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简介：植物侵略创造新奇plantinsect相互作用。EICA(增加的竞争能力的进化)因为他们逃离他们的共同演变的昆虫天赋敌人，假设建议侵略植物将从防卫重新分配资源到生长或复制。由monophagous和寡食性的草食动物和各种各样的植物特点的同时的测量的严峻的多重herbivory将提供新卓见进侵略植物的进化变化。在这上下文，我们进行了一个普通花园实验比较植物生长和复制，化学、物理的防卫，和对由在侵略北美的人口和mile-a-minute的本国的东方亚洲人口之间的草食动物的不同类型的herbivory的植物回答除草，Persicariaperfoliata。我们发现侵略mile-a-minute展出了更低的生物资源，flowered更早、有的更大的繁殖输出比从本国的范围的植物。与本国的人口相比，从侵略人口的植物有更低的丹宁内容，但是在节点和叶子上展出了更高的皮刺密度。因此，我们的结果部分支持EICA假设。当暴露了到monophagous昆虫，Rhinoncomimuslatipes和寡食性的昆虫时，Gallerucidagrisescens和Smaragdinanigrifrons，由herbivory的更多的损坏比在土著人上在侵略植物上被发现。R。latipes，G。grisescens和S。nigrifrons分别地在mile-a-minute的生长和繁殖上有强壮、中等、弱的影响。结果显示mile-a-minute可能发展了一个更高繁殖的能力在里面与缺乏一起的介绍范围，和这寡食性并且在新范围的monophagous草食动物可能在北美洲贡献了它的侵略。

简介：精子不是成熟的直到他们运输他们获得使肥沃的活动性和能力的epididymis通过顺序的修正的一颗卵。epididymis有三功能的区域，头，语料库，和尾，和epididymis的钠蛋白质在上述修正起重要作用。然而，有在头和尾之间的微分丰富的蛋白质大部分仍然是未知的。在精子成熟期间揭示头和尾的函数，从鼠标的头和尾的钠蛋白质被等压的标签为相对、绝对的quantitation(iTRAQ)分析。总的来说，128差别充实蛋白质被发现，哪个46是充实的头，82是充实的尾。生物信息的分析证明那类脂化合物新陈代谢在头是活跃的；当阴离子绑定和阳离子绑定活动和磷和organophosphate新陈代谢在尾是活跃的时。新epididymal钠蛋白质，包含1的充实头的PDZ领域(Pdzk1)，也把Na+/H+交换称为规章的余因子3(NHERF3)，它在胆固醇新陈代谢和肉毒碱运输起一个关键作用，在类脂化合物新陈代谢被发现。西方的弄污和immunofluorescence分析证明Pdzk1在epididymis然而并非在睾丸被表示，并且在精子尾巴的中间的片局部性。Pdzk1蛋白质水平也在normozoospermic人与那相比在asthenozoospermic病人的情况下在精子被减少，建议Pdzk1可以参予精子成熟规定并且可以与男不孕被联系。这些结果可以提供新卓见进精子成熟和男不孕的机制。

简介：瞄准：在正常检测易碎的组氨酸三个一组(FHIT)的表示，并且分析它的关系，织物CRC，和联系apoptosis的蛋白质展示clinicopathological渲染表面的织物，渲染表面的腺瘤并且渲染表面的癌症(CRC)(Bcl-2，Bax，survivin)并且在颜色的apoptosis表面的癌症。方法：FHITmRNA分析被嵌套的反向的抄写聚合酶执行链反应(RT-PCR)试金。织物微数组(TMA)被建立在80个CRC织物标本检测FHIT，Bcl-2，Bax和survivin基因的表示，16在象控制的时间的一样的时期期间渲染表面的腺瘤织物标本和16个痔(PPH)织物标本。Citrate-microwave-SP被用作免疫组织化学的方法。在clinicopathological因素之间的关系，例如区别，等级和5年的幸存率被观察。TUNEL试金被用来在80个CRC织物标本检测apoptosis索引。结果：十(38.5%)从26，CRC织物标本表示了异常FHIT抄本，任何一个都没在匹配的正常织物异常FHIT抄本被观察并且由嵌套的RT-PCR渲染表面的腺瘤织物试金。在正常的FHIT基因表示的积极的率渲染表面的织物，渲染表面的腺瘤和癌织物分别地是93.75%，68.75%和46.25%。病人的Clinicopathological分析证明减少的FHIT基因表示没与年龄，性别，浆液CEA层次，肿瘤地点和尺寸被联系，组织学的分类。然而，FHIT的表示与等级，病理学的阶段，淋巴节点转移和5年的幸存在操作以后评估的区别被相关。在CRC织物的联系apoptosis的蛋白质(Bax，Bcl-2和survivin)的积极的率分别地是72.50%，51.25%和77.50%。在CRC织物的这些联系apoptosis的蛋白质的表示与FHIT的表示被相关。在FHIT否定肿瘤的吝啬的apoptosis索引在FHIT积极肿瘤是比那显著地低的(5.41+/-0.23对0.56+/-0.10，P<0.01)。结论：FHIT基因在apoptosis的规定起一个重要作用，减少的FHIT表示在肤色的开始和前进起一�

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简介：AbstractBackground:Healthcare workers (HCWs) were the priority group for influenza vaccination, in China during the 2020/2021 and 2021/2022 influenza seasons. However, vaccination rates in HCWs have always been low. This study investigated influenza vaccination status among Chinese HCWs and analyzed the factors driving vaccination.Methods:We provided electronic questionnaires to HCWs from January 27, 2022 to February 21, 2022, using the WeChat platform "Breath Circles". HCWs who received the link could also forward it to their colleagues. Binary logistic regression models were used to analyze vaccination-associated factors among HCWs.Results:Among the 1697 HCWs surveyed, vaccination coverage was 43.7% (741/1697) during the 2020/2021 influenza season, and 35.4% (600/1697) during the 2021/2022 influenza season, as of February 21, 2022. Additionally, 22.7% (385/1697) and 22.1% (358/1697) of HCWs reported that their workplaces implemented a free vaccination policy for all employees during the 2020/2021 and 2021/2022 influenza seasons. HCWs who were required to be vaccinated according to hospital regulations, and whose hospitals implemented the free influenza vaccine policy were more likely to be vaccinated (2020/2021 and 2021/2022; P < 0.05). In addition, the economic level of the HCWs' province (2021/2022, P < 0.05) and the HCWs’ knowledge about vaccination and willingness to get vaccinated, such as active learning about vaccines (2020/2021, P < 0.05), supportive attitude toward vaccination for all HCWs (2020/2021 and 2021/2022; P < 0.05), also had an impact on vaccine coverage.Conclusions:A free influenza vaccination policy and workplace required vaccination are effective in improving influenza vaccination coverage among HCWs. Influenza vaccination coverage of Chinese HCWs remained low and showed a downward trend after the COVID-19 outbreak. Further effective measures, such as advocacy campaigns, free vaccine policies, and on-site vaccination could be implemented to improve influenza vaccination coverage.

简介：Usingaspecialconstantdeflectiondevice,thechangesindislocationconfigurationaheadofaloadedcracktipfor60Fe40Nialloy,beforeandaftermagnetizationinamagneticfield,havebeenstudiedinTEM.Theresultsshowedthatthemagnetizationfor60Fe40Nialloycouldenhancedislocationemission,multiplicationandmotion.Also,themechanicalpropertiesof60Fe40Nialloy,inairandinthemagneticfieldrespectively,havebeeninvestigatedusingtheslowstrainratetension.Andtheresultsindicatedthatmagnetizationcouldmaketheyieldstrengthcorrespondingtodecreaseby26percent,butdidnotinfluencetheultimatetensilestrengthandthefracturestrain,whichshowedthatmagnetizationcouldenhanceplasticdeformation.

简介：<正>Usingsubtractioncloning,weidentifiedthehumanN-MycDownstream-RegulatedGene-2(hNDRG2),locatedat14q11.2,asacandidatetumorsuppressorgene.Semi-quantitativeRT-PCRshowedthattheexpressionofhNDRG2in15of27(56%)humanGBMtissuesandall6humanglioblastomacelllineswassignificantlylowerthanthatinthenormalbrain.TheexpressionofhNDRG2alsowasevaluatedin60lung-carcinomapatients.17of26casesofsquamouscarcinomaand4of11casesofsmallcelllungcancerdisplayed

简介：AbstractBackground:Whether smoking is related to a decreased risk of meningioma in women is still controversial. We conducted a systematic review and meta-analysis examining the association between smoking and risk of meningiomas in women.Methods:Two authors independently performed a systematic literature review in the PubMed, Cochrane Library, and EMBASE databases. We identified case-control and cohort studies quantifying associations between smoking and risk of meningioma in women. A meta-analysis by pooling studies was performed according to the multivariate-adjusted risk estimates and 95% confidence intervals (CIs) preferentially. We further conducted additional subgroup and sensitivity analyses to explore possible explanations of the results.Results:A total of seven observational studies were included, with a total of 2132 female patients diagnosed with meningiomas. Ever smoking was associated with a significantly reduced risk of meningioma in women, with pooled odds ratio (OR) of 0.83 (95% CI 0.70-0.98). Similar findings were noted for current (OR 0.78, 95% CI 0.66-0.93) and past (OR 0.82, 95% CI 0.71-0.94) smokers. However, considering the areas, the OR of ever smoking was 0.77 (95% CI 0.68-0.87) in three American studies, but 0.99 (95% CI 0.73-1.35) in four studies conducted in other countries.Conclusions:Based on limited epidemiological evidence, a decreased risk of meningioma in women smokers was only observed in American studies rather than studies conducted in other countries.

简介：Objectiveandbackground:Althoughp21rashasbeenreportedtobeupregulatedinhepatocellularcarcinomacomplicatingchronichepatitisCtypeI,p21rashasadifferentroleinadvancedstages,asithasbeenfoundtobedownregulated.Thegoalofthisstudywastoinvestigatethestatusofp21rasinearly-stage/low-gradeandlate-stage/high-gradehepatocellularcarcinomaanditspossiblelinktoapoptosis.Materialandmethods:Thirty-fivecaseseachofchronicHCVhepatitistype4(groupI)andcirrhosiswithhepatocellularcarcinoma(HCC)complicatingchronicHCVhepatitis(groupsIIandIII)wereimmunohistochemicallyevaluatedusingap21raspolyclonalantibody.Theapoptoticindexwasdeterminedinhistologicsectionsusingtheterminaldeoxynucleotidyltransferase-mediatedd-UTPbiotinnickendlabeling(TUNEL)assay.Results:Significantdifferences(P=0.001)weredetectedinp21rasproteinexpressionbetweenthethreegroups.Anear2-foldincreaseinp21rasstainingwasobservedinthecirrhoticcasescomparedtothehepatitiscases,andp21rasexpressionwasdecreasedintheHCCgroup.p21rasexpressioncorrelatedwithstage(r=0.64,P=0.001)andgrade(r=-0.65,P=0.001)intheHCCgroupandgradeintheHCVgroup(r=0.44,P=0.008).Bothp21rasexpressionandTUNEL-LIweresignificantlylowerinlargeHCCscomparedtosmallHCCs(P=0.01each).TheTUNELvalueswerenegativelycorrelatedwithstageintheHCCgroup(r=-0.85,P=0.001).TheTUNELvalueswerealsonegativelycorrelatedwithgradeinboththeHCVandHCCgroups(r=0.89,P=0.001andr=-0.53,P=0.001,respectively).Thep21rasscoresweresignificantlycorrelatedwiththeTUNEL-LIvaluesintheHCCgroup(r=0.63,P=0.001)andHCVgroup(r=0.88,P=0.001).Conclusions:p21rasactsasaninitiatorinHCCcomplicatingtype4chronicHCVandisdownregulatedwithHCCprogression,whichmostlikelypromotestumorcellsurvivalbecauseitfacilitatesthedownregulationofapoptosiswithtumorprogression.