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214 个结果
  • 简介:Intramolecularvibrationsoflargemacromoleculesresideintheterahertzrange.Inparticular,proteinvibrationsarecloselyspacedinfrequency,resultinginanearlycontinuousvibrationaldensityofstates.Thisdensityofvibrationsinterfereswiththeidentificationofspecificabsorptionlinesandtheirsubsequentassociationwithspecificfunctionalmotions.Thischallengeiscompoundedwiththeabsorptionbeingdominatedbythesolventandlocalrelaxationalmotions.Astrategyforremovingtheisotropicrelaxationallossandisolatingspecificvibrationsistousealignedsamplesandpolarization-sensitivemeasurements.Here,wedemonstrateatechniquetorapidlyattaintheanisotropicresonantabsorbanceusingterahertztimedomainspectroscopyandaspinningsample.Thetechnique,modulatedorientation-sensitiveterahertzspectroscopy(MOSTS),hasanonzerosignalonlyforanisotropicsamples,asdemonstratedbyacomparisonbetweenasiliconwaferandawiregridpolarizer.Forsucroseandoxalicacidmolecularcrystals,theMOSTSresponseisinagreementwithmodeledresultsfortheintermolecularvibrations.Further,wedemonstratethat,eveninthepresenceofalargerelaxationalbackground,MOSTSisolatesunderlyingvibrationalresonances.

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  • 简介:AbstractPreoperative neoadjuvant chemoradiotherapy, combined with total mesorectal excision, has become the standard treatment for advanced localized rectal cancer (RC). However, the biological complexity and heterogeneity of tumors may contribute to cancer recurrence and metastasis in patients with radiotherapy-resistant RC. The identification of factors leading to radioresistance and markers of radiosensitivity is critical to identify responsive patients and improve radiotherapy outcomes. MicroRNAs (miRNAs) are small, endogenous, and noncoding RNAs that affect various cellular and molecular targets. miRNAs have been shown to play important roles in multiple biological processes associated with RC. In this review, we summarized the signaling pathways of miRNAs, including apoptosis, autophagy, the cell cycle, DNA damage repair, proliferation, and metastasis during radiotherapy in patients with RC. Also, we evaluated the potential role of miRNAs as radiotherapeutic biomarkers for RC.

  • 标签: MicroRNAs Rectal cancer Radiotherapy Mechanisms
  • 简介:Forearthquakedisastermitigation,weusehistoricalrecordsandmorecompleteintensityinvestigationdatafrom1500to2015toanalyzeandestimatetheseismicintensityandfrequencyoftheearthquake-proneareasinYunnan.WedigitizedintensityobservationsanddividedtheYunnanregionintocellsizeof0.2°x0.2°tocalculatetheseismicintensity-frequencyrelationshipforeachcell.CombinedwitharepeatedcycleofintensityofonehundredyearsandpopulationeconomicsdatainYunnan,weanalyzefutureareasofconcern.Theresultscanprovideareferenceforearthquakehazardousareazoning.Thismethodisbasedonhistoricalearthquakedata,reducingasmuchaspossiblethevarioushypothesesfortheassessment,andthuscanconciselyreflectthedifferentintensityfrequencydistributionsoftheregion.

  • 标签: Intensity-frequency SEISMIC INTENSITY YUNNAN area
  • 简介:Arecentlyintroducednonlinearmodelundergoesevaluationsbasedontwoisotropicturbulentcases:aUniversityofWiscosion-MadisoncaseatamoderateReynoldsnumberandaJohnsHopkinsUniversitycaseatahighReynoldsnumber.Themodelusesanestimationofthesubgrid-scale(SGS)kineticenergytomodelthemagnitudeoftheSGSstresstensor,andusesthenormalizedvelocitygradienttensortomodelthestructureoftheSGSstresstensor.Testingisperformedforthefirstcasethroughacomparisonbetwee...

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  • 简介:Thecombinationofradiotherapy(RT)andfunction-preservingsurgeryisthemostusualcontemporaryapproachinthemanagementofsofttissuesarcomas(STS).Pre-andpostoperativeRTresultinsimilarlocalcontrolrates,asshownbyalandmarktrialinextremitySTS.Inthisreview,theroleofRTinthemanagementofextremitySTSwillbediscussed,butSTSinothersites,includingretroperitonealSTS,willalsobeaddressed.ThefocuswillconsidervariousaspectsofRTincludingstrategiestoreducethevolumeoftissuebeingirradiated,dose,scheduling,andthepossibleofomissionofRTinselectedcases.Finally,technologyadvancesthroughtheuseofintensity-modulatedradiotherapy(IMRT),image-guidedIMRT,intraoperativeradiotherapy(IORT)andparticletherapywillalsobediscussed.

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  • 简介:Macroseismic紧张数据在可靠地震损失模型发展也在地震危险分析的过程起一个重要作用。这份报纸论述一个物理底的模型基于在时间时期1975-2013在伊朗获得的560紧张数据预言macroseismic紧张变细。几何传播和震波的精力吸收在建议模型被考虑了。求婚对工具关系容易简单地把紧张描述为时刻大小,到地点距离的来源和焦点的深度的功能。建议模型的预言能力借助于剩余分析被估计。预言结果与为意大利,土耳其,伊朗和中亚的另外的紧张预言模型的那些相比。结果在远处为学习区域显示更高的变细率不到70km。

  • 标签: 伊朗 损失模型 危险分析 预言 模型基 意大利
  • 简介:Theglassytransitionofthepolyethyleneterephthalate(PET)sampleswhichhavebeensubjectedtosolventinducedcrystallization(SINC)wasinvestigatedbymodulateddifferentialscanningcalorimetry(MDSC)anddensitymeasurement.Thedif-ferentialofheatcapacitysignal,dC_p/dTfromMDSC,wasusedtomonitortheSINCprocess.ItrevealsthattheT_gtemperatureshiftstohighervaluewiththeadvancementofSINC.Whenthetoluene-immersingtimewaslonger(168h),thedetectionofT_gbecomemoredifficult,becausesomesmallerpeaksemergedatthelowertemperaturesandtheseareexplainedasthemovementofsmallsegmentsintheamorphousregion.TheseobservedresultsareduetothemorphologyandstructureintroducedbytheSINCprocess.

  • 标签: MODULATED DSC POLYETHYLENE TEREPHTHALATE SINC
  • 简介:这个工作被奉献给从被另一Markov链调制的随机的序列(称为的主要序列)的实验措施产生的随机的系统。Markov链被用来为没在主要序列被代表的随机的分离事件建模。一个新奇特征是代替在实验措施序列的平常的可伸缩,作者考虑在空间和时间可伸缩,它导致新限制结果。在宽广条件下面,实验措施的一个放大序列微弱地收敛到连续时间的Markov链调制的很多座Brownian桥,这被显示出。分枝和特殊情况也被考虑。

  • 标签: 随机系统 连续时间马尔可夫链 随机序列 经验测度 离散事件 弱收敛
  • 简介:Incomparisonwiththenormalpeoplegroup,valuesofbloodCD2+andCD4+inpa-tientswithmallgnanttumorstreatedwithradiotherapyandchemotherapyweresignificantlylowerandtheratioofCD助+andCD8+decreasedobviously(allP<0.001);CD8+hadnoapparentchange(P>0.05).Followingacupuncturaltreatment,valuesofCD2+,CD4+andtheratioofCD4+toCD8+increasedobviously(allP<0.001);whilethoseofthemedicinalcontrolgrouphadnosignificantchangeaftertreatment(P>0.05).ValuesofIgG,IgAandIgMinpatients’serumpresentedanabnormalde-creasingorincreasingtendency,andC3inminorityofpatientswereraised.ResultsindicatedthattherewasabiphasicregulatoryeffectofacupunctureonthedisturbanceofhumoralimmunityandcouldcorrectthedeviationofC3level;anditseffectwasbetterthanorsimilartothatofthemedicinecontrolgroup.Itdemonstratesthatacupuncturecanenhanceandregulate.theimmunefunctionofpa-tientstreatedwithradiotherapya

  • 标签: RADIOTHERAPY and chemotherapy/side-effects IMMUNE activity ACUPUNCTURE
  • 简介:Wepresentamethodtogenerateafrequency-doubledmicrowavesignalbyemployingacoupling-modulatedringresonator.CriticalcouplingisachievedwhentheresonatorintrinsiclossisperfectlybalancedbytheexternalcouplingenabledbyaMach–Zehnderinterferometercoupler.Thehighsuppressionofthecarrierleadstoacleantwo-toneopticalsignalwiththefrequencyintervaltwotimeslargerthanthatoftheinputmicrowavefrequency.Thebeatingofthetwo-tonesignalataphotodiodegeneratesthefrequencyupconvertedmicrowavesignal.Atheoreticalmodelisestablishedtoanalyzethemodulationprocessandthemicrowavesignalgeneration.Experimentalresultsshowthattheelectricalharmonicsuppressionratioisaround~20dB(29dB)foraninputmicrowavesignalwith5dBm(10dBm)power.

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  • 简介:ConsiderastoragemodelfedbyaMarkovmodulatedBrownianmotion.Weprovethatthestationarydistributionofthemodelexitsandthattherunningmaximumofthestorageprocessovertheinterval[0,t]growsasymptoticallylikelogtast→∞.

  • 标签: 马尔可夫过程 随机过程 固定分布 渐近性
  • 简介:Theevolutioncharacteristicsofamatter-wavebrightsolitonareinvestigatedbymeansofthevariationalapproachinthepresenceofspatiallyvaryingnonlinearity.Itisfoundthattheatomdensityenvelopeofthesolitonischangedasaresultofthespatialvariationofthes-wavescatteringlength.Thestablesolitoncanexistinappropriateinitialconditions.Themovementofthesolitondependsonthesignandvalueofthecoefficientofspatiallymodulatednonlinearity.Thesetheoreticalpredictionsareconfirmedbythefullnumericalsimulationsoftheone-dimensionalGross-Pitaevskiiequation.

  • 标签: 非线性系数 空间调制 亮孤子 演化 物质波 变分方法
  • 简介:当常规时近地的声学的雷射摄影术不技术是健全的地由调制信号导致了的appliedto,modulating频率不能被重建的结果揭示。解决这个问题,一不,为调制健全来源的分析方法论被建议。第一,Hilbert变换被介绍使解调信号,然后modulating部件被重建由不技术。数字模拟和实验结果证明精确重建分析能被建议方法获得。

  • 标签: 调制信号 全息分析 近场 声源 声全息技术 希尔伯特变换
  • 简介:Thephysicalmeasuresofmacroscopicseismicintensityhavebeenextensivelystudiedbasedonthenewunderstandingofseismicintensityandthenewanalyticalmethodandnewdatabaseofstronggroundmotion.Newphysicalmeasuresofseismicintensityhavebeenproposed.

  • 标签: ACCELERATION SRSS method SEISMIC INTENSITY