简介：AbstractTraumatic brain injury (TBI), a growing public health problem, is a leading cause of death and disability worldwide, although its prevention measures and clinical cares are substantially improved. Increasing evidence shows that TBI may increase the risk of mood disorders and neurodegenerative diseases, including Alzheimer's disease (AD). However, the complex relationship between TBI and AD remains elusive. Metabolic dysfunction has been the common pathology in both TBI and AD. On the one hand, TBI perturbs the glucose metabolism of the brain, and causes energy crisis and subsequent hyperglycolysis. On the other hand, glucose deprivation promotes amyloidogenesis via β-site APP cleaving enzyme-1 dependent mechanism, and triggers tau pathology and synaptic function. Recent findings suggest that TBI might facilitate Alzheimer's pathogenesis by altering metabolism, which provides clues to metabolic link between TBI and AD. In this review, we will explore how TBI-induced metabolic changes contribute to the development of AD.

简介：病原的Wolbachia紧张wMelPop很快在果蝇melanogaster，引起的严重组织退化和主人的早熟的死亡的大脑，肌肉，和视网膜的在复制上。这endosymbiont的唯一的特征成为被用于人的疾病的昆虫，害虫，和向量的生物控制是一个优秀工具。在我们使用了的神经房间跟随细菌的形态学和titer的动力学3-d-old女性大脑的传播电子显微镜学。从苍蝇的中央大脑的神经原和glial房间有不同Wolbachiatiters从单个细菌到大累积，分开撕房间并且入侵细胞外的空间。大脑的neuropile区域没有wMelPop。Wolbachia紧与宿主细胞细胞器交往了并且在神经细胞经历了几个词法变化。在主人的体的织物以内把wMelPop动力学的一个计划基于我们第一次建议的描述的细菌的不同词法类型。

简介：BACKGROUND:Oxidativestressplaysanimportantroleinthepathophysiologyofepilepsy.Glutathione,knownasoneofthecompoundsofantioxidantdefense,hasbeenshowntoinhibitconvulsions.Nitricoxidehasaproconvulsanteffectonapentylenetetrazole-inducedanimalmodel.OBJECTIVE:Toevaluatetheeffectsofglutathioneadministrationonnitricoxidelevelsinbrainregionsofconvulsiveandkindlingpentylenetetrazole-inducedseizuremodels.DESIGN,TIME,ANDSETTING:Arandomized,controlled,animalexperiment.ThestudywasperformedattheDepartmentofPhysiology,GaziantepUniversityandDepartmentofChemistry-Biochemistry,KahramamarasSutcuImamUniversityin2006.MATERIALS:PentylenetetrazoleandglutathionewerepurchasedfromSigma,USA.METHODS:Atotalof80micewereassignedto8groups(n=10):normalcontrol,salinecontrol(1mLnormalsaline),convulsivepentylenetetrazole(singleintraperitonealadministrationofpentylenetetrazole,60mg/kg),convulsivepentylenetrazoleplusglutathione(singleadministrationof60mg/kgpentylenetetrazoleand200mg/kgglutathione),five-doseglutathione(intraperitonealinjectionof200mg/kgglutathionerespectivelyat1,3,5,7,and10days),single-doseglutathione(singleadministrationof200mg/kgglutathione),pentylenetetrazolekindling(intraperitonealadministrationofpentylenetetrazoleof40mg/kgat1,3,5,7,and10days),andpentylenetetrazolekindlingplusglutathionegroup(intraperitonealinjectionof40mg/kgpentylenetetrazoleand200mg/kgglutathionerespectivelyat1,3,5,7,and10days).MAINOUTCOMEMEASURES:Allmiceweresacrificed1hourafterthelastadministration.Brainnitricoxidelevelsweredeterminedbyspectrophotometry.RESULTS:Therewerenosignificantdifferencesinnitricoxidelevelsbetweenthenormalcontrol,salinecontrol,five-doseglutathione,andsingle-doseglutathionegroups(P>0.05).Nitricoxidelevelsinthecerebralhemisphereandcerebellumweresignificantlylessintheconvulsivepentylenetetrazolegroup,comparedwiththeconvu

简介：Thecingulum,theneuraltractconnectingtheorbitofrontalcortexwiththemedialtemporallobe,playsanimportantroleincognition(Bushetal.,2000).Itisalsoimportantinmemorybecauseitprovidescholinergicinnervationstothecerebralcortexafterobtaininginnervationfromthemedialseptalnucleus,the

简介：ＩＭＭＵＮＯＣＹＴＯＣＨＥＭＩＣＡＬＣＨＡＲＡＣＴＥＲＩＺＡＴＩＯＮＯＦＣＤ４４ＭＯＬＥＣＵＬＥＳＥＸＰＲＥＳＳＥＤＩＮＨＵＭＡＮＢＲＡＩＮＭＥＴＡＳＴＡＳＥＳＬｉＨｏｎｇ李宏；ＬｉｕＪｉａ刘佳；ＭａｒｔｉｎＨｏｆｍａｎｎ；Ｍａｒｉａｅ－Ｆｒａｎｃｅ...

简介：Theirretrievablefateofneuronsdominatedtheneurosciencerhetoricforthefirsthalfofthiscentury,apositionthatwasfiercelycontestedandrecentlydebunkedbyextensivestudiescarriedoutinthefieldofneuroregenerationresearch.Theturningpointcameintheyear1928,whenRamonY.Cajal’s(Lobato,2008)worksuggestedthattheregenerativecapacityof

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简介：目的将从寄生于的网膜的动脉(POA)与血供应分析hepatocellular癌(HCC)的angiographic外观，并且经由POA评估技术可行性，安全和chemoembolization的治疗学的功效。

简介：Thehemodynamicmechanismofrollingmanipulation(RM)oftraditionalChinesemedicalmassage(TCMM)isinvestigated.AnaxisymmetricalnonlinearmodelandanarbitraryLagrangian-Eulerianfiniteelementmethod(ALE-FEM)withrezoningalgorithmwereintroducedtostudytheviscousflowthroughanaxisymmetricalrigidtubewithaxiallymovingstenosistosimulatetherollingmanipulation.FlowrateandwallshearstresswereobtainedbysolvingcompleteNavier-Stokesequationsnumerically.Thenumericalresultsshowthatthestenosismovingfrequency,namelythefrequencyofrollingmanipulation,hasgreateffectonthedisturbanceofflowandthewallshearstress.Thestenosiscoefficient,whichcharacterizestheseverityofthestenosis,anotheradjustableparameterinrollingmanipulation,alsoshowsthesignificanteffectonflowrateandwallshearstress.Thesenumericalresultsmayprovidesomedatathatcanbetakenintoconsiderationwhenmassageisusedinclinic.

简介：AbstractBackground:Total and differential white blood cell counts are important for the diagnostic evaluation of suspected diseases. To facilitate the interpretation of total and differential white blood cell counts in pediatric patients, the present study investigated age-dependent changes in total and differential white blood cell counts in healthy reference children.Methods:Data were obtained from the Pediatric Reference Intervals in China study (PRINCE), which aims to establish and verify pediatric reference intervals for Chinese children based on a nationwide multicenter cross-sectional study from January 2017 to December 2018. Quantile curves were calculated using the generalized additive models for location, shape, and scale method. The 2.5th, 50th, and 97.5th quantile curves were calculated for both total and differential white blood counts. Percents of stacked area charts were used to demonstrate the proportions of differential white blood cells. All statistical analyses were performed using R software.Results:Both 50th and 97.5th quantiles of total white blood cell count and monocyte count were highest at birth, then rapidly decreased in the first 6 months of life; relatively slow reduction continued until 2 years of age. The lymphocyte count was low during infancy and increased to its highest level at 6 months of age; it then exhibited moderate and continuous reduction until approximately 9 years of age. The pattern of neutrophil count changed with age in a manner opposite to that of lymphocyte count. Besides, there were two inter-sections of lymphocyte count and neutrophil count during infancy and at approximately 5 years of age, based on locally weighted regression (LOESS) analysis. There were no apparent age-related changes in eosinophil or basophil counts.Conclusion:These data regarding age-related changes in total and differential white blood cell counts can be used to assess the health of pediatric patients and guide clinical decisions.

简介：FGSwasisolatedandpurifiedfromlaminariajaponicabyenzymolysis,chromatographymethodsandsoon.ThehighbloodfatmodelwasestablishedbyfeedingmouseonhighfatfeedstuffComparedwithcontrolgroup,theconcentrationofHDL-C,theratioofHDL-C/TCincreased;whiletheconcentrationofTC,LDL-CandTGdecreasedinexperimentalgroups.Conclusion:FGSwasaneffectiveserumhipidregulatorandcanbedevelopedasmedicineandheahhfood.

简介：Basedonestablishednumericalmethodsandhydrodynamicperformancetestingfacilities,CFDtechniqueareappliedtoimprovethedesignoftheimplantableaxialflowbloodpumpandtheflowanalysis.(1)Applyingbrushlessmachinemagnetsteel,reducingitsthicknesswhileincreasingthelength,theflowchannel'scross-sectionisincreased,withnospaceconnectionbetweenthelargeandthesmallrotators,andwithaconetransitionsegmentfromthebearingtotheprincipalaxis,theflowismadesmoother.Therotatingspeedisloweredby1000rpm-1200rpmunderthesameflowrateandpressurehead,andthusthehemolysiscanbeavoided.(2)Differentoutletstatorguidingvanesareselectedforthesamebloodpumpforanalysesofhydrodynamicperformancesandflowfields.Anexcellentdesignnotonlycanregulatetherotatingflowfieldintoanaxialone,reducethecirculationlossandimprovethepumpefficiency,butalsocanavoidbackflow,vortexandsecondaryflowatthepumpoutlet,andthusthethrombuscanbeprevented.(3)Thecalflivetestsshowthatsomeresidualclotsexistattheinnerwalloftheoutletconnectionbends,whichareanalyzedandexplainedbyCFDtechniquesandthecorrespondingimprovementsareproposed.AllresultsareverifiedbyhydrodynamicperformancetestsandPIVflowfieldtests,andconsistentconclusionsareobtained.

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简介：ＡＦＲＥＱＵＥＮＣＹＤＯＭＡＩＮＱＵＡＮＴＩＴＡＴＩＶＥＭＥＡＳＵＲＥＭＥＮＴＭＥＴＨＯＤＦＯＲＢＬＯＯＤＦＬＯＷＶＥＬＯＣＩＴＹＷＩＴＨＢＩＤＩＲＥＣＴＩＯＮＡＬＤＯＰＰＬＥＲＵＬＴＲＡＳＯＵＮＤＡＶＯＩＤＩＮＧＤＯＷＮ－ＢＡＮＤＣＨＡＮＮＥＬＷａ...

简介：AIMTo评估变化在phacoemulsification(PC)和femtosecond激光(FSL)期间帮助了的血压(BP)奔流surgery.METHODSA回顾的图表评论为从2013年7月收到了传统的phacoemulsification外科(PC组)和帮助FSL的奔流外科(FS组)到2014年12月的所有病人被执行。完全，从收到过程的二种类型的133个病人的206只眼睛被包括。耐心的特征(年龄，性，和高血压历史)，外科手术前、手术后的位／秒是收缩的collected.RESULTSThe支持operative，心脏舒张的位／秒(公里Hg)是124.89摥琠?桴?楳楬潣敮瀠畬？

简介：Recombinanthumanprolactin(rhPRL)wasadministeredtohuPBL-SCIDmicetodetermineitseffectsonhumanimmunologicreconsfitutionandfunction.ThehuPBL-SCIDmiceweregiven10μgI.p.InjectionofrhPRLeveryotherdayforatotalof10injectionsafterhuPBLweretransferred.TheresultsdemonstratedthatrhPRLimprovedtheengraftmentoflymphocytesintothymus,lymphnodesandspleens,showingthatthecellularitiesoftheseorgansincreasedalthoughthecellularitiestendedtovarydependingonthedonor.TheamountsofhumanTcells(HLA-ABC+/CD3+)increasedgreatlyinthymus(14.2folds),spleen(4.16folds)andlymphnodes(40.18folds)afterrhPRLinjections.TheamountsofhumanBcells(HLA-ABC+/CD19+)alsoincreasedgreatlyinlymphnodes(42.5folds)andspleen(5.78folds).ThelymphnodecellsfromtherhPRL-treatedhuPBL-SCIDmiceweremoresensitivetoPHAstimulation([3H]thymidineincorporation).ThesupernatantofPHA-stimulatedPBLfromrhPRL-treatedhuPBL/SCIDchimerismcontainedmorecytokines(IFN-γandIL-2).Thenaturalcytotoxicityagainsthumansensitivetargetcells,K562cells,fromspleenandbonemarrowofhPBL/SCIDchimerismwassignificantlyenhancedbyrhPRLadministration.ThelymphnodecellswerestimulatedwithLPSinvitrofor3daysandthelymphocytesfromtherhPRL-treatedhuPBL-SCIDmiceweremoresensitivetomitogenstimulation.BothserumtotalIgGlevelandIgMlevelofrhPRL-treatedhuPBL/SCIDchimerismwereincreased,andevenwithoutDT-rechallengethebaselineofDT-specificIgGwaselevatedafterrhPRLtreatmentinhuPBL-SCIDmice.Thus,rhPRLstimulationpromotesreconstitutionofhumanimmunesysteminhuPBL-SCIDmice.

简介：AbstractBackground:The association between dietary sodium intake and blood pressure variability (BPV) in hypertensive patients remains unclear. The objective of this study was to demonstrate whether dietary sodium intake is a predictor of elevated BPV in Chinese patients with hypertension.Methods:A total of 235 patients with essential hypertension were enrolled in the Department of Cardiology, Chinese People’s Liberation Army (PLA) General Hospital in 2018 to 2019, all of whom underwent 24-h ambulatory blood pressure monitoring. BPV was calculated as the standard deviation (SD), coefficient of variation (CV), variation independent of mean (VIM) of blood pressure measurements, respectively, and divided into diurnal systolic BPV (SBPV), diurnal diastolic BPV (DBPV), nocturnal SBPV, and nocturnal DBPV. 24-h urine samples were collected to measure 24-h urine sodium excretion, which represents dietary sodium intake. The relationship between dietary sodium intake and BPV was analyzed by using Spearman correlations and multiple linear regression analysis.Results:Nocturnal SBPV-SD, CV, VIM, and nocturnal DBPV-SD in the high urine sodium excretion group were significantly higher than those in the medium and low urine sodium excretion groups, whereas diurnal SBPV-SD, CV, VIM, diurnal DBPV-SD, CV, VIM, and nocturnal DBPV-CV, VIM were not. Using the Spearman correlation analysis, we found a linear correlation between 24-h urine sodium excretion and nocturnal SBPV-SD, CV, VIM (SD, r= 0.22, P= 0.001; CV, r= 0.17, P= 0.009; VIM, r= 0.16, P = 0.020), nocturnal DBPV-SD (r = 0.21, P = 0.001), respectively. After further adjusting for confounding factors by multiple linear regression, the positive correlations remained between 24-h urine sodium excretion and nocturnal SBPV-SD, CV, VIM (SD, β= 0.224, P < 0.001; CV, β= 0.211, P= 0.001; VIM, β= 0.213, P= 0.001), nocturnal DBPV (SD, β= 0.215, P= 0.001), respectively.Conclusions:Dietary sodium intake is associated with nocturnal SBPV in Chinese patients with hypertension.

简介：Inthepresentstudy,theeffectofelectroacupuncture(EA)onimmunesystemwasobservedintheratbyusingmicro-wholeblooddirectimmunofluoreseenceStainingassaytodetectchangesoftheperipheralbloodTlymphocytesubgroupandemployingredbloodcell(RBC)C3breceptor-yeastrosettetestandredbloodcell-ICrosettetesttoanalyzeerythroeyticimmunefunction.ResultsshowedthatafterEAof“Zusanli”(ST36),CD4^+,RBC-C3bRRandRBC-ICRintheperipheralbloodofthenormalratsincreasedsignificantlywhileCD8^+hadnoanyconsiderablechangesandapositivecorrelationbetweenCD4+andRBC-C3bRRwasfound.Inimmuoosuppressionmodelrats,thevaluesofCD4^+andRBC-C3bRRwereobviouslylowerthanthoseofthenormalcontrolgroupwhileCD8^+hadnoanystrikingchanges;butafterEAtreatment,therewerenoevidentdifferencesbetweenEAgroupandnormalcontrolgroupintheabove-mentionedindexes.Therewerealsonoanysignificantdifferencesbetweennon-acupointgroupandnormalcontrolgroupinthoseindexes.ResultssuggestthatEAof“Zusanli”(ST36)canraiseTcellimmunefunctionandRBCadhesionfunctioninbothnormalratsandimmunosuppressionmodelrats,bothofwhichpresentapositivecorrelation.

简介：点刺耳穴目1和目2,并挤压出血,治疗85例麦粒肿患者,经过5次治疗,治愈63例,好转17例,无效5例,总有效率94.1%.

简介：Objective:Toobservetheeffectofacupunctureandmoxibustiononbloodlipidlevelinapoplectichemiplegiapatientswithomalgia.Methods:90casesofapoplecticherniplegiapatientswithomalgiawererandomlydividedintosimpleacupuncture(n=30),acupuncture+medication(n=30)andsimplemedication(n=30)groups.MainacupointsusedwereShuigou(GV26),Neiguan(PC6),Tongli(HT5),