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简介：Phasecontrastimagingtechniquehasbeenimprovedpromptlyinrecentyears.Amongthesetechniquesin-linephase-contrastimagingiswidelyused.Variousalgorithmsforin-linephaseretrievalhavebeenproposedsofarsuchasTIE(transportofintensityequation),CTF(contrasttransferfunction),firstborn-approximations,GSF(Gerchberg-Saxton-Fienup),etc.Bronnikov'salgorithm(BA)isatypeoflinearalgorithmthatissimpleandefficient.Butitcanonlybeusedwithoutabsorptionsituations.Inthispaper,animprovedalgorithmbasedonBAwaspresented.TheapproachaddsΔφ(x,y)tothephasemapφ_b(x,y)retrievedbyBAtomakethereconstructedphasemapmoreprecise.Further,theapproachwasevaluatedonsimulatedimagesandconfirmedtobeaccurateathigherabsorptionrates.

简介：AnewmethodofphasespectralanalysisofEEGisproposedforthecomparativeanalysisofphasespectrabetweennormalEEGandepilepticEEGsignalsbasedonthewaveletdecompositiontechnique.Byusingmultiscalewaveletdecomposition,theoriginalEEGsaremappedtoanorthogonalwaveletspace,suchthatthevariationsofphasecanbeobservedatmultiscale.Itisfoundthatthephase(andphasedifference)spectraofnormalEEGsaredistinctfromthatofepilepticEEGs.Thatisthevariationsofphase(andphasedifference)ofnormalEEGshaveadistinctperiodicpatternwiththeelectricalactivityproceedsinthebrain,butdonottheepilepticEEGs.ForepilepticEEGs,onlyatthosetransientpoints,thephasevariationsareobvious.Inordertoverifytheseresultswiththeobservationaldata,thephasevariationsofEEGsinprincipalcomponentspaceareobservedandfoundthat,thefeaturesofphasespectraisincorrespondencewiththatthewaveletspace.TheseresultsmakeitpossibletoviewthebehaviorofEEGrhythmsasadynamicspectrum.

简介：AbstractIntroduction:Eruptive cutaneous collagenoma is non familial connective tissue nevi of unknown etiology presented with an abrupt onset. To date, the literatures on eruptive cutaneous collagenoma are extremely rare in china.Here, we report two women with eruptive cutaneous collagenoma.Case present:Two women presented with multiple asymptomatic, skin-colored papules and nodules on the trunk and extremities with no systemic involvement. Histopathology revealed dense, coarse collagen fibers by hematoxylin-esoin stain and decreased, fragmented elastic fibers by Elastic stain compared with the normal skin. Basing on these findings, the diagnosis of eruptive cutaneous collagenoma was made. No specific treatment was given.Discussion:Eruptive cutaneous collagenoma is a very rare dermatosis that is often misdiagnosed as other connective tissue nevi. The pathogenesis is unclear, and also no efficient treatment is available. It is usually diagnosed based on clinical and histopathological findings.Conclusion:The present cases are relatively rare type of eruptive cutaneous collagenoma that provide more experience for clinician, and may be helpful for them to make correct diagnosis for suspicious cases.

简介：2CasesofMediterraneanspottedfeverinFrancewerereportedinthispaper.Bothhadtraveledintheendemicareasbeforeonset.Theirclinicalmanifestationsincludedfever,headache,myalgia,eruptionandblackeschar.SerologictestssuchasWeil-Felixreaction,Indirectimmunoflurescenceandcomplementfixationconfirmedthediagnosis.Thepatientsrecoveredwithoutcomplicationsandweredischargedfromhospitalaftereffectivetreatment.Simultaneously,theepidemiology,clinicaldiagnosis,treatmentandpreventionofthediseasewerereviewedandthepossibilityofthediseasebeingintroducedintothisterritorywasdiscussed.Theauthorheldthatattentionshouldbepaidtotheprophylaxisandtreatmentofthediseaseintheinternationaltravelhealthcare.

简介：Theetiologyofneurodegenerativediseasesisdiverse,howevermostofthemsharecommoncharacteristics:accumulationofmisfoldedproteins,chronicandsustainedneuroinflammation,andthedysfunctionanddeathofcertainpopulationsofneurons.ThebrainofAlzheimer’sdisease(AD)patientspresents

简介：关键词针灸治疗-头疼-症候群区别处理-医药记录鍏抽敭璇？?堝埡鐤楁硶-澶寸棝-杈ㄨ瘉璁烘不-鐥呮CLC数字R246.1作者：黄蔷(1979鈥?，女性，居民，药的主人

简介：A28YEAR-OLDmalepatientpresentedatthedepartmentofgenitourinarymedicineonAugust14,2000withgenitalpapules,generalizederythematousmacules,andscalesofmorethan2months'duration.Twomonthsearlier,thepatienthadpresentedatthelocalhospitalwiththreesitesoferythematousmacularpapulesontheglanspenis,ofnoclearcause.Atthattime,guttateerythematousmaculeswithscalesalsoappearedonthewholebodywithseverepruritus.Hewasdiagnosedwithpsoriasisvulgaris,wasadministeredcapsulesofretinoicacid,andtreatedfortwomonths.However,whenthelesionsandprurituswerenotrelieved,hepresentedatourclinic.

简介：Heartratevariaty(HRV)of85caseswithAMIwasobservedintheearlyphaseafteronsetandrehabilitationphaseatfirstmonthandsixthmonth,andwascontrastedwithsixtimethresholdindicesof111caseswithcoronaryheartdiseaseandthatof35normalcontrol.WefoundtheHRVofAMIwasapperantlylowerintheacutephasethanthatofcoronaryheartdiseaseandnormalcontrols.HRVrecoveredgraduallywithincliningtobestableafterhalfayear,butitwasstilllowerthanthatofcontrols.LowHRVinearlyphaseofAMIsuggestedthepoorprognosis.

简介：AIMTocomparevonoprazan10and20mgvslansoprazole15mgasmaintenancetherapyinhealederosiveesophagitis(EE).METHODSAtotalof607patientsaged≥20years,withendoscopically-confirmedhealedEEfollowing8wkoftreatmentwithvonoprazan20mgoncedaily,wererandomized1:1:1toreceivelansoprazole15mg(n=201),vonoprazan10mg(n=202),orvonoprazan20mg(n=204),oncedaily.Theprimaryendpointofthestudywastherateofendoscopically-confirmedEErecurrenceduringa24-wkmaintenanceperiod.ThesecondaryendpointwastheEErecurrencerateatWeek12duringmaintenancetreatment.Additionalefficacyendpointsincludedtheincidenceofheartburnandacidreflux,andtheEEhealingrate4wkaftertheinitiationofmaintenancetreatment.Safetyendpointscomprisedadverseevents(AEs),vitalsigns,electrocardiogramfindings,clinicallaboratoryresults,serumgastrinandpepsinogenⅠ/Ⅱlevels,andgastricmucosahistopathologyresults.RESULTSRatesofEErecurrenceduringthe24-wkmaintenanceperiodwere16.8%,5.1%,and2.0%withlansoprazole15mg,vonoprazan10mg,andvonoprazan20mg,respectively.Vonoprazanwasshowntobenon-inferiortolansoprazole15mg(P<0.0001forbothdoses).Inapost-hocanalysis,EErecurrenceatWeek24wassignificantlyreducedwithvonoprazanatboththe10mgandthe20mgdosevslansoprazole15mg(5.1%vs16.8%,P=0.0002,and2.0%vs16.8%,P<0.0001,respectively);bycontrast,theEErecurrenceratedidnotdiffersignificantlybetweenthetwodosesofvonoprazan(P=0.1090).Thesafetyprofilesofvonoprazan10and20mgweresimilartothatoflansoprazole15mginpatientswithhealedEE.Treatment-relatedAEswerereportedin11.4%,10.4%,and10.3%ofpatientsinthelansoprazole15mg,vonoprazan10mg,andvonoprazan20mgarms,respectively.CONCLUSIONOurfindingsconfirmthenon-inferiorityofvonoprazan10and20mgtolansoprazole15mgasmaintenancetherapyforpatientswithhealedEE.

简介：AbstractIntroduction:Lichen planus pigmentosus inversus (LPPI) is a rare a rare variant of lichen planus characterized by hyperpigmented patches with predominating localization in intertriginous areas. Due to its rarity, only a few LPPI cases are reported. We herein describe two rare cases of LPPI.Case presentation:The two patients were all with a brownish macular lesion on the intertriginous area. A diagnosis of LPPI was made based on their clinical manifestations, dermoscopic features, and histopathologic features, which revealed an interface change, lichenoid infiltration, and pigmentary incontinence.Discussion:LPPI is pruritic or asymptomatic, hyperpigmented macules and patches on the flexural folds. The axillae and flanks were the most commonly affected areas, followed by the groin and genitalia. About half of the female patients had inframammary fold lesions. LPPI shows higher female predominance than Lichen planus pigmentosus. There were fewer cases that lasted more than 3 years compared to LPP.Conclusion:LPPI is a rare variant of lichen planus, with a locational characteristic and female predominance. Therefore, in the case of a pigmented disease occurring in the flexural folds, it should be placed in the differential diagnosis.

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简介：Reiter'ssyndromeisasecondarydiseaseofurethrainfection.Itconsistsofurethritis,nonsuppurativearthritis,conjunctivitisandcutaneousmucosalesions.YoungmalesaremorelikelytogetReiter'ssyndromethanfemales.Thusfar,therearenoreportsofwomeninChinawithReiter'sSyndrome.ThisreportdocumentstwofemaleswithReiter'sSyndrome.

简介：从血盆草的水提取物的正丁醇部分分离得到两个微量酚甙，根据理化常数及波谱分析鉴定为异槲皮甙和紫云英甙。这两个化合物均为首次从该植物中分得。

简介：ThepresentstudywasdesignedtoinvestigatethechemicalconstituentsoftherootsofCudraniafruticosaWight.Compoundswereisolatedbyvariouscolumnchromatographicmethodsincludingsilicagel,polyamide,sephadexLH-20,andsemi-preparativeHPLC.Theirstructureswereelucidatedbyacombinationof1Dand2DNMRtechniques,massspectrometry,andchemicalmethods.Twonewxanthones,CudraxanthoneTandU(1-2),alongwithfourknowncompounds(3-6)wereisolatedfromtherootsofCudraniafruticosaWight.

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简介：用小浪分解和嵌入的阶段空间，脑电图(EEG)的阶段轨道被描述。它基于现在的工作被说明，也就是说，EEG的小浪分解是实质上，EEG混乱引起注意的人的设计由小浪过滤器向量通向小浪空间，它在与一样的EEG嵌入的阶段空间的通讯。换句话说，嵌入的小浪分解和阶段空间在方法论是相等的。我们的试验性的结果证明在小浪空间和嵌入的空间，EEG的阶段轨道的结构类似于对方。这些结果证明那小浪分解在描绘EEG时间系列上是有效的。

简介：AbstractBackground:As reported by the World Health Organization, a novel coronavirus (2019-nCoV) was identified as the causative virus of Wuhan pneumonia of unknown etiology by Chinese authorities on 7 January, 2020. The virus was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by International Committee on Taxonomy of Viruses on 11 February, 2020. This study aimed to develop a mathematical model for calculating the transmissibility of the virus.Methods:In this study, we developed a Bats-Hosts-Reservoir-People transmission network model for simulating the potential transmission from the infection source (probably be bats) to the human infection. Since the Bats-Hosts-Reservoir network was hard to explore clearly and public concerns were focusing on the transmission from Huanan Seafood Wholesale Market (reservoir) to people, we simplified the model as Reservoir-People (RP) transmission network model. The next generation matrix approach was adopted to calculate the basic reproduction number (R0) from the RP model to assess the transmissibility of the SARS-CoV-2.Results:The value of R0 was estimated of 2.30 from reservoir to person and 3.58 from person to person which means that the expected number of secondary infections that result from introducing a single infected individual into an otherwise susceptible population was 3.58.Conclusions:Our model showed that the transmissibility of SARS-CoV-2 was higher than the Middle East respiratory syndrome in the Middle East countries, similar to severe acute respiratory syndrome, but lower than MERS in the Republic of Korea.

简介：BackgroundStatinsreduceadversecardiovascularoutcomesandslowtheprogressionofcoronaryatherosclerosisinproportiontotheirabilitytoreducelow-densitylipoprotein(LDL)cholesterol.However,fewstudieshaveeitherassessedtheabilityofintensivestatintreatmentstoachievediseaseregressionorcomparedalternativeapproachestomaximalstatinadministration.MethodsWeperformedserialintravascularultrasonographyin1039patientswithcoronarydisease,atbaselineandafter104weeksoftreatmentwitheitheratorvastatin,80mgdaily,orrosuvastatin,40mgdaily,tocomparetheeffectofthesetwointensivestatinregimensontheprogressionofcoronaryatherosclerosis,aswellastoassesstheirsafetyandside-effectprofiles.ResultsAfter104weeksoftherapy,therosuvastatingrouphadlowerlevelsofLDLcholesterolthantheatorvastatingroup(62.6vs.70.2mgperdeciliter[1.62vs.1.82mmolperliter],P<0.001),andhigherlevelsofhigh-densitylipoprotein(HDL)cholesterol(50.4vs.48.6mgperdeciliter[1.30vs.1.26mmolperliter],P=0.01).Theprimaryefficacyendpoint,percentatheromavolume(PAV),decreasedby0.99%(95%confidenceinterval[CI],1.19to-0.63)withatorvastatinandby1.22%(95%CI,-1.52to-0.90)withrosuvastatin(P=0.17).Theeffectonthesecondaryefficacyendpoint,normalizedtotalatheromavolume(TAV),wasmorefavorablewithrosuvastatinthanwithatorvastatin:-6.39mm3(95%CI,-7.52to-5.12),ascomparedwith?4.42mm3(95%CI,-5.98to-3.26)(P=0.01).Bothagentsinducedregressioninthemajorityofpatients:63.2%withatorvastatinand68.5%withrosuvastatinforPAV(P=0.07)and64.7%and71.3%,respectively,forTAV(P=0.02).Bothagentshadacceptableside-effectprofiles,withalowincidenceoflaboratoryabnor-malitiesandcardiovascularevents.ConclusionsMaximaldosesofrosuvastatinandatorvastatinresultedinsignificantregressionofcoronaryatherosclerosis.DespitethelowerlevelofLDLcholesterolandthehi