简介:Thequestforneuroprotectivedrugstoslowtheprogressionofneurodegenerativediseases(NDDs),includingAlzheimer'sdisease(AD),Parkinson'sdisease(PD),andHuntington'sdisease(HD),hasbeenlargelyunrewarding.Preclinicalevidencesuggeststhatrepurposingquetiapine,lithium,valproate,fluoxetine,donepezil,andmemantineforearlyandpre-symptomaticdisease-modificationinNDDsmaybepromisingandcanspareregulatorybarriers.Theliteratureofthesepsychotropicsinearlystageandpre-symptomaticAD,PD,andHDisreviewedandpropitiousfindingsfollow.Mildcognitiveimpairment(MCI)phaseofAD:salutaryhumanrandomizedcontrolledtrialfindingsforlow-doselithiumand,inselectedpatients,donepezilawaitreplication.Pre-symptomaticAD:humanepidemiologicaldataindicatethatlithiumreducesADrisk.Animalmodelstudies(AMS)revealencouragingresultsforquetiapine,lithium,donepezil,andmemantine.EarlyPD:valproateAMSfindingsshowpromise.Pre-symptomaticPD:lithiumandvalproateAMSfindingsareencouraging.EarlyHD:uncontrolledclinicaldataindicatenon-progressionwithlithium,fluoxetine,donepezil,andmemantine.Pre-symptomaticHD:lithiumandvalproateareauspiciousinAMS.Manyotherpromisingfindingsawaitingreplication(valproateinMCI;lithium,valproate,fluoxetineinpre-symptomaticAD;lithiuminearlyPD;lithium,valproate,fluoxetineinpre-symptomaticPD;donepezilinearlyHD;lithium,fluoxetine,memantineinpre-symptomaticHD)arereviewed.Dose-andstage-dependenteffectsareconsidered.Suggestionsforsignal-enhancementinhumantrialsareprovidedforeachNDDstage.
简介:摘要目的通过对35至64岁农村妇女开展免费宫颈癌检查的方式,了解自流井区农村妇女宫颈癌的发病情况,提高农村妇女宫颈癌早发现、早诊断,早治疗率,探索宫颈癌及癌前病变与年龄的关系以及防治措施。方法对全区7个乡镇35~64岁的部分农村妇女共5000人,采用巴氏涂片的方法进行宫颈癌筛查,初筛异常者104人进行阴道镜检查,其中阴道镜检查异常者11人,行阴道镜下宫颈组织病理学检查。结果5000名妇女参加免费筛查,筛查率21.16%,宫颈脱落细胞异常者104人(2.08%),35至40岁17例,41~50岁50例,51~60岁20例,61~65岁17例;阴道镜检查结果显示异常11例(0.22%),活检结果,CIN11例,CIN22例,CIN31例,慢性宫颈炎7例。CIN1-CIN3的发病高峰年龄为41~50岁的妇女。结论农村妇女宫颈癌筛查率较低,我国开展的适龄农村妇女宫颈癌免费筛查项目是早期发现宫颈癌前病变和宫颈癌的重要措施,对提高农村妇女宫颈癌早诊早治率,提高农村妇女自我保健意识和健康水平具有积极的意义。