简介：TheNCARcommunityclimatemodelwasrunfor20yearsandthesimulatedEastAsianclimatewasanalyzedandcheckedagainsttheobservationdata.Itisfoundthatthelarge-scalefeaturesoftheEastAsiaclimateweresimulatedprettywellbythemodel,thoughtherearestillsomediscrepanciesbetweenthemodeloutputandtheobservation.Thesimulatedgeopotentialheight,windandtemperaturefieldsareveryclosetotheobservations.Thelargescalesystemssuchassubtropicalhigh.Mongoliahigh,IndianlowwhichhaveimportantinfluenceontheEastAsiamonsoonalsosimulatedprettywell.Itisalsofoundthatthemoisturefieldisnotsimulatedsowellasthosefieldsmentionedabove.Thesimulatedprecipitationisratherdifferentfromtheobservations.ThesesuggestthatsomephysicalprocessesintheCCM2needtobeimproved.

简介：AbstractBackground:Cerebral cavernous malformations (CCMs), a major neurosurgical condition, characterized by abnormally dilated intracranial capillaries, result in increased susceptibility to stroke. KRIT1 (CCM1), MGC4607 (CCM2), and PDCD10 (CCM3) have been identified as causes of CCMs in which at least one of them is disrupted in most familial cases. Our goal is to identify potential biomarkers and genetic modifiers of CCMs, using a global comparative omics approach across several in vitro studies and multiple in vivo animal models. We hypothesize that through analysis of the CSC utilizing various omics, we can identify potential biomarkers and genetic modifiers, by systemically evaluating effectors and binding partners of the CSC as well as second layer interactors.Methods:We utilize a comparative omics approach analyzing multiple CCMs deficient animal models across nine independent studies at the genomic, transcriptomic, and proteomic levels to dissect alterations in various signaling cascades.Results:Our analysis revealed a large set of genes that were validated across multiple independent studies, suggesting an important role for these identified genes in CCM pathogenesis.Conclusion:This is currently one of the largest comparative omics analysis of CCM deficiencies across multiple models, allowing us to investigate global alterations among multiple signaling cascades involved in both angiogenic and non-angiogenic events and to also identify potential biomarker candidates of CCMs, which can be used for new therapeutic strategies.

简介：摘要目的报道一家族性多发脑海绵状血管瘤(CCM)家系中CCM1基因新发突变情况。方法长期跟踪观察于哈尔滨医科大学附属第一医院神经外科确诊的一家族性多发CCM家系，并对家系中部分患者、健康成员的血液和(或)病理组织基因组DNA进行全外显子测序及生物信息学分析以筛选出该家系可能的致病基因，然后对致病基因进行Sanger测序验证及其蛋白产物三维结构预测。结果全外显子测序显示，患者均存在一种CCM1基因缺失-移码突变(c.1635delA)，该突变导致参考碱基"T"的缺失且该突变目前尚未被报道，而健康成员未存在上述突变。Sanger测序验证显示，CCM1基因第15号外显子1635处碱基"A"缺失，引起CCM1基因阅读框架改变，导致1652~1654位的核苷酸提前出现终止密码子TAG。蛋白产物三维结构预测显示该新发突变可能导致KRIT1蛋白功能区(C-末端)的Ferm-3结构域部分缺失。结论一种CCM1基因新发缺失-移码突变(c.1635delA)致使该家系中家族性多发CCM的发生。

简介：TheWannianchangNeighbor-hoodCommunityintheChenghuaDistrict,ChengduCityinSichuanProvince,coversanareaofabout5.2squareki-lometersandhasapopulationofabout58,000.

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简介：Bothintheirmid-70s,ShanBaoruiandhiswifearenowlivingatamodelhomefortheagedinnorthChina.Thecouplelivesinasingleroomwithheatinginwinterandanindoortoilet.Outsideisagarden-likecompoundwithowerscolorfullybrightintherefreshingbreeze.

简介：这篇论文以一个社区是最小的在下面条件在复杂网络研究讨论一个流行社区定义，也就是说，社区不能被分成几个更小的社区或裂口并且与另外的网络元素重新组织进新社区。结果提供为社区鉴定的量的措施的进一步的优化计算能在上被认识到的一个底。

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简介：为改善冷却风扇的气动性能,提升整车冷却系统的散热能力,对比分析外插入式、内插入式、迷宫槽式3种导风罩结构形式对环形风扇气动性能的影响,建立相关导风罩CFD计算模型,结合某型牵引车整车模型,对比分析了3种导风罩下,流经散热器的空气流量,根据一维仿真计算数据,对发动机冷却系统的冷却能力进行评估。结果表明：导风罩与风扇的径向间隙、导风罩圆柱区域的长度、导风罩的安装形式对风扇的气动性能均有一定的影响。

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简介：<正>Thehistoryofhuman’ssocialdevelopmentindicatesthattheprogressanddevelopmentofasocietyistheresultofthecollaborativeroleofscienceandtechnologyadvancementandhumanesocietyprogress.”Humanslivenotonly

简介：Thispaperstudiesasimpleasymmetricallyevolvedcommunitynetworkwithacombinationofpreferentialattachmentandrandomproperties.Animportantissueaboutcommunitynetworksistodiscoverthedifferentutilityincrementsoftwonodes,wheretheutilityisintroducedtoinvestigatetheasymmetricaleffectofconnectingtwonodes.Ontheotherhand,theconnectionoftwonodesincommunitynetworkscanbeclassifiedastwonodesbelongingtothesameortodifferentcommunities.Thesimulationresultsshowthatthemodelcanreproduceapower-lawutilitydistributionP(u)～uσ,σ=2+1p,whichcanbeobtainedbyusingmean-fieldapproximationmethods.Furthermore,themodelexhibitsexponentialbehaviourwithrespecttosmallvaluesofaparameterdenotingtherandomeffectinourmodelatthelow-utilityregionandapower-lawfeaturewithrespecttobigvaluesofthisparameteratthehigh-utilityregion,whichisingoodagreementwiththeoreticalanalysis.Thiskindofcommunitynetworkcanreproduceauniqueutilitydistributionbytheoreticalandnumericalanalysis.

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简介：在网络的社区察觉在最后十年广泛地被学习了。许多标准，表示分区的质量获得，以及一些准确算法和很多启发规则被建议了。吝啬标准在最小化增加或从给定的网络搬迁了以便把它转变成一套disjoint派系的边的数字在于。最近，张，丘和张建议了一个重量系数在被介绍平衡插入并且删除的边的数字的一个加权的吝啬模型。这些作者建议规则选择系数的好值，使用模仿了退火发现最佳或在最佳附近的解决方案并且解决一系列真实、人工的例子。在现在的纸，一个算法为确切为参数的所有价值解决加权的吝啬问题被建议。这个算法反复地基于用一个排产生算法为参数的一套给定的价值解决这个问题。这个过程与一个搜索过程被相结合发现值曲线的所有最低断点即，插入并且删除的边的加权的和。从文学的一系列人工、真实的世界网络上的计算结果被报导。看来，为一样的几个分区联网可能增进知识并且解决方案的集合通常包含至少一个直觉地呼吁的分区。