简介：ObjectivesToinvestigatetherelationshipofserumleptinconcentrationwiththelipidsandbodymassindex(BMI)inpatientswithchroniccongestiveheartfailure(CHF).MethodsTheserumconcentrationofleptinin39patientswithCHF(14incardiacfunctionclassⅡ,21inclassⅢ,4inclassⅣ,NYHA)andin46patientswithcardiacfunctionclassⅠ(NYHA)wereassessedbyradioimmunoassay.ResultsTheserumconcentrationofleptinwere9.018±4.519μg/linCHFgroup(cardiacfunctionclassⅡ11.492±5.649μg/l,classⅢ7.763±3.321μg/l,classⅣ6.100±2.657μg/l);11.674±6.911μg/linclassⅠgroup.TheserumconcentrationsofleptinweresignificantlylowerinCHFgroup,ascomparedwithclassⅠgroup(P<0.05).Moreover,thedecreaseofserumleptinconcentrationwassignificantlycorrelatedwiththedecreasedserumconcentrationsoftotalcholesterol,triglyceride,bodymassindexandleftventricularejectionfractioninCHFgroup,respectively(P<0.05).ConclusionsThesignificanceofthedecreaseinserumleptininCHFpatientsneedsfurtherstudy.
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