简介:AIM:Toexaminethemechanismofthedevelopmentofpseudoexfoliation(PSX)syndromeviabothcytokineformationandendothelialvasorelaxingandgrowthfactorsthatwillprovideusnewtherapeuticinsightsforthetreatment.METHODS:Thisisacrosssectionalstudyincludedtwogroups;Group1:controlpatientswithnuclearcataract(n=20,aged51-80years).Group2:PSXpatientswithnuclearcataract(n=18,aged50-90years).Patientswithotherophthalmicproblemsandsystemicdiseaseswereexcluded.Vascularendothelialgrowthfactor(VEGF),interleukin-6(IL-6)andinterleukin-1β(IL-1β)andnitrotyrosinelevelsweredeterminedthroughserumsamplesbyEnzyme-linkedimmunosorbentassay(ELISA)method.Nitrite-nitratelevelsweremeasuredwithphotometricendpointdetermination.RESULTS:Therewerenosignificantdifferencesbetweenthegroupsintermsofage,VEGF,IL-1β,nitrite-nitrateandnitrotyrosine.ThesignificantresultswerethemeanIL-6levelsthatwerehigherinPSXgroup2(37.68±29.52pg/mL)comparedtothatincontrolgroup1(15.32±10.08pg/mL)(P<0.001).CONCLUSION:SeveralinteractingandextendingbiochemicalpathwaysmayleadtothepromotionofVEGFandIL-6expressions.IL-6whichistheonlyalteredmarkerinourstudymayindirectlycauseanincreaseofvascularpermeabilityandneovascularization.WesuggestinflammationasafactorthatcanbeinvolvedinetiopathogenesisofPSX.
简介:目的对照观察和评价弥可保和腺苷钴胺片治疗外伤性视神经挫伤的临床疗效,评估弥可保的治疗有效性和优越性。方法将37例外伤性视神经挫伤患者随机分为二组,分别用弥可保和腺苷钴胺片治疗,比较两组间视力改善及视神经萎缩发生情况。结果弥可保治疗组视力改善有效率为63.15%,腺苷钴胺片对照组视力改善有效率为27.78%;两组差别具有统计学意义(P〈0.05);弥可保治疗组视神经萎缩发生率为46.15%,腺苷钴胺片对照组视神经萎缩发生率为72.22%,两组差别具有统计学意义(P〈0.05)。结论弥可保对外伤性视神经挫伤的治疗有明显的临床疗效,是一种疗效肯定的治疗外伤性视神经挫伤的药物,其对视功能的恢复优于腺苷钴胺片。
简介:目的通过快速评估可避免盲系统评估四川省冕宁县50岁以上人群视力障碍的患病率和致残原因。方法在2011年6月至8月使用RAAB系统对四川省冕宁县50岁以上居民采用分层、整群随机抽样方法抽取2850人,根据人口比例,分为57个人群组,每个人群组人数为50人,每个人群组采用紧凑段抽样(compactsegmentsampling,CSS),当紧凑段抽样不可行时,采用配额抽样。使用简易视力卡检测视力,用便携式裂隙灯和直接检眼镜检查晶状体及眼底情况以明确导致视力残疾的原因。结果在冕宁县抽样调查的2850人中,2817人接受了检查(98.8%),参照1973年世界卫生组织(WorldHealthOrganization,WHO)视力损伤标准,共有视力残疾者537人,患病率为19.1%,其中盲111人,盲的患病率为3.9%(95%可信区间:3.2%-4.7%),严重视力损伤69人,其患病率2.4%(95%可信区间:1.8%-3.1%);视力损伤357人,其患病率12.7%(95%可信区间:10.5%-14.9%),其中可避免盲占87.4%。结论1.冕宁县50岁及以上人群盲的患病率为3.9%,严重视力损伤的患病率2.4%;视力损伤的患病率12.7%,其中可避免盲占87.4%。未经治疗的白内障仍然是该县最主要的致残原因。2.RAAB系统作为一种在人群中快速筛查可避免盲的调查方法,准确性好,简单实用、高效,重复性强。
简介:AIM:Topresentretinalmicrostructure,metabolismandfunctionabnormalitiesinthecourseofmultipleevanescentwhitedotsyndrome(MEWDS)byHeidelbergspectralismodalityimagingplatformandobserveitsoutcomebyEDI-SD-OCTandtwowavelengthautofluorescence.METHODS:Acaseofmultipleevanescentwhitedotsyndromeina23-year-oldfemalepresentedinitiallywitha15-dayhistoryoffloatersandacentralscotomaintherighteye.Toestablishthediagnosis,multimodalityimagingwasperformed,namely,bluelight-fundusautofluorescence(BL-FAF,excitation488nm,emission>500nm),near-infraredfundusautofluorescence(NIR-FAF,excitation787nm,emission>800nm)usingaconfocalscanninglaserophthalmoscope,fundusfluoresceinangiography(FFA),indocyaninegreenangiography(ICGA),spectrum-domainenhancedepthimagingopticalcoherencetomography(SD-EDI-OCT),multifocalelectroretinography(mf-ERG)andfundusphotograghwereperformedandfollowedupattheeighthmonthafterinitiallyvisiting.RESULTS:Opticalcoherencetomography(OCT)showedatransientdisruptionofthefovealphotoreceptoroutersegmentsincorrespondencetofovealgranularity.NIR-FAFshowedhypoautofluorescentareas,≤40μminsize,mostlyconcentratedaroundtheposteriorpoleanditstemporalsidelessthanthatinBL-FAF.Mf-ERGshowpinnacledisappearedinfoveaandmaculaandresponsesdecreasedmarkedlycomparedwiththefolloweye.Attheeighthmonthfollowup,hyperfluorescenceinBL-FAFweredisappear,while,NIR-FAFHypofluorescentspotsinearlystageofsuchlesionwerereduced.ButOCTdemonstratedthestructurewasrecoveredinresidualHypofluorescentareainNIR-FAF.Thesubfovealchoroidalthicknesswasdecreasedfrom372μmto307μmslightlyandcostlinewasrecovered.CONCLUSION:MEWDSisabenignself-healingdiseaseandthereisnopathologicalevidencetoinvestigatethenaturalcourseofsuchdisease.SD-OCTallowshighlydetailedimagesapproachinghistopathologytocertifythemicrostructura
简介:AIM:ToevaluatethecornealendothelialcelldensityandmorphologyinChinesepatientswithpseudoexfoliationsyndrome(PEX).·METHODS:Medicalrecordsof16patients(20eyes)withPEXwhopresentedtoourinstitutionbetweenJuly2008andJune2010wereretrospectivelyreviewed.Thirteeneyeshadcombinedglaucoma.Theinformationoffiveapparentlynormalfelloweyesinthesepatientswasalsorecorded.Lefteyesof20patientswithbilateralsenilecataractsbutnoothereyediseasewereincludedascontrols.Specularmicroscopywasperformedinalleyestoanalyzeforcornealendothelialcelldensityandmorphology.Celldensity,coefficientofvariationincellsize,andpercentageofhexagonalcellsincornealendotheliumwereevaluated.·RESULTS:ThemeancornealendothelialcelldensityinthePEXeyeswas2298±239cells/mm2,significantlylowerthanthatinthecataracteyes(2652±18cells/mm2,P=0.026),buttherewerenosignificantdifferencesincoefficientofvariationofcellsizeandfrequencyofhexagonalitybetweenthesetwogroups.NosignificantdifferencesinthethreeparameterswerefoundbetweentheapparentlynormalfelloweyesandthePEXeyesorthecataracteyes,orbetweenthePEXeyeswithandwithoutglaucoma.·CONCLUSION:CornealendothelialcelldensitymaydecreaseinChinesepatientswithPEX.ThedevelopmentofglaucomainPEXeyesdoesnotseemtoberelatedwiththechangeincornealendothelialcelldensityormorphology.