简介：Objective:Toobservethelong-termeffectofhomoharringtonine(HHT)onchronicgranulocyticleukemia(CGL)anditspharmacologicalmechanism.Methods:76patientswithnewlydiagnosedearlychronicphaseCGLreceivedtreatmentofmerely1.5mg/m2dailyHHTforinductionremissionandlong-termmaintenancetreatment.TheapoptosisrateofbonemarrowCD34+cellsinducedbyHHTwasassayedwithflowcytometer.Results:86.8%patientsachievedCHR,13.2%patientsPHRand31.8%patientsgotcytogeneticresponseinHHTtreatmentgroup,whichwaslongerthan31(8-54)monthsinhydroxyurea(HU)group(P<0.05).TheeffectofapoptosisinductionHHTwasstrongeronCGL-CPpatientsbonemarrowCD34+cellsthanonnormalpersonbonemarrowCD34+cells.Conclusion:HHTisaveryeffectivedrugforremissioninductionandlong-termmaintenancetreatmentinearlychronicphaseCGLpatients.

简介：Objective:Toinvestigatetheprevalenceoflong-termfatigue,anxiety,depressionandsocialsupport,andtherelationshipsamongthesesymptomsinpostoperativepatientswithbreastcancer.Methods:Atotalof180postoperativepatientswithbreastcancermeetingcriterionwererecruitedinthiscross-sectionalstudy.TheBriefFatigueInventory(BFI),HospitalAnxietyandDepressionScale(HADS)andTheSocialSupportSurvey-Chineseversionwereusedtoassessingthefatigue,anxietyanddepression,Socialsupportofparticipants.ThemagnitudeoftherelationshipamongthesymptomsoffatigueandothervariableswasmeasuredbySpearmanRhocorrelation.Results:Theprevalenceoflong-termfatiguewas52.7%,and18.3%occurredmoderate/severefatigue.Two-thirdsofpatientshadabasalsocialsupport,only12.8%ofpatientshadbetter-perceivedsocialsupport.ResultsofHADSshowedthat16.7%and21.1%oftheparticipantshaveanxietyordepressiondisorder.Moderate/severefatiguewasnegativelycorrelatedwithsocialsupport(r=–0.158,P=0.038)andpositivelycorrelatedwithage(r=0.132,P=0.042),chemotherapy(r=0.297,P=0.027),anxiety(r=0.324,P=0.018)anddepression(r=0.211,P=0.034).Conclusions:Long-termfatiguewashighlyprevalentamongoverhalfofpostoperativepatientswithbreastcancer,andmoderate/severefatiguewasassociatedwithsocialandpsychologicalfactorssuchassocialsupport,anxietyanddepression.Ourresultssuggestthatoverallnursingcaremaybeamoreeffectivemannerinimprovingfatigueandqualityoflife.

简介：Molecularsubtypingofbreastcancermayprovideadditionalprognosticinformationregardingpatientoutcome.Theepidermalgrowthfactorreceptor(HER2)overexpressingbreastcancersaredesignatedasHER2-postive(HER2+)breastcancerandcarryaparticularlyunfavorableprognosis.WepresenttwocasesofHER2-postivemetastaticbreastcancer(MBC)whoarefoundtobeachallengetotreat,especiallyduetotheoccurrenceofbrainmetastasis.Trastuzumab-basedtherapyimprovesclinicaloutcomes,evenifthepatienthasundergonemulti-linetreatment.ThesecasereportsalsoemphasizetheimportanceofretestingHER2statusbecauseitcanbediscordanceinreceptorstatusbetweenprimaryandrecurrentbreastcancer.

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简介：Non-small-celllungcancer(NSCLC)accountforapproximately80%ofalllungcancer.Onlyalowpercentageofpatientspresentdiseasesusceptibletosurgicalresection.30%to40%ofpatientswithNSCLCpresentwithlocallyorregionallyadvancedunresectabletumors.lllChestirradiationp...

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