简介：IthasbeenrevealedthatpolyⅠ:CisapotentstimulatorforNKcells,whichcaninduceNKcellrapidactivationandpreferentialaccumulationintoliver.However,theprocessmediatingtheinfluxofNKcellsremainsobscure.Inthisstudy,wefoundthatpolyⅠ:CadministrationincreasedtheportionandabsolutenumberofNKcellsinliver,butlargelydecreasedthoseinspleen.Therewerenoobviouschangesoftheselymphocytesinotherimmuneorgans.TheresultsfromsplenicadoptivetransferandsplenectomyshowedthattherecruitedspleenNKcellscontributedtotheaccumulationofNKcellsinliver,andthisprocesswasregulatedbytheproductionofchemokinesandthepresenceofTcells.Thisinvestigationwillhelptounderstandtheenhancedimmunecellrecruitmentinliveruponviralinfection.

简介：Aseriesofcarboxylate-substitutedtrinudearmolybdenumdus-tercompoundsformulatedasMo3S4(DTP)3(RCO2)(L),whereRffiH,CH3,C2H5,CH2Cl,CCl3,R^1C6H4(R^1isthegrouponthebenzeneringofaromaticcarboxylate),L=pyridine,CH3CN,DMF,havebeensynthesizedbytheligandsubstitu-tionreaction.Thedissociationoftheloosely-coordinatedligandLfromtheclustercorewasstudiedby^31pNMR.Thedissocia-tionprocessofLisrelatedtothesolvent,temperature,andacidityofcarboxylategroups,soastoaffectthesolutionstruc-tureandreactivepropertiesoftheduster.Thelong-distancein-teractionbetweenligandsRCO2andListransportedbyMo3S4core.

简介：三新混合器官/无机的聚合ligand交换chiral静止阶段被激进的链转移反应和表面grafting在硅石胶化上开发，并且成功地为dl氨基的酸和dl氢氧根酸的enantioseparations使用了。决定被使用包含2.0×的水完成10?是的CuAc2的4mol/L一个活动阶段，40°C的列温度，1.0mL/min和察觉在的流动率紫外254nm。在l异构体前的d异构体的elution顺序为除了dl职业人员，解决的所有dl氨基的酸被观察。

简介：Mostoftheoculartumorshavepoorprognosis,andtheyremainadifficultproblemintheareaofophthalmology.Withtherapiddevelopmentofmolecularbiologyandimmunologictechniquesandthedeepresearchonoculartumorrelatedgenes,itbecomespossibletodiagnoseandtreatmalignanttumorsfromthemolecularlevel.Thetumornecrosisfactorrelatedapoptosis-inducingligand(TRAIL),amemberofthetumornecrosisfactor(TNF)superfamily,isapromisingcandidate,eitheraloneorincombinationwithestablishedcancertherapies,sinceitcaninitiateapoptosisthroughtheactivationoftheirdeathreceptors.TheabilityofTRAILtoselectivelyinduceapoptosisoftransformed,virus-infectedortumorcellsbutnotnormalcellspromotesthedevelopmentofTRAIL-basedcancertherapy.Here,wewillreviewTRAILanditsreceptors’structure,function,mechanismofactionandapplicationinoculartumorstherapy.

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简介：Inthiswork,DSCandSEMstudiesindicatethation-ligandinteractioncanbeutilizedtoenhancetheinteractionofpoly(styrene-block-2-vinylpyridine)[P(S-b-2VP)]andpolyethylenebasedionomer(Surlyn).Thecompatibilityforthisblendingsystemcanbeimprovedbythisspecialinteractionand20/80wtistheoptimumblendingcompositionwithgoodcompatibility.FTIRresultsfurthercertifythatstronginteractionsexistintheblendingsystem.

简介：Thecreationandpropagationoflongitudinalacousticphonons(LAPs)inhighqualityhematitethinfilms(α-Fe2O3)epitaxiallygrownondifferentsubstrates(BaTiO3,SrTiO3,andLaAlO3)areinvestigatedusingthefemtosecondpump–probetechnique.Transientreflectionmeasurements(?R/R)indicatethephoto-excitedelectrondynamics,andtheinitialdecaylessthan1psandtheslowdecayof～500psareattributedtotheelectron-LOphononcouplingandelectron–holenonradiativerecombination,respectively.LAPsinα-Fe2O3filmcanbecreatedbyultrafastexcitationoftheligandfieldstate,suchastheligandfieldtransitionsunder800-nmexcitationaswellastheligandtometalcharge-transferwith400-nmexcitation.Thestrainmodulationsofthesoundvelocityandtheout-of-planeelasticpropertiesaredemonstratedinα-Fe2O3filmondifferentsubstrates.

简介：Objective:Toinvestigatetheexpressionofmatrixmetalloproteinase-7(MMP-7)andFasligand(FasL)ingastriccancerandexploretheirroleinprogressionofgastriccancer.Methods:Formalin-fixedparaffinandembeddedtissuesofprimarygastriccancerandadjacentnon-tumormucosafrom113caseswereevaluatedforMMP-7,FasLandCapase-3expressionbystreptavidin-peroxidase(S-P)immunohistochemistry.Theexpressionofthefirsttwoproteinsincancercellsofprimaryfociwascomparedwithclinicopathologicalparametersoftumors.WealsoobservedthecorrelationofMMP-7andFasLexpressionwithCaspase-3expressionincancercellsofprimaryfoci.Results:MMP-7positiveimmunostainingwaslessfrequentlydetectedinadjacentepithelialcellsthanincancercellsofprimaryfociofgastriccancer(P<0.05,29.2%vs69.0%),andsowasFasL(P<0.05,34.5%vs54.0%).MMP-7expressionwasassociatedwithtumorsize,Borrmann'sclassification,invasivedepth,metastasisandTNMstaging(P<0.05),butnotwithgrowthpattern,Lauren'sclassification,orhistologicalclassification(P>0.05).FasLexpressionwascorrelatedwithtumorsize,invasivedepth,metastasis,Lauren'sclassification,histologicalclassification(P<0.05),whilenotwithBorrmann'sclassification,TNMstagingorgrowthpattern(P>0.05).CancercellsofprimaryfociexpressedlessCaspase-3thantheiradjacentepithelialcells(P<0.05,32.7%vs50.4%).TherewasanobviouscorrelationbetweenFasL,MMP-7andCaspase-3expressionincancercellsofprimaryfoci(P<0.05).Co-expressionofMMP-7andFasLparalleledwithCaspase-3expressionincancercellsofprimaryfoci(P<0.05).Conclusion:MMP-7andFasLexpressionwasup-regulatedingastriccarcinogenesisandwasprincipallyinvolvedinprogressionofgastriccancer.FasLexpressioncouldreflectthedifferentiationofgastriccancercellsandunderliethemolecularmechanismsofdifferentpathwaysofgastrictumorigenesis.Co-expressionofMMP-7andFasLcouldhaveapoptosis-inducingeffe

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简介：AbstractBackground:Perioperative neurocognitive disorders (PND) are a series of severe complications in the perioperative and anesthetic periods with a decline in memory, execution ability, and information processing speed as the primary clinical manifestation. This study aimed to evaluate the impact of edaravone (EDA) on PND and peripheral blood C-X-C motif chemokine ligand 13 (CXCL13) levels in elderly patients with hip replacement.Methods:A total of 160 elderly patients undergoing hip arthroplasty in Affiliated Dongguan People’s Hospital of Southern Medical University (from March 2016 to March 2018) were randomly and double-blindly categorized into an EDA group and a control group (CON). Group EDA was administered intravenously EDA 30 min before surgery, and group CON was administered intravenously saline. The cognitive function of the two groups was evaluated 1-day before the operation and at 1 and 12 months after surgery, and the incidence of post-operative delirium was tested on days 1, 3, and 7 after surgery using the Chinese version of the confusion assessment method. Serum CXCL13 and interleukin (IL)-6 concentrations were measured before anesthesia, during surgery (30 min after skin incision), and on days 1, 3, and 7 after surgery. The continuous variables in accordance with normal distribution were tested using the Student’s t test, the continuous variables without normal distribution using the Mann-Whitney U test, and categorical variables by the χ2 test or Fisher exact test.Results:The incidence of post-operative delirium within 7 days after surgery was significantly higher in group CON than that in group EDA (31.3% vs. 15.0%, t=-5.6, P < 0.001). The modified telephone interview for cognitive status and activities of daily life scores were significantly higher in the group EDA than those in the group CON at 1 month (39.63 ± 4.35 vs. 33.63 ± 5.81, t = -2.13, P < 0.05 and 74.3 ± 12.6 vs. 61.2 ± 13.1, t = -1.69, P < 0.05) and 12 months (40.13 ± 5.93 vs. 34.13 ± 5.36, t = -3.37, P < 0.05 and 79.6 ± 11.7 vs. 65.6 ± 16.6, t= -2.08, P < 0.05) after surgery; and the incidence of neurocognitive dysfunction was significantly lower in the group EDA than that in the group CON (P < 0.05). Serum CXCL13 and IL-6 concentrations were significantly lower in the group EDA than those in the group CON during and after surgery (P < 0.05).Conclusion:EDA can significantly reduce the serum concentrations of CXCL13 and IL-6 and improve the PND of patients.

简介：LigandeffectofthecatalyticsystemWCl6-Et2AlClforringopeningmetathesispolymerization(ROMP)ofdicyclopentadiene(DCPD)wasinvestigated.Theexperimentalresultsshowthataddingstericallyhinderedphenol-2.6-di-tert-butylcresylol(DTBC)inthecatalyticsystemnotonlycanobviouslyincreasethemonomerconversionofpolymerizationbutalsoimprovethemechanicalproperties,suchasnotchedimpactstrength(NIS),tensilestrength(TS)ect.,ofthesynthesizedpolydicyclopentadiene(PDCPD),Asimilareffectcanbeobservedbyusingastericallyhinderdpolymericphenol-linearphenolformaldehyderesin(LPF)asaligand.

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简介：ObjectivesToinvestigatethechangeandclinicalsignificanceofclopidogrelonplateletmembraneCD40Lincoronaryarterydiseasepatientsbeforeandafterpercutaneouscoronaryintervention(PCI).Methods30caseswhowerediagnosiscoronaryarterydiseases(CAD)bycoronaryangiography,meanage56±9yearsold.Allthepatientswhohadnoantiplateletaggregationcontraindication,weretreatedwithstandardantianginapectorisdrugs.BeforePCI,allthepatientstookclopidogrel75mgperday.ActivatedplateletmembraneCD40LexpressratewasmeasuredbyflowcytometrybeforeandafterPCI6hours.ResultsActivatedplateletmembraneCD40Lexpressratewere3.73±2.15and2.46±0.90,respectivelyin30patientsbeforeandafterPCI6hours.ActivatedplateletmembraneCD40LexpressratewassignificantlydecreaseafterPCI6hoursthanthatbeforePCI(P<0.01).ConclusionsClopidogrelhassignificanceeffectonplateletmembraneCD40LincoronaryarterydiseasepatientsundergoingPCI.Clopidogrelcansuppressionplateletactivationandpreventthromboembolismeventoccurrence.

简介：TheL-proline-functionalizedpolystyrenewith1-methyldecylenespacerwassynthesizedfrom2%divinylbenzene-crosslinkedpolystyrenegelvia10-bromo-1-methyldecylpolystyreneintermediate.Aftercomplexedwithcopper(Ⅱ）ion,thepolymerwithL-prolineligandwasusedasthechiralstationaryphase(CSP)forligandexchangechromatographyofaminoacidracemates.TheresultsshowedthattheCSPpossessedpowerfulenantioselectivityandallracematesofthefifteentriedaminoacidswerecompletelyseparated.

简介：Tetrazole-1-aceticacidwasfoundtoserveasasuperiorligandforCuI-catalyzedN-arylationofimidazoleswitharyliodidesunderalowcatalystloading(5mol%ofCuI).AvarietyofaryliodidescouldbeaminatedtoprovidetheN-arylatedproductsingoodtoexcellentyieldswithouttheneedofaninertatmosphere.