简介：

简介：Objective:Toevaluatetheassociationbetweenobesityandtheriskofcolorectalcancer.Methods:331patientswithrectalcancerand175withcoloncancerwhoacceptedsurgicaloperationatBeijingCancerHospitalduring1995and2002wereenrolled.Datawerecollectedbyreviewingthepathologymaterialsandhospitalrecords.258healthypeoplewhoacceptedhealthexaminationatBeijingCancerHospitalduring2000and2002werealsoenrolledascontrol.Dataofheight,weightandgenderatthetimeofexaminationwerealsocollected.Obesitywasestimatedbybodymassindex(BMI),computedasweightinkilogramsdividedbyheightinmeterssquared(kg/m2).ThedegreeofobesitywascomparedbetweenthetwogroupsusingBMI(18.5,24-27.9and(28(kg/m2)asthecut-offpointsforunderweight,overweightandobesity.Associationswithobesitywereestimatedbyoddsratios(ORs)and95%confidenceintervals(CIs).AllORswereadjustedforageandsex.Results:Obesitywassignificantlyprevalentinfemalepatientswithrectalcancer.AllthepatientswithcoloncancershowedlowerlevelofBMIthancontrolsubjects.TheORsforrectalcancerrosewithincreasingBMIinwomen.Meanwhile,theORsforcoloncancerdroppedwithincreasingBMIinbothmenandwomen.Obesitywasanindependentriskfactorforrectalcancer,butnotanindependentriskfactorforcoloncancer.Conclusion:Rectalcancerandcoloncancermayhavedifferentbiologicalbehavior.Obesewomenhaverelativelyhighriskforrectalcancer.

简介：Objective:ToevaluatetherelationshipbetweentheefficienciesofsubsegmentalTAEandtheexpressionofPCNAwithABCimmunohistochemicalstaininginHCCs.Methods:Ultrasound-guidedneedlebiopsieswereperformedin43patients(41men,2women;agerange:32～75years,mean,55.6years).PCNAwereexaminedusingABCimmunohistochemicalstaining.TumorscoresofPCNAwereassessedbycountingthepositivenucleiper1,000cells.AllthecasesreceivedsubsegmentalTAEwithiodizedoilandgelatinsponge.AcorrelationbetweentheexpressionofPCNAandtheefficienciesofsubsegmentalTAEwassought.Normalitytest,ranksumtestandChi-squaretestwereusedinstatisticalanalyseswithSASpackage.Results:ThemeanPCNAlabelingindexwas58±29(range,27-100%)in43patients.Whencomparedwiththemacroscopicandpathologicparameters,PCNAlabelingindexwasfoundtobesignificantlyrelatedtothepresenceandactivityofcirrhosis.PCNAlabelingindexdidnotrelatedtopatients'age,sex,HbsAgstatusorserumα-fetoproteinlevel.ThePCNAlabelingindexcorrespondedtothedegreeofhistologicaldifferentiation(Edmenderson-Steinergrading).ThesurvivalratesaftersubsegmentalTAEwererespectively86.05%,65.12%and51.16%inone-,two-andthree-years,andweresignificantlyhigherinthelowlabelingindexgroupthanthatinthehighlabelingindexgroup.Conclusion:ThePCNAlabelingindexwasshowntobecloselyrelatedtohistologicalcharacteristicsandsurvivalofthepatients.

简介：Objective:Thepredictiveandprognosticroleofprognosticnutritionalindex(PNI)ingastriccancerpatientswithperitonealdisseminationremainsunclear.ThisstudyaimstoexploretheroleofthePNIinpredictingoutcomesofgastriccancerpatientswithperitonealdissemination.Methods:Atotalof660patientsdiagnosedwithgastricadenocarcinomawithperitonealmetastasisbetweenJanuary2000andApril2014atSunYat-senUniversityCancerCenterandtheSixthAffiliatedHospitalofSunYatsenUniversitywereretrospectivelyanalyzed.Theclinicopathologiccharacteristicsandclinicaloutcomesofpatientswithperitonealdisseminationwereanalyzed.Results:ComparedwithPNI-highgroup,PNI-lowgroupwascorrelatedwithadvancedage(P=0.036),worseperformancestatus(P<0.001),higherfrequencyofascites(P<0.001)andhigherfrequencyofmultisitedistantmetastasis(P<0.001).Kaplan-MeiersurvivalcurvesshowedthatPNI-highgrouphadasignificantlylongermedianoverallsurvivalthanPNI-lowgroup(13.13vs.9.03months,P<0.001).MultivariatesurvivalanalysisrevealedthatBorrmanntypeIV(P=0.014),presenceofascites(P=0.017)andlowerPNI(P=0.041)wereindependentpoorprognosticfactors,andpalliativesurgery(P<0.001)andfirst-linechemotherapy(P<0.001)weregoodprognosticfactors.Forpatientsreceivingpalliativesurgery,thepostoperativemorbidityratesinthePNI-lowgroupandPNIhighgroupwere9.1%and9.9%,respectively(P=0.797).ThepostoperativemortalityratewasnotsignificantlydifferentbetweenPNI-lowandPNI-highgroups(2.3%vs.0.9%,P=0.362).Conclusions:PNIisausefulandpracticaltoolforevaluatingthenutritionalstatusofgastriccancerpatientswithperitonealdissemination,andisanindependentprognosticfactorforthesepatients.

简介：Objective:Patientswithheadandneckcanceroftensufferfrommalnutrition.Thisstudyaimstoinvestigatetheinfluenceofbodymassindex(BMI)ontheprognosisoflaryngealsquamouscellcarcinoma(LSCC).Methods:Atotalof473patientswithLSCCinitiallytreatedatSunYat-senUniversityCancerCenterbetweenJanuary2005andJuly2009wereretrospectivelyreviewed.SurvivalanalysiswasperformedbytheKaplan-MeiermethodandCoxregressionmodel.Results:LowBMIbeforetreatmentwassignificantlyassociatedwithpooroverallsurvivalinpatientswithLSCC(P<0.001).BMIwasanindependentprognosticfactorforpatientswithLSCC.Conclusion:LeannessbeforetreatmentwasassociatedwithpoorprognosisinpatientswithLSCC.GoodnutritionalstatusisfavorabletoimprovesurvivalinpatientswithLSCC.

简介：ＩＮＶＥＳＴＩＧＡＴＩＯＮＯＦＲＥＬＡＴＩＯＮＳＨＩＰＳＢＥＴＷＥＥＮＫＩ－６７ＳＣＯＲＥ，ＤＮＡＩＮＤＥＸ，ＡＮＤＨＩＳＴＯＬＯＧＩＣＧＲＡＤＥＩＮＳＯＦＴＴＩＳＳＵＥ　ＳＡＲＣＯＭＡＳＷａｎｇｙａｎｏｎｇ王亚农；ＳｈｉＤａｒｅｎ施达仁；ＳｈｅｎＺ...

简介：Objective:Tovalidatemalnutritionscreeningtoolofnutritionriskindex(NRI)againstpatient-generatedsubjectiveglobalassessment(PG-SGA)asagoldstandardtoolincolorectalcancerpatientsbeforeradiotherapy.Methods:Nutritionalstatusof52volunteercolorectalcancerpatientswithameanageof54.1±16.8yearswhoreferredtoradiotherapycenterwereassessedbyPG-SGA(goldstandardmethod)andNRI.Serumalbuminlevelsofpatientsweredeterminedbycolorimetricmethod.Acontingencytablewasusedtodeterminethesensitivity,specificity,andpredictivevalueoftheNRIinscreeningpatientsatriskofmalnutrition,incomparisonwiththePG-SGAinpatientsbeforeradiotherapy.Results:ThefindingsofPG-SGAandNRIshowedthat52%and45%ofpatientsinourstudyweremoderatelyorseverelymalnourishedrespectively.TheNRIhadasensitivityof66%andaspecificityof60%againstPG-SGA.Thepositivepredictivevaluewas64%andthenegativepredicativevaluewas62%.TheagreementbetweenNRIandPG-SGAwasstatisticallyinsignificant(kappa=0.267;P>0.05).Conclusions:Thefindingsofpresentstudyshowedthattheprevalenceofmalnutritionwashighinpatientswithcolorectalcancer.Moreover,NRImethodhadlowsensitivityandspecificityinassessingnutritionalstatusofpatientswithcancer.Itseemsthatthecombinationofanthropometric,laboratoryparametersandasubjectivescoringsystemmaybehelpfultoolsinscreeningofmalnutritionincancerpatients.

简介：Objective:ToinvestigatewhethervitaminDreceptorgene(VDR)BsmI-rs1544410andFokI-rs2228570polymorphisms,smokingduration,andbodymassindex(BMI)areriskfactorsforcutaneousmelanoma,especiallymetastaticmelanoma.Methods:Westudied120cutaneousmelanomacases[68stageIandIInon-metastaticmelanoma(NMetM)patients,plus52StageIIIandIVmetastaticmelanoma(MetM)patients],and120matchinghealthycontrolsfromnortheastItaly.VDRpolymorphismsweremeasuredbyrestrictionfragmentlengthpolymorphismanalysis.AbsenceorpresenceofBsmIandFokIrestrictionsiteswasdenotedby'B'and'F'orby'b'and'f,'respectively.Results:VDR-BsmIbbgenotypewasmorefrequentamongMetM(32.7%)thanamongNMetMcases(13.2%),withoddsratio(OR)=3.18.Comparisonofallmelanomapatientsvshealthycontrolsshowedthatthefollowingbiomarkerswereatrisk:≥20yearsofsmoking(OR=2.43);≥20yearsofsmokingcombinedwithbb(OR=4.78),Bb+bb(OR=2.30),Ff(OR=3.04),andFf+ff(OR=3.08);obesity(BMI>30Conclusions:RiskfactorsforcutaneousMetMincludetwoVDRpolymorphismscombinedwithsmokingdurationandobesity.Resultssuggestgene-environmentimplicationsinmelanomasusceptibilityandseverity.Futurestudiesinlargercohortsandinsubjectswithdifferentgeneticbackgroundarewarrantedtoextendourfindings.