简介：Objective:Tocomparethetherapeuticeffectofpointpenetrationmethodoflongneedleandthatofwesterndruginthetreatmentofkneeosteoarthritis.Methods:Thesimpleandrandomizedgroupingmethodwasusedinpresentstudy.Results:Theeffectiverateintheacupuncturegroupwas87.5%,andinthewesterndruggroupwas55.6%,thesignificantdifferencewasfoundbetweentwogroupsinthetherapeuticeffect(P＜0.01).Conclusions:Thetherapeuticeffectofpointthroughpointwithlongneedleinthetreatmentofkneeosteoarthritiswasbetterthanthatofwesterndrug.

简介：ＡＤＶＡＮＣＥＳＩＮＴＨＥＭＯＮＴＨＬＹ，ＳＥＡＳＯＮＡＬＡＮＤＹＥＡＲＬＹＬＯＮＧ－ＲＡＮＧＥＮＵＭＥＲＩＣＡＬＷＥＡＴＨＥＲＰＲＥＤＩＣＴＩＯＮ￥ＺｈｅｎｇＱｉｎｇｌｉｎ（郑关林）ＡＤＶＡＮＣＥＳＩＮＴＨＥＭＯＮＴＨＬＹ，ＳＥＡＳＯＮＡＬＡＮＤＹ...

简介：BackgroundTheimpactofincompleterevascularization(IR)onadverseoutcomesafterpercutaneouscoronaryinterventionremainsinconclusive,andfewstudieshaveexaminedmortalityduringfollow-upslongerthan5years.TheobjectiveofthisstudyistotestthehypothesisthatIRisassociatedwithhigherriskoflong-term(8-year)mortalityafterstentingformultivesselcoronarydisease.MethodsandResultsAtotalof13016patientswithmultivesseldiseasewhohadundergonestentingpro-cedureswithbaremetalstentsin1999to2000wereidentifiedintheNewYorkState'sPercutaneousCoronaryInterventionReportingSystem.Alogisticregressionmodelwasfittopredicttheprobabilityofachievingcompleterevascularization(CR)inthesepatientsusingbaselineriskfactors;then,theCRpatientswerematchedtotheIRpatientswithsimilarlikelihoodsofachievingCR.Eachpatient'svitalstatuswasfollowedthrough2007usingtheNationalDeathIndex,andthedifferenceinlong-termmortalitybetweenIRandCRwascompared.ItwasfoundthatCRwasachievedin29.2%(3803)ofthepatients.Forthe3803pair-matchedpatients,therespective8-yearsurvivalrateswere80.8%and78.5%forCRandIR(P=0.04),respectively.TheriskofdeathwasmarginallysignificantlyhigherforIR(hazardratio=1.12;95%confidenceinterval,1.01-1.26,P=0.04).The95%bootstrapconfidenceintervalforthehazardratiowas0.98to1.32.ConclusionsIRmaybeassociatedwithhigherriskoflong-termmortalityafterstentingwithBMSinpatientswithmultivesseldisease.Moreprospectivestudiesareneededtofurthertestthisassociation.

简介：Tosutdythemechanicalpropertiesandtheclinicalresultsofminimum-contactplateinthetreatmentoffractures.Methods:Four-pointbendingandtorsiontestswereconductedtocomparethenewminimumcontactplate(MCP)withdynamiccompressionplate(DCP)andlimitedcontactdynamiccompressionplate(LC-DCP).Thefracturehealingtimeandgrowthofhonycalluswereobservedin29casesoflongbonefracturefixedwithMCPtoevaluatetheadvantagesofthiskindofplate.Results:The29patientswhounderwentMCPwerefollowedupfrom6to14months.Theaveragehealingtimeforfemoral,tibialandhumeralfractureswas12,13and10weeks,respectively.Allfractureswerehealed.Nodisplacementoffracture,screwpullout,deformationorhreakoftheplatewerefound.Conclusions:ThebendingstiffnessofMCPissignificantlygreaterthanthatofDCPandLC-DCP(P<0.05).MCPcanprotecttheperiostealhloodsupplyagainstavascularosseousnecrosisandacceleratehonehealing.Itisakindofreliableandeffectiveplateintreatmentoffractures.

简介：Thetransmissionspectrumofthecoatedphase-shiftedlong-periodfibergratings(LPFGs)withsingleandmultiplephaseshiftsisanalyzedbythecoupled-modetheoryandthetransfermatrixmethod,andtheinfluencesofthefilmparametersonthespectralcharacteristicsarealsostudied.ItisshownthattheseparameterswillaffecttheLPFGfilteringcharacteristics.Thelosspeakoftransmissionspectrumdecreaseswiththeincreaseoffilmthickness,andthepeakpositionshiftswiththefilmrefractiveindex.Comparedwiththenon-coatedphase-shiftedLPFG,thecoatedonehasthesimilardesirablefilteringcharacteristics,andithasaflexibleabilitytoadjustthetransmissionproperties.

简介：韦伯斯特和杨季风索引(WYI)—在第850a200hPa之间的带的风切变根据NCEP/NCAR分析数据计算、修改。在分析150-100和200hPa的发行量和分叉地以后，然而，我们发现200-hPalevel不能反映亚洲夏季风，特别特征和变化的upper-tropospheric发行量的真实变化热带在东方是upper-tropospheric发行量的最重要的特征的喷气。比U_(850)-U_(200),并且这样大的带的风切变U_(850)-U_((150+100))is大部分它能更适当地反映季风的力量。另外，分叉在150hPa而非200hPa是最大的，因此在上面对流层的罐头的150hPa反映联合季风系统。因此，WYI是重新定义的asDHI，即，I_(DH)=U_(850)~*-U_((150+100))~*，它能在亚洲描绘带的风切变的中心的紧张的可变性不仅，而且在上面、更低的对流层的季风系统。DHI比在展示它在那里显示的Asiansummer季风的长期的变化的WYI优异是明显的内部在亚洲夏季风和气候的十的变化突然的变化发生在1980。亚洲夏季风在第1980a前是更强壮的它由于变弱在然后以后变弱在150-100hPa的层在东方，当时在200hPa在东方没显著地变弱。在气候以后跳年一般来说，在在亚洲削弱的上面的对流层在东方，显示变弱夏季风；land-seapressure差别和热差别减少了，导致变弱季风；相应上面的分叉以及水汽运输在印度半岛，中央印度支那半岛，诺思中国，和东北中国减少了，显示也变弱夏季风。在学习茶碱紧张和亚洲夏季风的长期的变化的NCEP/NCAR和ERA-40分析数据之间的差别也为参考最后被比较。

简介：Inthiswork,westudythephotonicbandofcumulativeFibonaccilattices,ofwhichthestructureiscomposedofallgeneratedunitsinaFibonaccisequence.TheresultsarecomparedwithdistributedBraggreflector(DBR)structureswiththesamenumbersoflayers.Photonicbandgapsarefoundattwocharacteristicfrequencies,symmetricallyseparatedfromthecentralbandgapintheDBRcounterpart.FieldamplitudeandphasedistributionintheFibonaccilatticeindicatesaninterferentialoriginofthebandgaps.Fouriertransformontherefractiveindexprofileiscarriedout,andtheresultconfirmsadeterminatelong-rangeperiodicitythatagreeswellwiththephotonicbandstructure.

简介：Objective:Tosearchfortheinterferenceoppoaunityoffatemboliafterfractureoflongboneorpelvis.Methods:86patientswereselectedanddividedintourineketonepositivegroup(UKPgroup)andurineketonenegativegroup(UKNgroup).Theclinicaldata(includingclinicalandsub-clinicalfatembolism)ofallcaseswereanalyzed.Theincidencerateoffatembo-lismandtheserumtriglyceride(TG)levelwerecomparedbetweenthetwogroups.Results:7patientswithketonuriahadfatem-bolism,3ofthemhadprogressivebloodsedimentationandplateletabnormality.TheincidencerateoffatembolismandtheserumTGlevelinUKPgroupwashigherthanthatinUKNgroup.TherewasasignificantdifferencebetweentheUKPgroup(P<0.05)andtheUKNgroup(P<0.01).Conclusion:TheresultssuggestedthatthepatientshaveahigherriskoffatembolismwhentheserumTGlevelishigh,andresultsinketonuria.Sothiscanbeconsideredastheinterferenceopportunityofthefatemboli.

简介：Basedonhydrographsof"81.7"floodandtopographiesof1980and1993,a1-DmathematicalmodeloffloodisdevelopedtostudytheeffectsoftheGezhoubaProjectonfloodpropagationalongtheYichang-JianliriverreachesintheYangtzeRiver.Calculationsandanalysisshowthat,after13years'operationoftheGezhoubaProject,thefloodpeakstageshavebeenlowered,thefloodcurvesofstage-dischargerelationshiphavebeenmoved,however,theeffectsontheflooddischargesandstoragescanbeneglectedrelatively.

简介：Inthispaper,numericalpredictionofshipmotionresponsesinlong-crestirregularwavesbytheURANS-VOFmethodispresented.Awhitenoisespectrumisappliedtogeneratetheincomingwavestoevaluatethemotionresponses.Theprocedurecanreplaceadecadeofsimulationsinregularwavewithonesingleruntoobtainacompletecurveoflinearmotionresponse,considerablyreducingcomputationtime.Acorrectionprocedureisemployedtoadjustthewavegenerationsignalbasedonthewavespectrumandachievesfairlybetterresultsinthewavetank.Threeshipmodelswithfivewaveconditionsareintroducedtovalidatethemethod.Thecomputationsinthispaperarecompletedbyusingthesolvernaoe-FOAM-SJTU,asolverdevelopedforshipandoceanengineeringbasedontheopensourcecodeOpenFOAM.Thecomputationalmotionresponsesbytheirregularwaveprocedurearecomparedwiththeresultsbyregularwave,experimentsandstriptheory.Transferfunctionsbyirregularwavecloselyagreewiththedataobtainedintheregularwaves,showingnegligibledifference.Thecomparisonbetweencomputationalresultsandexperimentsalsoshowgoodagreements.TheresultsbetterpredictedbyCFDmethodthanstriptheoriesindicatethatthismethodcancompensatefortheinaccuracyofthestriptheories.Theresultsconfirmthattheirregularwaveprocedureisapromisingmethodfortheaccuratepredictionofmotionresponseswithlessaccuracylossandhigherefficiencycomparedwiththeregularwaveprocedure.

简介：AbstractLong noncoding RNAs (lncRNAs) have recently been discovered and are increasingly recognized as vital components of modern molecular biology. Accumulating evidence shows that lncRNAs have emerged as important mediators in diverse biological processes such as cell differentiation, pluripotency, and tumorigenesis, while the function of lncRNAs in the field of normal and malignant hematopoiesis remains to be further elucidated. Here, we widely reviewed recent advances and summarize the characteristics and basic mechanisms of lncRNAs and keep abreast of developments of lncRNAs within the field of normal and malignant hematopoiesis. Based on gene regulatory networks at different levels of lncRNAs participation, lncRNAs have been shown to regulate gene expression from epigenetics, transcription and post transcription. The expression of lncRNAs is highly cell-specific and critical for the development and activation of hematopoiesis. Moreover, we also summarized the role of lncRNAs involved in hematological malignancies in recent years. LncRNAs have been found to play an emerging role in normal and malignant hematopoiesis, which may provide novel ideas for the diagnosis and therapeutic targets of hematological diseases in the foreseeable future.

简介：Thispaperreportsthesynthesisofaseriesofpolysiloxanesbearinglongsidechainmeltedatlowtemperature.Thedrug(LNG)releasingpropertiesofthesiciconerubberfilmscontainingthesepolyorganosiloxaneswerestudied.Thereleaseratesofthedrugincreaseasthetemperatureriseupabovethemeltingtemperatureofthesepolyorganosiloxanes.

简介：识别北半球(NH)温度重建和仪器的数据过去的1000年证明气候在最后千年includeslong术语趋势和各种各样的摆动变化。二个长期的趋势和quasi-70-year摆动在全球温度系列被检测最后140年和NH千年系列。一个重要特征被强调那温度慢慢地减少，但是它基于不同系列的分析很快增加。好处能从理解各种各样的长期的趋势和摆动气候变化被获得。从自然气候系统和非线性的模型系统的时间序列的千年的温度代理在理解自然气候变化并且认识到由使用小浪的方法的潜在的好处转变分析被使用。从主要摆动在数值解释包含了在上的数字当模特儿的表演的结果内部十的时间规模与自然代理的一致。看起来，在气候变化的这些摆动直接没作为外部强迫与太阳辐射被连接。这调查可以断定在interdecadaltimescale的气候可变性强烈在气候系统取决于内部非线性的效果。

简介：Thispaperanalysesthefiveyears'monitoredstrainscollectedfromalong-termhealthmonitoringsysteminstalledonabridgewithwavelettransform.Intheanalysis,themonitoredstrainsarepre-processed,featuresofthemonitoreddataaresummarizedbriefly.Theinfluencesofthebasefunctionsontheresultsofwaveletanalysisarestudiedsimultaneously.Theresultsshowthatthedbwaveletisagoodmotherwaveletfunctionintheanalysis,andtheorderNshouldbelargerthan20,butlessthan46indeco...

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简介：在男孩，中央早熟的发身(CPP)是以前垂体促性腺激素分泌物驾驶的第二等的性别特征的外观9年的年龄。在最后年里，在CPP的处理的相关改进被完成了。因为CPP在男孩是稀罕的，这个问题上的报纸的多数集中于女孩并且不关于结束结果和安全探讨男病人的特定的特征。在现在的纸，有在男人的GnRH类似物的CPP管理的最近的进展被总结。在未经治疗、对待的病人的结束结果被最近出版的文学的分析也在男人在CPP的治疗上考察。可得到的数据显示没有重要不利短期、长期的效果，有GnRH类似物的那治疗能改进最后的高度进目标高度的范围，但是病人的更大的系列的更长的后续是仍然要求了得出权威的结论。

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简介：AbstractPurpose:Olecranon fractures are particularly vulnerable to distraction and subsequent fracture dislocation due to the high tensile forces. Surgical treatment aims at reducing the fracture and restoring the anatomical joint surface condition, as well as neutralizing the strain inhibiting fracture healing. The XS nail® (Intercus GmbH, Bad Blankenberg, Germany), an intramedullary implant exerting compression across the entire fracture surface, unlike plates, leaves a minimal extra-cortical profile, and can be secured with threaded locking wires, thereby retaining the anatomical reduction without displacement or steps within the articular surface, which was often found in tension band wiring. After encouraging initial results, the long-term outcome was assessed.Methods:This retrospective study evaluated the long-term outcome of patients surgically treated at our trauma center between January 2002 and December 2005 using the XS nail®. Patients over the age of 18 years eligible for the study must have undergone surgery for isolated, recent (less than 14 days) traumatic olecranon fractures, without concomitant injuries to the ipsilateral elbow and forearm. Further exclusion criteria were pseudarthrosis, re-fractures and osteotomy for distal humerus surgery, as well as polytraumatized patients unable to aid in their own recovery. Data were retrospectively gathered by standardised questionnaire and patient records, as well as surgery and anesthesiology reports. Data analysis was performed using Microsoft Office Excel® 2016.Results:There were 32 patients, 13 males (mean age 49.0 years) and 19 females (mean age 68.9 years) with 11 Schatzkers type D, 7 each type A and C, 5 type B and 2 type E at an average of 55.2 months, all showing complete consolidation. Of them, 6 patients had a loss of range of motion with more than 10° in the sagittal plane, and only 1 patient exceeded 10° reduction of supination. Twenty-five patients reported being pain-free under all circumstances, and all but 2 patients (93.75%) had returned to their previous activity level. The average disabilities of the arm, shoulder and hand score was 21.15 (range 0-88.3), and the overall Mayo elbow performance index was 91.87, without complications, such as wound infection, neurovascular impairment or premature hardware removal.Conclusion:Using the XS nail® system, all fracture types can be successfully treated and the rate of complications was lower than that treated by standard methods published in current literature. An excellent functional outcome, high range of motion as well as good retention of reduction without soft tissue irritation makes this a very suitable implant for fractures subject to tension.

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简介：SeasonalvariationandtopographyofthemixedlayerintheSeaofJapanarestudiedbycomparisonofresultsfromlong-termobservationdataanalysisandfromnumericalsimulationwiththeMHIoceanicmodel(Shapiro.1998.MarineHydrophysicalJournal,6:26～40).ThedataareretrievedfromOceanographicAtlasoftheBeringSea,OkhotskSea,andJapan/EastSea(Rostov,Rostov,Dmitrieva,etal.2003.PacificOceanography,1(1):70～72).Thesimulatedandlong-termpatternsarecompared.Animpactofsurfacebuoyancyflux,wind,andconvergence/divergenceofsurfacecurrentsuponthemixedlayerintheSeaofJapanisanalyzed.