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简介：Developinganewjournalisnotaneasytask.Icanthinkoffourgoodreasons,andthereareprobablymore.Thesereasonsareasfollows:1.Potentialauthorsmaybereluctanttosendmanuscriptstoanunknown"newjournal."2.Potentialauthorsmaybeconcernedaboutthelackofan"impactfactor."3.Potentialauthorsmayhaveconcernsaboutreadershipoftheauthors'work.4.Potentialreviewersmaybereluctanttoreviewmanuscriptssenttoanewjournalbecausemosthavemultiplemanuscriptstoreviewsenttothemfromknownjournals.

简介：Thedendriticcellsystemcontainsconventionaldendriticcells(DCs)andplasmacytoidpre-dendriticcells(pDCs).BothDCsandpDCsarebonemarrowderivedcells.AlthoughthecommonfunctionsofDCsareantigen-processingandT-lymphocyteactivation,theydifferinsurfacemarkers,migratorypatterns,andcytokineoutput.ThesedifferencescandeterminethefateoftheTcellstheyactivate.SeveralsubsetsofmatureDCshavebeendescribedinbothmouseandhumanandthedevelopmentalprocessesofthesespecializedDCsubsetshavebeenstudiedextensively.TheoriginalconceptthatallDCswereofmyeloidoriginwasquestionedbyseveralrecentstudies,whichdemonstratedthatinadditiontotheDCsderivedfrommyeloidprecursors,someDCscouldalsobeefficientlygeneratedfromlymphoid-restrictedprecursors.Moreover,ithasbeenshownrecentlythatbothconventionalDCsandpDCscanbegeneratedbytheFlt3expressinghemopoieticprogenitorsregardlessoftheirmyeloid-orlymphoid-origin.ThesefindingssuggestanearlydevelopmentalflexibilityofprecursorsforDCsandpDCs.ThisreviewsummarizessomerecentobservationsonthedevelopmentofDCsysteminbothhumanandmouse.

简介：Severalriskfactors,whichincludeheredity,ultra-violet(UV)lightandchronicinflammation,contributetopterygiumdevelopment.However,thereisnoreportintegratingthesefactorsinthepathogenesisofpterygium.Theaimofthisreviewistodescribetheconnectionbetweenheredity,UV,andinflammationinpterygiumdevelopment.ExistingreportsindicatethatsunlightexposureisthemainfactorinpterygiumoccurrencebyinducinggrowthfactorproductionorchronicinflammationorDNAdamage.Hereditymaybeafactor.Ourstudiesonfactorsinpterygiumoccurrenceandrecurrenceidentifythatheredityiscrucialforpterygiumtodevelop,andthatsunlightisonlyatrigger,andthatchronicinflammationpromotespterygiumenlargement.WeproposethatgeneticfactorsmayinterferewiththecontroloffibrovascularproliferationwhileUVlightor(sunlight)mostlikelyonlytriggerspterygiumdevelopmentbyinducinggrowthfactorswhichpromotevibrantfibrovascularproliferationinpredisposedindividuals.Italsojusttriggersinflammationandcollagenolysis,whichmaybepromotersoftheenlargementofthefibrovascularmass.Pterygiumprobablyoccursinthepresenceofexuberantcollagenproductionandprofuseneovascularisation.

简介：Drugdevelopmentinoncologyisundergoingasubstantialshiftnowadays.Thedriversforthisaremulti-factorial.Ontheoneside,drugdevelopmentisperformedmorerationallythanever,profitingfromthescientificadvancesinmolecularbiologyingeneralandtheelucidationofthevarious'omes'fromgenometometabolomeinparticular.Ontheotherside,itisbasedonenormoustechnologicalprogress,e.g.,inthefieldofgenome

简介：肝疾病包含许多肝条件，包括肝失败，肝肝硬化和尖锐、长期的肝炎的一个系列，例如酒鬼，丰满，药，病毒、长期的肝炎。肝损害是在肝疾病的一个主要原因的因素；通常，这些因素包括直接的肝损坏和调停免疫者的肝损害。Neutrophils(也作为neutrophilicgranulocytes或polymorphonuclear白血球(PMN)知道)是在人的最丰富的传播的白血房间类型，并且PMN是一个主要天生的有免疫力的房间子集。到微脉管系统的neutrophils的不恰当的激活和homing贡献肝疾病的许多类型的病理学的表明。这评论总结基于临床的电流和动物模型研究的嗜中性调停肝损害的新奇概念。

简介：1ThebackgroundofthedevelopmentofInternationalTravelMedicineinChina1.1Thenumberofexitpersonsin1993is93000000,duetotheexpansionofopenesstotheoutside,internationaltravelandthedevelopmentofforeigntrade.1.2Fitforthedevelopmentofthesocialistmarketeconomyandmeettheneedsofdaily—risinginternationaltravelhealthcareatdifferentlevels.

简介：Glioblastoma(GBM)isatypeoftumorthatishighlylethaldespitemaximaltherapy.Standardtherapeuticapproachesprovidemodestimprovementinprogression-freeandoverallsurvival,necessitatingtheinvestigationofnoveltherapies.Oncologictherapyhasrecentlyexperiencedarapidevolutiontoward'targetedtherapy',withdrugsdirectedagainstspecifictargetswhichplayessentialrolesintheproliferation,survival,andinvasivenessofGBMcells,includingnumerousmoleculesinvolvedinsignaltransductionpathways.Inhibitorsofthesemoleculeshavealreadyenteredorareundergoingclinicaltrials.However,significantchallengesintheirdevelopmentremainbecauseseveralpreclinicalandclinicalstudiespresentconflictingresults.Inthisarticle,wewillprovideanup-to-datereviewofthecurrenttargetedtherapiesinGBM.

简介：AbstractAs an emerging field, telesurgery robotic system is changing the traditional medical mode and can delivery remote surgical treatment anywhere in the world. Advances in telesurgery robotic technology achieve the remote control beyond the current limitation of distance and special medical environment. This review introduces the development history, the current status and the potential in future of the telesurgery robotic system. In addition, it presents the construction of control platform and the application, especially in trauma treatment, as well as the challenge in clinic.

简介：Thetechniqueofcomputersimulationsisaveryefficientmethodininvestigatingmechanismsofmanydiseases.Thispaperreviewshowthesimulationsofthehumanheartstartedasasimplemathematicalmodelsinthepastanddevelopedtothepointwheregeneticinformationisneededtodosuitableworklikefindingoutnewmedicamentsagainstheartdiseases.AlsotheInfluenceofthedevelopmentofcomputerperformanceinthefutureaswellasthedatapresentationisdescribed.

简介：Theoccurrenceanddevelopmentofmicrosurgicaltechniqueisoneofthemostwonderfulmedicalachievementsinthetwentiethcentury.Byassistanceofopticsystem,ithassuccessfullymadesurgeryfrommacroscopicfieldintomicrocosmicworldandevidentlybroadenedtheappliedscopeofsurgicaltechnique.Themicrosurgicaltechniquehasalsomadesurgerymoreaccurate.Nowithasbeenusedmostwidelyinthereparativeandreconstructivesurgeryandalmostleavesnothingtobedesiredinsmallvascularanastomosis.Microsurgeryhasgreatlyextendedthescopeanddepthofthereparativeandreconstructivesurgeryandmademanyaccurateoperationswhichwereneverproceededtocometruebefore.Manynewsubjectsthereforehavebeenformedforthisreason.

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简介：AbstractCilia are microtubule-based filamentous organelles that play a vital role in embryogenesis. Multiple signal transduction pathways are orchestrated by cilia, such as Hedgehog and planar cell polarity signals. Various studies, spanning over last 2 decades, have emphasized the role of cilia-mediated signaling cascades in regulating neural tube patterning and development. Moreover, the deficiency of certain ciliary genes have been reported to cause neural tube defects (NTDs), which are a set of disorders that occur due to perturbation of normal neural tube closure. However, the mechanisms underlying cilia dysfunction resulting NTDs remain unclear. Recent studies have highlighted the association of phosphoinositide signaling with cilia, thereby conferring novel insights into the function of cilia during neural tube development. Here, we have reviewed recent studies on cilia, focusing on the molecular mechanism underlying the involvement of cilia in neural tube development and the role of ciliary disruption in the development of NTDs.

简介：AbstractServing as the interface between the fetal and maternal environments during gestation, the placenta plays critical roles in the protection of the developing fetus and the maintenance of maternal health. The placenta is primarily derived from the embryonic trophectoderm which differentiates into various subtypes of trophoblast cells through villous and extravillous pathways. The interactions among trophoblasts and multiple decidual cells and immune cells at the maternal-fetal interface fundamentally form the functional units of the placenta, which are responsible for blood perfusion and maternal-fetal material exchange, immune tolerance, and the regulation of pregnancy adaptation. Defects in placental development and functional maintenance are in tight association with adverse pregnancy outcomes such as preeclampsia. In this article, we review recent advances on human trophoblast cell differentiation and the construction of placental functional units and discuss the placental and maternal factors that may contribute to the occurrence of preeclampsia.

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简介：Developmentofsensorneedlesforchinesetraditionalmedicineisalongtermre-searchprojectinouruniversity.Now,temperature.PH,PO2andpotentialsensorneedleshavebeendeveloped.Thesenewelementsarederivedfromthecombinationbetweenasensorandanac-tuator.Thedesignprinciple,functionalmaterials,fabricationtechnic,calibrationmethodandclin-icalapplicationoftheseneedlesarereportedinthispaper.

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简介：Inthepresentpaper,theauthorsreviewrecentdevelopmentofclinicaltreatmentofconstipationwithacupunctureandmoxibustionfrom①bodyacupuncturetherapyincludingspecialneedlingmanipulations,asZiwuDaojiuNeedling,etc.andacupointcombination,②electroacupuncturetherapy,③scalp-acupuncturetherapy,④auricularacupuncturetherapy,⑤needle-embeddingandacupoint-catgut-embeddingtherapies,⑥acupoint-applicationtherapy,⑦combinedacupunctureandmedicationtherapy,⑧othertherapiessuchascuppingtherapyandholo-therapy,and⑨considerationsabouttheactionofacupunctureinthetreatmentofconstipationanditsprospect.Uptonow,researchesontheeffectofacupunctureintreatingconstipationareseldomseen,thus,muchattentionshouldbepaidaboutthisbyclinicalandexperimentalresearchers.

简介：Introduction,ThemembersoftheCardiovascularDivisionattheUniversityofFlorida,DepartmentofMedicinehavelongrecognizedtheneedforcardiacrehabilitationofourpatients.PriortoJuly2016,arehabilitationprogramforcardiovascularpatientsattheUniversityofFloridadidnotexist.InJuly2016weinitiatedatotalpatientrehabilitationprogramforallcardiacpatients,whethertheirdiseasewasrelatedtomyocardialischemia,myocardialinfarction,arrhythmia,orheartfailure.Whenbeginningsuchaprogramthereareseveraltopicsthatmustbeconsidered.Theseincludespaceforpatientsandequipment,aswellaspersonneltostafftheprogram.Initially,personnelshouldincludeaphysiologist,anurseandaphysician.

简介：WorldFederationofAcupuncture-MoxibustionSocieties(WFAS),establishedinChinain1987,isthefirstnon-governmentalinternationalacademicunionwithitsheadquartersinBeijing,andalsotheinternationalnon-governmentalorganizationadmittedintoofficialrelationswith