简介：Acupuncture,asacomplementarytherapy,hasbeenusedtomanagethecancerassociatedsymptomsofcancerpatients.Toidentifytheefficacyandsafetyofacupunctureinthemanagementofcancer,thisreviewcriticallyanalysestherelevantpublicationsincludingbothexperimentalandclinicalstudies.Themajorityofstudiessuggestthatacupunctureeffectivelyrelievessomecancerrelatedsymptomssuchascancerpain,andsomeadverseeffectscausedbythecancerconventionaltreatmentssuchasnausea,vomiting,neutropeniaandxerostomia.

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简介：ObjectivesToevaluatethesafetyandefficacyoftransradialcoronaryprocedures(TRCP).MethodsThedataof83caseswhoacceptedtransradialcoronaryangiography(CAG)andtransradialpercutaneouscoronaryintervention(PCI)inourdepartmentweresummarized.Thesuccessrates,proximalcoronarycomplications,peripheralvascularcomplications,severevagalreflex,meanoperationtime(MOT),meanrecumbenttime(MRT),meanhospital-stayingtime(MHT)wereanalyzed.Thedatawerecomparedwiththatof420casesoftransfemoralcoronaryprocedures(TFCP)inthesameperiod.ResultsSuccessratesandproximalcoronarycomplicationsweresimilarinbothgroups.SeverevagalreflexeswerelessinTRCPgroupthaninTFCPgroup.MOTwaslongerinTRCPgroup.MRTandMHTwereshorterinTRCPgroup.12(14.5%)radialarteryspasm,3(3.6%)radialarteryobstruction,1suddenrespiratoryarrestcausedbyjugularhematomawereobservedinTRCPgroup.ConclusionsTheefficacyandsafetyofTRCParedefinite.TRCPismoreeconomical.ForthepurposeofproperlyevaluatetheperipheralvascularcomplicationsofTRCP,itisnecessarytopayspecialattentiontoradialarteryocclusion,radialarterystenosis,andjugularhematoma.

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简介：为fibromyalgia症候群(FMS)观察tuina操作的功效。

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简介：Thetraditionaleyesensitivityfunctionbasedonphotopicvisionisnotapplicableinthemesopicvisionstate.Themesopicvisionisstudiedbyusingthephotopicandscotopicvisionstatesensitivityfunctions.Andthemodelwhichlinksthemesopicsensitivitywiththephotopicandscotopicstatesisbuilt.Basedonthemodel,theluminousefficacyofmesopicvisioniscalculatedandappliedtothespectrumdistributionofLEDlightsources.TheresultsshowthattheluminousefficacyofacommercialYAGphosphorconvertedwhiteLEDisupto172.7lm/Watmesopicvision,whichis67.2%higherthanthatofphotopicvisionstate.WealsoconcludethattheoptimalspectralpowerdistributionoftheLEDwillgreatlyincreasethemesopicluminousefficacy.

简介：瞄准：评估功效和vardenafil的toler能力，一个phosphodiesterasetype-5(PDE-5)禁止者，在有可勃起的机能障碍(编辑)的亚洲种族的人。方法：在这未来，双窗帘，多民族的学习，亚洲人被使随机化收到vardenafil(10mg)或安慰剂(4:1比率)12个星期。主要功效变量是可勃起的功能的国际索引可勃起的功能领域(IIEF-EF)，和性相遇侧面(9月)与穿入和交际结束有关询问。重要吝啬的改进在所有三项措施被要求显示出vardenafil处理的积极好处。第二等的功效变量在勃起改进上包括了全球评价问题(GAQ)。结果：最少平方的吝啬的基线IIEF-EF领域分数(vardenafil14.6，安慰剂13.4)与在12个星期以后的中等编辑一致，vardenafil处理与安慰剂相比在IIEF-EF领域分数从基线与重要增加被联系(22.4对14.3；P<0.001)。Vardenafil在吝啬的成功为SEP-2评估的最少的广场(LS)从基线与重要改进被联系(vardenafil82.2对安慰剂43.6；P<0.001)并且SEP-3(vardenafil66.1对安慰剂24.0；P<0.001)。积极GAQ回答被81.8%vardenafil接受者对24.3%安慰剂接受者报导。不利事件被25.4%vardenafil组，报导温和、短暂的多数。结论：Vardenafil(10mg)是为在亚洲男人的中等编辑的一个高度有效、容忍得好的处理。这些结果增加在耐心的人口的一个范围为编辑的治疗表明vardenafil的安全和功效的数据的增加的数量。

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简介：客观化疗是治疗乳癌的一个有效工具，并且癌症特定的replicative侵入人体气管粘膜的病菌也是最近的年里的一个有希望的反肿瘤代理人。我们表明那个CNHK300罐头的调查目的调停选择的反肿瘤功效并且在HER-2过去表示的乳癌上与化疗生产协同的细胞毒性。我们由把E1A基因放在人的hTERT倡导者的控制下面设计了telomerase依赖的replicative侵入人体气管粘膜的病菌CNHK300的方法。由E1A表示的分析，我们在telomerase积极的乳癌房间然而并非在正常成纤维细胞房间在侵入人体气管粘膜的病菌染色体和E1A的选择表示证明了hTERT倡导者的忠实。由增长测试，我们进一步在正常成纤维细胞房间与显然稀释的增长在乳癌房间显示出CNHK300的有效复制。最后，我们由那个CNHK300病毒引起了有势力细胞溶解并且在正常细胞上与稀释细胞毒性在乳癌房间与化疗生产了协同的细胞毒性的MTT方法示威了。在这个病毒的结果，E1A基因成功地被放在人的hTERT倡导者的控制下面。象野类型的侵入人体气管粘膜的病菌一样高效地复制并且引起了集中的房间在HER-2过去表示的乳癌房间在试管内杀死的CNHK300病毒。相反，telomerase否定的正常成纤维细胞房间，没表示hTERT活动，不能支持CNHK300复制。有paclitaxel的CNHK300的联合治疗在癌症房间上改进了细胞毒性。我们结束那CNHK300的结论能生产选择的反肿瘤功效并且在表示乳癌上在HER-2上提高化疗的在试管内反应。

简介：AbstractIntroduction:Basal cell carcinoma (BCC) is the most common skin cancer which mainly affects the population over 50 years of age. In addition to surgical treatment, nonsurgical treatment is also an attractive option for some patients.We herein report a case of an 82-year-old man with BCC successfully treated with acitretin.Case presentation:An 82-year-old man presented with BCC on his left nose wing more than 2 years ago. Due to his unwillingness to accept treatment that may lead to pain, discomfort, or trauma, the patient was prescribed oral acitretin 25 mg twice daily [0.8 mg/(kg·d)] and was instructed to apply 2% fusidic acid cream topically once daily for trauma protection. The lesion progressively shrank in size after 4 weeks of treatment, and was almost completely resolved after 28 weeks of follow-up. The patient reported mild adverse effects, such as mild skin fragility and cheilitis, and apparent scaling skin, which caused minor discomfort but did not affect the continuation of treatment.Discussion:The pathogenesis of BCC is still unclear, but it has been demonstrated to be linked to overactive hedgehog signaling and its crosstalk with other pathways such as phosphoinositide 3-kinase and mammalian target of rapamycin. Acitretin could obviously inhibit cell growth and proliferation and down-regulate AMP-dependent protein kinases that plays critical role in the blocking of malignant progression of several tumors including BCC.Conclusion:We provide an effective alternative for the patients with BCC who are unwilling to receive surgical therapy.

简介：AbstractSevere fever with thrombocytopenia syndrome (SFTS), caused by a novel identified bunyavirus SFTS virus (SFTSV), was an emerging viral infectious disease that was firstly reported in China. There are no licensed vaccines and therapeutics against SFTSV currently. B-Propiolactone (BPL) inactivated whole virions of SFTSV strain AH12 were prepared as experimental vaccine in different antigen dose with or without Al(OH)3 adjuvant. The experimental SFTS vaccine was a satisfying immunogen, which could efficiently trigger the development of high levels of SFTSV NP-specific IgG antibodies and neutralizing antibodies against SFTSV Strain HB29 in BALB/c and C57/BL6 mice, and could induce SFTS virus-specific cellular immune responses to a certain extent. A single dose of vaccine was immunogenically insufficient in BALB/c mice; the second and third dose resulted in significant boost in antibody response. The use of Al(OH)3 adjuvant resulted in higher antibody titers. The mediate-dose of vaccine could induce as high and equivalent level of antibody titer as that of high-dose. The experimental SFTS vaccine in mediate-and high antigen dose with adjuvant resulted in solid protection of C57/BL6 mice against wild-type SFTSV challenge with markedly accelerated virus clearance from blood and spleen compared with controls. The experimental SFTS vaccine prepared in this study could efficiently elicit virus specific humoral and cellular immune responses in both BALB/c and C57/BL6 mice, and could protect C57/BL6 mice against SFTS virus challenge. These results supplied evidence that inactivated vaccine was a promising vaccine candidate for the prevention of SFTSV infection.

简介：BackgroundBasedonpreviousstudies,afragmentedQRS(fQRS)complex,asapredictivebiomarkerofmyocardialscarringcondition,couldbeusedtopredicttheoutcomesofcardiacresynchronizedtherapy(CRT).However,thisconclusionisstilldebatable.MethodsFiftyischemicornon-ischemiccardiomyopathypatientsfailure(aged65±10yrs,34males,16females)withrefractoryheart,diagnosedbythecriteriaofNewYorkHeartAssociationreceivedCRT.TheECGsof18patientswithafQRScomplex(dividedbyDas)werecomparedwiththoseof32patientswithoutafQRScomplex,whowereevaluatedby12-leadECGbeforeCRT.Thepatientswerefollowedupforsixmonths,and12-leadECGandechocardiographywerereviewed.Atleast15%reductionintheleftventricularend-systolicvolume(LVESV)wasdefinedasrespondersaccordingtothedataobtainedforbetween-groupandintra-groupanalysis.ResultsSixpatients(33.3%)inthefQRSgroupand24patients(75%)inthenon-fQRSgrouprespondedwell.Inaddition,comparisonsofindicatorsfromsurfaceECGandechocardiography6monthsafterCRTshowedthatthenon-fQRSgroupbenefitedfromCRTsignificantlymorethanthefQRSgroup.ConclusionsThefQRScomplexhasgoodpredictivevalueforresponsivenesstoCRT.Non-fQRScomplexpatientswithrefractoryheartfailuremaybenefitmorefromCRT,andthesepatientsneedtoreceivethistreatmentasearlyaspossible.

简介：QigongisapartoftraditionalChinesemedicine.Accordingtotheantiquetreaties,thefoundationsoftraditionalChinesemedicinearebasedinmaintainingtheharmonybetweenQi(energy),Jing(essence)andShen(spirit).Alterationsinthisharmonycandevelopanddeterminetheappearanceofdisease.TherapeuticeffectsofQigongarehelpfulinthepreventionandtreatmentofseveraldiseases.It'smainroleinrestoringbodyfunctionsisduetothecommunicationbetweeninternalorgans,tissuesandcells.ThemaingoalofthisworkistoshowtheefficacyofQigonginthetreatmentofadermatologicaldiseasecharacterizedbytheappearanceofcircularorovalpatchesofmissinghair,knownasalopeciauniversalis.Forwesternmedicinetheexactcauseofthisillnessisnottotallyrevealed,however,it'sattributedtopsycological,geneticsandmetabolicalterations.FromthetraditionalChinesemedicineperspective,hairalterationsareframedintheareaofthewaterenergy,representedbythekidneyorgan.TheresultsofQigongtreatmentsuggestedthatthecranialhairfollicleshadbeenactivatedsincethefirsttreatment.Astreatmentprogressed,thecranialhairfolliclescontinuedtogrow,what'smore,thebrightnessandpigmentationofthehairalsoincreased.Therefore,intheclinicalconditionsevaluated,Qigongcouldbeaneffectivealternativetreatmentinconsiderationofthevisibleevidenceaboutrapidandlonglastingresults.Besides,wedidnotobserveanysideeffectsofQigonginthiscase.

简介：From1990to2000,weusedHanssonpin,AOhollow-pullingscrew,andbendablescrewtotreat150casesoffreshfemoralneckfractureandtheresultwasanalysedtocomparetheefficacyofthethreemethodsofinternalfixation.

简介：摘要The COVID-19 pandemic affects a large number of patients with a rapid progression of respiratory failure often requiring hospitalization or intensive care unit treatment in some patients. Survivors of severe COVID-19 suffer from persistent weakness and cardiorespiratory failure. Feasibility and potential benefit of cardiopulmonary rehabilitation (CR) after COVID-19 remains unclear. Therefore, we retrospectively analyzed a cohort of COVID-19 patients in a single center inpatient rehabilitation clinic and describe performance and outcome during CR.Patients were referred from acute care hospitals for rehabilitation after severe COVID-19. The cohort (n＝28) was divided in ventilated or not ventilated patients for further analysis. 50% were female, mean age was 66 years and patients stayed in the acute hospital for 19.3±10.7 days before referral for CR. 17 patients (61%) needed previous ICU treatment in the acute care hospital. Risk factors, assessments and questionnaires on admission were comparable in both groups. Significant enhancements were observed in 6-minute walking test and Feeling Thermometer which were independent of previous ventilation status.In conclusion, comprehensive CR following COVID-19 is safe, feasible and effective. Improvements in physical performance and subjective health status were independent of previous ventilation.

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简介：AbstractImportance:Children with 5-alpha-reductase deficiency (5α-RD) and hypospadias present with micropenis, which makes it difficult to obtain sufficient tissue for urethral reconstruction.Objective:We investigated the therapeutic effects of oral testosterone undecanoate and established a standard androgen treatment protocol for patients with 5α-RD with micropenis.Methods:Patients with 5α-RD were treated with oral testosterone undecanoate for 3 months as a course. All patients were treated with no more than 3 courses. If the penile length (PL) reached 2.5 cm (the minimum criterion for surgery) or greater than or equal to -2.5 standard deviations (SDs) (lower limit of normal), testosterone undecanoate was considered to be effective.Results:The median age of 90 patients with 5α-RD was 1.7 years (0.9, 3.1 years). The baseline PL was 1.9 ± 0.6 cm before treatment. At the end of the first course, the PL of 63 patients (70%) reached 2.5 cm, and 49 patients (54%) reached greater than or equal to -2.5 SDs. After two treatment courses, the PL of 81 patients (90%) reached 2.5 cm, and 90 patients (100%) reached greater than or equal to -2.5 SDs. After three courses, the PL of all patients reached 2.5 cm, and all patients reached a PL greater than or equal to -2.5 SDs. No abnormal increase was observed in height-SD score, weight-SD score, or ratio of bone age to chronological age during the 1-3-year follow-up.Interpretation:After 3-9 months of treatment, PL increased to the target length. No severe adverse reactions were observed during follow-up. Testosterone undecanoate was safe and effective in children with 5α-RD with micropenis.

简介：观察aerosolized组A的吸入的功效的目的链状球菌(气体)在在老鼠治疗orthotopic肺癌症的准备当模特儿并且为肺癌症估计这个管理模式的可行性，安全，和有效性。方法路易斯肺癌(LLC)房间紧张经由intrathoracic注射被管理建立orthotopic肺癌症老鼠模型。在忍受肿瘤的模型成功地被建立，由计算断层摄影术证实了以后，老鼠被吸入与aerosolized气体准备(煤气的组)或aerosolized正常管理盐(控制组)。aerosolized气体准备的反肿瘤效果组织学地被评估；同时，生活的幸存和质量在这二个组之间被比较。aerosolized气体准备显著地显示出的结果反肿瘤效果，在忍受肿瘤的老鼠引起orthotopic肺癌症房间的坏死。而且，在煤气的组的鼠标在控制组比那些有生活和更长的幸存的显著地更好的质量。aerosolized气体准备的吸入可以是肺癌症的一个可行、安全、有效的解决方案的结论。