简介：BandTlymphocyteattenuator(BTLA),identifiedasanimmuneinhibitoryreceptorrecently,playswidespreadrolesonTandBcells.EmergingevidencehasgeneratedplentifulinformationonthemechanismswhichBTLAmediatesnegativeregulationinimmuneresponsesandinvolvesinavarietyofphysiologicalandpathologicalprocesses.TheexplorationofthebiologicalmechanismsandregulationofBTLAwillopenpossibilitiesonnoveltherapeuticstrategiesinimmune-relateddiseases.

简介：

简介：ObjectiveToinvestigatetheeffectoffamilytherapyonprognosisofpatientswithschizophrenis.Method200patientsafterdischargingfromhospitalwererandomlydividedintotwogroups:controlgroup(n=100)andexperimentgroup(n=100).Familytherapywasactualizedinpatientsofexperimentgroup.ResultsTherewassignificantdifferenceinpercentofrecurrenceratebetweencontrolgroup(38%)andexperimentgroup(18%,P<0.05).ConclusionFamilytherapymaydecreaserecurrencerateofschizophrenicafterdischargingfromhospital.

简介：Purposes:Wereportedtherolesandfunctionsofnursesinhomevisitsforbraintumorpatientsusingthefamilyhealthassessmentguideinthestudy.Methods:Onepatientofbraingliomawaschosenasthecaseillustration.Thenursesassessedthepatients’situation,theirfamiliesandlivingenvironmentindividually.Allthesefactorswereanalyzedtogether.Results:Thenursesthenimplementedtheirknowledgeandskillstoadoptdifferentmeasuresindifferentconditions,investigatedthepatients’healthproblemsandcarriedoutpersonalizedeffectiveactions.Conclusions:Nursesshouldputeffortintocommunitynursingtoallowpatientstoliveinasafeenvironment,tosatisfythehealthneedsofhumanbeingandtheirneedsforhealthknowledge,andenhancetheirself-careabilities.

简介：Waardenburgsyndromeisararediseasecharacterizedbysensorineuraldeafnessinassociationwithpigmentarydefects.Dependingonadditionalsymptoms,WShavebeenclassifiedintofourtypes.Waardenburgsyndrometype4,alsocalledasWaardenburgShahSyndromeisaveryrarecongenitaldisorderwithastoundingvariableclinicalexpression,characterizedbypigmentaryabnormalitiesofthehair(Awhiteforelockofhair,prematuregraying)andpigmentarychangesoftheirissuchasheterochromiaorhomochromiairides,sensorineuraldeafnessandHirschsprungdisease.ThreegeneshavebeenbestowedsofarinconsociationwithEDNRB,EDN3,andSOX10genes.ThepatternofinheritanceismultifariouswiththeSOX10mutationaffiliationwithautosomaldominantinheritancewhereastheEDNRBandEDN3genesarepasseddowninanautosomallyrecessivepattern.

简介：无

简介：

简介：肿瘤immunoevasion是肿瘤房间在获得能力围绕主人免疫系统并且利用protumorigenic发炎的癌症immunosurveillance的一个先进阶段。T房间免疫球蛋白粘蛋白(提姆)基因家庭成员作为调整多重有免疫力的反应阶段并且维持有免疫力的动态平衡的批评检查点蛋白质出现了。积累的证据证明肿瘤房间利用提姆基因家庭成员躲避immunosurveillance，而提姆基因家庭成员便于发炎相关的肿瘤前进的预防。因此，在肿瘤前进澄清提姆基因家庭成员的相对贡献的全面分析可以阐明在癌症病人的immunosurveillance系统。

简介：无

简介：

简介：AbstractFamily integrated care (FICare) is a collaborative model of neonatal care which aims to address the negative impacts of the neonatal intensive care unit (NICU) environment by involving parents as equal partners, minimizing separation, and supporting parent-infant closeness. FICare incorporates psychological, educational, communication, and environmental strategies to support parents to cope with the NICU environment and to prepare them to be able to emotionally, cognitively, and physically care for their infant. FICare has been associated with improved infant feeding, growth, and parent wellbeing and self-efficacy; important mediators for long-term improved infant neurodevelopmental and behavioural outcomes. FICare implementation requires multi-disciplinary commitment, staff motivation, and sufficient time for preparation and readiness for change as professionals relinquish power and control to instead develop collaborative partnerships with parents. Successful FICare implementation and culture change have been applied by neonatal teams internationally, using practical approaches suited to their local environments. Strategies such as parent and staff meetings and relational communication help to break down barriers to change by providing space for the co-creation of knowledge, the negotiation of caregiving roles and the development of trusting relationships. The COVID-19 pandemic highlighted the vulnerability within programs supporting parental presence in neonatal units and the profound impacts of parent-infant separation. New technologies and digital innovations can help to mitigate these challenges, and support renewed efforts to embed FICare philosophy and practice in neonatal care during the COVID-19 recovery and beyond.

简介：AbstractThe global spread of SARS-CoV-2 is currently continuing, and the World Health Organization has announced the risk assessment of the viruses as high. In this study, we analyzed virology features of SARS-CoV-2 causing a family cluster outbreak. Among the six family members, five have been laboratory-confirmed infection of SARS-CoV-2 viruses. A total of five SARS-CoV-2 viruses have been isolated from the nasopharyngeal swabs. The complete genome of the viruses exhibited 100% nucleotide identity with each other. Only two nucleotide differences have been observed between genomes of the isolated viruses and the HCoV/Wuhan/IVDC-HB-01/2019 strain. Therefore, SARS-CoV-2 has been confirmed as the causation of the family cluster infections.

简介：AbstractObjectives:Hearing loss is a worldwide disease. In 50% of the patients, hearing loss is caused by genetic problems associated with GJB2, MTRNR1, SLC26A4, and other genes. Considering the recent development and cost reduction of whole-exome sequencing, it is possible to filter out the normal genes and find which among the more novel genes contributed to the loss of hearing.Methods:After prescreening all individuals for GJB2, MTRNR1 and SLC26A4 mutations, whole-exome sequencing was performed in the proband, and the pathogenic variant was confirmed via Sanger sequencing.Results:The compound-heterozygous variant namely c.8076G>C:p.E2692D and c.6362T>C:p.V2121A in OTOG was identified as a candidate gene of a consanguineous Kazakh family.Conclusion:This is the first reported case of severe deafness caused by an OTOG compound-heterozygous variant in the world and the first case of deafness caused by an OTOG variant in China. This discovery identified the important contribution of OTOG toward deafness and expanded the spectrum of variants responsible for human hearing loss.

简介：Colorectalcancer(CRC)isthethirdmostcommoncancerinmenandthesecondmostcommoncancerinwomen,worldwide.Intheearlystagesofthedisease,biomarkerspredictingearlyrelapsewouldimprovesurvivalrates.Inmetastaticpatients,theuseofpredictivebiomarkerscouldpotentiallyresultinmorepersonalizedtreatmentsandbetteroutcomes.TheCXCfamilyofchemokines(CXCL1to17)aresmall(8to10kDa)secretedproteinsthatattractneutrophilsandlymphocytes.Thesechemokinessignalthroughchemokinereceptors(CXCR)1to8.Severalstudieshavereportedthatthesechemokinesandreceptorshavearoleineitherthepromotionorinhibitionofcancer,dependingontheircapacitytosuppressorstimulatetheactionoftheimmunesystem,respectively.Ingeneralterms,activationoftheCXCR1/CXCR2pathwayortheCXCR4/CXCR7pathwayisassociatedwithtumoraggressivenessandpoorprognosis;therefore,thespecificinhibitionofthesereceptorsisapossibletherapeuticstrategy.Ontheotherhand,thelesserknownCXCR3andCXCR5axesaregenerallyconsideredtobetumorsuppressorsignalingpathways,andtheirstimulationhasbeensuggestedasawaytofightcancer.Thesepathwayshavebeenstudiedintumortissues(usingimmunohistochemistryormeasuringmRNAlevels)orserum[usingenzyme-linkedimmunosorbentassay(ELISA)ormultiplexingtechniques],amongothersampletypes.CommonvariantsingenesencodingfortheCXCchemokineshavealsobeeninvestigatedaspossiblebiomarkersofthedisease.ThisreviewsummarizesthemostrecentfindingsontheroleofCXCchemokinesandtheirreceptorsinCRCanddiscussestheirpossiblevalueasprognosticorpredictivebiomarkersaswellasthepossibilityoftargetingthemasatherapeuticstrategy.

简介：

简介：biflavonoidisochamaejasmin主要在StellerachamaejasmeL的根被散布。(Thymelaeaceae)那在繁体中文药(TCM)被使用治疗肿瘤，肺结核，和干癣。此处，isochamaejasmin被发现对Bcl-2家庭蛋白质显示出类似的bioactivity到参考Bcl-2ligand(−)通过3D类似搜索的-gossypol。它有选择地跳了到Bclx有K和Mcl-1>是的i价值1.93±0.13mol·L−1和9.98±0.21mol·L−1,分别地。另外，isochamaejasmin显示出细微生长对有是的IC50价值的HL-60的禁止的活动50.40±1.21mol·L−1和中等生长对有IC50价值的K562细胞的禁止的活动是24.51±1.62mol·L−1。而且，isochamaejasmin由增加在Bcl-2-inducedapoptosis小径包含了的caspase-9，caspase-3，和PARP的劈开的蛋白质的细胞内部的表示层次导致了K562房间的apoptosis。这些结果显示isochamaejasmin由禁止Bcl-2家庭蛋白质的活动在白血病房间导致apoptosis，提供为进一步学习S的内在的反癌症机制的证据。chamaejasmeL。

简介：我们以前识别了其在胸腺的表示被减少在的称为的Rwdd1变老或氧化地强调了的新奇蛋白质老鼠。在现在的学习，我们发现在原核生物、真核细胞的房间表示的Rwdd1在SDS页胶化上显示出更慢的迁居率。另外，Rwdd1对朊酶解朊作用更敏感。而且，是包含一个RWD领域的高度酸的蛋白质，Rwdd1与Gir2分享了顺序类似的高水平，内在地未组织的蛋白质(IUP)的一个成员。这些调查结果建议Rwdd1是IUP家庭的一个新奇成员。

简介：BackgoundEssentialhypertension(EH)isapolygenicinheritabledisease,generallyknownasacombinedresultofgeneticandenvironmentalelements.ItispossiblethatIR、AngiotensinⅡ(AngⅡ)andNOplayimportantrolesinthepathogenesisofEH.MethodsSixtynormalsubjectswithafamilyhistoryofEH,aged30to40yearsold,wererecruitedandrandomizedintotwogroups:30withoneparentand30withbothparentswithEH,and30subjectswithoutfamilyhistoryofEHascontrols.TheplasmalevelofNOwasdeterminedbyelectrophotometerwhiletheplasmaleveloffastinsulin(FINS)andAngⅡweredeterminedbyradioimmuno-assay,andinsulinresistanceindex(IRI)wascalculated.Results①TheplasmalevelsofFINS,AngⅡ,NOincreasedsignificantlyinstudygroupscomparedwiththoseinthecontrolgroup(P<0.01),whiletherewerenodifferencesinthelevelsofAngII,NObetweenthetwostudygroups(P>0.05).②TheplasmalevelofAngIIwerepositivelycorrelatedwiththatofNO(r=0.378,P<0.01).ConclusionsThehigherlevelsofIRandplasmaAngIIandNOexistbeforethedevelopmentofEHinnormaloffspringwithafamilyhistoryofEH,andmaybetheyareinitialagentsinthepathogenesisofEH.ItindicatesthatthepeoplewithIRandhighlevelsofplasmaAngⅡandNOwithafamilyhistoryofEHareathigherrisktodevelopEH.

简介：AbstractBackground:Family clustering of esophageal cancer (EC) has been found in high-risk areas of China. However, the relationships between cancer family history and esophageal cancer and precancerous lesions (ECPL) have not been comprehensively reported in recent years. This study aimed to provide evidence for identification of high-risk populations.Methods:This study was conducted in five high-risk areas in China from 2017 to 2019, based on the National Cohort of Esophageal Cancer. The permanent residents aged 40 to 69 years were examined by endoscopy, and pathological examination was performed for suspicious lesions. Information on demographic characteristics, environmental factors, and cancer family history was collected. Unconditional logistic regression was applied to evaluate odds ratios between family history related factors and ECPL.Results:Among 33,008 participants, 6143 (18.61%) reported positive family history of EC. The proportion of positive family history varied significantly among high-risk areas. After adjusting for risk factors, participants with a family history of positive cancer, gastric and esophageal cancer or EC had 1.49-fold (95% confidence interval [CI]: 1.36-1.62), 1.52-fold (95% CI: 1.38-1.67), or 1.66-fold (95% CI: 1.50-1.84) higher risks of ECPL, respectively. Participants with single or multiple first-degree relatives (FDR) of positive EC history had 1.65-fold (95% CI: 1.47-1.84) or 1.93-fold (95% CI: 1.46-2.54) higher risks of ECPL. Participants with FDRs who developed EC before 35, 45, and 50 years of age had 4.05-fold (95% CI: 1.30-12.65), 2.11-fold (95% CI: 1.37-3.25), and 1.91-fold (95% CI: 1.44-2.54) higher risks of ECPL, respectively.Conclusions:Participants with positive family history of EC had significantly higher risk of ECPL. This risk increased with the number of EC positive FDRs and EC family history of early onset. Distinctive genetic risk factors of the population in high-risk areas of China require further investigation.Trial registration:ChiCTR-EOC-17010553.

简介：miRNA-183family,innormalbiology,isexpressedinaharmoniousandstablemannerintheneurosensoryorgansandcells.StudieshavealsoshownthatmiRNA-183family,indifferentpathways,affectstheneurosensorydevelopment,maintenance,survivalandfunction.Inaddition,ithaspotentialneuroprotectiveeffectsinresponsetoneurosensorydestructivestimulations.miRNA-96mutationcauseshereditarydeafnessinhumansandmice,andthereforeaffectstheinnerearactivityanditsmaintenance.CertainroleshavebeenidentifiedformiR-96inthemaintenanceandfunctionoftheinnerear.Thecomparisonofthetargetgenesoffamily-183intranscriptomesofnewbornandadulthaircellsshowsthathundredsoftargetgenesinthisfamilymayaffectdevelopmentandmaintenanceoftheears.IdentifyingthegenesthatareregulatedbymiRNA-183familyprovidesresearcherswithimportantinformationaboutthecomplexdevelopmentandenvironmentalregulationoftheinnerear,andcanoffernewapproachestothemaintenanceandregenerationofhaircellsandauditorynerve.