicCandorganicNfractionsbetweentheNPKMandOMtreatments.TheseindicatedthatorganicmanureapplicationwithorwithoutchemicalfertilizersplayedthemostsignificantroleinenhancingsoilorganicCandNquantityandqualityinthepaddyfieldstudied.

简介：Thecomplexityoftheloadsactingontheoffshorewindturbines(OWTs)structuresandthesignificanceofinvestigationonstructuredynamicsareexplained.Testresultsobtainedfromascaledwindturbinemodelarealsosummarized.Themodelissupportedonmonopile,subjectedtodifferenttypesofdynamicloadingusinganinnovativeoutofbalancemasssystemtoapplycyclic/dynamicloads.Thetestresultsshowthenaturalfrequencyofthewindturbinestructureincreaseswiththenumberofcycles,butwithareducedrateofincreasewiththeaccumulationofsoilstrainlevel.Thechangeisfoundtobedependentontheshearstrainlevelinthesoilnexttothepilewhichmatcheswiththeexpectationsfromtheelementtestsofthesoil.Thetestresultswereplottedinanon-dimensionalmannerinordertobescaledtopredicttheprototypeconsequencesusingelementtestsofasoilusingresonantcolumnapparatus.

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简介：InthispaperweprovethatthesolutionofexplicitdifferenceschemeforaclassofsemilinearparabolicequationsconvergestothesolutionofdifferenceschemesforthecorrespondingnonlinearellipticequationsinH1normast→∞.Wegetthelongtimeasymptoticbehaviorofthediscretesolutionswhichisinterestedincomparingtothecaseofcontinuoussolutions.

简介：由离子的第二代的高温度的超导的磁带的准备帮助横梁的免职(IBAD)要求扁平的金属底层。在这个工作，长长度的HastelloyC-276合金的电气化学的擦亮被学习，并且它的过程参数，描绘的粗糙和另外的性质被调查。A10-meter-longHastelloyC-276合金被电气化学的擦亮准备。下列优化处理参数被获得：45的温度？？

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简介：Poly(vinylalcohol)/hydroxylapatite(PVA/HA)compositehydrogelwaspreparedbyrepeatedfreezingandthawing.Thewaterlosspropertiesoftheresultanthydrogelwereinvestigatedbyusingopticalmicroscope.LongtimeimmersiontestsofPVA/HAcompositehydrogelwerecarriedoutinthedilutedcalfserumsolutiontostudythechangelawsofswellingpropertieswiththefreezing-thawingcyclesandHAcontent.Themicro-morphologiesofPVA/HAcompositehydrogelafterlongtimeimmersionwereobservedbymeansofthehigh-accuracy3Dprofiler.TheresultsshowthattheswellingprocessofPVA/HAcompositehydrogelistheconverseprocessofitswaterloss.LongtimeswellingratiocurvesofPVA/HAcompositehydrogelinthecalfserumsolutionaremanifestedasfourstagesofquickincrease,decrease,slowdecreaseandstablebalance,anditsequilibriumswellingratiodecreaseswiththeincreaseoffreezing-thawingcyclesandHAcontent.ItisrevealedthatthenetworkstructureofthecompositehydrogelimmersedforalongperiodissignificantlyimprovedwiththeincreaseofHAcontent.PerfectnetworkstructuresofPVA/HAcompositehydrogelaswellasfullandequilibriumtissuesafterswellingequilibriumareobtainedwhentheHAcontentis3%andthenumberoffreezing-thawingcyclesis7.

简介：Liquidcompositemoulding(LCM)processesareusedtomanufacturehighqualityandcomplex-shapedcompositepartsintheautomotive,marine,aerospaceandcivilindustries.On-linesensingplaysanimportantroleincontrollingthequalityofthefinalproductintheLCMmanufacturingenvironment.Thelong-periodfibergrating(LPG)technology,anewreal-timefiberopticsensorsystem,wasdevelopedtomonitortheflowfrontprogression.Thesensoroperationandcharacterizationundervariousprocessconditionswerediscussedindetail.TheexperimentalresultsshowedthatLPGsensorswererobustandreliabletodetectthearrivalofresinatpre-selectedlocationsinstructureswithlow-mediumfibervolumefraction;howeverwerelimitedatdifferentdepthsinstructureswithhighfibervolumefraction.

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简介：AbstractBackground:Synovectomy has been introduced into total knee arthroplasty (TKA) with the aim of relieving pain and inflammation of the synovium. However, there are no long-term, comparative data to evaluate the effect of synovectomy in TKA. This study was aimed at assessing pain, function, and complications in patients undergoing synovectomy during TKA for osteoarthritis (OA) at long-term follow-up.Methods:This was a prospective randomized controlled trial of 42 consecutive patients who underwent staged bilateral TKA. Patients undergoing the first-side TKA were allocated to receive TKA with or without synovectomy followed by a 3-month washout period and crossover to the other strategy for the opposite-side TKA. The overall efficacy of both strategies was evaluated by determination of blood loss, the Knee Society score (KSS), and knee inflammation conditions during a 3-month postoperative period. The postoperative pain, range of motion (ROM), and complications were sequentially evaluated to compare the two groups until 10 years after surgery.Results:At the 10-year follow-up, both groups had a similarly significantly improved ROM (114.88 ± 9.84° vs. 114.02 ± 9.43°, t = 0.221, P = 0.815) and pain relief with no differences between the two groups (1.0 [1.0] vs. 1.0 [1.5], U = 789.500, P = 0.613). Similar changes in total blood loss, KSS, and knee inflammation were found in both groups during 3 months postoperatively (P > 0.05). Additionally, there was no significant difference regarding complications and satisfaction between the two groups (P > 0.05).Conclusions:Synovectomy in conjunction with TKA for primary OA does not seem to provide any benefit regarding postoperative pain, ROM, and satisfaction during a 10-year follow-up. In addition, it may not result in more blood loss and increased incidence of long-term complications. Based on our long-term findings, it should not be performed routinely.Trial registration:Chinese Clinical Trial Registry, ChiCTR-INR-16008245; https://www.chictr.org.cn/showproj.aspx?proj= 13334.

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简介：AbstractBackground:The development of the technique has improved the success rate of percutaneous coronary intervention (PCI) for instent chronic total occlusion (IS-CTO). However, long-term outcomes remain unclear. The present study sought to investigate long-term outcomes of PCI for IS-CTO.Methods:A total of 474 IS-CTO patients were enrolled at two cardiac centers from 2015 to 2018 retrospectively. These patients were allocated into either successful or failed IS-CTO PCI groups. The primary endpoint (major adverse cardiac events [MACE]) consisted of recurrent angina pectoris (RAP), target-vessel myocardial infarction (MI), heart failure, cardiac death, or ischemia-driven target-vessel revascularization (TVR) at follow-up. Multivariable Cox regression analysis was used to investigate the association between treatment appropriateness and clinical outcomes.Results:A total of 367 patients were successfully treated with IS-CTO PCI while 107 patients had failed recanalization. After a median follow-up of 30 months (interquartile range: 17-42 months), no significant difference was observed between the two groups for the following parameters: cardiac death (successful PCI vs. failed PCI: 0.9% vs. 2.7%; adjusted hazard ratio [HR]: 1.442; 95% confidence interval [CI]: 0.21-9.887; P = 0.709), RAP (successful PCI vs. failed PCI: 40.8% vs. 40.0%; adjusted HR: 1.025; 95% CI: 0.683-1.538; P = 0.905), heart failure (successful PCI vs. failed PCI: 6.1% vs. 2.7%; adjusted HR: 0.281; 95% CI: 0.065-1.206; P = 0.088), target-vessel related MI (successful PCI vs. failed PCI: 1.5% vs. 2.7%; adjusted HR: 1.150; 95% CI: 0.221-5.995; P = 0.868), MACE (successful PCI vs. failed PCI: 44.2% vs. 45.3%; adjusted HR: 1.052; 95% CI: 0.717-1.543; P = 0.797). More patients were free of angina in the successful IS-CTO PCI group compared with failed PCI in the first (80.4% vs. 60%, P < 0.01) and second years (73.3% vs. 60.0%, P = 0.02) following up. Successful IS-CTO PCI had a lower incidence of MACE in the first and second years (20.2% vs. 40.0%, P < 0.01; 27.9% vs. 41.3%, P = 0.023) compared with failed PCI. After a median follow-up of 30 months, the reocclusion rate was 28.5% and TVR was 26.1% in the successful IS-CTO PCI group. Receiving >18 months of dual antiplatelet therapy (DAPT) was an independent predictor of decreased risk of TVR (HR: 2.682; 95% CI: 1.295-5.578; P = 0.008) or MACE (without TVR) (HR: 1.898; 95% CI: 1.036-3.479; P = 0.038) in successful IS-CTO PCI.Conclusions:After a median follow-up of 30 months, the successful IS-CTO PCI group had MACE similar to that of the failed PCI group. However, the successful IS-CTO PCI group had improved angina symptoms and were free from requiring coronary artery bypass grafting in the first or second years. To decrease MACE, DAPT was found to be essential and recommended for at least 18 months for IS-CTO PCI.

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简介：Neutralbeaminjection(NBI)isrecognizedasoneofthemosteffectivemeansforplasmaheating.A100slongpulseneutralbeamwith30keVbeamenergy,10Abeamcurrentanda100slongpulsemodulatingneutralbeamwith50keVbeamenergy,16AbeamcurrentwereachievedintheEASTneutralbeaminjectoronthetest-stand.ThepreliminaryresultssuggestthatEAST-NBIsysteminitiallypossesstheabilityoflongpulsebeamextraction.

简介：Inaccordancewithanewcompensationprincipleofdiscretecomputations,thetraditionalmeteo-rologicalglobal(pseudo-)spectralschemesofbarotropicprimitiveequation(s)aretransformedintoperfectenergyconservativefidelityschemes,thusresolvingtheproblemsofbothnonlinearcomputa-tionalinstabilityandincompleteenergyconservation,andraisingthecomputationalefficiencyofthetraditionalschemes.Asthenumericaltestsofthenewschemesdemonstrate,insolvingtheproblemofenergyconser-vationinoperationalcomputations,thenewschemescaneliminatethe(nonlinear)computationalin-stabilityand,tosomeextenteventhe(nonlinear)computationaldivergingasfoundinthetraditionalschemes,Furthercontrastsbetweennewandtraditionalschemesalsoindicatethat,indiscreteopera-tionalcomputations,thenewschemeinthecaseofnondivergenceiscapableofprolongingthevalidin-tegraltimeofthecorrespondingtraditionalscheme,andeliminatingcertainkindofsystematicalcom-putational“climatedrift”,meanwhileincreasingitscomputationalaccuracyandreducingitsamountofcomputation.Theworkingprincipleofthispaperisalsoapplicabletotheproblemconcerningbaroclin-icprimitiveequations.