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简介:AbstractBackground:TheNnewlyreportedcasesofcongenitalsyphilishavebeenincreasedingsubstantiallyoverthepastfewyears.Tocontroltheepidemic,amunicipalprogramaimedatpreventingmother-to-childtransmissionofsyphiliswasintroducedinJuly,2001,whichwasdesignedaimedtoscreenallpregnantwomenforsyphilisattheirfirstvisittoantenatalclinicsoratadmissiontohospitalsinShenzhen.Objectives:TheaimofthestudyistTodeterminetheprevalenceofsyphilisamongwomenattendingantenatalclinicsandothermedicalinstitutionsinShenzhenandidentifiesitspatternsofinfection.Methods:Upongivinginformedconsent,wWomenwhoattendedantenatalcarecentersinShenzhenfromJanuarytoDecember2003wereincludedinthisstudysubjecttoobtaininginformedconsent.AbloodsamplewasharvestedforsyphilisscreenedforsyphUisingbyusingrapidplasmareagenttest(RPR)andconfirmedbyTPHAforthosewhowereRPRpositive.Thewomenwithpregnantsyphilispositiveserologyweresystematicallyinterviewedtoobtain.Duringtheinterview,theirdemographicdetailsinformation,patternsofriskbehaviorsandotherdata.Datawerecollectedandwereanalyzedretrospectively.Results:AmongOf118,235pregnantwomensurveyed,555pregnantwomenwereconfirmedtohavesyphilis(prevalenceof4.69%),withaincidenceof4.69‰123womenwereexcludedfromtheanalysisbecauseofincompletemedicalrecords.Of432infectedsubjectswithcompletemedicalrecords,theaverageagewas26.8,witharangeof19to41.7.41%(32/432)ofthemsufferedfromprimarysyphilis,3.24%(14/432)wereofhadsecondarysyphilis,and89.35%(386/432)hadlatentsyphilis,withoutanyconspicuousclinicalsignsandsymptoms.Conclusions:Theprevalenceofsyphilisamongthepregnantwomeninourserieswashighandmostofthemwereasymptomatic.ScreeningforsyphilisamongpregnantwomeninShenzhenisofimportantceforthepreventionofmother-to-childtransmissionofsyphilis.
简介:Objective:Tostudythecellularimmunitystatusofpatientswithrecurrentgenitalherpes.Methods:Serumlevelsofinterlukin-2anditssolublereceptorandinterlukin-6weremeasuredbyELISAin34patientswithrecurrentgenitalherpes.Results:SerumlevelsofIL-2andIL-6weresignificantlydecreasedinpatientscomparedtohealthycontrols(P<0.01),andthelevelofsIL-2Rwassignificantlyincreasedinpatientswithrecurrentgenitalherpes(P<0.01).Therewerenosignificantdifferencesinallvariablesamongstpatientsregardingrelapsestageandremissionstage(P>0.05).Conclusion:Therewasacellularimmunedeficiencyinpatientswithrecurrentgenitalherpes.
简介:Objectiwe:InordertodetecttheroleofmonocytesinHSV-2infection,westudiedtheeffectofherpessim-plexVirus-2infectionontheproductionoftumorne-crosisfactor(TNF-α),interleukin-6(IL-6)secretedbymonocytes.Methods:MonocyteswereinfectedbyHSV-2(333Strain).Culturesupernatantswerecollectedat1,3,5,7dayspost-infection.ThelevelsofTNF-α,IL-6weremeasuredbyenzyme-linkedimmunosorbentas-say(ELISA).Results:ThelevelsofTNF-αsecretionbymono-cytessignificantlydecreasedonfirstdaypost-infection.ThelevelsofIL-6significantlydecreasedonfirstandthirddayspost-infection,andthengradu-allyincreasedtothecontrolonseventhdaypost-infection.Conclusions:TNF-αandIL-6productionbymono-cyteswasinhibitedduringHSV-2infection.Thepro-ductionofcytokinesmayplayanimportantroleinherpessimplexviurs-2pathogenicityandimmunity.
简介:目的探讨IL-17和IL-6在白癜风患者外周血中的变化及临床意义。方法酶联免疫吸附试验法检测60例白癜风患者和30例正常对照者外周血中IL-17和IL-6的表达水平。结果(1)寻常型白癜风患者组外周血中IL-17和IL-6水平均显著高于对照组(P〈0.01)。(2)节段型白癜风患者组外周血中IL-17和IL-6水平与正常对照组相比差异无统计学意义(P〉0.05)。(3)寻常型白癜风患者组中,进展期患者外周血IL-17水平显著高于稳定期患者(P〈0.01)。结论IL-17和IL-6可能在白癜风的发病机制中发挥重要作用;IL-17与寻常型白癜风的活动性有关。