简介:AbstractObjective:The aim of this work was to explore the feasibility of in vivo and non-invasive monitoring of deuterium/hydrogen (2H/1H) exchange at the metabolic level upon exposure to heavy water (2H2O).Methods:The healthy female mice were randomly assigned to two groups after day 0 when both mice received standard drinking water. The treated mouse was fed with 2H2O (80%, v/v) and the control mouse fed with standard drinking water (H2O) over next 13 days. Real-time mass spectrometric analysis of volatile metabolism emitted through breathing and the skin was performed on days 1, 2, 3, 10, 12, and 13. Animal experiment was approved by the Laboratory Animal Ethics Committee of Jinan University (approval No. 20161117163322) on October 29, 2021.Results:We observed a replacement of 1H by 2H in 52 mass spectral features (60 2H/1H isotopologue pairs) for the mouse fed with 2H2O, but not for the control mouse. These included pyruvic acid and lactic acid, lysine and methyl-lysine as well as short-chain fatty acids comprising acetic acid, propionic acid, butyric acid and valeric acid.Conclusion:Secondary electrospray ionization-high resolution mass spectrometry allows monitoring in vivo2H-incorporation of metabolites in a non-invasive and real-time setup and opens new opportunities to use 2H tracing to extend current metabolic studies, especially those with a focus on anaerobic glycolysis, lysine methylation and gut microbiome via monitoring of short-chain fatty acids.
简介:ThispaperstudiestheinfinitetimehorizonmixedH-two/H-infinitycontrolproblemfordescriptorsystemsusingNashgameapproach.Anecessary/sufficientconditionfortheexistenceofinfinitehorizonH-two/H-infinitycontrolispresentedintheformoftwocoupledalgebraicRiccatiequations,respectively.Finally,asuboptimalH-two/H-infinitycontrollerdesignisgivenbasedonaniterativelinearmatrixinequalityalgorithm.
简介:Thispaperreportstwolanthanidecomplexesofformula(C9H7)Ln(C8H8)·(THF)2whereLnisProrNd,C9H7isindenyl,andC8H8iscyclooctatetraene(COT).ThecomplexeswerepreparedbythereactionofLnCl3withK(C9H7)andK2(C8H8)inTHF.(C9H7)Pr(C8H8)·(THF)2crystallizesinTHFat-15℃inthemonoclinicspacegroupP21:withunitcelldimensionsa=8.446(0),b=10.083(2),c=13.407(3),β=105.48(1)°,V=1100.43(35)3,Dc=1.52g/cm3andZ=2.ThefinalRvalueis0.033,Rwvalueis0.030,respectively.In(C9H7)Pr(C8H8)·(THF)2afive-memberedringcentroidofC9H7,theC8H8ringcentroidandthetwooxygenatomsfromthetwoTHFmoleculesformadistortedtetrahedralgeometryaroundthemetal.
简介:摘要:《幼儿园教师专业标准》指出,幼儿园教师是履行幼儿园教育工作职责的专业人员,需要经过严格的培养与培训,具有良好的职业道德,掌握系统的专业知识和专业技能。这是国家对合格幼儿园教师专业素质的基本要求,也是幼儿园教师专业发展的基本准则。为使每一位教师都能驶入专业发展的快车道,有专业傍身,我园从厚言值、重研值、亮颜值三个维度开展了多种形式的学习和研训活动,让老师们在专业学习场中学习、历练和成长。
简介:摘要:社会经济的高速发展下,现代科学技术得到快速的进步,使得人们的物质生活水平不断提升,但同时也为电力行业带来了巨大的压力,尤其大量电子产品、电器在人们生活当中的广泛应用,对电力能源的需求急剧增长。在电力系统中,变压器是其重要的组成设备,在正常运行过程中,往往会受到多种因素的影响。而导致变压器发生一些故障或受到多种安全隐患的威胁。本篇文章将主要针对220KV变压器中性点间隙过电压保护与中性点间隙距离配合进行细致的分析,首先进行中性点零序电压向量分析,再确定继电保护间隙保护定值整定原则,最后从变压器中性点间隙距离的选择提出如何进行220KV变压器中性点间隙过电压保护与中性点间隙距离配合的建议。